{"id":"https://openalex.org/W3176973685","doi":"https://doi.org/10.1186/s12931-021-01881-y","title":"FERMT3 mediates cigarette smoke-induced epithelial\u2013mesenchymal transition through Wnt/\u03b2-catenin signaling","display_name":"FERMT3 mediates cigarette smoke-induced epithelial\u2013mesenchymal transition through Wnt/\u03b2-catenin signaling","publication_year":2021,"publication_date":"2021-11-06","ids":{"openalex":"https://openalex.org/W3176973685","doi":"https://doi.org/10.1186/s12931-021-01881-y","mag":"3176973685","pmid":"https://pubmed.ncbi.nlm.nih.gov/34742298","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8571878"},"language":"en","primary_location":{"id":"doi:10.1186/s12931-021-01881-y","doi":"https://doi.org/10.1186/s12931-021-01881-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-021-01881-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12931-021-01881-y.pdf","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12931-021-01881-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030979598","display_name":"Xiaoshan Su","orcid":"https://orcid.org/0000-0002-1433-1041","observed_orcids":["https://orcid.org/0000-0002-1433-1041"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoshan Su","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365539","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-1493-2189","observed_orcids":["https://orcid.org/0000-0002-1493-2189"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjie Chen","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017081556","display_name":"Xiaoping Lin","orcid":"https://orcid.org/0000-0002-8785-0694","observed_orcids":["https://orcid.org/0000-0002-8785-0694","https://orcid.org/0009-0005-1078-793X"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Lin","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100463021","display_name":"Xiaoyang Chen","orcid":"https://orcid.org/0000-0002-7356-8129","observed_orcids":["https://orcid.org/0000-0002-7356-8129"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyang Chen","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004446271","display_name":"Zhixing Zhu","orcid":"https://orcid.org/0000-0002-5991-3264","observed_orcids":["https://orcid.org/0000-0002-5991-3264"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixing Zhu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102231710","display_name":"Weijing Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijing Wu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102923832","display_name":"Hai Lan Lin","orcid":"https://orcid.org/0009-0005-6284-6946","observed_orcids":["https://orcid.org/0009-0005-6284-6946"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Lin","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707505","display_name":"Jianming Wang","orcid":"https://orcid.org/0000-0002-7265-1764","observed_orcids":["https://orcid.org/0000-0002-7265-1764","https://orcid.org/0000-0002-7461-6284"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianming Wang","raw_affiliation_strings":["Department of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070300689","display_name":"Xiangjia Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangjia Ye","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036955542","display_name":"Yiming Zeng","orcid":"https://orcid.org/0000-0001-6429-0682","observed_orcids":["https://orcid.org/0000-0001-6429-0682"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiming Zeng","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China. ymzeng08@163.com","Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-6429-0682","affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China. ymzeng08@163.com","institution_ids":["https://openalex.org/I4210134617"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036955542"],"corresponding_institution_ids":["https://openalex.org/I4210134617"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":3.6726,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.9437946,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"286","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fermt3","display_name":"FERMT3","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cigarette-smoke-extract","display_name":"cigarette smoke extract","score":0.8999999761581421},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.8960000276565552},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8544774055480957},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7714253664016724},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7028970122337341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6235038042068481},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5883152484893799},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.55876225233078},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5474569797515869},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4284895658493042},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4246622323989868},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.41772234439849854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38279488682746887},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3751339912414551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3745849132537842},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29923057556152344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2812230587005615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25881636142730713},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.19743764400482178},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08079451322555542}],"mesh":[{"descriptor_ui":"D000073865","descriptor_name":"Cigarette Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056151","descriptor_name":"Airway Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12931-021-01881-y","doi":"https://doi.org/10.1186/s12931-021-01881-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-021-01881-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12931-021-01881-y.pdf","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7463539","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8571878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8571878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8571878","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmid:34742298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34742298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ae224e6ff6af4f55b41a3822698a99e7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ae224e6ff6af4f55b41a3822698a99e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12931-021-01881-y","doi":"https://doi.org/10.1186/s12931-021-01881-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-021-01881-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12931-021-01881-y.pdf","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7816659774","display_name":null,"funder_award_id":"2016YFC1304003","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3176973685.pdf","grobid_xml":"https://content.openalex.org/works/W3176973685.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1566263874","https://openalex.org/W1612356843","https://openalex.org/W1800913983","https://openalex.org/W1963501822","https://openalex.org/W1994331544","https://openalex.org/W1998539678","https://openalex.org/W2016229346","https://openalex.org/W2076368781","https://openalex.org/W2084666520","https://openalex.org/W2090413955","https://openalex.org/W2116799626","https://openalex.org/W2128491978","https://openalex.org/W2137765073","https://openalex.org/W2138791138","https://openalex.org/W2232088318","https://openalex.org/W2270895460","https://openalex.org/W2401244321","https://openalex.org/W2543262968","https://openalex.org/W2671981991","https://openalex.org/W2736378801","https://openalex.org/W2740327936","https://openalex.org/W2744408082","https://openalex.org/W2751718383","https://openalex.org/W2757119252","https://openalex.org/W2788656261","https://openalex.org/W2790001041","https://openalex.org/W2800430194","https://openalex.org/W2890549971","https://openalex.org/W2899053328","https://openalex.org/W2908504721","https://openalex.org/W2946563491","https://openalex.org/W2947303777","https://openalex.org/W2951663586","https://openalex.org/W2971644665","https://openalex.org/W2982681722","https://openalex.org/W3011080115","https://openalex.org/W3023347616","https://openalex.org/W3044307541","https://openalex.org/W3045682979","https://openalex.org/W3092153780","https://openalex.org/W3095675897","https://openalex.org/W3119376040","https://openalex.org/W3127754343","https://openalex.org/W6636695924"],"related_works":["https://openalex.org/W6902123670","https://openalex.org/W2989682421","https://openalex.org/W4293716267","https://openalex.org/W2138791138","https://openalex.org/W2971644665","https://openalex.org/W3128833438","https://openalex.org/W4401052358","https://openalex.org/W2556375105","https://openalex.org/W2943881582","https://openalex.org/W3016629160"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cigarette":[1,197],"smoking":[2],"is":[3,20,46],"a":[4,50,289],"major":[5],"risk":[6],"factor":[7],"for":[8,292],"chronic":[9],"obstructive":[10],"pulmonary":[11],"disease":[12],"(COPD)":[13],"and":[14,27,36,48,84,108,127,136,204,210,234,285,295],"lung":[15,54,185,296],"cancer.":[16,55,297],"Epithelial-mesenchymal":[17],"transition":[18,269],"(EMT)":[19],"an":[21,29],"essential":[22],"pathophysiological":[23],"process":[24],"in":[25,32,53,61,82,100,149,164,170,174,184,208,211,226],"COPD":[26,83,171,188,284,294],"plays":[28,49],"important":[30],"role":[31,52,58,79],"airway":[33],"remodeling,":[34],"fibrosis,":[35],"malignant":[37],"transformation":[38],"of":[39,59,80,125,147,187,218,249,283],"COPD.":[40,101],"Previous":[41],"studies":[42],"have":[43],"indicated":[44,275],"FERMT3":[45,60,81,96,126,148,162,179,202,219,241,250,264,277],"downregulated":[47],"tumor-suppressive":[51],"However,":[56],"the":[57,77,123,143,194,201,230,255,281],"COPD,":[62],"including":[63],"EMT,":[64],"has":[65],"not":[66],"yet":[67],"been":[68],"investigated.":[69],"METHODS:":[70],"The":[71,213],"present":[72],"study":[73,245],"aimed":[74],"to":[75,94,121,141],"explore":[76],"potential":[78,144,290],"its":[85],"underlying":[86],"molecular":[87],"mechanisms.":[88],"Three":[89],"GEO":[90],"datasets":[91],"were":[92,139,238],"utilized":[93],"analyse":[95],"gene":[97],"expression":[98,124,163,180,203],"profiles":[99],"We":[102],"then":[103],"established":[104],"EMT":[105,128,206,222,253],"animal":[106],"models":[107,110],"cell":[109,134,137,232,235],"through":[111,254,270],"cigarette":[112,116,266],"smoke":[113,117,198],"(CS)":[114],"or":[115,176],"extract":[118],"(CSE)":[119],"exposure":[120,199],"detect":[122],"markers.":[129],"RT-PCR,":[130],"western":[131],"blot,":[132],"immunohistochemical,":[133],"migration,":[135],"cycle":[138,236],"employed":[140],"investigate":[142],"regulatory":[145],"effect":[146],"CSE-induced":[150,231,252],"EMT.":[151],"RESULTS:":[152],"Based":[153],"on":[154],"Gene":[155],"Expression":[156],"Omnibus":[157],"(GEO)":[158],"data":[159,262],"set":[160],"analysis,":[161],"bronchoalveolar":[165],"lavage":[166],"fluid":[167],"was":[168,181,278],"lower":[169],"smokers":[172],"than":[173],"non-smokers":[175],"smokers.":[177],"Moreover,":[178],"significantly":[182],"down-regulated":[183],"tissues":[186],"GOLD":[189],"4":[190],"patients":[191],"compared":[192],"with":[193,280],"control":[195],"group.":[196],"reduced":[200],"induces":[205],"both":[207,293],"vivo":[209],"vitro.":[212],"results":[214],"showed":[215,246],"that":[216,247,276],"overexpression":[217,248],"could":[220],"inhibit":[221],"induced":[223],"by":[224,240],"CSE":[225],"A549":[227],"cells.":[228],"Furthermore,":[229],"migration":[233],"progression":[237],"reversed":[239],"overexpression.":[242],"Mechanistically,":[243],"our":[244],"inhibited":[251],"Wnt/\u03b2-catenin":[256,271],"signaling.":[257,272],"CONCLUSIONS:":[258],"In":[259],"summary,":[260],"these":[261],"suggest":[263],"regulates":[265],"smoke-induced":[267],"epithelial-mesenchymal":[268],"These":[273],"findings":[274],"correlated":[279],"development":[282],"may":[286],"serve":[287],"as":[288],"target":[291]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}
