{"id":"https://openalex.org/W3176776083","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1133.5","title":"The role of inflammation and adaptive immunity in aortic stiffening","display_name":"The role of inflammation and adaptive immunity in aortic stiffening","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W3176776083","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1133.5","mag":"3176776083"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.1133.5","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1133.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.1133.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056524939","display_name":"Jing Wu","orcid":"https://orcid.org/0000-0003-2013-2863","observed_orcids":["https://orcid.org/0000-0003-2013-2863"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JING WU","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pharmacology Vanderbilt Unversity Nashville TN","1--> Pharmacology Vanderbilt Unversity Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"1--> Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057803887","display_name":"Salim Thabet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salim Thabet","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344576","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0003-3461-6658","observed_orcids":["https://orcid.org/0000-0003-3461-6658","https://orcid.org/0000-0002-9800-5760"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053739175","display_name":"Anna E. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Goldstein","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021624277","display_name":"Meena S. Madhur","orcid":"https://orcid.org/0000-0002-0407-634X","observed_orcids":["https://orcid.org/0000-0002-0407-634X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meena Madhur","raw_affiliation_strings":["<!--<label><sup>4</sup></label>--> Medicine Emory University Atlanta GA","4--> Medicine Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>4</sup></label>--> Medicine Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"4--> Medicine Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090550074","display_name":"Billy G. Hudson","orcid":"https://orcid.org/0000-0002-5420-4100","observed_orcids":["https://orcid.org/0000-0002-5420-4100"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Billy Hudson","raw_affiliation_strings":["<!--<label><sup>3</sup></label>--> Nephrology Vanderbilt Unversity Nashville TN","3--> Nephrology Vanderbilt Unversity Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>3</sup></label>--> Nephrology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"3--> Nephrology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Harrison","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"2--> Clinical Pharmacology Vanderbilt Unversity Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37797117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.12240000069141388,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.8600000143051147},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9210000038146973},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8700000047683716},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vascular-hypertrophy","display_name":"vascular hypertrophy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/rag1-knockout-mice","display_name":"Rag1 knockout mice","score":0.9020000100135803},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7049999833106995},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.7453728318214417},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6946189403533936},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6459766030311584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5933032631874084},{"id":"https://openalex.org/C2776716733","wikidata":"https://www.wikidata.org/wiki/Q1890226","display_name":"Adventitia","level":2,"score":0.5843274593353271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.579710841178894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5530428290367126},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5176942348480225},{"id":"https://openalex.org/C163031210","wikidata":"https://www.wikidata.org/wiki/Q3325848","display_name":"Masson's trichrome stain","level":3,"score":0.4819902777671814},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.45764607191085815},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.45628389716148376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3025379776954651},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19715356826782227},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.18783408403396606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12063688039779663},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.1133.5","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.1133.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.1133.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2612538137","https://openalex.org/W3176045292","https://openalex.org/W2524610039","https://openalex.org/W2304913076","https://openalex.org/W1893432180","https://openalex.org/W1605684907","https://openalex.org/W3184794683","https://openalex.org/W2150582762","https://openalex.org/W7172206358","https://openalex.org/W4408499069"],"abstract_inverted_index":{"Clinical":[0],"studies":[1],"show":[2],"an":[3,241],"association":[4],"between":[5],"inflammation":[6,244],"and":[7,20,35,52,99,127,203,234,245],"arterial":[8,222],"stiffness.":[9],"We":[10,42,87],"have":[11],"previously":[12],"demonstrated":[13],"that":[14,45,221],"T":[15,28,49],"lymphocytes":[16,142],"mediate":[17],"experimental":[18],"hypertension":[19],"vascular":[21,232],"dysfunction":[22],"in":[23,60,72,76,109,133,167,196,201,209,229,248],"various":[24],"models.":[25],"In":[26],"addition,":[27],"cells\u2010derived":[29],"pro\u2010inflammatory":[30],"cytokines":[31,56],"such":[32],"as":[33],"IL\u201017":[34],"TGF\u2010\u03b2":[36],"are":[37],"known":[38],"to":[39,157,187],"induce":[40,48],"fibrosis.":[41],"therefore":[43],"propose":[44],"hypertensive":[46],"stimuli":[47],"cell":[50],"activation":[51],"the":[53,73,91,110,155,249],"secretion":[54],"of":[55,93,112,236,243,251],"promote":[57],"aortic":[58,74,182,252],"stiffening":[59,223],"hypertension.":[61],"Using":[62],"masson":[63],"trichrome":[64],"staining,":[65],"we":[66],"initially":[67],"observed":[68],"profound":[69],"collagen":[70,107,158],"deposition":[71],"adventitia":[75],"C57Bl/6J":[77,113,197],"mice":[78,114,139,211],"receiving":[79],"chronic":[80],"angiotensin":[81,164,179],"II":[82,103,165,180],"infusion":[83,166],"(490ng/kg/min,":[84],"14":[85],"days).":[86],"then":[88],"biochemically":[89],"determined":[90],"alteration":[92,228],"ECM":[94,230],"proteins":[95],"using":[96],"hydroxyproline":[97],"assay":[98],"ninhydrin":[100],"assay.":[101],"Angiotensin":[102],"treatment":[104],"significantly":[105,161],"increased":[106,181],"content":[108,151],"aortas":[111],"by":[115,163,227],"more":[116],"than":[117],"two":[118],"fold":[119],"(1.3\u00b10.1":[120],"\u03bcg/mm":[121,144],"v.s.":[122,145,171,175],"3.5":[123],"\u00b10.3":[124],"\u03bcg/mm,":[125,147],"p<0.01)":[126],"this":[128],"increase":[129],"was":[130,152,160],"further":[131],"amplified":[132],"Recombination":[134],"Activating":[135],"Gene\u20101":[136],"knockout":[137],"(Rag1\u2212/\u2212)":[138],"lacking":[140],"mature":[141],"(1.3\u00b10.2":[143],"5.6\u00b10.8":[146],"p<0.01).":[148,177],"Although":[149],"elastin":[150,156],"not":[153],"reduced,":[154],"ratio":[159,189],"depressed":[162],"both":[168],"strains":[169],"(23.4\u00b11.2":[170],"9.5\u00b10.9,":[172],"p<0.01;":[173],"25.5\u00b13.5":[174],"7.5\u00b10.9,":[176],"Consistently,":[178],"wall":[183],"thickness":[184],"(p<0.01),":[185],"media":[186],"lumen":[188],"(p<0.01)":[190,195],"while":[191],"decreased":[192],"extensibility":[193],"index":[194],"mice.":[198],"These":[199],"changes":[200],"pathology":[202],"mechanical":[204],"properties":[205],"were":[206],"less":[207],"impressive":[208],"Rag1\u2212/\u2212":[210],"(p<0.01":[212],"for":[213],"all":[214],"three":[215],"parameters).":[216],"Collectively,":[217],"our":[218],"data":[219],"demonstrate":[220],"might":[224],"be":[225],"caused":[226],"proteins,":[231],"hypertrophy":[233],"loss":[235],"elasticity.":[237],"There":[238],"is":[239],"clearly":[240],"involvement":[242],"adaptive":[246],"immunity":[247],"pathogenesis":[250],"stiffening.":[253]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-07-05T00:00:00"}