{"id":"https://openalex.org/W3176567943","doi":"https://doi.org/10.1212/wnl.96.15_supplement.2530","title":"Cognitive Profile of Patients with Late-Onset Unexplained Epilepsy (2530)","display_name":"Cognitive Profile of Patients with Late-Onset Unexplained Epilepsy (2530)","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3176567943","doi":"https://doi.org/10.1212/wnl.96.15_supplement.2530","mag":"3176567943"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.96.15_supplement.2530","doi":"https://doi.org/10.1212/wnl.96.15_supplement.2530","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.96.15_supplement.2530","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016923302","display_name":"Mallika Purandare","orcid":"https://orcid.org/0000-0002-2318-1962","observed_orcids":["https://orcid.org/0000-0002-2318-1962"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mallika Purandare","raw_affiliation_strings":["Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003811348","display_name":"Patrick Trouten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Trouten","raw_affiliation_strings":["Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068947552","display_name":"Page B. Pennell","orcid":"https://orcid.org/0000-0003-0568-2795","observed_orcids":["https://orcid.org/0000-0003-0568-2795"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Page Pennell","raw_affiliation_strings":["Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064793425","display_name":"Gad A. Marshall","orcid":"https://orcid.org/0000-0002-9096-2355","observed_orcids":["https://orcid.org/0000-0002-9096-2355"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gad Marshall","raw_affiliation_strings":["Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035748074","display_name":"Rani A. Sarkis","orcid":"https://orcid.org/0000-0001-8291-7864","observed_orcids":["https://orcid.org/0000-0001-8291-7864"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rani Sarkis","raw_affiliation_strings":["Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0994142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":"15_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.18410000205039978,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-profile","display_name":"cognitive profile","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7186877131462097},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5310863256454468},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5110658407211304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5066081285476685},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3806813955307007},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3253752589225769}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.96.15_supplement.2530","doi":"https://doi.org/10.1212/wnl.96.15_supplement.2530","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.96.15_supplement.2530","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407028602","https://openalex.org/W4410958244","https://openalex.org/W7117131727","https://openalex.org/W7135391861","https://openalex.org/W7126274107","https://openalex.org/W4385628513","https://openalex.org/W4406550501","https://openalex.org/W7166197876","https://openalex.org/W7120258304","https://openalex.org/W7166197864"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"characterize":[2],"the":[3,40,84,248,259,263,312,330,348,376],"cognitive":[4,41,97,245],"profile":[5,42],"of":[6,16,45,73,79,250,258,266,283,314,332,350,378],"patients":[7],"with":[8,19,238],"late-onset":[9],"unexplained":[10],"epilepsy":[11,17,251],"(LOUE)":[12],"Background:":[13],"Approximately":[14],"25\u201350%":[15],"cases":[18],"elderly-onset":[20],"do":[21],"not":[22,48],"have":[23,30,47],"a":[24,34,91,299,319,337,355],"clear":[25],"etiology.":[26],"Large":[27],"database":[28],"studies":[29],"identified":[31],"LOUE":[32,46,239],"as":[33,318,336,382],"risk":[35],"factor":[36],"for":[37,210,316,321,334,339,352,363,380,392],"dementia,":[38],"however":[39],"and":[43,57,60,78,90,109,114,127,133,158,175,191,196,229,262],"trajectory":[44],"been":[49],"well-described.":[50],"Design/Methods:":[51],"Patients":[52,82,237],"were":[53,140,167,172,202],"recruited":[54],"from":[55,181,290,298],"Brigham":[56],"Women\u2019s":[58],"Hospital":[59],"affiliated":[61],"hospitals.":[62],"Inclusion":[63],"criteria:":[64],"new":[65],"onset":[66,69],"seizures":[67],">60yo,":[68],"<3":[70],"years,":[71],"absence":[72],"cortical":[74],"lesions":[75],"on":[76,203,354],"MRI":[77],"provoking":[80],"factors.":[81],"underwent":[83],"Clinical":[85],"Dementia":[86],"Rating":[87],"(CDR)":[88],"Scale":[89],"neuropsychological":[92],"battery":[93],"to":[94,142,273,279,302,400],"assess":[95],"4":[96],"domains:":[98],"global":[99,211],"cognition":[100,212],"(Preclinical":[101],"Alzheimer":[102],"Cognitive":[103],"Composite),":[104],"delayed":[105,218],"verbal":[106,219],"recall":[107,220],"(Free":[108],"Cued":[110],"Selective":[111],"Reminding":[112],"Test":[113,121,131],"Logical":[115],"Memory),":[116],"processing":[117,224],"speed":[118,225],"(":[119],"Trailmaking":[120],"A,":[122],"Digit":[123],"Symbol":[124],"Substitution":[125],"Test),":[126],"executive":[128,230],"function":[129,231],"(Trailmaking":[130],"B":[132],"Controlled":[134],"Oral":[135],"Word":[136],"Association":[137],"Test).":[138],"Performances":[139],"normalized":[141],"generate":[143],"z-scores.":[144],"Results:":[145],"We":[146],"enrolled":[147],"25":[148],"patients.":[149],"Mean":[150],"(\u00b1SD)":[151],"age":[152],"was":[153,161,213],"69":[154],"\u00b1":[155,163],"5.79":[156],"years":[157,160],"educational":[159],"18":[162],"2.16":[164],"years.":[165],"44%":[166],"male.":[168],"Global":[169],"CDR":[170,178],"scores":[171],"0.0":[173],"(n=17)":[174],"0.5":[176],"(n=8);":[177],"sum-of-boxes":[179],"ranged":[180],"0.0\u20133.5.":[182],"Ambulatory":[183],"EEG":[184,198],"findings":[185],"included":[186],"bi-temporal":[187],"(n=9),":[188,190],"left-temporal":[189],"right-temporal":[192],"(n=3)":[193],"epileptiform":[194],"abnormalities,":[195],"normal":[197],"(n=4).":[199],"17":[200],"subjects":[201],"antiseizure":[204],"medicine":[205],"monotherapy.":[206],"The":[207,281],"mean":[208],"z-score":[209],"\u22120.51":[214],"(range":[215],"3.75,":[216],"1.01),":[217],"\u22120.74":[221],"(\u22123.64,":[222],"1.17),":[223],"\u22120.37":[226],"(\u22126.45,":[227],"1.67),":[228],"\u22121.055":[232],"(range,":[233],"\u22127.78,":[234],"1.67).":[235],"Conclusions:":[236],"exhibit":[240],"mild":[241],"deficits":[242],"across":[243],"multiple":[244],"domains":[246],"around":[247],"time":[249],"diagnosis.":[252],"Our":[253],"future":[254],"directions":[255],"include":[256],"characterization":[257],"underlying":[260],"factors":[261],"natural":[264],"history":[265],"LOUE.":[267],"Disclosure:":[268],"Mallika":[269,275],"Purandare":[270,276],"has":[271,277,286,294,307,325,343,371,398],"nothing":[272,278,399],"disclose.":[274,280,401],"institution":[282],"Dr.":[284,292,305,323,341,369,396],"Pennell":[285,293],"received":[287,295,308,326,344,372],"research":[288],"support":[289],"NIH.":[291],"publishing":[296],"royalties":[297],"publication":[300],"relating":[301],"health":[303],"care.":[304],"Marshall":[306,324,342,370],"personal":[309,327,345,373],"compensation":[310,328,346,374],"in":[311,329,347,375],"range":[313,331,349,377],"$5,000-$9,999":[315],"serving":[317,335,353,381],"Consultant":[320,338],"Eisai.":[322],"$500-$4,999":[333,379],"Grifols.":[340],"$0-$499":[351],"Scientific":[356],"Advisory":[357,389],"or":[358,387],"Data":[359],"Safety":[360],"Monitoring":[361],"board":[362],"Beth":[364],"Israel":[365],"Deaconess":[366],"Medical":[367],"Center.":[368],"an":[383],"Editor,":[384,386],"Associate":[385],"Editorial":[388],"Board":[390],"Member":[391],"Harvard":[393],"Health":[394],"Publications.":[395],"Sarkis":[397]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}