{"id":"https://openalex.org/W3176566044","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1138.7","title":"Novel anti\u2010atherogenic effects of trivalent chromium in vascular smooth muscle cells: therapeutic implication for diabetic vascular complications","display_name":"Novel anti\u2010atherogenic effects of trivalent chromium in vascular smooth muscle cells: therapeutic implication for diabetic vascular complications","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W3176566044","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1138.7","mag":"3176566044"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.1138.7","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1138.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1138.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111080405","display_name":"Rituparna Ganguly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rituparna Ganguly","raw_affiliation_strings":["Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049054442","display_name":"Soumyadip Sahu","orcid":"https://orcid.org/0000-0002-2497-864X","observed_orcids":["https://orcid.org/0000-0002-2497-864X"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soumyadip Sahu","raw_affiliation_strings":["Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009593270","display_name":"Priya Raman","orcid":"https://orcid.org/0000-0002-7519-2524","observed_orcids":["https://orcid.org/0000-0002-7519-2524"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Raman","raw_affiliation_strings":["Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39686001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.13230000436306,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cr-iii","display_name":"trivalent chromium","score":0.996999979019165},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/diabetic-vascular-complications","display_name":"diabetic vascular complications","score":0.9129999876022339},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.878000020980835},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.6890000104904175},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6200000047683716},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9739999771118164},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/glutamine-fructose-6-phosphate-amidotransferase","display_name":"glutamine:fructose-6-phosphate amidotransferase","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hexosamine-biosynthesis-pathway","display_name":"hexosamine biosynthetic pathway","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/anti-atherogenic-effects","display_name":"antiatherogenic effects","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.7356688976287842},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5415483117103577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5352827310562134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5048995614051819},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.43637409806251526},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42807650566101074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.358845055103302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35250186920166016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3049980401992798},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.10717001557350159}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.1138.7","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1138.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1138.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1504785957","https://openalex.org/W3175334331","https://openalex.org/W2124814311","https://openalex.org/W2341989706","https://openalex.org/W2600386851","https://openalex.org/W2280878449","https://openalex.org/W2009925182","https://openalex.org/W2466735464","https://openalex.org/W3037438060","https://openalex.org/W2067730295"],"abstract_inverted_index":{"Trivalent":[0],"chromium":[1],"(Cr)":[2],"is":[3,125],"proposed":[4],"to":[5,55,84,103,109],"have":[6,40],"a":[7,19,95,110,171,179],"therapeutic":[8,173],"potential":[9,172],"in":[10,24,32,112,122,129,159,185],"glycemic":[11],"and":[12,50,57,76,177],"cardiovascular":[13],"health.":[14],"While":[15],"emerging":[16],"evidence":[17,67],"support":[18],"protective":[20],"role":[21],"of":[22,29,43,59,78,86,106,131,141,144,175],"Cr":[23,30,69,93,151,176,184],"atherosclerosis,":[25,107],"the":[26,65,136],"underlying":[27],"mechanisms":[28],"action":[31],"diabetic":[33,186],"vascular":[34,44],"disease":[35],"remain":[36],"unknown.":[37],"Diabetic":[38],"patients":[39],"increased":[41],"incidence":[42],"smooth":[45],"muscle":[46],"cell":[47],"(VSMC)":[48],"migration":[49,75],"proliferation,":[51],"key":[52,137],"events":[53],"leading":[54],"initiation":[56,105],"development":[58],"atherosclerosis.":[60],"The":[61],"present":[62],"study":[63],"provides":[64],"first":[66],"that":[68,92,119,150],"inhibits":[70,152],"high":[71,153],"glucose":[72,145],"(30mM)":[73],"induced":[74],"proliferation":[77],"human":[79],"aortic":[80],"SMC":[81],"(HASMC)":[82],"coupled":[83],"attenuation":[85],"ERK1/2":[87],"phosphorylation.":[88],"We":[89,115],"showed":[90],"earlier":[91],"downregulates":[94],"potent":[96],"proatherogenic":[97],"matricellular":[98],"protein":[99,113],"Thrombospondin\u20101":[100],"(TSP\u20101),":[101],"known":[102],"accelerate":[104],"concomitant":[108],"decrease":[111,121],"O\u2010glycosylation.":[114],"now":[116],"further":[117],"demonstrate":[118],"this":[120],"TSP\u20101":[123,169],"expression":[124,130],"accompanied":[126],"by":[127],"reduction":[128,158],"Glutamine:":[132],"fructose\u20106\u2010phosphate":[133],"amidotransferase":[134],"(GFAT),":[135],"rate":[138],"limiting":[139],"enzyme":[140],"hexosamine":[142],"pathway":[143],"metabolism.":[146],"Additionally,":[147],"we":[148],"found":[149],"glucose\u2010induced":[154],"oxidative":[155],"stress":[156],"via":[157],"cellular":[160],"reactive":[161],"oxygen":[162],"species":[163],"(ROS).":[164],"Together,":[165],"these":[166],"data":[167],"suggest":[168],"as":[170],"target":[174],"provide":[178],"novel":[180],"anti\u2010atherogenic":[181],"mechanism":[182],"for":[183],"atherosclerotic":[187],"complications.":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}
