{"id":"https://openalex.org/W3176483148","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.6","title":"Possible effects of ASIC\u2010BK interaction on glial growth at normal and acidic pH","display_name":"Possible effects of ASIC\u2010BK interaction on glial growth at normal and acidic pH","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W3176483148","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.6","mag":"3176483148"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.25.1_supplement.860.6","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.860.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017154370","display_name":"Jennifer C. Guercio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer C Guercio","raw_affiliation_strings":["Biology and Molecular Biology, Montclair State University, Montclair, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology and Molecular Biology, Montclair State University, Montclair, NJ","institution_ids":["https://openalex.org/I166088655"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051074092","display_name":"Elena Petroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Petroff","raw_affiliation_strings":["Biology and Molecular Biology, Montclair State University, Montclair, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology and Molecular Biology, Montclair State University, Montclair, NJ","institution_ids":["https://openalex.org/I166088655"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166088655"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33341549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acid-sensing-ion-channels","display_name":"acid-sensing ion channels","score":0.9449999928474426},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.875},{"id":"https://openalex.org/keywords/glial-proliferation","display_name":"glial cell proliferation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extracellular-ph","display_name":"extracellular pH","score":0.8949999809265137},{"id":"https://openalex.org/keywords/low-ph","display_name":"low pH","score":0.7540000081062317},{"id":"https://openalex.org/keywords/charybdotoxin","display_name":"charybdotoxin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/potassium-channel-inhibition","display_name":"potassium channel inhibition","score":0.6790000200271606},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2780419564","wikidata":"https://www.wikidata.org/wiki/Q5087002","display_name":"Charybdotoxin","level":3,"score":0.9359127283096313},{"id":"https://openalex.org/C61144316","wikidata":"https://www.wikidata.org/wiki/Q4835827","display_name":"BK channel","level":3,"score":0.8809794187545776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7016018629074097},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6160618662834167},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5799350738525391},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5672608613967896},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5518855452537537},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.5008723735809326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4997284412384033},{"id":"https://openalex.org/C149614440","wikidata":"https://www.wikidata.org/wiki/Q5018801","display_name":"Calcium-activated potassium channel","level":3,"score":0.4779791235923767},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4387015998363495},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4100000858306885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38805240392684937},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.25088751316070557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19532549381256104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13597741723060608},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.25.1_supplement.860.6","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.860.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309637","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W327522378","https://openalex.org/W2287294645","https://openalex.org/W2043744055","https://openalex.org/W2160045262","https://openalex.org/W2054866867","https://openalex.org/W3138797401","https://openalex.org/W1503701196","https://openalex.org/W4245249906","https://openalex.org/W3095107364","https://openalex.org/W2763251409"],"abstract_inverted_index":{"Normal":[0],"glia":[1],"and":[2,11,15,28,32,66,116,121,171],"glioma":[3],"tissue":[4],"express":[5],"acid":[6],"sensing":[7],"ion":[8],"channels":[9,70],"(ASICs)":[10],"large":[12],"conductance":[13],"calcium":[14],"voltage\u2010activated":[16],"potassium":[17,130,174],"(BK)":[18],"channels.":[19],"At":[20,58],"normal":[21,50,98,104,149],"brain":[22,105],"pH":[23,40,51,99,110,119,144,150,170],"(7.4),":[24],"ASICs":[25],"interact":[26],"with":[27],"inhibit":[29,53],"BK":[30,48,69],"channels,":[31],"this":[33,62],"interaction":[34,63],"is":[35,64,140,183],"disrupted":[36],"at":[37,49,77,97,107,117,143,160],"an":[38,59],"acidic":[39,60],"(Petroff":[41],"et":[42],"al.,":[43],"PNAS":[44],"2008).":[45],"Inhibition":[46],"of":[47,55,80,111,126,128,155,168,173],"may":[52,71],"growth":[54,159],"glial":[56,92,158,178],"cells.":[57],"pH,":[61],"disrupted,":[65],"the":[67,95,124,129,166,186],"active":[68],"foster":[72],"cell":[73,138,179],"proliferation,":[74],"such":[75],"as":[76,146],"a":[78,103,108],"site":[79],"trauma":[81],"or":[82],"injury.":[83],"This":[84,181],"hypothesis":[85],"was":[86],"tested":[87],"by":[88,185],"growing":[89],"isolated":[90],"mouse":[91],"cells":[93],"from":[94],"cortex":[96],"(7.4)":[100],"to":[101,148],"simulate":[102],"environment,":[106],"low":[109],"7.0":[112,122,145],"present":[113],"in":[114,123],"tumors,":[115],"both":[118,161],"7.4":[120],"presence":[125,154],"200nM":[127],"channel":[131,175],"blocker":[132],"charybdotoxin.":[133],"Our":[134],"data":[135],"demonstrate":[136],"that":[137],"proliferation":[139],"significantly":[141],"increased":[142],"compared":[147],"conditions":[151],"(7.4).":[152],"The":[153],"charybdotoxin":[156],"inhibited":[157],"pH's.":[162],"These":[163],"results":[164],"suggest":[165],"importance":[167],"extracellular":[169],"regulation":[172],"activity":[176],"for":[177,190],"proliferation.":[180],"work":[182],"supported":[184],"MSU":[187],"startup":[188],"funds":[189],"EP.":[191]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}
