{"id":"https://openalex.org/W3176437985","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.666.4","title":"Activation of G protein\u2010coupled estrogen receptor 1 (GPER) induces coronary artery relaxation via cAMP/PKA pathway","display_name":"Activation of G protein\u2010coupled estrogen receptor 1 (GPER) induces coronary artery relaxation via cAMP/PKA pathway","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W3176437985","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.666.4","mag":"3176437985"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.666.4","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.666.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.666.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054123870","display_name":"Xuan Yu","orcid":"https://orcid.org/0000-0003-3343-7105","observed_orcids":["https://orcid.org/0000-0003-3343-7105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuan Yu","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","1--> Vet. Physiology &amp; Pharmacology College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]},{"raw_affiliation_string":"1--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fen Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fen Li","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","1--> Vet. Physiology &amp; Pharmacology College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]},{"raw_affiliation_string":"1--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111517580","display_name":"Richard E. White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard White","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Georgia Health Science University Augusta GA","2--> Georgia Health Science University Augusta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Georgia Health Science University Augusta GA","institution_ids":[]},{"raw_affiliation_string":"2--> Georgia Health Science University Augusta GA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074440355","display_name":"John N. Stallone","orcid":"https://orcid.org/0000-0002-2917-806X","observed_orcids":["https://orcid.org/0000-0002-2917-806X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Stallone","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","1--> Vet. Physiology &amp; Pharmacology College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]},{"raw_affiliation_string":"1--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080428979","display_name":"Guichun Han","orcid":"https://orcid.org/0000-0001-5269-0363","observed_orcids":["https://orcid.org/0000-0001-5269-0363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guichun Han","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","1--> Vet. Physiology &amp; Pharmacology College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]},{"raw_affiliation_string":"1--> Vet. Physiology &amp; Pharmacology College Station TX","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38386701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-estrogen-receptor","display_name":"G protein-coupled estrogen receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/coronary-artery-relaxation","display_name":"coronary artery relaxation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/camp-pka-signaling","display_name":"cAMP/PKA signaling","score":0.9639999866485596},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/a-kinase-anchoring-proteins","display_name":"A-kinase anchoring proteins","score":0.6970000267028809},{"id":"https://openalex.org/keywords/g1-agonist","display_name":"G1 agonist","score":0.671999990940094},{"id":"https://openalex.org/keywords/porcine-coronary-artery","display_name":"porcine coronary artery","score":0.8029999732971191},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C166471694","wikidata":"https://www.wikidata.org/wiki/Q18268232","display_name":"GPER","level":5,"score":0.9848470091819763},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.6434207558631897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.613498866558075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6128361225128174},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6020654439926147},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.600941002368927},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.528576672077179},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4828796684741974},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46287229657173157},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4564204216003418},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.42838963866233826},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.4185495376586914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2912259101867676},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.23034459352493286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11372548341751099},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.666.4","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.666.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.666.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1560750784","https://openalex.org/W2095988413","https://openalex.org/W7028597249","https://openalex.org/W3175083240","https://openalex.org/W2591768181","https://openalex.org/W3183143291","https://openalex.org/W2287784306","https://openalex.org/W1979986181","https://openalex.org/W2295278894","https://openalex.org/W2793470165"],"abstract_inverted_index":{"Activation":[0],"of":[1,27,33,49,57,78,149,165,182],"the":[2,55,65,85,90,131,137,141,150,155,162],"membrane":[3],"estrogen":[4],"receptor,":[5],"GPER,":[6],"may":[7],"lower":[8],"high":[9],"blood":[10],"pressure":[11],"and":[12,83,109,135,154],"preserve":[13],"cardiac":[14],"function":[15],"after":[16],"reperfusion.":[17],"We":[18,62],"reported":[19],"that":[20,64,95],"GPER":[21,101],"activation":[22],"induces":[23,170],"a":[24],"rapid":[25],"relaxation":[26,77,133,163,174],"porcine":[28,80,171],"coronary":[29,59,81,172],"arteries":[30,122],"by":[31,114],"opening":[32],"BK":[34],"Ca":[35],"channels.":[36],"However,":[37],"downstream":[38],"signaling":[39],"events":[40],"in":[41,100],"this":[42,110],"pathway":[43],"are":[44],"poorly":[45],"understood.":[46],"The":[47],"objective":[48],"our":[50],"study":[51],"was":[52,112],"to":[53,89,140],"investigate":[54],"mechanism":[56],"GPER\u2010mediated":[58],"artery":[60,173],"relaxation.":[61],"found":[63],"adenylyl":[66],"cyclase":[67],"(AC)":[68],"inhibitor,":[69],"SQ\u201022538":[70],"(100":[71],"\u03bcM),":[72],"attenuated":[73,161],"G\u20101":[74,86,104,132,169],"(GPER":[75,118],"agonist)\u2010induced":[76],"pre\u2010constricted":[79],"arteries,":[82],"shifted":[84,136],"concentration\u2010relaxation":[87],"curve":[88,139],"left.":[91,142],"These":[92],"findings":[93],"suggest":[94],"AC":[96],"plays":[97],"functional":[98],"role":[99],"action.":[102],"Furthermore,":[103],"(1\u03bcM)":[105],"stimulated":[106],"cAMP":[107],"production,":[108],"stimulation":[111],"blocked":[113],"5":[115],"\u03bcM":[116,145],"G15":[117],"selective":[119,127],"antagonist).":[120],"Treating":[121],"with":[123,186],"5\u03bcM":[124],"Rp\u20108CPT\u2010cAMP":[125],"(PKA":[126],"inhibitor)":[128],"significantly":[129],"inhibited":[130],"effect,":[134],"concentration\u2010response":[138],"Lastly,":[143],"100":[144],"FMP\u2010API\u20101":[146],"(an":[147],"inhibitor":[148],"interaction":[151,185],"between":[152],"PKA":[153,183],"A":[156],"kinase":[157],"anchoring":[158],"protein,":[159],"AKAP)":[160],"effect":[164],"G\u20101.":[166],"In":[167],"conclusion,":[168],"via":[175,184],"cAMP/PKA":[176],"signaling,":[177],"which":[178],"involves":[179],"subcellular":[180],"localization":[181],"AKAP.":[187]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2021-07-05T00:00:00"}
