{"id":"https://openalex.org/W3176187811","doi":"https://doi.org/10.18632/aging.203199","title":"Effects of long-term low dose saxitoxin exposure on nerve damage in mice","display_name":"Effects of long-term low dose saxitoxin exposure on nerve damage in mice","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3176187811","doi":"https://doi.org/10.18632/aging.203199","mag":"3176187811","pmid":"https://pubmed.ncbi.nlm.nih.gov/34197336"},"language":"en","primary_location":{"id":"doi:10.18632/aging.203199","doi":"https://doi.org/10.18632/aging.203199","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203199","pdf_url":"https://www.aging-us.com/article/203199/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/203199/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103090090","display_name":"Qian Sun","orcid":"https://orcid.org/0009-0006-7495-5936","observed_orcids":["https://orcid.org/0009-0006-7495-5936"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Sun","raw_affiliation_strings":["Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People\u2019s Republic of China","Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683149","display_name":"Xiao Chen","orcid":"https://orcid.org/0000-0002-1544-9703","observed_orcids":["https://orcid.org/0000-0002-1544-9703"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210104954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432007","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0003-4798-6594","observed_orcids":["https://orcid.org/0000-0003-4798-6594"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210104954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037436220","display_name":"Shenpan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenpan Li","raw_affiliation_strings":["Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhou","raw_affiliation_strings":["Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210104954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059563024","display_name":"Xingfen Yang","orcid":"https://orcid.org/0000-0001-5806-4507","observed_orcids":["https://orcid.org/0000-0001-5806-4507"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xingfen Yang","raw_affiliation_strings":["School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People\u2019s Republic of China","Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100439806","display_name":"Jianjun Liu","orcid":"https://orcid.org/0000-0002-9662-8294","observed_orcids":["https://orcid.org/0000-0002-9662-8294"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Liu","raw_affiliation_strings":["Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210104954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059563024"],"corresponding_institution_ids":["https://openalex.org/I4210104954","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":1.2943,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.75700634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"13","first_page":"17211","last_page":"17226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saxitoxin","display_name":"saxitoxin","score":1.0},{"id":"https://openalex.org/keywords/paralytic-shellfish-poisoning","display_name":"paralytic shellfish poisoning","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chronic-low-dose-exposure","display_name":"chronic low-dose exposure","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ca1-region","display_name":"CA1 region","score":0.7400000095367432},{"id":"https://openalex.org/keywords/neuronal-damage","display_name":"neuronal injury","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8140000104904175},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.9010000228881836},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/arylsulfatase-a","display_name":"arylsulfatase A","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8960000276565552},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/drinking-water-exposure","display_name":"drinking water exposure","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2777646408","wikidata":"https://www.wikidata.org/wiki/Q412694","display_name":"Saxitoxin","level":3,"score":0.7680608034133911},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6196771860122681},{"id":"https://openalex.org/C2778706303","wikidata":"https://www.wikidata.org/wiki/Q2612896","display_name":"Nerve agent","level":4,"score":0.494718998670578},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3486860692501068},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3211786150932312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2733510136604309},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.15491536259651184},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15207317471504211},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.203199","doi":"https://doi.org/10.18632/aging.203199","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203199","pdf_url":"https://www.aging-us.com/article/203199/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmid:34197336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34197336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8312470","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8312470","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/aging.203199","doi":"https://doi.org/10.18632/aging.203199","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203199","pdf_url":"https://www.aging-us.com/article/203199/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3176187811.pdf","grobid_xml":"https://content.openalex.org/works/W3176187811.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1599452655","https://openalex.org/W1978308357","https://openalex.org/W1980367397","https://openalex.org/W2015629419","https://openalex.org/W2021816790","https://openalex.org/W2036233390","https://openalex.org/W2039296219","https://openalex.org/W2080112438","https://openalex.org/W2140408113","https://openalex.org/W2148107816","https://openalex.org/W2152589735","https://openalex.org/W2198424459","https://openalex.org/W2268943164","https://openalex.org/W2274431857","https://openalex.org/W2291881989","https://openalex.org/W2292477050","https://openalex.org/W2401930651","https://openalex.org/W2523456649","https://openalex.org/W2523954981","https://openalex.org/W2579122492","https://openalex.org/W2601193296","https://openalex.org/W2746275624","https://openalex.org/W2762747291","https://openalex.org/W2767450049","https://openalex.org/W2809902849","https://openalex.org/W2886511151","https://openalex.org/W2889396703","https://openalex.org/W2955924525","https://openalex.org/W2969289931","https://openalex.org/W2990002653","https://openalex.org/W2994076401","https://openalex.org/W3033803128","https://openalex.org/W3046213812"],"related_works":["https://openalex.org/W2312282521","https://openalex.org/W2460124723","https://openalex.org/W2141092363","https://openalex.org/W1981836532","https://openalex.org/W2586226594","https://openalex.org/W4390719667","https://openalex.org/W2030762095","https://openalex.org/W2064563896","https://openalex.org/W1980275855","https://openalex.org/W2117765351"],"abstract_inverted_index":{"Saxitoxin":[0],"(STX),":[1],"as":[2],"a":[3,65,168,180],"type":[4],"of":[5,40,115,152,159,183,187],"paralytic":[6],"shellfish":[7],"poisoning":[8],"(PSP),":[9],"is":[10,30,167],"gaining":[11],"widespread":[12],"attention":[13],"due":[14],"to":[15,171],"its":[16],"long":[17],"existence":[18],"in":[19,64,81,108,121,140],"edible":[20],"shellfish.":[21],"However,":[22],"the":[23,37,82,109,141,184],"mechanism":[24],"underlying":[25],"STX":[26,43,77,123,160,188],"chronic":[27],"exposure-induced":[28],"effect":[29],"not":[31],"well":[32],"understood.":[33],"Here,":[34],"we":[35],"evaluated":[36],"neurotoxicity":[38],"effects":[39],"long-term":[41,156],"low-dose":[42],"exposure":[44,161],"on":[45],"C57/BL":[46],"mice":[47,62,93],"by":[48,99],"behavioral":[49,58],"tests,":[50],"pathology":[51],"analysis,":[52],"and":[53,103,134,145],"hippocampal":[54,110],"proteomics":[55],"analysis.":[56],"Several":[57],"tests":[59],"showed":[60,128],"that":[61,129,155],"were":[63,118,138],"cognitive":[66],"deficiency":[67],"after":[68],"treated":[69],"with":[70,89],"0,":[71],"0.5,":[72],"1.5,":[73],"or":[74],"4.5":[75],"\u03bcg":[76],"equivalents/kg":[78],"body":[79],"weight":[80],"drinking":[83],"water":[84],"for":[85],"3":[86],"months.":[87],"Compared":[88],"control":[90],"mice,":[91],"STX-exposed":[92],"exhibited":[94],"brain":[95],"neuronal":[96,101,164],"damage":[97],"characterized":[98],"decreasing":[100],"cells":[102],"thinner":[104],"pyramidal":[105],"cell":[106],"layers":[107],"CA1":[111],"region.":[112],"A":[113,136],"total":[114],"29":[116],"proteins":[117],"significantly":[119],"altered":[120],"different":[122],"dose":[124],"groups.":[125],"Bioinformatics":[126],"analysis":[127],"protein":[130],"phosphatase":[131],"1":[132],"(Ppp1c)":[133],"arylsulfatase":[135],"(Arsa)":[137],"involved":[139],"hippo":[142],"signaling":[143],"pathway":[144],"sphingolipid":[146],"metabolism":[147],"pathway.":[148],"The":[149],"decreased":[150],"expression":[151],"Arsa":[153],"indicates":[154],"low":[157],"doses":[158],"can":[162],"cause":[163],"inhibition,":[165],"which":[166],"process":[169],"related":[170],"spatial":[172],"memory":[173],"impairment.":[174],"Taken":[175],"together,":[176],"our":[177],"study":[178],"provides":[179],"new":[181],"understanding":[182],"molecular":[185],"mechanisms":[186],"neurotoxicity.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
