{"id":"https://openalex.org/W3176187580","doi":"https://doi.org/10.1161/atvb.36.suppl_1.32","title":"Abstract 32: Analysis of Serum Clopidogrel Active Metabolite Concentration Identifies Novel Genetic Variants Associated With Clopidogrel Pharmacokinetics","display_name":"Abstract 32: Analysis of Serum Clopidogrel Active Metabolite Concentration Identifies Novel Genetic Variants Associated With Clopidogrel Pharmacokinetics","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W3176187580","doi":"https://doi.org/10.1161/atvb.36.suppl_1.32","mag":"3176187580"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.36.suppl_1.32","doi":"https://doi.org/10.1161/atvb.36.suppl_1.32","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.36.suppl_1.32","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086605628","display_name":"Joshua Backman","orcid":"https://orcid.org/0000-0001-7262-0880","observed_orcids":["https://orcid.org/0000-0001-7262-0880"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D Backman","raw_affiliation_strings":["Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","Joshua D Backman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Joshua D Backman","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011015228","display_name":"Joshua P. Lewis","orcid":"https://orcid.org/0000-0002-4107-6066","observed_orcids":["https://orcid.org/0000-0002-4107-6066"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua P Lewis","raw_affiliation_strings":["Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","Joshua P Lewis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Joshua P Lewis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114251164","display_name":"Richard B. Horenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B Horenstein","raw_affiliation_strings":["Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","Richard B Horenstein"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Richard B Horenstein","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069686574","display_name":"Michael A. Pacanowski","orcid":"https://orcid.org/0009-0004-2620-7779","observed_orcids":["https://orcid.org/0009-0004-2620-7779"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Pacanowski","raw_affiliation_strings":["Cntr for Drug Evaluation and Rsch, FDA, Silver Spring, MD","Michael A Pacanowski"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cntr for Drug Evaluation and Rsch, FDA, Silver Spring, MD","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]},{"raw_affiliation_string":"Michael A Pacanowski","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079418869","display_name":"William Douglas Figg","orcid":"https://orcid.org/0000-0003-2428-5613","observed_orcids":["https://orcid.org/0000-0003-2428-5613"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D Figg","raw_affiliation_strings":["Cntr for Cancer Rsch, National Cancer Institute, Bethesda, MD","William D Figg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cntr for Cancer Rsch, National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"William D Figg","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009070946","display_name":"Alan R. Shuldiner","orcid":"https://orcid.org/0000-0001-9921-4305","observed_orcids":["https://orcid.org/0000-0001-9921-4305"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R Shuldiner","raw_affiliation_strings":["Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","Alan R Shuldiner"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Alan R Shuldiner","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043833054","display_name":"Jeffrey R. O\u2019Connell","orcid":"https://orcid.org/0000-0002-7046-6688","observed_orcids":["https://orcid.org/0000-0002-7046-6688"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R O'Connell","raw_affiliation_strings":["Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","Jeffrey R O'Connell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Jeffrey R O'Connell","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110221654","display_name":"Laura M. Yerges\u2010Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura M Yerges-Armstrong","raw_affiliation_strings":["Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","Laura M Yerges-Armstrong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Personalized and Genomic Medicine, Univ of Maryland-Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Laura M Yerges-Armstrong","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.9800000190734863},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7860000133514404},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clopidogrel-response-variability","display_name":"clopidogrel response variability","score":0.6499999761581421},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.6480000019073486},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.5899999737739563},{"id":"https://openalex.org/keywords/amish","display_name":"Amish","score":0.6570000052452087},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.9705417156219482},{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.8045415282249451},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.7783396244049072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6163981556892395},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5990387797355652},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.4812707304954529},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.43254554271698},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.426414430141449},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4156278371810913},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4151607155799866},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.41415682435035706},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4016497731208801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34920063614845276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2133672833442688},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19695031642913818},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17518529295921326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07981973886489868},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.36.suppl_1.32","doi":"https://doi.org/10.1161/atvb.36.suppl_1.32","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.36.suppl_1.32","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4234973638","https://openalex.org/W2336778042","https://openalex.org/W4244371829","https://openalex.org/W52644939","https://openalex.org/W2942385418","https://openalex.org/W3198137207","https://openalex.org/W1570992506","https://openalex.org/W2266302726","https://openalex.org/W2366396248","https://openalex.org/W2153837110"],"abstract_inverted_index":{"Clopidogrel":[0],"with":[1,16,192],"aspirin":[2],"is":[3,50,282],"standard":[4],"of":[5,11,38,44,70,92,121,138,141,199,266,288,296,307],"care":[6,293],"for":[7,183,218,274,317,321],"the":[8,45,71,139,167,203,220,262,286,308,315,325],"secondary":[9],"prevention":[10],"ischemic":[12],"events":[13],"in":[14,24,28,31,47,133,235,324],"patients":[15,33,323],"acute":[17],"coronary":[18],"syndromes.":[19],"However,":[20],"substantial":[21],"inter-individual":[22],"variation":[23,46],"clopidogrel":[25,48,83,88,108,122,125,150,268,275,297,309],"response":[26],"results":[27],"sub-optimal":[29],"therapy":[30],"some":[32],"and":[34,55,110,159,162,181,187,214,250,279,312],"an":[35,178],"increased":[36],"risk":[37],"recurrent":[39],"events.":[40],"Up":[41],"to":[42,52,86,103,116,166,226,284,303],"73%":[43],"efficacy":[49,276],"found":[51],"be":[53,96],"heritable,":[54],"while":[56],"key":[57],"genetic":[58,72],"variants":[59,290],"such":[60],"as":[61,99],"CYP2C19":[62,206,221],"*2":[63,222],"have":[64,81],"been":[65],"identified,":[66,278],"a":[67,117,147,304],"large":[68],"portion":[69],"heritability":[73],"remains":[74],"unaccounted":[75],"for.":[76],"To":[77],"date,":[78],"few":[79],"studies":[80],"used":[82],"active":[84,126,269,298],"metabolite":[85,127,270,299],"evaluate":[87],"pharmacogenomics.":[89],"The":[90,195],"evaluation":[91],"this":[93,227,258],"biomarker":[94],"may":[95,111],"particularly":[97],"informative":[98],"it":[100],"enables":[101],"us":[102],"focus":[104],"almost":[105],"exclusively":[106],"on":[107,237,291],"pharmacokinetics":[109],"allow":[112],"new":[113],"discoveries":[114],"leading":[115],"more":[118],"thorough":[119],"understanding":[120,306],"activation.":[123],"Serum":[124],"concentration":[128,300],"was":[129,154,175,202,215],"measured":[130],"by":[131,219],"HPLC-MS/MS":[132],"506":[134],"healthy,":[135],"Amish":[136],"participants":[137,191],"Pharmacogenomics":[140],"Anti-Platelet":[142],"Intervention":[143],"(PAPI)":[144],"Study":[145],"after":[146],"7-day":[148],"75-mg/day":[149],"intervention.":[151],"Genome-wide":[152],"genotyping":[153],"performed":[155],"using":[156],"Affymetrix":[157],"5.0":[158],"6.0":[160],"arrays,":[161],"SNPs":[163],"were":[164,233,277],"imputed":[165],"1000":[168],"Genomes":[169],"cosmopolitan":[170],"panel.":[171],"Mixed":[172],"models":[173],"analysis":[174,295],"conducted":[176,261],"under":[177],"additive":[179],"model":[180],"adjusted":[182],"age,":[184],"sex,":[185],"BMI,":[186],"relatedness":[188],"among":[189],"study":[190,259,281],"MMAP":[193],"(http://edn.som.umaryland.edu/mmap).":[194],"most":[196],"significant":[197,231],"signal":[198],"our":[200],"GWAS":[201,265],"previously":[204],"identified":[205,234],"/":[207],"CYP2C9":[208],"locus":[209],"(P=":[210],"9.2x10":[211],"-15":[212],"),":[213,243,249],"fully":[216],"accounted":[217],"variant.":[223],"In":[224,257],"addition":[225],"signal,":[228],"novel":[229],"genome-wide":[230],"signals":[232],"loci":[236],"Chr.":[238,244,251],"3":[239],"(rs187941554,":[240],"P=4.7x10":[241],"-11":[242],"7":[245],"(rs73407739,":[246],"p=3.6x10":[247],"-8":[248,255],"17":[252],"(rs80343429,":[253],"P=3.7x10":[254],").":[256],"we":[260],"first":[263],"ever":[264],"serum":[267],"concentration.":[271],"Novel":[272],"associations":[273],"further":[280],"required":[283],"determine":[285],"impact":[287],"these":[289],"clinical":[292],"Continual":[294],"will":[301],"contribute":[302],"better":[305],"metabolic":[310],"pathway,":[311],"potentially":[313],"lay":[314],"groundwork":[316],"improved":[318],"anti-platelet":[319],"treatment":[320],"CVD":[322],"future.":[326]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}