{"id":"https://openalex.org/W3176046461","doi":"https://doi.org/10.1182/blood.v130.suppl_1.4019.4019","title":"Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway","display_name":"Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway","publication_year":2017,"publication_date":"2017-12-08","ids":{"openalex":"https://openalex.org/W3176046461","doi":"https://doi.org/10.1182/blood.v130.suppl_1.4019.4019","mag":"3176046461"},"language":"en","primary_location":{"id":"mag:3176046461","doi":"https://doi.org/10.1182/blood.v130.suppl_1.4019.4019","is_oa":false,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S0006497119845354","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060928962","display_name":"Jian Yu","orcid":"https://orcid.org/0000-0002-2774-6270","observed_orcids":["https://orcid.org/0000-0002-2774-6270"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Yu","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0002-2774-6270","affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416535","display_name":"Yun Chen","orcid":"https://orcid.org/0000-0002-2516-0946","observed_orcids":["https://orcid.org/0000-0002-2516-0946","https://orcid.org/0009-0002-5557-4995"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Chen","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0002-2516-0946","affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036294739","display_name":"Liguang Chen","orcid":"https://orcid.org/0000-0001-5325-781X","observed_orcids":["https://orcid.org/0000-0001-5325-781X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liguang Chen","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112805891","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0003-0076-2470","observed_orcids":["https://orcid.org/0000-0003-0076-2470"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0003-0076-2470","affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010336471","display_name":"Laura Z. Rassenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Z. Rassenti","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033222332","display_name":"George F. Widhopf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George F. Widhopf","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Kipps","raw_affiliation_strings":["Moores Cancer Center - University of California San Diego, La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0002-0064-4549","affiliations":[{"raw_affiliation_string":"Moores Cancer Center - University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34894726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":null,"first_page":"4019","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.19259999692440033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ibrutinib","display_name":"ibrutinib","score":0.8659999966621399},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7879999876022339},{"id":"https://openalex.org/keywords/lymphoma-cell-proliferation","display_name":"lymphoma cell proliferation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/rho-gtpase-signaling","display_name":"Rho GTPase signaling","score":0.6359999775886536},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.9324673414230347},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.8692293763160706},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.7576515078544617},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6892498731613159},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6775423884391785},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5668720006942749},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.531003475189209},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41542378067970276},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.40913665294647217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40813279151916504},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.40162408351898193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3556053042411804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.310634970664978},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.26342707872390747},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15631002187728882},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1254979372024536}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3176046461","doi":"https://doi.org/10.1182/blood.v130.suppl_1.4019.4019","is_oa":false,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S0006497119845354","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9492999911308289}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2612940040","https://openalex.org/W2559064918","https://openalex.org/W2810600203","https://openalex.org/W2345102372","https://openalex.org/W2967953400","https://openalex.org/W3214314307","https://openalex.org/W3093496689","https://openalex.org/W2573910666","https://openalex.org/W2015363069","https://openalex.org/W2336296285"],"abstract_inverted_index":{"Abstract":[0],"Signaling":[3],"via":[4,105,420],"the":[5,15,33,74,134,154,170,193,218,246,274,284,301,311,361,369,378,432,466],"B":[6],"cell":[7,26,372],"receptor":[8],"(BCR)":[9],"plays":[10],"an":[11,37,495],"important":[12],"role":[13],"in":[14,63,142,235,239,245,300,465],"pathogenesis":[16],"and":[17,103,266,271,339,343,357,368,389,414,456],"progression":[18],"of":[19,36,39,76,81,85,95,136,157,176,220,227,248,257,313,326,346,351,363,371,377,391,396,416,468],"chronic":[20],"lymphocytic":[21],"leukemia":[22],"(CLL)":[23],"or":[24,56,263,450],"mantle":[25],"lymphoma":[27],"(MCL).":[28],"This":[29,67,400,452],"is":[30,163],"underscored":[31],"by":[32,124,329,429,441],"clinical":[34],"effectiveness":[35],"inhibitor":[38],"Bruton's":[40],"tyrosine":[41],"kinase":[42],"(BTK),":[43],"ibrutinib,":[44,261,308,385,442],"which":[45,130,409],"can":[46,92,405,426],"block":[47],"BCR-signaling.":[48,451],"However,":[49],"ibrutinib":[50,137,265,457],"cannot":[51,438],"induce":[52,316,406],"complete":[53],"responses":[54],"(CR)":[55],"durable":[57],"remissions":[58],"without":[59,290],"continued":[60],"therapy,":[61],"particularly":[62],"patients":[64,221,236,259,469],"with":[65,222,237,260,276,333,354,381,470],"MCL.":[66,471],"suggests":[68],"that":[69,78,90,153,166,217,229,295,403,425,446,454],"ancillary":[70],"pathways":[71],"contribute":[72],"to":[73,99,138,232,315,320,349,411],"growth/survival":[75],"MCL/CLL":[77],"are":[79],"independent":[80],"BCR-signaling":[82],"and/or":[83],"inhibition":[84],"BTK.":[86],"Studies":[87],"have":[88,459],"found":[89,216,234,294],"Wnt5a":[91,228,241,278,296,314,348,404],"promote":[93],"activation":[94,120,299],"Rho":[96],"GTPase":[97],"Rac1":[98,119,298,407],"enhance":[100,133],"CLL-cell":[101],"proliferation":[102,325,390,413],"survival":[104,388,415],"a":[106,126,421],"ROR1-dependent,but":[107],"BTK-independent":[108],"pathway":[109,424,437],"(Yu":[110],"J,":[111],"et":[112,209],"al.,":[113,210],"Leukemia":[114],"31:1333,":[115],"2017).":[116],"Furthermore,":[117],"Wnt5a-induced":[118],"could":[121,132,309],"be":[122,427,439],"blocked":[123,386,428,440],"cirmtuzumab,":[125,262,382],"humanized":[127],"anti-ROR1":[128],"mAb,":[129],"significantly":[131,190,359],"capacity":[135,312],"clear":[139],"CLL":[140,168,198],"cells":[141,146,162,199,256,275,287,319,328,332,335,353,356,380,393,419],"vivo":[143],".":[144],"MCL":[145,161,181,223,255,286,303,318,327,331,352,365,379,392,418],"also":[147,215],"express":[148],"ROR1.":[149],"Moreover,":[150],"we":[151],"find":[152],"median":[155,171,194],"level":[156],"ROR1":[158,177,195],"on":[159,167,180,197],"primary":[160,254,302,317,417],"higher":[164,191],"than":[165,192],"cells;":[169],"absolute":[172],"mean":[173],"fluorescence":[174],"intensity":[175],"(ROR1":[178],"DMFI)":[179],"(87.5":[182],"\u00b1":[183,201],"18.5":[184,202],"(S.D.),":[185,203],"N":[186,204],"=":[187,205],"8)":[188],"was":[189,242],"DMFI":[196],"(38.5":[200],"1567;":[206],"(Cui":[207],"B,":[208],"Blood":[211],"128:2931,":[212],"2016)).":[213],"We":[214,252,293,323],"plasma":[219,247],"had":[224],"high":[225],"levels":[226],"were":[230,288],"comparable":[231],"those":[233],"CLL;":[238],"contrast":[240],"virtually":[243],"undetectable":[244],"age-matched":[249],"healthy":[250],"adults.":[251],"cultured":[253,289],"different":[258,398],"both":[264],"cirmtuzumab":[267,455],"for":[268,279],"2":[269],"h,":[270],"then":[272],"stimulated":[273],"exogenous":[277,291,347],"30":[280],"min.":[281],"In":[282],"parallel,":[283],"same":[285],"Wnt5a.":[292],"induced":[297,324],"cells.":[304],"Cirmtuzumab,":[305],"but":[306,383],"not":[307,384,462],"inhibit":[310,448],"activate":[321],"Rac1.":[322],"co-culturing":[330],"HeLa":[334],"expressing":[336],"CD154":[337],"(HeLaCD154)":[338],"recombinant":[340],"interleukin":[341],"(IL)-4":[342],"IL-10.":[344],"Addition":[345],"co-cultures":[350],"HeLaCD154":[355],"IL-4/10":[358],"enhanced":[360,412],"proportion":[362],"dividing":[364],"entering":[366],"S/G2":[367],"numbers":[370],"divisions":[373],"over":[374],"time.":[375],"Treatment":[376],"Wnt5a-enhanced":[387],"from":[394],"each":[395],"3":[397],"patients.":[399],"study":[401],"demonstrates":[402],"activation,":[408],"leads":[410],"ROR1-dependent":[422],"signaling":[423,436],"cirmtuzumab.":[430],"On":[431],"other":[433],"hand,":[434],"this":[435],"even":[443],"at":[444],"concentrations":[445],"completely":[447],"BTK":[449],"implies":[453],"may":[458],"additive,":[460],"if":[461],"synergistic,":[463],"activity":[464],"treatment":[467],"Disclosures":[475],"Kipps:":[477],"Celgene:":[478],"Consultancy,":[479,484,489,498,501],"Honoraria,":[480,485,490],"Research":[481,486,504],"Funding;":[482,487],"AbbVie:":[483],"Gilead:":[488],"Speakers":[491],"Bureau;":[492],"Pharmacyclics,":[493],"LLC,":[494],"AbbVie":[496],"Company:":[497],"Honoraria;":[499,502],"Roche:":[500],"Oncternal:":[503],"Funding.":[505]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}