{"id":"https://openalex.org/W3175995000","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.724.7","title":"Prolactin regulates ZnT2 transcription through the JAK2\u2010STAT5 signaling pathway","display_name":"Prolactin regulates ZnT2 transcription through the JAK2\u2010STAT5 signaling pathway","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W3175995000","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.724.7","mag":"3175995000"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.724.7","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.724.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.724.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053198596","display_name":"Shannon L. Kelleher","orcid":"https://orcid.org/0000-0003-0613-6294","observed_orcids":["https://orcid.org/0000-0003-0613-6294"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Kelleher","raw_affiliation_strings":["Nutritional Sciences, Pennsylvania State University, University Park, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences, Pennsylvania State University, University Park, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110183406","display_name":"Linxi Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linxi Qian","raw_affiliation_strings":["Nutritional Sciences, Pennsylvania State University, University Park, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences, Pennsylvania State University, University Park, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060725632","display_name":"Ver\u00f3nica L\u00f3pez","orcid":"https://orcid.org/0000-0001-9432-3238","observed_orcids":["https://orcid.org/0000-0001-9432-3238"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Lopez","raw_affiliation_strings":["Nutritional Sciences, Pennsylvania State University, University Park, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences, Pennsylvania State University, University Park, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038541716","display_name":"Young Ah Seo","orcid":"https://orcid.org/0000-0003-3884-0665","observed_orcids":["https://orcid.org/0000-0003-3884-0665"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Ah Seo","raw_affiliation_strings":["Nutritional Sciences, Pennsylvania State University, University Park, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences, Pennsylvania State University, University Park, PA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50105179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2551000118255615,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/znt2","display_name":"ZnT2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/jak2-stat5-signaling","display_name":"JAK2/STAT5 signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.48500001430511475},{"id":"https://openalex.org/keywords/zinc-homeostasis","display_name":"zinc homeostasis","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.8314025402069092},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6115901470184326},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.49840497970581055},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.49582943320274353},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4770314395427704},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.47683659195899963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4497959613800049},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.43883216381073},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4113995134830475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4030057489871979},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39364564418792725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.367607444524765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2983212471008301},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21941182017326355},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2076929807662964},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.09997919201850891},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.724.7","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.724.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.724.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000638098","https://openalex.org/W2051634390","https://openalex.org/W1230452193","https://openalex.org/W3176733817","https://openalex.org/W4243977743","https://openalex.org/W12212036","https://openalex.org/W2110803617","https://openalex.org/W1998051987","https://openalex.org/W2031132506","https://openalex.org/W2075207336"],"abstract_inverted_index":{"ZnT2":[0,34,44,67,85,125,163,177,187],"plays":[1],"an":[2],"important":[3],"role":[4],"in":[5,36,47,106,123,179],"zinc":[6],"(Zn)":[7],"secretion":[8,202],"from":[9],"the":[10,23,28,59,66,84,102,107,124,137,147,176,192,197],"mammary":[11,37,49,200],"gland":[12],"and":[13,76,119],"it":[14],"is":[15],"regulated":[16],"by":[17,56,89],"prolactin":[18],"(PRL)":[19],"during":[20],"lactation.":[21],"Herein,":[22],"objective":[24],"was":[25,54,69,87],"to":[26,136,175],"explore":[27],"mechanisms":[29],"through":[30,189],"which":[31,53],"PRL":[32,42,90,132,171,185],"regulates":[33,186],"expression":[35],"cells.":[38,80],"We":[39],"determined":[40],"that":[41,131,159,170,184],"increases":[43],"mRNA":[45],"level":[46],"cultured":[48],"epithelial":[50],"cells":[51],"(HC11)":[52],"inhibited":[55],"pre\u2010treatment":[57],"with":[58,94,141,146],"Jak2":[60],"inhibitor":[61],"AG490.":[62],"A":[63],"fragment":[64],"of":[65,83,110,153,191,199],"promoter":[68,86,178],"subcloned":[70],"into":[71,78],"a":[72,95],"luciferase":[73],"reporter":[74],"vector":[75],"transfected":[77],"HC11":[79],"The":[81],"activity":[82],"increased":[88],"treatment.":[91],"Cells":[92],"co\u2010transfected":[93],"dominant\u2010negative":[96],"STAT5":[97,115,134,173],"abrogated":[98],"this":[99],"effect":[100],"implicating":[101],"Jak2/STAT5":[103,193],"signaling":[104,194],"pathway":[105,195],"transcriptional":[108],"regulation":[109,198],"ZnT2.":[111],"Two":[112],"putative":[113],"consensus":[114],"binding":[116,135,174],"sequences":[117],"(GAS1":[118],"GAS2)":[120],"were":[121],"identified":[122],"promoter.":[126],"Gel":[127],"shift":[128],"assays":[129,168],"indicated":[130],"induced":[133],"proximal":[138],"GAS2":[139],"element":[140],"greater":[142],"efficiency":[143],"as":[144],"compared":[145],"distal":[148],"GAS1":[149],"element.":[150],"Mutagenesis":[151],"analysis":[152],"these":[154],"two":[155],"GAS":[156],"elements":[157],"suggests":[158],"they":[160],"synergistically":[161],"modulate":[162],"transcription.":[164],"Finally,":[165],"chromosome":[166],"immunoprecipition":[167],"confirmed":[169],"activates":[172],"vivo.":[180],"Our":[181],"results":[182],"indicate":[183],"transcription":[188],"activation":[190],"coordinating":[196],"Zn":[201],"processes.":[203]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}