{"id":"https://openalex.org/W3175969873","doi":"https://doi.org/10.1126/science.abi4506","title":"Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice","display_name":"Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice","publication_year":2021,"publication_date":"2021-06-22","ids":{"openalex":"https://openalex.org/W3175969873","doi":"https://doi.org/10.1126/science.abi4506","mag":"3175969873","pmid":"https://pubmed.ncbi.nlm.nih.gov/33758837","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7986996"},"language":"en","primary_location":{"id":"doi:10.1126/science.abi4506","doi":"https://doi.org/10.1126/science.abi4506","is_oa":true,"landing_page_url":"https://doi.org/10.1126/science.abi4506","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1126/science.abi4506","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014451298","display_name":"David R. Martinez","orcid":"https://orcid.org/0000-0002-2940-8961","observed_orcids":["https://orcid.org/0000-0002-2940-8961"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David R. Martinez","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113264782","display_name":"Alexandra Sch\u00e4fer","orcid":"https://orcid.org/0000-0002-4760-4923","observed_orcids":["https://orcid.org/0000-0002-4760-4923"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Sch\u00e4fer","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052239466","display_name":"Sarah R. Leist","orcid":"https://orcid.org/0000-0002-4989-5381","observed_orcids":["https://orcid.org/0000-0002-4989-5381"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah R. Leist","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022435465","display_name":"Gabriela De la Cruz","orcid":"https://orcid.org/0000-0002-6019-5853","observed_orcids":["https://orcid.org/0000-0002-6019-5853"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela De la Cruz","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086018472","display_name":"Ande West","orcid":"https://orcid.org/0000-0001-7381-9533","observed_orcids":["https://orcid.org/0000-0001-7381-9533"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ande West","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056068190","display_name":"Elena N. Atochina\u2010Vasserman","orcid":"https://orcid.org/0000-0001-7950-7004","observed_orcids":["https://orcid.org/0000-0001-7950-7004"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena N. Atochina-Vasserman","raw_affiliation_strings":["Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046400231","display_name":"Lisa C. Lindesmith","orcid":"https://orcid.org/0000-0001-9567-0522","observed_orcids":["https://orcid.org/0000-0001-9567-0522"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa C. Lindesmith","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067992777","display_name":"Norbert Pardi","orcid":"https://orcid.org/0000-0003-1008-6242","observed_orcids":["https://orcid.org/0000-0003-1008-6242"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norbert Pardi","raw_affiliation_strings":["Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084461087","display_name":"Robert Parks","orcid":"https://orcid.org/0000-0002-6259-7610","observed_orcids":["https://orcid.org/0000-0002-6259-7610"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Parks","raw_affiliation_strings":["Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032841971","display_name":"Maggie Barr","orcid":"https://orcid.org/0000-0002-0408-0728","observed_orcids":["https://orcid.org/0000-0002-0408-0728"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maggie Barr","raw_affiliation_strings":["Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419597","display_name":"Dapeng Li","orcid":"https://orcid.org/0000-0002-8232-3094","observed_orcids":["https://orcid.org/0000-0002-8232-3094"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dapeng Li","raw_affiliation_strings":["Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052355885","display_name":"Boyd L. Yount","orcid":"https://orcid.org/0000-0002-6099-8429","observed_orcids":["https://orcid.org/0000-0002-6099-8429"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boyd Yount","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074729687","display_name":"Kevin O. Saunders","orcid":"https://orcid.org/0000-0001-7399-7954","observed_orcids":["https://orcid.org/0000-0001-7399-7954"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin O. Saunders","raw_affiliation_strings":["Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068253145","display_name":"Drew Weissman","orcid":"https://orcid.org/0000-0002-1501-6510","observed_orcids":["https://orcid.org/0000-0002-1501-6510"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew Weissman","raw_affiliation_strings":["Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051827275","display_name":"Barton F. Haynes","orcid":"https://orcid.org/0000-0002-7643-9023","observed_orcids":["https://orcid.org/0000-0002-7643-9023","https://orcid.org/0000-0002-2847-1854"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barton F. Haynes","raw_affiliation_strings":["Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062608685","display_name":"Stephanie A. Montgomery","orcid":"https://orcid.org/0000-0001-8012-5302","observed_orcids":["https://orcid.org/0000-0001-8012-5302"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie A. Montgomery","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of North Carolina School of Medicine, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017501496","display_name":"Ralph Steven Baric","orcid":"https://orcid.org/0000-0001-6827-8701","observed_orcids":["https://orcid.org/0000-0001-6827-8701"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ralph S. Baric","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014451298","https://openalex.org/A5017501496"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":11.3634,"has_fulltext":false,"cited_by_count":174,"citation_normalized_percentile":{"value":0.98790313,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"373","issue":"6558","first_page":"991","last_page":"998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarbecovirus","display_name":"Sarbecovirus","score":0.9240000247955322},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.9679999947547913},{"id":"https://openalex.org/keywords/heterologous-challenge","display_name":"heterologous challenge","score":0.6710000038146973},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9319999814033508},{"id":"https://openalex.org/keywords/breakthrough-infection","display_name":"breakthrough infection","score":0.6679999828338623},{"id":"https://openalex.org/keywords/variants-of-concern","display_name":"variants of concern","score":0.6859999895095825},{"id":"https://openalex.org/keywords/beta-variant","display_name":"Beta variant","score":0.8820000290870667},{"id":"https://openalex.org/keywords/d614g-mutation","display_name":"D614G mutation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.7853949069976807},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7033696174621582},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.642413854598999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5827029943466187},{"id":"https://openalex.org/C2909509916","wikidata":"https://www.wikidata.org/wiki/Q22329850","display_name":"Spike Protein","level":5,"score":0.5610271692276001},{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.4791938066482544},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.47107329964637756},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4573918581008911},{"id":"https://openalex.org/C2776844884","wikidata":"https://www.wikidata.org/wiki/Q1134583","display_name":"Coronaviridae","level":5,"score":0.4255712032318115},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4206177294254303},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.41638386249542236},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2535122036933899},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2525017559528351},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.19852414727210999},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.1845059096813202},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16632863879203796},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0982830822467804},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.1126/science.abi4506","doi":"https://doi.org/10.1126/science.abi4506","is_oa":true,"landing_page_url":"https://doi.org/10.1126/science.abi4506","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"doi:10.1101/2021.03.11.434872","doi":"https://doi.org/10.1101/2021.03.11.434872","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.03.11.434872","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/11/2021.03.11.434872.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8899822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8899822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmid:33758837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33758837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:34214046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34214046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7986996","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7986996","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:mg74qw235","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/cdpr-yf34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science","raw_type":"Article"},{"id":"doi:10.17615/cdpr-yf34","doi":"https://doi.org/10.17615/cdpr-yf34","is_oa":true,"landing_page_url":"https://doi.org/10.17615/cdpr-yf34","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.21430/m3kg3agbnr","doi":"https://doi.org/10.21430/m3kg3agbnr","is_oa":true,"landing_page_url":"https://doi.org/10.21430/m3kg3agbnr","pdf_url":null,"source":{"id":"https://openalex.org/S7407052242","display_name":"ImmPort","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210134534","host_organization_name":"National Institute of Allergy and Infectious Diseases","host_organization_lineage":["https://openalex.org/I4210134534"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1126/science.abi4506","doi":"https://doi.org/10.1126/science.abi4506","is_oa":true,"landing_page_url":"https://doi.org/10.1126/science.abi4506","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G117826003","display_name":"Human antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2","funder_award_id":"R01AI157155","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1272105088","display_name":"Determinants of Coronavirus Fidelity in Replication and Pathogenesis","funder_award_id":"R01AI108197","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G160339935","display_name":"Broad-spectrum antiviral GS-5734 to treat MERS-CoV and related emerging CoV","funder_award_id":"5r01ai132178-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1679713219","display_name":null,"funder_award_id":"R01-AI132178","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2298674817","display_name":null,"funder_award_id":"AI142759","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2678568294","display_name":null,"funder_award_id":"AI100625","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2846262537","display_name":"Defining viral and immune mechanisms of Dengue virus serotype 2 immune evasion","funder_award_id":"1f32ai152296-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3055706296","display_name":null,"funder_award_id":"AI108197","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3116999541","display_name":"Respiratory Virus Vaccine and Adjuvant Exploration","funder_award_id":"U01AI149644","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4389937464","display_name":"North Carolina Seronet Center for Excellence","funder_award_id":"U54CA260543","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4560865878","display_name":null,"funder_award_id":"5P30CA016086-41","funder_id":"https://openalex.org/F4320310773","funder_display_name":"National Cancer Center"},{"id":"https://openalex.org/G515833432","display_name":"Systems Immunogenetics of Biodefense and Emerging Pathogens in the Collaborative Cross","funder_award_id":"U19AI100625","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5247632879","display_name":null,"funder_award_id":"AI152296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5854035082","display_name":null,"funder_award_id":"NIAID F32 AI152296","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G59380150","display_name":null,"funder_award_id":"HHSN272201700036I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5985459936","display_name":"Nucleoside modified mRNA based HIV vaccine","funder_award_id":"R01AI124429","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6054129285","display_name":null,"funder_award_id":"F32 AI152296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6648906605","display_name":null,"funder_award_id":"NIH NIAID T32 AI007151","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6659894428","display_name":"Antiviral Drug Discovery and Development Center (AD3C)","funder_award_id":"U19AI142759","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7258925289","display_name":null,"funder_award_id":"AI124429","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7549273204","display_name":"Cell entry, cross-species transmission and pathogenesis of novel coronavirus from","funder_award_id":"R01AI110700","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G918283569","display_name":null,"funder_award_id":"AI007151","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G938927560","display_name":"Infectious Disease Pathogenesis Research Training Program","funder_award_id":"T32AI007151","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320310773","display_name":"National Cancer Center","ror":"https://ror.org/0065zqt33"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3175969873.pdf","grobid_xml":"https://content.openalex.org/works/W3175969873.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1561528540","https://openalex.org/W1963580683","https://openalex.org/W1990819855","https://openalex.org/W1993577573","https://openalex.org/W1995367098","https://openalex.org/W2035269438","https://openalex.org/W2037987211","https://openalex.org/W2057164767","https://openalex.org/W2074618762","https://openalex.org/W2103503670","https://openalex.org/W2109538392","https://openalex.org/W2166867592","https://openalex.org/W2195009776","https://openalex.org/W2298153446","https://openalex.org/W2725497285","https://openalex.org/W2775086803","https://openalex.org/W2782068718","https://openalex.org/W2794573360","https://openalex.org/W2973308780","https://openalex.org/W2975856930","https://openalex.org/W3000413850","https://openalex.org/W3000834295","https://openalex.org/W3004280078","https://openalex.org/W3009906937","https://openalex.org/W3014708904","https://openalex.org/W3016394521","https://openalex.org/W3030748957","https://openalex.org/W3034680516","https://openalex.org/W3036529319","https://openalex.org/W3036912690","https://openalex.org/W3037923073","https://openalex.org/W3043722389","https://openalex.org/W3044168259","https://openalex.org/W3044651071","https://openalex.org/W3044660350","https://openalex.org/W3045596302","https://openalex.org/W3045734160","https://openalex.org/W3046061621","https://openalex.org/W3047091198","https://openalex.org/W3049233984","https://openalex.org/W3087207483","https://openalex.org/W3090717270","https://openalex.org/W3092011752","https://openalex.org/W3092544928","https://openalex.org/W3093213262","https://openalex.org/W3093367571","https://openalex.org/W3102513150","https://openalex.org/W3109969518","https://openalex.org/W3113734454","https://openalex.org/W3118886905","https://openalex.org/W3119412259","https://openalex.org/W3121833403","https://openalex.org/W3129733558","https://openalex.org/W3132479927","https://openalex.org/W3136616180","https://openalex.org/W3139036184","https://openalex.org/W3144506870","https://openalex.org/W3158062106","https://openalex.org/W3160252417","https://openalex.org/W3160811128","https://openalex.org/W3161032756","https://openalex.org/W3176969175","https://openalex.org/W3210035900","https://openalex.org/W4205483821","https://openalex.org/W4210893818","https://openalex.org/W6805911003"],"related_works":["https://openalex.org/W3197528781","https://openalex.org/W4410192808","https://openalex.org/W4404128501","https://openalex.org/W6047510","https://openalex.org/W4220918900","https://openalex.org/W4388443769","https://openalex.org/W4308153474","https://openalex.org/W4391753946","https://openalex.org/W4383753333","https://openalex.org/W4402673140"],"abstract_inverted_index":{"A":[0],"broad":[1],"defense":[2],"against":[3,36,101],"SARS-like":[4,40],"viruses":[5],"Severe":[6],"acute":[7],"respiratory":[8],"syndrome":[9],"coronavirus":[10,16],"2":[11],"(SARS-CoV-2)":[12],"is":[13],"the":[14,26,59,85,97],"third":[15],"that":[17,32],"has":[18],"emerged":[19],"as":[20,79,81],"a":[21],"serious":[22],"human":[23],"pathogen":[24],"in":[25],"past":[27],"20":[28],"years.":[29],"Treatment":[30],"strategies":[31],"are":[33,42],"broadly":[34],"protective":[35],"current":[37],"and":[38,76,106,111],"future":[39],"coronaviruses":[41,83,113],"needed.":[43],"Martinez":[44],"et":[45],"al":[46],".":[47],"take":[48],"on":[49,56],"this":[50],"challenge":[51,102],"by":[52],"developing":[53],"vaccines":[54,66,99],"based":[55],"chimeras":[57],"of":[58,71,109],"viral":[60],"spike":[61,68],"protein.":[62],"The":[63],"messenger":[64],"RNA":[65],"encode":[67],"proteins":[69],"composed":[70],"domain":[72],"modules":[73],"from":[74,103],"epidemic":[75],"pandemic":[77,115],"coronaviruses,":[78],"well":[80],"bat":[82],"with":[84,114],"potential":[86],"to":[87,89,95],"cross":[88],"humans.":[90],"In":[91],"aged":[92],"mice":[93],"vulnerable":[94],"infection,":[96],"chimeric":[98],"protected":[100],"SARS-CoV,":[104],"SARS-CoV-2":[105],"tested":[107],"variants":[108],"concern,":[110],"zoonotic":[112],"potential.":[116],"\u2014VV":[117]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":63},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}
