{"id":"https://openalex.org/W3175873749","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.707.2","title":"Effect of Inhibiting Interleukin\u20101\u03b2 with Neutralizing Antibody on Tight Junction Protein Expression after Brain Ischemia in Ovine Fetus","display_name":"Effect of Inhibiting Interleukin\u20101\u03b2 with Neutralizing Antibody on Tight Junction Protein Expression after Brain Ischemia in Ovine Fetus","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W3175873749","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.707.2","mag":"3175873749"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.707.2","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.707.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.707.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058192036","display_name":"Xiaodi F. Chen","orcid":"https://orcid.org/0000-0002-1860-2814","observed_orcids":["https://orcid.org/0000-0002-1860-2814"]},"institutions":[{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodi Chen","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]},{"raw_affiliation_string":"1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025733362","display_name":"Grazyna Barbara Sadowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grazyna B Sadowska","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]},{"raw_affiliation_string":"1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841924","display_name":"Jiyong Zhang","orcid":"https://orcid.org/0000-0001-7880-1711","observed_orcids":["https://orcid.org/0000-0001-7880-1711"]},"institutions":[{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyong Zhang","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]},{"raw_affiliation_string":"1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064007757","display_name":"Erin E. Cummings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Cummings","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]},{"raw_affiliation_string":"1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064312491","display_name":"Yow\u2010Pin Lim","orcid":"https://orcid.org/0000-0003-2697-7963","observed_orcids":["https://orcid.org/0000-0003-2697-7963"]},"institutions":[{"id":"https://openalex.org/I4210142502","display_name":"ProThera Biologics (United States)","ror":"https://ror.org/03yzb9c23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142502"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yow Pin Lim","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> ProThera Biologics East Providence RI","2--> ProThera Biologics East Providence RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> ProThera Biologics East Providence RI","institution_ids":["https://openalex.org/I4210142502"]},{"raw_affiliation_string":"2--> ProThera Biologics East Providence RI","institution_ids":["https://openalex.org/I4210142502"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011689741","display_name":"Barbara S. Stonestreet","orcid":"https://orcid.org/0000-0002-6532-7683","observed_orcids":["https://orcid.org/0000-0002-6532-7683"]},"institutions":[{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara S Stonestreet","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]},{"raw_affiliation_string":"1--> Pediatrics Women &amp; Infants Hospital of Rhode Island Providence RI","institution_ids":["https://openalex.org/I4210133025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41811515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neutralizing-monoclonal-antibodies","display_name":"neutralizing monoclonal antibodies","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.9049999713897705},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8629999756813049},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":1.0},{"id":"https://openalex.org/keywords/fetal-brain","display_name":"fetal brain","score":0.7210000157356262},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6784076690673828},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6361200213432312},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.6114184260368347},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5670152902603149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46345043182373047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40713244676589966},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34485551714897156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22524115443229675},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.20422300696372986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20195862650871277},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.707.2","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.707.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.707.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1973675734","https://openalex.org/W4253740776","https://openalex.org/W2125953344","https://openalex.org/W2569001682","https://openalex.org/W3174647003","https://openalex.org/W2740582592","https://openalex.org/W2061705395","https://openalex.org/W2275684378","https://openalex.org/W182093223","https://openalex.org/W2003725128"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2,24,75,110,129,144,167,217],"hypothesis":[3],"that":[4],"inhibiting":[5],"interleukin-1\u03b2":[6],"(IL-1\u03b2)":[7],"with":[8,178],"neutralizing":[9,56],"monoclonal":[10],"antibody":[11],"(mAb)":[12],"alters":[13],"tight":[14],"junction":[15],"(TJ)":[16],"protein":[17,60,91,185],"expression":[18,92,132,136,154,162,186],"after":[19,34,82,138,199],"brain":[20,83,192],"ischemia-reperfusion":[21],"(I/R)":[22],"in":[23,61,98,109,166,187,196,212,216],"ovine":[25],"fetus.":[26,218],"Ovine":[27,44],"fetuses":[28,76],"at":[29],"85%":[30],"gestation":[31],"were":[32,72,93,163],"studied":[33],"30":[35],"min":[36,78],"of":[37,42,160],"ischemia":[38],"and":[39,50,55,79,89,104,116,134,201],"24":[40],"h":[41,81],"reperfusion.":[43],"IL-1\u03b2":[45,59,67,179,202],"mAb":[46,68,140,180,203],"has":[47],"been":[48],"generated,":[49],"showed":[51],"high":[52],"sensitivity,":[53],"specificity,":[54],"effects":[57],"to":[58,74,123,143],"vitro.":[62],"Intravenous":[63],"placebo":[64],"(PL)":[65],"or":[66,171],"(5":[69],"mg/kg)":[70],"infusions":[71],"given":[73],"15":[77],"4":[80],"ischemia.":[84],"Occludin":[85],"(Occl),":[86],"claudin-1":[87],"(CL-1),":[88],"CL-5":[90,135],"determined":[94],"by":[95,210],"Western":[96],"immunoblot":[97],"non-ischemic":[99],"(sham,":[100],"n=5),":[101],"I/R+PL":[102],"(n=6),":[103],"I/R+IL-1\u03b2":[105,139],"mAb-treated":[106],"(n=7)":[107],"groups":[108],"cerebral":[111,168],"cortex,":[112,169],"caudate":[113,172],"nucleus,":[114],"cerebellum,":[115],"medulla.":[117],"Results":[118],"are":[119],"expressed":[120],"as":[121],"ratio":[122],"an":[124],"internal":[125],"control":[126],"protein.":[127],"In":[128],"medulla,":[130],"Occl":[131],"decreased":[133],"increased":[137],"treatment":[141,204],"compared":[142],"sham":[145],"group":[146],"(Fig.,":[147],"M":[148],"\u00b1":[149],"SD,":[150],"P<0.05),":[151],"but":[152,189],"CL-1":[153],"did":[155],"not":[156,164,175,190,206],"change.":[157],"Similar":[158],"patterns":[159],"TJ":[161,184,214],"observed":[165],"cerebellum":[170],"nucleus":[173],"(data":[174],"shown).":[176],"Treatment":[177],"affects":[181],"I/R-related":[182],"transmembrane":[183,213],"some,":[188],"all":[191],"regions":[193],"studied.":[194],"Alterations":[195],"BBB":[197],"function":[198],"I/R":[200],"may":[205],"be":[207],"directly":[208],"regulated":[209],"changes":[211],"proteins":[215],"NIH-HD-057100":[219]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2021-07-05T00:00:00"}