{"id":"https://openalex.org/W3175867775","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1156.4","title":"Chronic Gastric Inflammation Drives the Malignant Transformation of Bone Marrow\u2010Derived Mesenchymal Stem Cells","display_name":"Chronic Gastric Inflammation Drives the Malignant Transformation of Bone Marrow\u2010Derived Mesenchymal Stem Cells","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W3175867775","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1156.4","mag":"3175867775"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.1156.4","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1156.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1156.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038664900","display_name":"Jessica M. Donnelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Donnelly","raw_affiliation_strings":["Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026484228","display_name":"Melinda Anne Engevik","orcid":"https://orcid.org/0000-0002-9742-9932","observed_orcids":["https://orcid.org/0000-0002-9742-9932"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda Engevik","raw_affiliation_strings":["Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060451374","display_name":"Xiao Chang","orcid":"https://orcid.org/0000-0003-0560-2441","observed_orcids":["https://orcid.org/0000-0003-0560-2441"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang Xiao","raw_affiliation_strings":["Division of Asthma Research Cincinnati Children's Hospital Medical Center Cincinnati OH","Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Asthma Research Cincinnati Children's Hospital Medical Center Cincinnati OH","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011685660","display_name":"Roger T. Worrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger T. Worrell","raw_affiliation_strings":["Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103159584","display_name":"Yana L. Zavros","orcid":"https://orcid.org/0000-0002-1266-6470","observed_orcids":["https://orcid.org/0000-0002-1266-6470","https://orcid.org/0000-0003-2384-3775"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yana Zavros","raw_affiliation_strings":["Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Physiology University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36623256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chronic-gastritis","display_name":"chronic gastritis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/atrophic-gastritis","display_name":"atrophic gastritis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.8769999742507935},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7490000128746033},{"id":"https://openalex.org/keywords/stem-cell-aging","display_name":"stem cell aging","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7987481355667114},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6500070095062256},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.629831075668335},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5584102272987366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5234826803207397},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47935324907302856},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.450944185256958},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39182811975479126},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36276108026504517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32626935839653015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17542120814323425}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.1156.4","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1156.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1156.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2555542403","https://openalex.org/W2026833771","https://openalex.org/W2086484123","https://openalex.org/W1561559402","https://openalex.org/W2597284313","https://openalex.org/W1990005320","https://openalex.org/W2054590679","https://openalex.org/W4393090487","https://openalex.org/W2736890584","https://openalex.org/W42072812"],"abstract_inverted_index":{"Bone":[0],"marrow\u2010derived":[1],"mesenchymal":[2],"stem":[3],"cells":[4,112],"(BM\u2010MSCs)":[5],"promote":[6],"gastric":[7,61,77,174],"cancer":[8],"progression":[9],"with":[10,20,123],"chronic":[11,60,173],"inflammation.":[12],"In":[13,118],"culture,":[14],"BM\u2010MSCs":[15,56,90,124,135,163],"are":[16],"prone":[17],"to":[18,30,45,59,110],"mutation":[19],"age":[21,138],"but":[22],"whether":[23],"this":[24],"occurs":[25],"in":[26,28,57],"vivo":[27],"response":[29,58],"gastritis":[31,73],"is":[32,37,63],"unknown.":[33],"Sonic":[34],"Hedgehog":[35],"(Shh)":[36],"often":[38],"secreted":[39],"by":[40,65,75,85,154,183],"tumors":[41],"and":[42,79,100,193],"may":[43],"contribute":[44],"BM\u2010MSC":[46],"transformation.":[47],"We":[48],"tested":[49],"the":[50,167,177,194],"hypothesis":[51],"that":[52,151],"malignant":[53,178],"transformation":[54,179],"of":[55,88,104,166,180],"inflammation":[62,175],"mediated":[64,153],"Shh":[66,157,159],"signaling.":[67,158,169],"GKO":[68,93,130,145],"mice":[69,94,121,141],"displayed":[70,95,132],"severe":[71],"atrophic":[72],"accompanied":[74],"elevated":[76,101],"tissue":[78],"circulating":[80],"transforming":[81],"growth":[82,150],"factor\u2010beta":[83],"(TGF\u03b2)":[84],"3":[86],"months":[87],"age.":[89],"isolated":[91,113],"from":[92,114,126,137],"an":[96],"increased":[97],"proliferative":[98],"rate":[99],"phosphorylated\u2010Smad3":[102],"indicative":[103],"active":[105],"TGF\u03b2":[106,155,168],"signaling":[107],"when":[108],"compared":[109],"those":[111],"BL/6":[115,140],"bone":[116],"marrow.":[117],"xenograft":[119],"assays,":[120],"injected":[122,142],"collected":[125,136],"6":[127],"month":[128],"old":[129],"animals":[131,146],"tumor":[133,149],"growth.":[134],"matched":[139],"into":[143],"inflamed":[144],"also":[147],"developed":[148],"was":[152,164],"or":[156],"pathway":[160],"activity":[161],"within":[162],"downstream":[165],"This":[170],"data":[171],"establishes":[172],"induces":[176],"BM\u2010MSCs.":[181],"Funded":[182],"American":[184],"Cancer":[185],"Society":[186],"Research":[187],"Scholar":[188],"Award":[189],"119072\u2010RSG\u201010\u2013167\u201001\u2010MPC":[190],"(Y.":[191],"Zavros)":[192],"Albert":[195],"J.":[196],"Ryan":[197],"Foundation":[198],"Fellowship":[199],"(J.":[200],"Donnelly)":[201]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-07-05T00:00:00"}
