{"id":"https://openalex.org/W3175652201","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.613.5","title":"Cardiomyocyte\u2010restricted PPAR\u03b4 deletion in PPAR\u03b1 null mice leads to cardiac hypertrophy and heart failure","display_name":"Cardiomyocyte\u2010restricted PPAR\u03b4 deletion in PPAR\u03b1 null mice leads to cardiac hypertrophy and heart failure","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W3175652201","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.613.5","mag":"3175652201"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.613.5","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.613.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.613.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100414710","display_name":"Jian Liu","orcid":"https://orcid.org/0000-0002-8969-8446","observed_orcids":["https://orcid.org/0000-0002-8969-8446"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Liu","raw_affiliation_strings":["Morehouse School of Medicine Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morehouse School of Medicine Atlanta GA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025866012","display_name":"Peiyong Wang","orcid":"https://orcid.org/0000-0001-6716-5174","observed_orcids":["https://orcid.org/0000-0001-6716-5174"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peiyong Wang","raw_affiliation_strings":["Morehouse School of Medicine Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morehouse School of Medicine Atlanta GA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066316498","display_name":"Lihong Cheng","orcid":"https://orcid.org/0000-0002-2522-4831","observed_orcids":["https://orcid.org/0000-0002-2522-4831"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihong Cheng","raw_affiliation_strings":["Morehouse School of Medicine Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morehouse School of Medicine Atlanta GA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084911428","display_name":"Lawrence A. Brako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence A. Brako","raw_affiliation_strings":["Morehouse School of Medicine Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morehouse School of Medicine Atlanta GA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101884781","display_name":"Qinglin Yang","orcid":"https://orcid.org/0000-0002-6024-2517","observed_orcids":["https://orcid.org/0000-0002-6024-2517"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinglin Yang","raw_affiliation_strings":["Morehouse School of Medicine Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morehouse School of Medicine Atlanta GA","institution_ids":["https://openalex.org/I6332465"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I6332465"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35827511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.996999979019165},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":1.0},{"id":"https://openalex.org/keywords/cardiomyocyte-specific-knockout","display_name":"cardiomyocyte-specific knockout","score":0.765999972820282},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.996999979019165},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cardiac-bioenergetics","display_name":"cardiac bioenergetics","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7390000224113464},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lipid-overload","display_name":"lipid overload","score":0.9490000009536743},{"id":"https://openalex.org/keywords/double-knockout-mice","display_name":"double knockout mice","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cardiac-gene-expression","display_name":"cardiac gene expression","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8004325032234192},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7306317687034607},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6653959155082703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.557931125164032},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5349558591842651},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.49707701802253723},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.45005109906196594},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4403771460056305},{"id":"https://openalex.org/C57708383","wikidata":"https://www.wikidata.org/wiki/Q260182","display_name":"Null allele","level":4,"score":0.42117398977279663},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.418737530708313},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.410678505897522},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.33675119280815125},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31990954279899597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23504820466041565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2288188934326172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0610654354095459},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.052982479333877563}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.613.5","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.613.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.613.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084025523","https://openalex.org/W33059909","https://openalex.org/W7098639368","https://openalex.org/W2138547211","https://openalex.org/W2079796426","https://openalex.org/W640016748","https://openalex.org/W2072261695","https://openalex.org/W2261332688","https://openalex.org/W3095603938","https://openalex.org/W4386018748"],"abstract_inverted_index":{"Mice":[0],"with":[1,47,109,186,191],"cardiac":[2,16,25,35,161,166],"PPAR\u03b4":[3,41,58,78,94,112,199],"deficiency":[4],"exhibit":[5],"basal":[6,34,135,212],"fatty":[7],"acid":[8],"oxidation":[9],"(FAO)":[10],"and":[11,18,95,113,165],"bioenergetic":[12],"deficits,":[13],"leading":[14],"to":[15,52,84,100,152],"hypertrophy":[17,167],"heart":[19,210],"failure.":[20],"While":[21],"PPAR\u03b1":[22,29,49,66,87,96,114,139,206],"also":[23],"regulates":[24],"FAO":[26,75,105,123],"gene":[27,106],"expression,":[28],"null":[30,50,79,88,140],"mice":[31,46,51,67,159,180],"display":[32],"no":[33,133],"phenotype.":[36],"We":[37,196],"crossed":[38],"cardiomyocyte\u2010restricted":[39],"the":[40,48,65,147,192,209],"\u2212/\u2212":[42,44,156,194],"(CR\u2010PPAR\u03b4":[43],")":[45],"generate":[53],"a":[54,201],"mouse":[55],"line":[56],"that":[57,71,178,198],"is":[59,176],"eliminated":[60],"specifically":[61],"from":[62,111],"cardiomyocytes":[63],"of":[64,74,92,103,121,154,171],"(DKO).":[68],"QPCR":[69],"revealed":[70],"transcript":[72],"expression":[73,107],"genes":[76],"in":[77,86,138,146,208],"hearts":[80,149],"was":[81,125,132],"depressed":[82,127],"similarly":[83,126],"those":[85,110,153],"hearts.":[89,117,141,157,195],"Double":[90],"knockout":[91,116],"both":[93],"did":[97],"not":[98],"lead":[99],"further":[101],"depression":[102],"selected":[104],"compared":[108,190],"single":[115],"The":[118],"protein":[119],"abundance":[120],"these":[122,129],"enzymes":[124],"among":[128],"mice.":[130],"There":[131],"overt":[134],"pathophysiological":[136,144],"change":[137],"In":[142],"contrast,":[143],"changes":[145],"DKO":[148,158,179],"were":[150],"similar":[151],"CR\u2010PPAR\u03b4":[155,193],"exhibited":[160,181],"dysfunction,":[162],"mitochondria":[163],"abnormality":[164],"after":[168],"4\u20135":[169],"month":[170],"their":[172],"ages.":[173],"However,":[174],"it":[175],"interesting":[177],"generally":[182],"delayed":[183],"dilated":[184],"cardiomyopathy":[185],"lipid":[187],"overload":[188],"when":[189],"conclude":[197],"plays":[200],"more":[202],"essential":[203],"role":[204],"than":[205],"does":[207],"at":[211],"condition.":[213]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-07-05T00:00:00"}
