{"id":"https://openalex.org/W3175525640","doi":"https://doi.org/10.1096/fasebj.20.4.a461","title":"The roles of cyclin\u2010dependent kinase 11 (CDK11) during mammalian development","display_name":"The roles of cyclin\u2010dependent kinase 11 (CDK11) during mammalian development","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W3175525640","doi":"https://doi.org/10.1096/fasebj.20.4.a461","mag":"3175525640"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.20.4.a461","doi":"https://doi.org/10.1096/fasebj.20.4.a461","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.4.a461","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019272170","display_name":"Tongyuan Li","orcid":"https://orcid.org/0009-0002-2120-2704","observed_orcids":["https://orcid.org/0009-0002-2120-2704"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tongyuan Li","raw_affiliation_strings":["Department of Molecular Sciences, University of Tennessee Health Science Center, 855 Madison Avenue, G01 Molecular Science Bldg, Memphis, TN, 38163","Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, University of Tennessee Health Science Center, 855 Madison Avenue, G01 Molecular Science Bldg, Memphis, TN, 38163","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akira Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akira Inoue","raw_affiliation_strings":["Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041113103","display_name":"Vincent J. Kidd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Kidd","raw_affiliation_strings":["Department of Molecular Sciences, University of Tennessee Health Science Center, 855 Madison Avenue, G01 Molecular Science Bldg, Memphis, TN, 38163","Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, University of Tennessee Health Science Center, 855 Madison Avenue, G01 Molecular Science Bldg, Memphis, TN, 38163","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052921260","display_name":"Jill M. Lahti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Lahti","raw_affiliation_strings":["Department of Molecular Sciences, University of Tennessee Health Science Center, 855 Madison Avenue, G01 Molecular Science Bldg, Memphis, TN, 38163","Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, University of Tennessee Health Science Center, 855 Madison Avenue, G01 Molecular Science Bldg, Memphis, TN, 38163","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Tumor Cell Biology St. Jude Children\u2019s Research Hospital 332 N. Lauderdale St. Memphis TN 38105","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.25850000977516174,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk11","display_name":"CDK11","score":0.8939999938011169},{"id":"https://openalex.org/keywords/p110","display_name":"p110","score":0.8169999718666077},{"id":"https://openalex.org/keywords/p58","display_name":"p58","score":0.972000002861023},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.8519999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5080000162124634},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.800000011920929},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.4869999885559082},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.9879999756813049},{"id":"https://openalex.org/keywords/internal-ribosome-entry-site","display_name":"internal ribosome entry site","score":0.8009999990463257},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.8650000095367432},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pre-tcr-signaling","display_name":"pre-TCR signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/null-mutant-mice","display_name":"null mice","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6690433025360107},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6512673497200012},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6053822040557861},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5183642506599426},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4696062505245209},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46409860253334045},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4586913287639618},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.44015973806381226},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4155806005001068},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.37203407287597656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.315008282661438},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.21863728761672974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2061379849910736},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1972847580909729},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.20.4.a461","doi":"https://doi.org/10.1096/fasebj.20.4.a461","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.4.a461","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G308998970","display_name":"Functional Analysis of CDKp110 Protein Kinase","funder_award_id":"R01GM044088","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6161521570","display_name":null,"funder_award_id":"CA0211765","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2103373652","https://openalex.org/W2746416421","https://openalex.org/W4412110418","https://openalex.org/W4402332166","https://openalex.org/W2392262124","https://openalex.org/W204582411","https://openalex.org/W2891472264","https://openalex.org/W3028287471","https://openalex.org/W2219642313","https://openalex.org/W1967647021"],"abstract_inverted_index":{"CDK11":[0,8,34,53,67,72,78,94,110,123,142,166,183],"gene":[1],"encodes":[2],"two":[3],"proteins,":[4],"p110":[5,9,54],"and":[6,22,31,55,76,86,90,101,118,164,192,201],"p58.":[7],"proteins":[10],"are":[11,113],"part":[12],"of":[13,66,141,175],"large\u2010molecular\u2010weight":[14],"complexes":[15],"containing":[16],"RNA":[17],"polymerase":[18],"II,":[19],"transcriptional":[20],"elongation":[21],"general":[23],"pre\u2010mRNA":[24,32],"splicing":[25,174,191],"factors,":[26],"suggesting":[27],"they":[28],"couple":[29],"transcription":[30],"splicing.":[33],"p58":[35],"is":[36],"expressed":[37],"only":[38],"during":[39],"G2/M":[40],"from":[41],"an":[42],"internal":[43],"ribosome":[44],"entry":[45],"site":[46],"(IRES)":[47],"present":[48],"in":[49,63,82,136,144,147,169,189],"the":[50,62,109,151,158],"mRNA":[51],"encoding":[52],"appears":[56],"to":[57,157],"regulate":[58],"mitosis.":[59],"To":[60],"examine":[61],"vivo":[64],"role":[65],"p110/p58":[68,73,79,111,124,143,167],"kinases,":[69],"we":[70],"generated":[71,129],"\u2010null":[74],"mice":[75,128],"found":[77],"deficiency":[80,168],"results":[81,106,146,180],"early":[83,120],"embryonic":[84,121],"lethality":[85],"apoptosis":[87],"between":[88],"E3.5":[89],"E4.0.":[91],"Cells":[92],"within":[93],"p110/p58\u2212/\u2212":[95],"embryos":[96],"exhibit":[97],"both":[98],"proliferative":[99],"defects":[100,135],"a":[102,148],"mitotic":[103,193],"arrest.":[104],"These":[105],"indicated":[107],"that":[108,182],"kinases":[112,185],"essential":[114],"for":[115],"cellular":[116],"viability":[117],"normal":[119],"development.":[122,139],"T":[125,137],"cell\u2010specific":[126],"knockout":[127],"by":[130,196],"using":[131],"Cre/loxP":[132],"system":[133],"show":[134],"cell":[138],"Deletion":[140],"thymocytes":[145,170],"block":[149],"at":[150],"double":[152],"negative":[153],"(DN)":[154],"stage":[155],"due":[156],"defective":[159],"pre\u2010TCR":[160],"signaling,":[161],"impaired":[162],"proliferation":[163],"apoptosis.":[165],"also":[171],"affects":[172],"alternative":[173],"CD45.":[176],"Taken":[177],"together,":[178],"these":[179],"indicate":[181],"protein":[184],"play":[186],"important":[187],"roles":[188],"transcription,":[190],"regulation.":[194],"(Supported":[195],"NIH":[197],"grants":[198],"GM44088,":[199],"CA0211765,":[200],"ALSAC)":[202]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}