{"id":"https://openalex.org/W3175299062","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb150","title":"Strategies to enhance T cell reconstitution following severe immunodepletion","display_name":"Strategies to enhance T cell reconstitution following severe immunodepletion","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W3175299062","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb150","mag":"3175299062"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.25.1_supplement.lb150","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb150","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.lb150","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049300478","display_name":"Mariela Raquel Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60388903","display_name":"University of Puerto Rico-Mayaguez","ror":"https://ror.org/00wek6x04","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037","https://openalex.org/I60388903"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Mariela Raquel Martinez","raw_affiliation_strings":["Biological Sciences, University of Puerto Rico Mayaguez, Mayaguez, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, University of Puerto Rico Mayaguez, Mayaguez, PR","institution_ids":["https://openalex.org/I60388903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016053915","display_name":"Jarrod A. Dudakov","orcid":"https://orcid.org/0000-0001-6220-5632","observed_orcids":["https://orcid.org/0000-0001-6220-5632"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarrod Dudakov","raw_affiliation_strings":["Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102946305","display_name":"Lauren F. Young","orcid":"https://orcid.org/0000-0003-2220-0508","observed_orcids":["https://orcid.org/0000-0003-2220-0508"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Young","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003503263","display_name":"Marcel R.M. van den Brink","orcid":"https://orcid.org/0000-0003-0696-4401","observed_orcids":["https://orcid.org/0000-0003-0696-4401"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel van den Brink","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48364786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-reconstitution","display_name":"T cell reconstitution","score":0.996999979019165},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/immunodepletion","display_name":"immunodepletion","score":0.6850000023841858},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cd150","display_name":"CD150","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.610347330570221},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.596361517906189},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5960575342178345},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5576879382133484},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5077772736549377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49965572357177734},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4787563681602478},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4554024934768677},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4207257926464081},{"id":"https://openalex.org/C2778828106","wikidata":"https://www.wikidata.org/wiki/Q905835","display_name":"Plerixafor","level":5,"score":0.41548633575439453},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.41207215189933777},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41152051091194153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39861559867858887},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3655358552932739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1869211494922638},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.17255684733390808},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16875684261322021},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.14212137460708618},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09952208399772644},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.07904809713363647},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.25.1_supplement.lb150","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.lb150","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.lb150","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173764194","https://openalex.org/W2979676604","https://openalex.org/W2093385003","https://openalex.org/W2038871229","https://openalex.org/W2922840548","https://openalex.org/W2587952432","https://openalex.org/W1965919969","https://openalex.org/W2567925064","https://openalex.org/W2567228314","https://openalex.org/W2133167641"],"abstract_inverted_index":{"Allogeneic":[0],"hematopoietic":[1],"stem":[2,76],"cell":[3,38,48,87,153,193],"transplant":[4],"(AHSCT)":[5],"is":[6,23,33,106],"one":[7],"of":[8,41,46,52,60,101,112,133,141,183,199],"the":[9,36,58,79,97,104,120,123,131,145,162,179,188,197],"only":[10],"curative":[11],"therapies":[12],"for":[13,151,165,190],"leukemia":[14],"patients":[15],"and":[16,43,55,99,181],"others":[17],"with":[18],"hematological":[19],"malignancies.":[20],"Its":[21],"use":[22],"restricted":[24],"by":[25,195],"major":[26],"complications":[27,54],"including":[28],"post\u2010transplant":[29],"immune":[30],"deficiency":[31],"which":[32],"devastating":[34],"to":[35,103,129],"T":[37,47,69,86,152,192],"compartment.":[39],"Promotion":[40],"rapid":[42],"effective":[44],"reconstitution":[45,88],"immunity":[49],"reduces":[50],"incidence":[51],"transplant\u2010related":[53],"significantly":[56,84],"improves":[57],"survival":[59],"HSCT":[61],"recipients.":[62,91],"Our":[63],"previous":[64],"studies":[65],"show":[66],"that":[67,138,158],"precursor":[68],"cells":[70,77],"(preT)":[71],"generated":[72],"ex":[73],"vivo":[74],"from":[75],"on":[78,170,178],"OP9\u2010DL1":[80,167],"culture":[81],"system":[82],"can":[83,147,174],"enhance":[85],"in":[89,119,161],"AHSCT":[90],"However,":[92],"despite":[93],"their":[94],"regenerative":[95],"benefits,":[96],"homing":[98],"seeding":[100,166],"preT":[102,117,134,200],"thymus":[105,146],"relatively":[107],"inefficient":[108],"(only":[109],"1":[110],"out":[111],"every":[113],"10,000":[114],"iv":[115],"injected":[116],"engraft":[118],"thymus).":[121],"In":[122],"present":[124],"study":[125],"we":[126],"examined":[127],"strategies":[128],"improve":[130],"effectiveness":[132],"treatment.":[135],"We":[136,155],"found":[137,157],"direct":[139],"administration":[140],"lineage\u2010depleted":[142],"BM":[143],"into":[144],"have":[148,175],"significant":[149,176],"benefit":[150],"reconstitution.":[154],"also":[156],"small":[159],"changes":[160],"purification":[163],"strategy":[164],"cultures":[168],"(based":[169],"differential":[171],"CD150":[172],"expression)":[173],"impacts":[177],"generation":[180],"output":[182],"preT.":[184],"These":[185],"findings":[186],"lay":[187],"foundation":[189],"improving":[191],"rejuvenation":[194],"enhancing":[196],"utility":[198],"as":[201],"a":[202],"potential":[203],"clinical":[204],"therapy.":[205]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}