{"id":"https://openalex.org/W3174848878","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.479.17","title":"Pharmacokinetics of soluble epoxide hydrolase inhibitors in canine, rodent, feline, and primate species","display_name":"Pharmacokinetics of soluble epoxide hydrolase inhibitors in canine, rodent, feline, and primate species","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W3174848878","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.479.17","mag":"3174848878"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.479.17","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.479.17","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.479.17","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111958205","display_name":"Hsing-Ju Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsing\u2010Ju Tsai","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358875","display_name":"Jun\u2010Yan Liu","orcid":"https://orcid.org/0000-0002-3018-0335","observed_orcids":["https://orcid.org/0000-0002-3018-0335"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Yan Liu","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066735935","display_name":"Sung Hee Hwang","orcid":"https://orcid.org/0000-0002-9891-928X","observed_orcids":["https://orcid.org/0000-0002-9891-928X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung Hee Hwang","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056758479","display_name":"Takeo Kasagami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takeo Kasagami","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646971","display_name":"In-Hae Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"In Hae Kim","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul D. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Jones","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013909385","display_name":"Christophe H.P. Morisseau","orcid":"https://orcid.org/0000-0002-5672-6631","observed_orcids":["https://orcid.org/0000-0002-5672-6631"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christophe Morisseau","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026538320","display_name":"Bruce D. Hammock","orcid":"https://orcid.org/0000-0003-1408-8317","observed_orcids":["https://orcid.org/0000-0003-1408-8317","https://orcid.org/0000-0003-4277-4736"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Hammock","raw_affiliation_strings":["Entomology, University of California-Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Entomology, University of California-Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-epoxide-hydrolase-inhibitors","display_name":"soluble epoxide hydrolase inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.5960000157356262},{"id":"https://openalex.org/keywords/primates","display_name":"primates","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rodents","display_name":"rodents","score":0.9150000214576721},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6010000109672546},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8840000033378601},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypertrophy","display_name":"hypertrophy","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8324458599090576},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7927780747413635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7798701524734497},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7266851663589478},{"id":"https://openalex.org/C18605011","wikidata":"https://www.wikidata.org/wiki/Q17916975","display_name":"Epoxide hydrolase 2","level":3,"score":0.570176362991333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5514281988143921},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4687006175518036},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3559165596961975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3280054032802582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31511223316192627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2526865005493164},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06379559636116028}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.479.17","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.479.17","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.479.17","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G368691575","display_name":"HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS","funder_award_id":"R37ES002710","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142219464","https://openalex.org/W2110690814","https://openalex.org/W3173603190","https://openalex.org/W3081102103","https://openalex.org/W3193807129","https://openalex.org/W2119391523","https://openalex.org/W2348000787","https://openalex.org/W2144006306","https://openalex.org/W7217444924","https://openalex.org/W6996564422"],"abstract_inverted_index":{"Soluble":[0],"epoxide":[1],"hydrolase":[2],"inhibitors":[3,22,113],"(sEHi)":[4],"have":[5,114],"been":[6],"shown":[7],"the":[8,21,29,65,77,81,102,112,123,132],"therapeutic":[9],"effects":[10,46],"on":[11],"hypertension,":[12],"sepsis,":[13],"and":[14,32,55,71,95,117,136,157],"hypertrophy":[15],"in":[16,47,69,72,82,105,138,145],"different":[17,89,108,115],"animal":[18],"models.":[19],"However,":[20,61],"were":[23,35,58,88],"hard":[24],"to":[25,38,130],"formulate":[26],"which":[27],"limits":[28],"administration":[30],"methods,":[31],"their":[33],"bioavailabilities":[34],"low":[36],"leading":[37],"high":[39],"dose":[40],"treatments":[41],"for":[42],"observing":[43],"some":[44,86],"biological":[45,139],"vivo.":[48],"Thus,":[49],"compounds":[50,66,87],"having":[51],"improved":[52],"physical":[53],"properties":[54],"similar":[56],"potency":[57,84,116],"recently":[59],"synthesized.":[60],"it":[62],"is":[63],"unknown":[64],"perform":[67],"consistent":[68],"vitro":[70,83],"vivo":[73,106],"among":[74,90,120],"species.":[75,121],"Herein,":[76],"results":[78],"showed":[79],"that":[80],"of":[85,107,134],"species,":[91],"especially":[92],"with":[93],"dog":[94],"cat":[96],"enzymes.":[97],"Further,":[98],"we":[99],"also":[100],"described":[101],"pharmacokinetic":[103,118],"profiles":[104,119],"animals.":[109],"In":[110],"summary,":[111],"With":[122],"information,":[124],"sEHi":[125],"will":[126],"be":[127],"invaluable":[128],"tools":[129],"investigate":[131],"role":[133],"sEH":[135],"eicosanoids":[137],"systems.":[140],"This":[141],"work":[142],"was":[143],"supported":[144],"part":[146],"by":[147],"NIEHS":[148,152,158],"Grant":[149,154,160],"R37":[150],"ES02710,":[151],"SBRP":[153],"P42":[155],"ES04699,":[156],"CEHS":[159],"P30":[161],"ES05707.":[162]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2021-07-05T00:00:00"}
