{"id":"https://openalex.org/W3174658121","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.698.7","title":"Poloxamer 188 does not Target Altered Ca 2+ Channels in Cardiomyocytes during Hypoxia/Reoxygenation Injury","display_name":"Poloxamer 188 does not Target Altered Ca 2+ Channels in Cardiomyocytes during Hypoxia/Reoxygenation Injury","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W3174658121","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.698.7","mag":"3174658121"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2018.32.1_supplement.698.7","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.698.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.698.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034827932","display_name":"Michele M. Henry Salzman","orcid":"https://orcid.org/0000-0003-4499-7415","observed_orcids":["https://orcid.org/0000-0003-4499-7415"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele M. Salzman","raw_affiliation_strings":["Pharmacology/Anesthesiology Vanderbilt University Medical Center Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology/Anesthesiology Vanderbilt University Medical Center Nashville TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032180677","display_name":"Benjamin J. Hackel","orcid":"https://orcid.org/0000-0003-3561-9463","observed_orcids":["https://orcid.org/0000-0003-3561-9463"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Hackel","raw_affiliation_strings":["Chemical Engineering &amp; Materials Science University of Minnesota Minneapolis MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering &amp; Materials Science University of Minnesota Minneapolis MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052318251","display_name":"Jason Alan Bartos","orcid":"https://orcid.org/0000-0003-0113-5305","observed_orcids":["https://orcid.org/0000-0003-0113-5305"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Bartos","raw_affiliation_strings":["Cardiology University of Minnesota Minneapolis MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology University of Minnesota Minneapolis MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080664595","display_name":"Matthias L. Riess","orcid":"https://orcid.org/0000-0001-8748-5757","observed_orcids":["https://orcid.org/0000-0001-8748-5757"]},"institutions":[{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias L. Riess","raw_affiliation_strings":["Anesthesiology TVHS VA Medical Center Nashville TN","Anesthesiology/Pharmacology Vanderbilt University Medical Center Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology TVHS VA Medical Center Nashville TN","institution_ids":["https://openalex.org/I4210101790","https://openalex.org/I4210103776"]},{"raw_affiliation_string":"Anesthesiology/Pharmacology Vanderbilt University Medical Center Nashville TN","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42263199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"32","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypoxia-reoxygenation-injury","display_name":"hypoxia/reoxygenation injury","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9670000076293945},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.8429999947547913},{"id":"https://openalex.org/keywords/calcium-exchangers","display_name":"calcium exchangers","score":0.6949999928474426},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.7350000143051147},{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.8349999785423279},{"id":"https://openalex.org/keywords/reverse-mode","display_name":"reverse mode","score":0.5180000066757202},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/membrane-stabilization","display_name":"membrane stabilization","score":0.7459999918937683},{"id":"https://openalex.org/keywords/bay-k-8644","display_name":"Bay K 8644","score":0.8420000076293945},{"id":"https://openalex.org/keywords/kb-r7943","display_name":"KB-R7943","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.697941780090332},{"id":"https://openalex.org/C153461711","wikidata":"https://www.wikidata.org/wiki/Q5072487","display_name":"Channel blocker","level":3,"score":0.6138184070587158},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5652989745140076},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5360069274902344},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.5276737809181213},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5097941756248474},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.4932350516319275},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.48594844341278076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4322459399700165},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3988332748413086},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29355359077453613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28762108087539673},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2783021926879883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20574951171875},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.12790167331695557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12737208604812622},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2018.32.1_supplement.698.7","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.698.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.698.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3090816583","display_name":"Reperfusion Injury Protection Strategies During Basic Life Support","funder_award_id":"R01HL123227","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389023795","https://openalex.org/W3093217732","https://openalex.org/W2607818431","https://openalex.org/W4380680515","https://openalex.org/W4389978123","https://openalex.org/W4200451154","https://openalex.org/W7100232503","https://openalex.org/W2887571708","https://openalex.org/W3174632327","https://openalex.org/W3157506652"],"abstract_inverted_index":{"Introduction":[0],"Ischemia/reperfusion":[1],"(I/R)":[2],"injury":[3,163],"is":[4,89,503,511],"a":[5,28,326,484],"complex":[6],"pathological":[7],"event.":[8],"Membrane":[9],"disruptions":[10,83,167],"and":[11,111,123,136,168,238,261,264,288,296,353,397,460,465,483],"altered":[12,59,96,170],"calcium":[13],"(Ca":[14],"2+":[15,26,38,40,49,61,98,109,119,134,172,216,223,251,290,317,338,347,358,375,389,402,422,437],")":[16,43],"transport":[17],"during":[18,121,143,406,443],"ischemia,":[19,122],"continue":[20],"in":[21,35,181,276,420,521],"early":[22],"reperfusion.":[23,126],"With":[24],"Ca":[25,37,48,60,97,108,118,133,171,215,222,337,346,374,388,401,421,436],"being":[27],"major":[29],"regulator":[30],"of":[31,107,140,189,232,242,246,269,285,448,494],"cardiomyocyte":[32],"function,":[33],"increases":[34],"intracellular":[36],"([Ca":[39],"]":[41,291,318,359],"i":[42,292,319,360],"can":[44],"have":[45],"detrimental":[46],"effects.":[47],"may":[50,114],"not":[51,90,432],"only":[52],"enter":[53],"through":[54,58],"membrane":[55,69,82,166,458,463],"disruptions,":[56,459],"but":[57,321],"channels":[62,99,110,173,438],"or":[63,100,174,185,439,469],"exchangers.":[64,101,175],"The":[65,209,445,522],"tri\u2010block":[66],"copolymer":[67],"cell":[68,286],"stabilizer,":[70],"Poloxamer":[71],"188":[72],"(P188),":[73],"has":[74],"been":[75],"shown":[76],"to":[77,116,131,434,456],"be":[78],"protective,":[79],"by":[80,85,164,341,378,392,476],"targeting":[81],"caused":[84,340,377,391],"I/R.":[86],"However,":[87],"it":[88],"known":[91],"if":[92],"P188":[93,141,330,367,383,414,430,449],"also":[94,416],"targets":[95],"We":[102],"investigated":[103],"the":[104,138,233,243,247,267,336,362,373,379,387,393,407,491,505],"potential":[105],"role":[106],"exchangers":[112,440],"that":[113,404],"contribute":[115],"increased":[117,315,356],"influx":[120,339,376,390,403,423],"more":[124],"importantly,":[125],"Pharmacologic":[127],"compounds":[128,211],"were":[129,179,253,283],"used":[130,257],"modify":[132],"influx,":[135],"assess":[137],"effect":[139,333,370,447],"present":[142],"reperfusion,":[144],"on":[145,334,371],"these":[146],"modifications.":[147],"Hypothesis":[148],"P188,":[149],"with":[150,517],"its":[151,454],"unique":[152],"hydrophobic/hydrophilic":[153],"properties,":[154],"protects":[155],"cardiomyocytes":[156],"(CMs)":[157],"against":[158],"hypoxia/reoxygenation":[159],"(H/R;":[160],"simulated":[161],"I/R)":[162],"stabilizing":[165],"blocking":[169],"Methods":[176],"Isolated":[177],"CMs":[178],"kept":[180],"control/normoxic":[182],"(C/N)":[183],"conditions":[184],"underwent":[186],"5":[187],"hrs":[188,201],"hypoxia":[190],"(0.01%":[191],"O":[192,204],"2":[193,200,205,273,327,363,408],";":[194,206],"serum\u2010":[195],"&":[196],"glucose\u2010free":[197],"medium),":[198],"then":[199],"reoxygenation":[202,270,365,410],"(21%":[203],"complete":[207],"medium).":[208],"pharmacologic":[210],"S\u2010(\u2212)\u2010BayK8644":[212,313,352],"(a":[213,220,227,240],"L\u2010type":[214,221],"channel":[217,224],"agonist),":[218],"R\u2010(+)\u2010BayK8644":[219,343,396],"blocker),":[225],"dobutamine":[226,322,354],"\u03b2":[228],"1":[229],"receptor":[230],"agonist/activator":[231],"voltage\u2010gated":[234],"Na":[235,248],"+":[236,249],"channel),":[237],"KB\u2010R7943":[239,398],"blocker":[241],"reverse":[244],"mode":[245],"/Ca":[250],"exchanger)":[252],"used.":[254],"Each":[255],"was":[256,415,424,474],"under":[258],"both":[259],"C/N":[260,277,311],"H/R":[262,350,394],"conditions,":[263,312,351],"added":[265],"at":[266],"start":[268],"(or":[271],"final":[272],"hr":[274,328,364,409],"period":[275],"conditions)":[278],"\u00b1":[279],"100\u03bcM":[280],"P188.":[281],"Endpoints":[282],"markers":[284],"number/viability":[287],"[Ca":[289,316,357],".":[293,525],"Statistics:":[294],"ANOVA":[295],"SNK":[297],"post":[298],"hoc":[299],"comparisons,":[300],"p<0.05":[301],"*vs":[302],"C/N,":[303],"**vs":[304],"H/R,":[305],"\u0197":[306],"vs":[307],"vehicle.":[308],"Results":[309],"Under":[310,349],"significantly":[314,344,355,385,399,425],",":[320],"did":[323,384],"not,":[324],"over":[325,361],"period.":[329,366],"had":[331,368],"no":[332,369,512],"attenuating":[335,372],"S\u2010(\u2212)\u2010BayK8644.":[342],"decreased":[345,400],"influx.":[348],"above":[380],"compounds;":[381],"however,":[382],"decrease":[386,419],"itself.":[395],"occurred":[405],"period;":[411],"and,":[412],"when":[413,441],"present,":[417],"this":[418,518],"enhanced.":[426],"Conclusions":[427],"In":[428],"CMs,":[429],"does":[431],"appear":[433],"target":[435],"administered":[442],"reoxygenation.":[444],"protective":[446],"most":[450],"likely":[451],"comes":[452],"from":[453,490,504],"ability":[455],"repair":[457],"thus":[461],"restore":[462],"integrity":[464],"cellular":[466],"function.":[467],"Support":[468],"Funding":[470],"Information":[471],"This":[472,501],"work":[473],"supported":[475],"institutional":[477],"funds,":[478],"NIH":[479],"grant":[480],"(5R01":[481],"HL123227),":[482],"Merit":[485],"Review":[486],"Award":[487],"(I01":[488],"BX003482)":[489],"U.S.":[492],"Department":[493],"Veteran":[495],"Affairs":[496],"Biomedical":[497],"Laboratory":[498],"R&D":[499],"Service.":[500],"abstract":[502,519],"Experimental":[506],"Biology":[507],"2018":[508],"Meeting.":[509],"There":[510],"full":[513],"text":[514],"article":[515],"associated":[516],"published":[520],"FASEB":[523],"Journal":[524]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}