{"id":"https://openalex.org/W3174635239","doi":"https://doi.org/10.1038/s41467-021-24342-y","title":"The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells","display_name":"The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3174635239","doi":"https://doi.org/10.1038/s41467-021-24342-y","mag":"3174635239","pmid":"https://pubmed.ncbi.nlm.nih.gov/34210968","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8249423"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-24342-y","doi":"https://doi.org/10.1038/s41467-021-24342-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-24342-y","pdf_url":"https://www.nature.com/articles/s41467-021-24342-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-021-24342-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053097935","display_name":"Damien A. Leach","orcid":"https://orcid.org/0000-0003-3203-9826","observed_orcids":["https://orcid.org/0000-0003-3203-9826"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. A. Leach","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079931511","display_name":"Andrea Mohr","orcid":"https://orcid.org/0000-0002-4295-0341","observed_orcids":["https://orcid.org/0000-0002-4295-0341"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Mohr","raw_affiliation_strings":["School of Life Sciences, University of Essex, Colchester, Essex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048631667","display_name":"Efstathios S. Giotis","orcid":"https://orcid.org/0000-0001-8908-7824","observed_orcids":["https://orcid.org/0000-0001-8908-7824"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. S. Giotis","raw_affiliation_strings":["Department of Infectious Diseases, Imperial College London, London, UK","School of Life Sciences, University of Essex, Colchester, Essex, UK"],"raw_orcid":"https://orcid.org/0000-0001-8908-7824","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067742939","display_name":"Emine Cil","orcid":"https://orcid.org/0000-0002-5097-1548","observed_orcids":["https://orcid.org/0000-0002-5097-1548"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. Cil","raw_affiliation_strings":["School of Life Sciences, University of Essex, Colchester, Essex, UK"],"raw_orcid":"https://orcid.org/0000-0002-5097-1548","affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110732433","display_name":"A. M. Isac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. M. Isac","raw_affiliation_strings":["School of Life Sciences, University of Essex, Colchester, Essex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018673554","display_name":"Laura L. Yates","orcid":"https://orcid.org/0000-0002-1620-1603","observed_orcids":["https://orcid.org/0000-0002-1620-1603"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. L. Yates","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038353299","display_name":"William Barclay","orcid":"https://orcid.org/0000-0002-3948-0895","observed_orcids":["https://orcid.org/0000-0002-3948-0895"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. S. Barclay","raw_affiliation_strings":["Department of Infectious Diseases, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-3948-0895","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044483462","display_name":"Ralf Michael Zwacka","orcid":"https://orcid.org/0000-0003-2821-0387","observed_orcids":["https://orcid.org/0000-0003-2821-0387"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. M. Zwacka","raw_affiliation_strings":["School of Life Sciences, University of Essex, Colchester, Essex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024566237","display_name":"Charlotte Lynne Bevan","orcid":"https://orcid.org/0000-0002-7533-0552","observed_orcids":["https://orcid.org/0000-0002-7533-0552"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"C. L. Bevan","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London, London, UK. charlotte.bevan@imperial.ac.uk","Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7533-0552","affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London, UK. charlotte.bevan@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020742188","display_name":"Greg Nicholas Brooke","orcid":"https://orcid.org/0000-0003-4501-4134","observed_orcids":["https://orcid.org/0000-0003-4501-4134"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"G. N. Brooke","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London, London, UK. gbrooke@essex.ac.uk","School of Life Sciences, University of Essex, Colchester, Essex, UK. gbrooke@essex.ac.uk","School of Life Sciences, University of Essex, Colchester, Essex, UK"],"raw_orcid":"https://orcid.org/0000-0003-4501-4134","affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London, UK. gbrooke@essex.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK. gbrooke@essex.ac.uk","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"School of Life Sciences, University of Essex, Colchester, Essex, UK","institution_ids":["https://openalex.org/I110002522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020742188","https://openalex.org/A5024566237"],"corresponding_institution_ids":["https://openalex.org/I110002522","https://openalex.org/I47508984"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":5560,"currency":"USD","value_usd":5560},"fwci":5.6425,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.96883496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"4068","last_page":"4068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tmprss2","display_name":"TMPRSS2","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9350000023841858},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.8650000095367432},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lung-cells","display_name":"lung cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/covid-19-treatment","display_name":"COVID-19 treatment","score":0.6209999918937683},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.943726122379303},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.8864599466323853},{"id":"https://openalex.org/C2910016293","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogens","level":5,"score":0.84441077709198},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.692650318145752},{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.6219062805175781},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5951212644577026},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.577448844909668},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5268988609313965},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5179795026779175},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4948534369468689},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4408688545227051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4179176688194275},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41735705733299255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37493306398391724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3019134998321533},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.24378517270088196},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18627989292144775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07422667741775513},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06674578785896301},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41467-021-24342-y","doi":"https://doi.org/10.1038/s41467-021-24342-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-24342-y","pdf_url":"https://www.nature.com/articles/s41467-021-24342-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-137931/v1","doi":"https://doi.org/10.21203/rs.3.rs-137931/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-137931/v1","pdf_url":"https://www.researchsquare.com/article/rs-137931/latest.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-34503/v1","doi":"https://doi.org/10.21203/rs.3.rs-34503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-34503/v1","pdf_url":"https://www.researchsquare.com/article/rs-34503/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8249423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8249423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:34210968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34210968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:repository.essex.ac.uk:30693","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-24342-y","pdf_url":"https://repository.essex.ac.uk/30693/1/s41467-021-24342-y.pdf","source":{"id":"https://openalex.org/S4306401236","display_name":"Open Access at Essex (University of Essex)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I110002522","host_organization_name":"University of Essex","host_organization_lineage":["https://openalex.org/I110002522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24342-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-021-24342-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:054d5eddfbac4f51bb25f10d584c7186","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/054d5eddfbac4f51bb25f10d584c7186","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/89864","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/89864","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"12","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-24342-y","doi":"https://doi.org/10.1038/s41467-021-24342-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-24342-y","pdf_url":"https://www.nature.com/articles/s41467-021-24342-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320311731","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320292","display_name":"Prostate Cancer UK","ror":"https://ror.org/04dkv6329"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3174635239.pdf","grobid_xml":"https://content.openalex.org/works/W3174635239.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W590561559","https://openalex.org/W1614690294","https://openalex.org/W1763675400","https://openalex.org/W1887068152","https://openalex.org/W1893038996","https://openalex.org/W1960802507","https://openalex.org/W1985066486","https://openalex.org/W1989069389","https://openalex.org/W1995296127","https://openalex.org/W2007303903","https://openalex.org/W2027508021","https://openalex.org/W2045176719","https://openalex.org/W2045273474","https://openalex.org/W2047150885","https://openalex.org/W2051827271","https://openalex.org/W2054438187","https://openalex.org/W2064076043","https://openalex.org/W2067948296","https://openalex.org/W2073726103","https://openalex.org/W2082107721","https://openalex.org/W2087305232","https://openalex.org/W2089158372","https://openalex.org/W2091671824","https://openalex.org/W2101506295","https://openalex.org/W2102637313","https://openalex.org/W2104548316","https://openalex.org/W2140674451","https://openalex.org/W2140952049","https://openalex.org/W2157122856","https://openalex.org/W2158616992","https://openalex.org/W2160975559","https://openalex.org/W2171758857","https://openalex.org/W2172256092","https://openalex.org/W2259938310","https://openalex.org/W2341923562","https://openalex.org/W2518965337","https://openalex.org/W2738159806","https://openalex.org/W2755770908","https://openalex.org/W2756240008","https://openalex.org/W2761275051","https://openalex.org/W2789430139","https://openalex.org/W2800410357","https://openalex.org/W2808561338","https://openalex.org/W2809569991","https://openalex.org/W2811205482","https://openalex.org/W2888204653","https://openalex.org/W2904478560","https://openalex.org/W2909787042","https://openalex.org/W2918748217","https://openalex.org/W2966112499","https://openalex.org/W2966840980","https://openalex.org/W2987040859","https://openalex.org/W2988716798","https://openalex.org/W3002108456","https://openalex.org/W3004280078","https://openalex.org/W3009912996","https://openalex.org/W3012045047","https://openalex.org/W3015134137","https://openalex.org/W3015403775","https://openalex.org/W3016473145","https://openalex.org/W3016489853","https://openalex.org/W3016846376","https://openalex.org/W3017114883","https://openalex.org/W3017129059","https://openalex.org/W3017302293","https://openalex.org/W3018199440","https://openalex.org/W3020512604","https://openalex.org/W3022435472","https://openalex.org/W3022704407","https://openalex.org/W3023316367","https://openalex.org/W3025559601","https://openalex.org/W3027426213","https://openalex.org/W3032927296","https://openalex.org/W3037538172","https://openalex.org/W3041318796","https://openalex.org/W3088109633","https://openalex.org/W3103254795","https://openalex.org/W3108487848","https://openalex.org/W3110752337","https://openalex.org/W3129019794","https://openalex.org/W3135051825","https://openalex.org/W3159140204","https://openalex.org/W3165051008","https://openalex.org/W6776880287","https://openalex.org/W7006444019"],"related_works":["https://openalex.org/W3157642495","https://openalex.org/W3119564542","https://openalex.org/W3129019794","https://openalex.org/W3135051825","https://openalex.org/W4415695918","https://openalex.org/W4319600561","https://openalex.org/W4410088898","https://openalex.org/W3170541304","https://openalex.org/W6940249771","https://openalex.org/W3033788509"],"abstract_inverted_index":{"Abstract":[0],"SARS-CoV-2":[1,92],"attacks":[2],"various":[3,56],"organs,":[4],"most":[5,58],"destructively":[6],"the":[7,42,67,126,138],"lung,":[8],"and":[9,19,84,94,114],"cellular":[10],"entry":[11,93],"requires":[12],"two":[13],"host":[14],"cell":[15,120],"surface":[16],"proteins:":[17],"ACE2":[18],"TMPRSS2.":[20],"Downregulation":[21],"of":[22,26,41,101,106,112,140],"one":[23],"or":[24],"both":[25],"these":[27],"is":[28,37],"thus":[29],"a":[30,38,45,143],"potential":[31],"therapeutic":[32],"approach":[33],"for":[34,146],"COVID-19.":[35,147],"TMPRSS2":[36,53,78],"known":[39],"target":[40],"androgen":[43,49],"receptor,":[44],"ligand-activated":[46],"transcription":[47],"factor;":[48],"receptor":[50],"activation":[51],"increases":[52],"levels":[54,79],"in":[55,74,80,85,96,117],"tissues,":[57],"notably":[59],"prostate.":[60],"We":[61],"show":[62],"here":[63],"that":[64],"treatment":[65,144],"with":[66],"antiandrogen":[68],"enzalutamide\u2014a":[69],"well-tolerated":[70],"drug":[71],"widely":[72],"used":[73],"advanced":[75],"prostate":[76],"cancer\u2014reduces":[77],"human":[81],"lung":[82,97,119],"cells":[83],"mouse":[86],"lung.":[87],"Importantly,":[88],"antiandrogens":[89,141],"significantly":[90],"reduced":[91],"infection":[95],"cells.":[98],"In":[99],"support":[100,133],"this":[102],"experimental":[103],"data,":[104],"analysis":[105],"existing":[107],"datasets":[108],"shows":[109],"striking":[110],"co-expression":[111],"AR":[113],"TMPRSS2,":[115],"including":[116],"specific":[118],"types":[121],"targeted":[122],"by":[123],"SARS-CoV-2.":[124],"Together,":[125],"data":[127],"presented":[128],"provides":[129],"strong":[130],"evidence":[131],"to":[132,136],"clinical":[134],"trials":[135],"assess":[137],"efficacy":[139],"as":[142],"option":[145]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}