{"id":"https://openalex.org/W3174589575","doi":"https://doi.org/10.5152/tjg.2021.19373","title":"Relationship between Pancreas Exocrine Insufficiency and Cardiac Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus","display_name":"Relationship between Pancreas Exocrine Insufficiency and Cardiac Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus","publication_year":2021,"publication_date":"2021-05-15","ids":{"openalex":"https://openalex.org/W3174589575","doi":"https://doi.org/10.5152/tjg.2021.19373","mag":"3174589575","pmid":"https://pubmed.ncbi.nlm.nih.gov/34231479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8975291"},"language":"en","primary_location":{"id":"doi:10.5152/tjg.2021.19373","doi":"https://doi.org/10.5152/tjg.2021.19373","is_oa":false,"landing_page_url":"https://doi.org/10.5152/tjg.2021.19373","pdf_url":null,"source":{"id":"https://openalex.org/S4210231941","display_name":"The Turkish Journal of Gastroenterology","issn_l":"1300-4948","issn":["1300-4948","2148-5607"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.turkjgastroenterol.org/index.php/tjg/article/view/3738/3401","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011593746","display_name":"Zeynel Abidin Say\u0131ner","orcid":"https://orcid.org/0000-0001-5105-0292","observed_orcids":["https://orcid.org/0000-0001-5105-0292"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynel Abidin Sayiner","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026531605","display_name":"Nida Uyar","orcid":"https://orcid.org/0000-0002-5904-8178","observed_orcids":["https://orcid.org/0000-0002-5904-8178"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nida Uyar","raw_affiliation_strings":["Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059413410","display_name":"Abdullah Emre Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0002-4386-9297","observed_orcids":["https://orcid.org/0000-0002-4386-9297"]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdullah Emre Y\u0131ld\u0131r\u0131m","raw_affiliation_strings":["Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59738393"],"apc_list":null,"apc_paid":null,"fwci":0.3524,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.54939963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"32","issue":"5","first_page":"481","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.19900000095367432,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.19900000095367432,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.17180000245571136,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-autonomic-neuropathy","display_name":"cardiac autonomic neuropathy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.972000002861023},{"id":"https://openalex.org/keywords/fecal-elastase-1","display_name":"fecal elastase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.7440000176429749},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9433814287185669},{"id":"https://openalex.org/C2779543035","wikidata":"https://www.wikidata.org/wiki/Q620639","display_name":"Dysautonomia","level":3,"score":0.8262767791748047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7547323107719421},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7090523838996887},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.575261116027832},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.4701326787471771},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.46375396847724915},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46346181631088257},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.44953659176826477},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.42052221298217773},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3861924707889557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33971062302589417},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.15936556458473206},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12396949529647827}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001342","descriptor_name":"Autonomic Nervous System Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001342","descriptor_name":"Autonomic Nervous System Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010188","descriptor_name":"Exocrine Pancreatic Insufficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010188","descriptor_name":"Exocrine Pancreatic Insufficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054969","descriptor_name":"Primary Dysautonomias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.5152/tjg.2021.19373","doi":"https://doi.org/10.5152/tjg.2021.19373","is_oa":false,"landing_page_url":"https://doi.org/10.5152/tjg.2021.19373","pdf_url":null,"source":{"id":"https://openalex.org/S4210231941","display_name":"The Turkish Journal of Gastroenterology","issn_l":"1300-4948","issn":["1300-4948","2148-5607"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:oai.turkjgastroenterol.org:article/3738","doi":null,"is_oa":true,"landing_page_url":"https://www.turkjgastroenterol.org/index.php/tjg/article/view/3738","pdf_url":"https://www.turkjgastroenterol.org/index.php/tjg/article/view/3738/3401","source":{"id":"https://openalex.org/S4210231941","display_name":"The Turkish Journal of Gastroenterology","issn_l":"1300-4948","issn":["1300-4948","2148-5607"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2148-5607","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:34231479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34231479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8975291","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8975291/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Gastroenterol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ce4e737e9f4f4689b28f194f35b5e90c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ce4e737e9f4f4689b28f194f35b5e90c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Turkish Journal of Gastroenterology, Vol 32, Iss 5 (2021)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:oai.turkjgastroenterol.org:article/3738","doi":null,"is_oa":true,"landing_page_url":"https://www.turkjgastroenterol.org/index.php/tjg/article/view/3738","pdf_url":"https://www.turkjgastroenterol.org/index.php/tjg/article/view/3738/3401","source":{"id":"https://openalex.org/S4210231941","display_name":"The Turkish Journal of Gastroenterology","issn_l":"1300-4948","issn":["1300-4948","2148-5607"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2148-5607","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3174589575.pdf","grobid_xml":"https://content.openalex.org/works/W3174589575.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W148355926","https://openalex.org/W1512135595","https://openalex.org/W1598021913","https://openalex.org/W1976255517","https://openalex.org/W1984561364","https://openalex.org/W1988212189","https://openalex.org/W1993883803","https://openalex.org/W1995053301","https://openalex.org/W1995359034","https://openalex.org/W2025382454","https://openalex.org/W2031942345","https://openalex.org/W2034277858","https://openalex.org/W2036816739","https://openalex.org/W2039265716","https://openalex.org/W2041715383","https://openalex.org/W2051587403","https://openalex.org/W2056571582","https://openalex.org/W2085610074","https://openalex.org/W2092360643","https://openalex.org/W2094210459","https://openalex.org/W2108572655","https://openalex.org/W2126945908","https://openalex.org/W2127740897","https://openalex.org/W2133190307","https://openalex.org/W2161885129","https://openalex.org/W2170019844","https://openalex.org/W2266929690","https://openalex.org/W2398201677","https://openalex.org/W2548961053","https://openalex.org/W2583633419"],"related_works":["https://openalex.org/W3196413098","https://openalex.org/W7219874408","https://openalex.org/W2130634648","https://openalex.org/W7217264815","https://openalex.org/W3197246992","https://openalex.org/W4401893767","https://openalex.org/W2463541045","https://openalex.org/W1696357680","https://openalex.org/W2036230558","https://openalex.org/W4391394825"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"exocrine":[2,64,204],"function":[3,48],"of":[4,24,34,49,105,124,139,166,182,203,214],"the":[5,10,32,47,50,55,103,137,180,191,201,208,212],"pancreas":[6,63,209],"is":[7,18,198,217],"controlled":[8],"by":[9],"autonomic":[11,16,35,59,221,232],"nervous":[12],"system":[13],"(ANS),":[14],"and":[15,21,62,82,94,96,143,162,185,223,236],"neuropathy":[17,36,60,87,222,233],"a":[19,156,175],"common":[20],"serious":[22],"complication":[23],"diabetes.":[25],"There":[26,131],"are":[27],"many":[28],"factors":[29],"contributing":[30],"to":[31,45,91,101,115,211,219],"development":[33],"in":[37,67,128,164,207,225,239],"diabetic":[38,68,220,240],"patients.":[39,69,130],"Cardiovascular":[40],"tests":[41,88],"have":[42],"been":[43],"developed":[44],"evaluate":[46],"ANS.":[51],"This":[52,71,227],"study":[53,72,228],"investigated":[54],"relationship":[56],"between":[57,159,179],"cardiovascular":[58],"(CAN)":[61],"insufficiency":[65],"(PEI)":[66],"METHODS:":[70],"evaluated":[73],"110":[74],"individuals":[75],"with":[76],"type":[77],"2":[78],"diabetes":[79],"mellitus":[80],"(T2DM)":[81],"40":[83],"healthy":[84],"volunteers.":[85],"Autonomous":[86],"were":[89,99,110],"utilized":[90],"diagnose":[92],"patients,":[93],"Ewing":[95],"Clarke's":[97],"criteria":[98],"employed":[100],"assess":[102],"severity":[104],"autonomous":[106],"dysfunction.":[107],"Stool":[108],"samples":[109],"also":[111,229],"collected":[112],"from":[113],"patients":[114,161,241],"measure":[116],"fecal":[117],"elastase-1":[118],"(FE-1).":[119],"RESULTS:":[120],"A":[121],"65.5%":[122],"incidence":[123],"PEI":[125,238],"was":[126,132,172,188],"observed":[127,189],"DM":[129,160],"no":[133],"significant":[134,157,177],"correlation":[135,178],"among":[136],"duration":[138],"disease,":[140],"C-peptide,":[141],"HbA1c,":[142],"PEI,":[144],"respectively":[145],"(P":[146,169,194],"=":[147,150,153,170],".782,":[148],"P":[149,152],".521,":[151],".580).":[154],"However,":[155],"difference":[158],"controls":[163],"terms":[165],"cardiac":[167,183],"dysautonomia":[168,184],".001)":[171],"seen.":[173],"Moreover,":[174],"statistically":[176],"degree":[181],"FE-1":[186],"level":[187],"within":[190],"patient":[192],"group":[193],"=.001).":[195],"CONCLUSION:":[196],"It":[197],"possible":[199],"that":[200,231],"disruption":[202],"hormone":[205],"secretion":[206],"due":[210],"impairment":[213],"enteropancreatic":[215],"reflexes":[216],"secondary":[218],"resulting":[224],"PEI.":[226],"showed":[230],"might":[234],"develop":[235],"cause":[237],"without":[242],"known":[243],"added":[244],"confounding":[245],"factors.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-07-05T00:00:00"}
