{"id":"https://openalex.org/W3174480971","doi":"https://doi.org/10.1182/bloodadvances.2020002993","title":"Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish","display_name":"Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish","publication_year":2021,"publication_date":"2021-06-25","ids":{"openalex":"https://openalex.org/W3174480971","doi":"https://doi.org/10.1182/bloodadvances.2020002993","mag":"3174480971","pmid":"https://pubmed.ncbi.nlm.nih.gov/34170285","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8288679"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2020002993","doi":"https://doi.org/10.1182/bloodadvances.2020002993","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020002993","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/13/2687/1810792/advancesadv2020002993.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ashpublications.org/bloodadvances/article-pdf/5/13/2687/1810792/advancesadv2020002993.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003141809","display_name":"Emanuele Gioacchino","orcid":"https://orcid.org/0000-0002-2787-6286","observed_orcids":["https://orcid.org/0000-0002-2787-6286"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Emanuele Gioacchino","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006134461","display_name":"Cansu Koyunlar","orcid":"https://orcid.org/0000-0002-9006-1135","observed_orcids":["https://orcid.org/0000-0002-9006-1135"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cansu Koyunlar","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":"https://orcid.org/0000-0002-9006-1135","affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011130737","display_name":"Joke Zink","orcid":"https://orcid.org/0000-0001-6829-244X","observed_orcids":["https://orcid.org/0000-0001-6829-244X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joke Zink","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":"https://orcid.org/0000-0001-6829-244X","affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000199982","display_name":"Hans W. J. de Looper","orcid":"https://orcid.org/0000-0003-3416-7581","observed_orcids":["https://orcid.org/0000-0003-3416-7581"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hans de Looper","raw_affiliation_strings":["Cancer Genome Editing Center, Erasmus MC, Rotterdam, The Netherlands;","Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genome Editing Center, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]},{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015507503","display_name":"Madelon M.E. de Jong","orcid":"https://orcid.org/0000-0002-6145-6154","observed_orcids":["https://orcid.org/0000-0002-6145-6154"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Madelon de Jong","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":"https://orcid.org/0000-0002-6145-6154","affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082586149","display_name":"Tomasz Dobrzycki","orcid":"https://orcid.org/0000-0002-7708-3188","observed_orcids":["https://orcid.org/0000-0002-7708-3188"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tomasz Dobrzycki","raw_affiliation_strings":["Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0002-7708-3188","affiliations":[{"raw_affiliation_string":"Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom;","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042356474","display_name":"Christopher B. Mahony","orcid":"https://orcid.org/0000-0003-4487-2540","observed_orcids":["https://orcid.org/0000-0003-4487-2540"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher B. Mahony","raw_affiliation_strings":["Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; and","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031536535","display_name":"Remco Michiel Hoogenboezem","orcid":"https://orcid.org/0000-0002-1719-6455","observed_orcids":["https://orcid.org/0000-0002-1719-6455"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Remco Hoogenboezem","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088216731","display_name":"Dennis A. Bosch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dennis Bosch","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108622270","display_name":"Paulina M. H. van Strien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paulina M. H. van Strien","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003510906","display_name":"Martin E. van Royen","orcid":"https://orcid.org/0000-0002-6814-0996","observed_orcids":["https://orcid.org/0000-0002-6814-0996"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4387154806","display_name":"Erasmus Optical Imaging Centre","ror":"https://ror.org/00hjpwn75","country_code":"NL","type":"facility","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4387154806"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin E. van Royen","raw_affiliation_strings":["Department of Pathology, Cancer Treatment Screening Facility, Erasmus MC Optical Imaging Centre, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Cancer Treatment Screening Facility, Erasmus MC Optical Imaging Centre, and","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4387154806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022651335","display_name":"Pim J. French","orcid":"https://orcid.org/0000-0002-0668-9529","observed_orcids":["https://orcid.org/0000-0002-0668-9529"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pim J. French","raw_affiliation_strings":["Department of Neurology, Cancer Treatment Screening Facility, Erasmus MC, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Cancer Treatment Screening Facility, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071446087","display_name":"Eric M. Bindels","orcid":"https://orcid.org/0000-0001-9502-669X","observed_orcids":["https://orcid.org/0000-0001-9502-669X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eric Bindels","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003297703","display_name":"Kirsten J. Gussinklo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kirsten J. Gussinklo","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068869985","display_name":"Rui M. Monteiro","orcid":"https://orcid.org/0000-0002-4223-8506","observed_orcids":["https://orcid.org/0000-0002-4223-8506"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rui Monteiro","raw_affiliation_strings":["Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; and"],"raw_orcid":"https://orcid.org/0000-0002-4223-8506","affiliations":[{"raw_affiliation_string":"Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; and","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019814633","display_name":"Ivo P. Touw","orcid":"https://orcid.org/0000-0002-4773-4074","observed_orcids":["https://orcid.org/0000-0002-4773-4074"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ivo P. Touw","raw_affiliation_strings":["Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051777951","display_name":"Emma de Pater","orcid":"https://orcid.org/0000-0002-7195-6769","observed_orcids":["https://orcid.org/0000-0002-7195-6769"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Emma de Pater","raw_affiliation_strings":["Cancer Genome Editing Center, Erasmus MC, Rotterdam, The Netherlands;","Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;"],"raw_orcid":"https://orcid.org/0000-0002-7195-6769","affiliations":[{"raw_affiliation_string":"Cancer Genome Editing Center, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]},{"raw_affiliation_string":"Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":3.8858,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94826235,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"5","issue":"13","first_page":"2687","last_page":"2700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gata2","display_name":"GATA2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adult-hematopoiesis","display_name":"adult hematopoiesis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/definitive-hematopoiesis","display_name":"definitive hematopoiesis","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7694001793861389},{"id":"https://openalex.org/C43821964","wikidata":"https://www.wikidata.org/wiki/Q18025461","display_name":"GATA2","level":4,"score":0.7633551359176636},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.739063024520874},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6796217560768127},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6419508457183838},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.64048171043396},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.6268947124481201},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6110789775848389},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5835897326469421},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.554168164730072},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4480309784412384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37870609760284424},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3207359313964844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25254079699516296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08086046576499939}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050989","descriptor_name":"GATA2 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1182/bloodadvances.2020002993","doi":"https://doi.org/10.1182/bloodadvances.2020002993","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020002993","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/13/2687/1810792/advancesadv2020002993.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmid:34170285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34170285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8288679","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8288679/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/a1240e15-5384-4457-b2fa-09a5919d8784","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/a1240e15-5384-4457-b2fa-09a5919d8784","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gioacchino, E, Koyunlar, C, Zink, J, de Looper, H, de Jong, M, Dobrzycki, T, Mahony, C B, Hoogenboezem, R, Bosch, D, van Strien, P M H, van Royen, M E, French, P J, Bindels, E, Gussinklo, K J, Monteiro, R, Touw, I P & de Pater, E 2021, 'Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish', Blood Advances, vol. 5, no. 13, pp. 2687-2700. https://doi.org/10.1182/bloodadvances.2020002993","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire/24190a85-ae08-4ceb-901f-766bd542a9aa","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/24190a85-ae08-4ceb-901f-766bd542a9aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gioacchino, E, Koyunlar, C, Zink, J, de Looper, H, de Jong, M, Dobrzycki, T, Mahony, C B, Hoogenboezem, R, Bosch, D, van Strien, P M H, van Royen, M E, French, P J, Bindels, E, Gussinklo, K J, Monteiro, R, Touw, I P & de Pater, E 2021, 'Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish', Blood advances, vol. 5, no. 13, pp. 2687-2700. https://doi.org/10.1182/bloodadvances.2020002993","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/24190a85-ae08-4ceb-901f-766bd542a9aa","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/24190a85-ae08-4ceb-901f-766bd542a9aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood advances, 5(13), 2687 - 2700. American Society of Hematology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2020002993","doi":"https://doi.org/10.1182/bloodadvances.2020002993","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020002993","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/13/2687/1810792/advancesadv2020002993.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2551573059","display_name":null,"funder_award_id":"#WT102345/Z/13/Z.","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G81155125","display_name":"The role of TGF\u00df signalling in angiogenic and haemogenic endothelial cell programming","funder_award_id":"FS/13/50/30436","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8374408139","display_name":null,"funder_award_id":"WT102345/Z/13/Z","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320310646","display_name":"European Hematology Association","ror":"https://ror.org/05hk0hn26"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3174480971.pdf"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1586011800","https://openalex.org/W1968644364","https://openalex.org/W1971958267","https://openalex.org/W1983600460","https://openalex.org/W1987191562","https://openalex.org/W1989543257","https://openalex.org/W1990196345","https://openalex.org/W1990580731","https://openalex.org/W1999580244","https://openalex.org/W2009110567","https://openalex.org/W2011096612","https://openalex.org/W2019351011","https://openalex.org/W2020179710","https://openalex.org/W2021516648","https://openalex.org/W2023089317","https://openalex.org/W2024520070","https://openalex.org/W2027173968","https://openalex.org/W2027703497","https://openalex.org/W2032417286","https://openalex.org/W2033560950","https://openalex.org/W2042531263","https://openalex.org/W2042982622","https://openalex.org/W2050195517","https://openalex.org/W2050376918","https://openalex.org/W2051397980","https://openalex.org/W2054508067","https://openalex.org/W2056868742","https://openalex.org/W2061740109","https://openalex.org/W2066236572","https://openalex.org/W2089311130","https://openalex.org/W2090814545","https://openalex.org/W2091760375","https://openalex.org/W2096364098","https://openalex.org/W2097416336","https://openalex.org/W2104513503","https://openalex.org/W2106495713","https://openalex.org/W2112528263","https://openalex.org/W2128537101","https://openalex.org/W2129812210","https://openalex.org/W2130422603","https://openalex.org/W2130699016","https://openalex.org/W2136182167","https://openalex.org/W2140367720","https://openalex.org/W2150731845","https://openalex.org/W2164695230","https://openalex.org/W2166749692","https://openalex.org/W2171944569","https://openalex.org/W2174044927","https://openalex.org/W2269309710","https://openalex.org/W2325223081","https://openalex.org/W2473235403","https://openalex.org/W2515907404","https://openalex.org/W2517782886","https://openalex.org/W2572647583","https://openalex.org/W2602848567","https://openalex.org/W2753518299","https://openalex.org/W2753940935","https://openalex.org/W2794480084","https://openalex.org/W2912490305","https://openalex.org/W2949685357","https://openalex.org/W2953332873","https://openalex.org/W2966647200","https://openalex.org/W3000502359","https://openalex.org/W3006281915","https://openalex.org/W4255759814","https://openalex.org/W6674920175","https://openalex.org/W7073641226"],"related_works":["https://openalex.org/W2970470176","https://openalex.org/W3132440543","https://openalex.org/W3201652819","https://openalex.org/W3185382935","https://openalex.org/W2288267116","https://openalex.org/W4317033411","https://openalex.org/W2767732706","https://openalex.org/W4388656193","https://openalex.org/W3006281915","https://openalex.org/W2909023621"],"abstract_inverted_index":{"The":[0],"differentiation":[1,200],"of":[2,33,42,60,78,111,139,148,192,209],"hematopoietic":[3,25,93],"stem":[4,94],"cells":[5],"(HSCs)":[6],"is":[7,22,36,53],"tightly":[8],"controlled":[9],"to":[10,106,178,188],"ensure":[11],"a":[12,23,88,154,160,180,203],"proper":[13],"balance":[14],"between":[15,82],"myeloid":[16,120,141],"and":[17,31,63,95,159,196],"lymphoid":[18,149,204],"cell":[19,70,97],"output.":[20],"GATA2":[21,35,79,112,193],"pivotal":[24],"transcription":[26],"factor":[27],"required":[28],"for":[29],"generation":[30],"maintenance":[32],"HSCs.":[34],"expressed":[37,67],"throughout":[38],"development,":[39],"but":[40,100,131],"because":[41],"early":[43],"embryonic":[44,91],"lethality":[45],"in":[46,68,90,113,128,132,153,156,163,168,182,206],"mice,":[47],"its":[48],"role":[49,110],"during":[50,194],"adult":[51,114],"hematopoiesis":[52,195],"incompletely":[54],"understood.":[55],"Zebrafish":[56],"contains":[57],"2":[58],"orthologs":[59],"GATA2:":[61],"Gata2a":[62],"Gata2b,":[64],"which":[65],"are":[66,80,101],"different":[69],"types.":[71],"We":[72],"show":[73],"that":[74,198],"the":[75,109,140,169,190,207],"mammalian":[76],"functions":[77,191],"split":[81],"these":[83],"orthologs.":[84],"Gata2b-deficient":[85,134],"zebrafish":[86],"have":[87,118],"reduction":[89],"definitive":[92],"progenitor":[96],"(HSPC)":[98],"numbers,":[99],"viable.":[102],"This":[103,151,166],"allows":[104],"us":[105],"uniquely":[107],"study":[108,186],"hematopoiesis.":[115],"gata2b":[116],"mutants":[117],"impaired":[119,137],"lineage":[121,170,183,199,205],"differentiation.":[122,184],"Interestingly,":[123],"this":[124],"defect":[125],"arises":[126],"not":[127],"granulocyte-monocyte":[129],"progenitors,":[130],"HSPCs.":[133],"HSPCs":[135],"showed":[136],"progression":[138],"transcriptional":[142],"program,":[143],"concomitant":[144],"with":[145],"increased":[146],"coexpression":[147],"genes.":[150],"resulted":[152],"decrease":[155],"myeloid-programmed":[157],"progenitors":[158],"relative":[161],"increase":[162],"lymphoid-programmed":[164],"progenitors.":[165],"shift":[167],"output":[171],"could":[172],"function":[173],"as":[174],"an":[175],"escape":[176],"mechanism":[177],"avoid":[179],"block":[181],"Our":[185],"helps":[187],"deconstruct":[189],"shows":[197],"flows":[201],"toward":[202],"absence":[208],"Gata2b.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-07-05T00:00:00"}
