{"id":"https://openalex.org/W3173777720","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.846.4","title":"Roles of Cell\u2010Cell Junction and Substrate Stiffness in Determining 3D Forces of Endothelial Cells","display_name":"Roles of Cell\u2010Cell Junction and Substrate Stiffness in Determining 3D Forces of Endothelial Cells","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W3173777720","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.846.4","mag":"3173777720"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2018.32.1_supplement.846.4","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.846.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.846.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013232529","display_name":"Sung Sik Hur","orcid":"https://orcid.org/0000-0003-4211-0497","observed_orcids":["https://orcid.org/0000-0003-4211-0497"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung Sik Hur","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, CA","Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082965827","display_name":"Yi\u2010Ting Yeh","orcid":"https://orcid.org/0000-0003-3002-3425","observed_orcids":["https://orcid.org/0000-0003-3002-3425"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi\u2010Ting Yeh","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA","Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025613971","display_name":"Kyunghang Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyunghang Lee","raw_affiliation_strings":["Department of NanoEngineering, University of California San Diego, La Jolla, CA","Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of NanoEngineering, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuanjia Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanjia Wang","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, CA","Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048522454","display_name":"Yi-Shuan Julie Li","orcid":"https://orcid.org/0000-0002-8162-8988","observed_orcids":["https://orcid.org/0000-0002-8162-8988"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi\u2010Shuan Li","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, CA","Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X","observed_orcids":["https://orcid.org/0000-0003-0332-285X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Chien","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, La Jolla, CA","Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28202594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-cell-junction","display_name":"cell-cell junction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mechanical-forces","display_name":"mechanical forces","score":0.5950000286102295},{"id":"https://openalex.org/keywords/traction-force-microscopy","display_name":"traction force microscopy","score":0.734000027179718},{"id":"https://openalex.org/keywords/cell-confluency","display_name":"cell confluence","score":0.8569999933242798},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.6740000247955322},{"id":"https://openalex.org/keywords/angiopoietins","display_name":"angiopoietins","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-matrix-adhesion","display_name":"cell-matrix adhesion","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.5249999761581421},{"id":"https://openalex.org/keywords/hydrogel-substrates","display_name":"hydrogel substrates","score":0.6100000143051147},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6762414574623108},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6580866575241089},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6075519323348999},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5816667675971985},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.558545708656311},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4380030930042267},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.41017013788223267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4061708152294159},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30449390411376953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08305394649505615},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08025288581848145}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2018.32.1_supplement.846.4","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.846.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.846.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011553458","https://openalex.org/W2032647105","https://openalex.org/W2561499578","https://openalex.org/W2032780005","https://openalex.org/W2118260907","https://openalex.org/W1996924444","https://openalex.org/W2067776924","https://openalex.org/W3175730677","https://openalex.org/W2074572112","https://openalex.org/W7167864253"],"abstract_inverted_index":{"Mechanical":[0],"forces":[1,183],"play":[2],"an":[3],"important":[4,170],"role":[5],"in":[6,25,77,90,102,118,138,171,193,236],"regulating":[7],"structure":[8,177],"and":[9,16,51,62,71,107,121,128,131,135,145,155,159,166,178,187,211],"functions":[10],"of":[11,20,29,40,74,97,124,152,174,197,205,208,213],"cells,":[12],"including":[13],"motility,":[14],"proliferation,":[15],"survival.":[17],"The":[18,110,237],"integrity":[19],"cell\u2010cell":[21,52,108,153],"junction":[22],"is":[23,34,218,226],"crucial":[24],"the":[26,38,81,94,119,172,182,190,206,220],"physiological":[27],"behavior":[28],"endothelial":[30,41,98,114,175,209],"cells.":[31],"Thus,":[32],"it":[33],"essential":[35],"to":[36,67,92,100,140,195,202],"understand":[37],"modulation":[39],"cells":[42,76,99,115,210],"by":[43],"their":[44],"micro\u2010environment":[45],"such":[46],"as":[47],"substrate":[48,103,141],"stiffness,":[49,104],"confluency,":[50,106],"junction.":[53,109],"We":[54,161],"have":[55,87,162],"developed":[56],"three\u2010dimensional":[57],"traction":[58],"force":[59,64],"microscopy":[60,65],"(3D\u2010TFM)":[61],"intracellular":[63,72,129],"(3D\u2010IFM)":[66],"measure":[68],"cell\u2010ECM,":[69],"cell\u2010cell,":[70],"stresses":[73],"live":[75],"three":[78],"dimensions":[79],"at":[80,189],"subcellular":[82,191],"level.":[83],"These":[84],"novel":[85],"methods":[86],"been":[88],"applied":[89],"order":[91],"investigate":[93],"mechanical":[95,125],"responses":[96],"changes":[101,196],"cell":[105,149,176],"results":[111],"indicate":[112],"that":[113,164],"exhibit":[116],"differences":[117],"magnitude":[120],"spatial":[122],"distribution":[123],"behaviors":[126],"(traction":[127],"stress)":[130],"morphological":[132],"features":[133],"(area":[134],"aspect":[136],"ratio)":[137],"response":[139,194],"stiffness":[142],"(1.5":[143],"kPa":[144,147],"10b":[146],"hydrogel),":[148],"confluency":[150],"(existence":[151],"junction),":[154],"junction\u2010affecting":[156],"drugs":[157],"(thrombin":[158],"angiopoietin).":[160],"shown":[163],"biophysical":[165],"biochemical":[167],"environments":[168],"are":[169,184],"control":[173],"function.":[179],"Studying":[180],"how":[181],"regulated":[185],"spatially":[186],"temporally":[188],"level":[192],"cellular":[198],"microenvironment":[199],"can":[200],"lead":[201],"further":[203],"understanding":[204],"physiology":[207],"pathogenesis":[212],"vascular":[214],"diseases.":[215],"This":[216],"abstract":[217,234],"from":[219],"Experimental":[221],"Biology":[222],"2018":[223],"Meeting.":[224],"There":[225],"no":[227],"full":[228],"text":[229],"article":[230],"associated":[231],"with":[232],"this":[233],"published":[235],"FASEB":[238],"Journal":[239],".":[240]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}
