{"id":"https://openalex.org/W3173763673","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb612","title":"Impact of Developmental Nicotine Exposure on Cholinergic Airway Signaling","display_name":"Impact of Developmental Nicotine Exposure on Cholinergic Airway Signaling","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W3173763673","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb612","mag":"3173763673"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2019.33.1_supplement.lb612","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb612","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb612","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023031995","display_name":"Benjamin D. Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D Rivera","raw_affiliation_strings":["Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ","Physiology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Physiology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022786967","display_name":"Nathan Borrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan G Borrero","raw_affiliation_strings":["Physiology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051041478","display_name":"Seres J. B. Cross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seres J.B. Cross","raw_affiliation_strings":["Physiology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045933923","display_name":"Ralph Frank Fregosi","orcid":"https://orcid.org/0000-0002-6849-7530","observed_orcids":["https://orcid.org/0000-0002-6849-7530"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph F Fregosi","raw_affiliation_strings":["Physiology, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012818050","display_name":"Scott A. Boitano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Boitano","raw_affiliation_strings":["Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ","Physiolgy, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Physiolgy, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18655793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.24719999730587006,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.23100000619888306,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-nicotine-exposure","display_name":"prenatal nicotine exposure","score":0.7229999899864197},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.8799999952316284},{"id":"https://openalex.org/keywords/trachea","display_name":"trachea","score":0.6299999952316284},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.9459999799728394},{"id":"https://openalex.org/keywords/epithelial-ion-transport","display_name":"epithelial ion transport","score":0.7379999756813049},{"id":"https://openalex.org/keywords/calcium-activated-chloride-channels","display_name":"calcium-activated chloride channels","score":0.777999997138977},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/airway-surface-liquid","display_name":"airway surface liquid","score":0.9330000281333923},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.6389999985694885},{"id":"https://openalex.org/keywords/maternal-smoking","display_name":"maternal smoking","score":0.3199999928474426},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.531000018119812},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8050304651260376},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6524814367294312},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6369509696960449},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.5657116174697876},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.5071988105773926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49000778794288635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47436222434043884},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.4503638744354248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3767518997192383},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35333341360092163},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.323589026927948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32214978337287903},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2019.33.1_supplement.lb612","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb612","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb612","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2018336436","display_name":null,"funder_award_id":"NIEHS/SBRPP ES094940","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8876618256","display_name":"Environmental Health Sciences: Transformational Research Undergraduate Experience (E-H-TRUE)","funder_award_id":"R25ES025494","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389020619","https://openalex.org/W2045710761","https://openalex.org/W3177437458","https://openalex.org/W3174630069","https://openalex.org/W1978158876","https://openalex.org/W1995051779","https://openalex.org/W1859270278","https://openalex.org/W2166262138","https://openalex.org/W2987447328","https://openalex.org/W2280641859"],"abstract_inverted_index":{"In":[0,267],"2014,":[1],"8.4%":[2],"of":[3,33,47,89,102,189,196,219,238,295,302,311],"US":[4],"women":[5],"reported":[6],"smoking":[7],"during":[8],"pregnancy.":[9],"Conservatively,":[10],"this":[11,339],"translates":[12],"into":[13],"approximately":[14],"360,000":[15],"smoke\u2010exposed":[16],"infants":[17],"born":[18],"in":[19,21,38,53,56,107,136,149,156,163,183,193,228,245,263,284,342],"2015":[20],"the":[22,39,71,87,100,194,217,220,231,264,271,291,326],"United":[23],"States.":[24],"Fetal":[25],"nicotine":[26,92,106,113],"exposure":[27,298],"alters":[28],"cholinergic":[29],"signaling":[30,97],"through":[31],"activation":[32,237],"Nicotinic":[34],"Acetylcholine":[35],"Receptors":[36],"(nAChRs)":[37],"developing":[40],"lung":[41,57],"and":[42,51,76,109,116,133,144,212,251,257,280],"nervous":[43],"system.":[44],"Altered":[45],"expression":[46,248,262],"nAChRs":[48],"can":[49,65],"persist":[50],"result":[52],"lasting":[54],"changes":[55,244,283,294],"function.":[58],"The":[59,153,343],"impact":[60,88],"on":[61,94],"airway":[62,72,95],"nAChRs,":[63],"which":[64],"influence":[66],"ion":[67],"transport":[68],"to":[69,85,105,139,151,172,185,230,242,299],"control":[70,252],"surface":[73],"liquid":[74],"layer":[75],"mucociliary":[77],"clearance,":[78],"remains":[79],"poorly":[80],"defined.":[81],"Here":[82],"we":[83,269],"begin":[84],"discern":[86],"an":[90],"acute":[91],"challenge":[93],"epithelial":[96,197],"by":[98,225,236],"evaluating":[99],"tracheae":[101,174,192,279],"animals":[103,158,177,253],"exposed":[104,119],"utero":[108],"after":[110],"birth":[111],"(developmental":[112],"exposure,":[114],"DNE)":[115],"controls":[117],"(saline":[118],"sham).":[120],"Tracheae":[121],"were":[122,134],"excised":[123],"from":[124,175,276,325],"neonate":[125,191,278],"rats":[126],"between":[127,249],"post\u2010natal":[128],"days":[129],"7":[130],"\u2013":[131],"12":[132],"mounted":[135],"Ussing":[137,273],"Chambers":[138],"measure":[140],"transtracheal":[141],"resistance":[142],"(TTR)":[143],"short":[145],"circuit":[146],"current":[147],"(Isc)":[148],"response":[150,184,229],"nicotine.":[152,186],"resting":[154],"TTR":[155],"DNE":[157,250],"trended":[159],"lower":[160],"than":[161],"that":[162,170,216],"sham\u2010treated":[164],"animals.":[165,266],"Additionally,":[166],"it":[167],"was":[168],"found":[169],"compared":[171],"sham,":[173],"DNE\u2010treated":[176,265],"displayed":[178],"significantly":[179],"larger":[180],"peak":[181,221],"Isc":[182,187,222,285],"experiments":[188,241],"whole":[190],"presence":[195],"Na":[198],"+":[199],"channel":[200],"(ENaC),":[201],"Ca\u2010induced":[202],"Cl":[203],"Channel":[204,208],"(CaCC)":[205],"or":[206,306],"CFTR":[207],"inhibitors":[209],"(amiloride,":[210],"DIDS":[211],"CFTRinh\u2010172,":[213],"respectively)":[214],"suggest":[215,259],"bulk":[218],"is":[223,324,332],"mediated":[224],"CaCC":[226],"secretion":[227],"Ca":[232],"2+":[233],"influx":[234],"triggered":[235],"nAChRs.":[239],"Preliminary":[240],"evaluate":[243],"nAChR":[246],"subunit":[247,261],"using":[254],"mRNA":[255],"extraction":[256],"qPCR":[258],"altered":[260],"summary,":[268],"report":[270],"first":[272],"Chamber":[274],"recordings":[275],"rat":[277],"demonstrate":[281],"significant":[282],"following":[286],"DNE.":[287],"These":[288],"data":[289],"highlight":[290],"potential":[292],"physiological":[293],"early":[296],"life":[297],"nicotine,":[300],"independent":[301],"cigarette":[303],"smoke.":[304],"Support":[305],"Funding":[307],"Information":[308],"National":[309],"Institutes":[310],"Health":[312],"Grants:":[313],"NIEHS/SBRPP":[314],"ES094940":[315],"(SB),":[316],"NIEHS/EHS\u2010TRUE":[317],"ES025494":[318],"(NGB),":[319],"NICHD":[320],"HD071302":[321],"This":[322],"abstract":[323,340],"Experimental":[327],"Biology":[328],"2019":[329],"Meeting.":[330],"There":[331],"no":[333],"full":[334],"text":[335],"article":[336],"associated":[337],"with":[338],"published":[341],"FASEB":[344],"Journal":[345],".":[346]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-07-05T00:00:00"}
