{"id":"https://openalex.org/W3173735554","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.685.6","title":"Kidney hyperfusion upregulates major histocompatibility complex expression in glomerular endothelial cells through c\u2010Jun N\u2010terminal kinase","display_name":"Kidney hyperfusion upregulates major histocompatibility complex expression in glomerular endothelial cells through c\u2010Jun N\u2010terminal kinase","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W3173735554","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.685.6","mag":"3173735554"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2019.33.1_supplement.685.6","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.685.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.685.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065620658","display_name":"Yi Shi","orcid":"https://orcid.org/0000-0003-3005-9655","observed_orcids":["https://orcid.org/0000-0003-3005-9655"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Shi","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727835","display_name":"Dong Zhu","orcid":"https://orcid.org/0000-0002-1152-1624","observed_orcids":["https://orcid.org/0000-0002-1152-1624"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Zhu","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112304947","display_name":"Qunye Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qunye Tang","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102188664","display_name":"Mei Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Meng","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenjie Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjie Liu","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081961473","display_name":"Tongyu Zhu","orcid":"https://orcid.org/0000-0002-6697-4209","observed_orcids":["https://orcid.org/0000-0002-6697-4209"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongyu Zhu","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100388269","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0003-0351-5184","observed_orcids":["https://orcid.org/0000-0003-0351-5184"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30134009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0478999987244606,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-endothelial-cells","display_name":"glomerular endothelial cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9319999814033508},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.7229999899864197},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ciita","display_name":"CIITA","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mica","display_name":"mica","score":0.9860000014305115},{"id":"https://openalex.org/keywords/5-6-nephrectomy","display_name":"5/6 nephrectomy","score":0.878000020980835},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.8199999928474426},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.6169999837875366},{"id":"https://openalex.org/keywords/sp600125","display_name":"SP600125","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.5899999737739563},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":1.0}],"concepts":[{"id":"https://openalex.org/C2775890610","wikidata":"https://www.wikidata.org/wiki/Q14914108","display_name":"CIITA","level":5,"score":0.7576180696487427},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.523685097694397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4932846426963806},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4751608073711395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46713709831237793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.448718786239624},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4300169348716736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34653159976005554},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.2669731080532074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21192669868469238}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2019.33.1_supplement.685.6","doi":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.685.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2019.33.1_supplement.685.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4231600276","https://openalex.org/W3081372461","https://openalex.org/W1590884354","https://openalex.org/W2997291147","https://openalex.org/W1584353300","https://openalex.org/W2056251903","https://openalex.org/W2018920909","https://openalex.org/W191179077","https://openalex.org/W7096138687","https://openalex.org/W4405603674"],"abstract_inverted_index":{"Objectives":[0],"The":[1,15,358],"endothelium":[2],"is":[3,339,347],"the":[4,12,120,145,170,174,242,259,270,278,286,326,341],"first":[5],"line":[6],"of":[7,21,75,104,127,144,162,192,230,272,302,331],"defense":[8],"while":[9],"contacting":[10],"with":[11,109,150,353],"immune":[13,171],"system.":[14],"present":[16,279],"study":[17],"was":[18,323],"investigated":[19],"roles":[20],"antigen":[22],"representing":[23],"in":[24,63,115,119,140,236,258,269,285,291,297,308,312,315,357],"glomerular":[25,58,141,183,238,298,309],"endothelial":[26,59,142,184,239,299,310],"cells.":[27,240,300],"Methods":[28],"C57/BL6":[29,53],"mice":[30,46,93,114,244],"were":[31,47,61,71,138],"randomly":[32],"grouped":[33],"into":[34],"sham\u2010operated":[35],"(2K)":[36],"and":[37,66,69,83,124,135,173,195,234,314,335],"5/6":[38],"nephrectomy":[39,91,281],"groups":[40],"(5/6Nx).":[41],"After":[42],"whole":[43],"body":[44],"irradiation,":[45],"received":[48],"splenic":[49],"lymphocytes":[50,151,176],"from":[51,152,340],"either":[52],"or":[54,224,246,256,318],"Balb/c":[55,153],"mice.":[56,147],"Human":[57],"cells":[60,143,311],"cultured":[62,182,237],"vitro.":[64],"Blood":[65],"renal":[67,97,105,179],"cortex,":[68],"glomeruli":[70],"collected":[72],"for":[73],"measurement":[74],"kidney":[76,167],"function,":[77,98],"Western":[78],"blotting,":[79],"fluorescence\u2010activated":[80],"cell":[81],"sorting":[82],"enzyme\u2010linked":[84],"immunosorbent":[85],"assays.":[86],"Results":[87],"Four":[88],"weeks":[89],"after":[90],"5/6Nx":[92,116,146,243,260],"had":[94,158],"a":[95,100,267],"normal":[96],"but":[99,155,203,253],"significantly":[101,159,188],"higher":[102,160],"level":[103],"blood":[106],"flow,":[107],"compared":[108],"2K":[110],"groups,":[111],"indicating":[112],"that":[113,166,263],"have":[117],"hyper\u2010perfusion":[118,168],"kidney.":[121],"Both":[122],"mRNA":[123],"protein":[125,190,214,228,295],"expressions":[126,229],"major":[128,292],"histocompatibility":[129,293],"complex":[130,294],"(MHC)":[131],"II,":[132],"CD80,":[133],"CD86,":[134],"interferon":[136,186],"\u03b3":[137,187,208],"upregulated":[139,189],"Mice":[148],"injected":[149],"mice,":[154,261],"not":[156,204,254],"C57/BL6,":[157],"levels":[161],"serum":[163],"creatinine,":[164],"confirming":[165],"initiate":[169],"reaction":[172],"allograft":[175],"transplant":[177],"accelerates":[178],"dysfunction.":[180],"In":[181,241,277],"cells,":[185],"expression":[191,296,307],"MHC":[193,196,205,232,250,273,306],"II":[194,233,251,274],"class":[197],"I":[198],"chain\u2010related":[199],"genes":[200],"A":[201],"(MICA),":[202],"I.":[206],"Interferon":[207],"also":[209],"increased":[210],"transcription":[211],"factor":[212],"CIITA":[213],"expression,":[215,252],"as":[216,218],"well":[217],"phosphorylation":[219],"JNK.":[220],"JNK":[221,225,247,264,303],"inhibitor,":[222],"SP600125":[223,245],"peptide,":[226,248],"reduced":[227,249],"CIITA,":[231],"MICA":[235],"CD80":[255],"CD86":[257],"suggesting":[262],"signalling":[265,304],"plays":[266],"role":[268],"regulation":[271],"protein.":[275],"Conclusion":[276],"study,":[280],"induces":[282],"hemodynamic":[283],"changes":[284],"kidney,":[287],"leading":[288],"to":[289],"increases":[290],"Inhibition":[301],"reduces":[305],"vitro":[313],"vivo.":[316],"Support":[317],"Funding":[319],"Information":[320],"This":[321,337],"work":[322],"supported":[324],"by":[325],"National":[327],"Nature":[328],"Science":[329],"Foundation":[330],"China":[332],"(No":[333],"81573418)":[334],"ZSYXRC\u2010014":[336],"abstract":[338,355],"Experimental":[342],"Biology":[343],"2019":[344],"Meeting.":[345],"There":[346],"no":[348],"full":[349],"text":[350],"article":[351],"associated":[352],"this":[354],"published":[356],"FASEB":[359],"Journal":[360],".":[361]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}
