{"id":"https://openalex.org/W3173731340","doi":"https://doi.org/10.1111/febs.16102","title":"Quantitative imaging and dynamics of tumor therapy with viruses","display_name":"Quantitative imaging and dynamics of tumor therapy with viruses","publication_year":2021,"publication_date":"2021-07-02","ids":{"openalex":"https://openalex.org/W3173731340","doi":"https://doi.org/10.1111/febs.16102","mag":"3173731340","pmid":"https://pubmed.ncbi.nlm.nih.gov/34213827"},"language":"en","primary_location":{"id":"doi:10.1111/febs.16102","doi":"https://doi.org/10.1111/febs.16102","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.16102","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088685356","display_name":"Iris Kemler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iris Kemler","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063062725","display_name":"Bhargav R. Karamched","orcid":"https://orcid.org/0000-0002-6926-7593","observed_orcids":["https://orcid.org/0000-0002-6926-7593"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhargav Karamched","raw_affiliation_strings":["Department of Mathematics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032283842","display_name":"Claudia M. Neuhauser","orcid":"https://orcid.org/0000-0001-8932-675X","observed_orcids":["https://orcid.org/0000-0001-8932-675X"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Neuhauser","raw_affiliation_strings":["Department of Mathematics, University of Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004","observed_orcids":["https://orcid.org/0000-0001-7477-3004"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Dingli","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA","Division of Hematology and Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0001-7477-3004","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology and Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007747233"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.074,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0921446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"288","issue":"21","first_page":"6273","last_page":"6285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/quantitative-imaging","display_name":"quantitative imaging","score":0.6179999709129333},{"id":"https://openalex.org/keywords/tumor-dynamics","display_name":"tumor dynamics","score":0.44999998807907104},{"id":"https://openalex.org/keywords/immune-response-to-viral-infection","display_name":"immune response to viral infection","score":0.5540000200271606},{"id":"https://openalex.org/keywords/non-invasive-monitoring","display_name":"non-invasive monitoring","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.5770000219345093},{"id":"https://openalex.org/keywords/gene-therapy-delivery","display_name":"gene therapy delivery","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9796949625015259},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.8937122821807861},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.6069265007972717},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5370617508888245},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5234717130661011},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4945320785045624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4402831196784973},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.42104169726371765},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3373781442642212},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2975582480430603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10033023357391357}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.16102","doi":"https://doi.org/10.1111/febs.16102","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.16102","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:34213827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34213827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W182566489","https://openalex.org/W1558969188","https://openalex.org/W1585788690","https://openalex.org/W1964668244","https://openalex.org/W1965497380","https://openalex.org/W1972703251","https://openalex.org/W1973582450","https://openalex.org/W1975251681","https://openalex.org/W1975463223","https://openalex.org/W1975670104","https://openalex.org/W1976892064","https://openalex.org/W1977402944","https://openalex.org/W1980695222","https://openalex.org/W1981123026","https://openalex.org/W1981468737","https://openalex.org/W1983236139","https://openalex.org/W1986513627","https://openalex.org/W1986711369","https://openalex.org/W1989035500","https://openalex.org/W1989839246","https://openalex.org/W1991259883","https://openalex.org/W2004891612","https://openalex.org/W2006810934","https://openalex.org/W2009994985","https://openalex.org/W2012611138","https://openalex.org/W2014838762","https://openalex.org/W2016165386","https://openalex.org/W2017720371","https://openalex.org/W2021539113","https://openalex.org/W2031297077","https://openalex.org/W2032074949","https://openalex.org/W2032496897","https://openalex.org/W2033083557","https://openalex.org/W2035290900","https://openalex.org/W2040921647","https://openalex.org/W2041468629","https://openalex.org/W2048013519","https://openalex.org/W2050379440","https://openalex.org/W2050987476","https://openalex.org/W2053032921","https://openalex.org/W2053518444","https://openalex.org/W2060417225","https://openalex.org/W2063512646","https://openalex.org/W2063931232","https://openalex.org/W2067885236","https://openalex.org/W2076111881","https://openalex.org/W2076264447","https://openalex.org/W2078023230","https://openalex.org/W2079376474","https://openalex.org/W2080273948","https://openalex.org/W2080602309","https://openalex.org/W2081344393","https://openalex.org/W2082526015","https://openalex.org/W2084122261","https://openalex.org/W2086293577","https://openalex.org/W2086570092","https://openalex.org/W2087365471","https://openalex.org/W2090400615","https://openalex.org/W2091071931","https://openalex.org/W2092055002","https://openalex.org/W2093350131","https://openalex.org/W2093780636","https://openalex.org/W2097201383","https://openalex.org/W2098560585","https://openalex.org/W2099449322","https://openalex.org/W2105321740","https://openalex.org/W2108883303","https://openalex.org/W2109539597","https://openalex.org/W2118524399","https://openalex.org/W2120633194","https://openalex.org/W2125612058","https://openalex.org/W2132426756","https://openalex.org/W2136929871","https://openalex.org/W2140542285","https://openalex.org/W2143884467","https://openalex.org/W2145205607","https://openalex.org/W2146231370","https://openalex.org/W2149323841","https://openalex.org/W2165671852","https://openalex.org/W2166990077","https://openalex.org/W2181283187","https://openalex.org/W2207230085","https://openalex.org/W2285340499","https://openalex.org/W2325297384","https://openalex.org/W2330432591","https://openalex.org/W2334462662","https://openalex.org/W2497822529","https://openalex.org/W2542373082","https://openalex.org/W2568628529","https://openalex.org/W2578562868","https://openalex.org/W2609151904","https://openalex.org/W2794593274","https://openalex.org/W2810988926","https://openalex.org/W2864786814","https://openalex.org/W2887992554","https://openalex.org/W2888879984","https://openalex.org/W2896077572","https://openalex.org/W2900615567","https://openalex.org/W2904256112","https://openalex.org/W2918848243","https://openalex.org/W2980042023","https://openalex.org/W3047351991","https://openalex.org/W3097797170"],"related_works":["https://openalex.org/W2062520099","https://openalex.org/W2305275648","https://openalex.org/W2734331726","https://openalex.org/W6926980357","https://openalex.org/W2330432591","https://openalex.org/W7118417663","https://openalex.org/W2963748208","https://openalex.org/W33245009","https://openalex.org/W2281299734","https://openalex.org/W2099449322"],"abstract_inverted_index":{"Cancer":[0],"therapy":[1],"remains":[2],"challenging":[3],"due":[4],"to":[5,26,32,51,58,138,173],"the":[6,10,13,43,78,96,102,106,110,114,122,132,155,159],"myriad":[7],"presentations":[8],"of":[9,17,75,92,101,158,178,184,186],"disease":[11],"and":[12,22,36,63,65,98,134,148,161,170],"vast":[14],"genetic":[15],"diversity":[16],"tumors":[18],"that":[19],"continuously":[20],"evolve":[21],"often":[23],"become":[24],"resistant":[25],"therapy.":[27,115],"Viruses":[28],"can":[29,45,68],"be":[30,46,69],"engineered":[31],"specifically":[33],"infect,":[34],"replicate,":[35],"kill":[37],"tumor":[38,97,107,162],"cells":[39],"(tumor":[40],"virotherapy).":[41],"Moreover,":[42],"viruses":[44,57],"\"armed\"":[47],"with":[48],"therapeutic":[49],"genes":[50],"enhance":[52],"their":[53],"oncolytic":[54,103,187],"effect.":[55],"Using":[56],"treat":[59],"cancer":[60,85],"is":[61,80,125],"exciting":[62],"novel":[64],"in":[66,182],"principle":[67],"used":[70],"for":[71,154],"a":[72],"broad":[73],"variety":[74],"tumors.":[76],"However,":[77],"approach":[79],"distinctly":[81],"different":[82],"from":[83],"other":[84,135],"therapies":[86],"since":[87],"success":[88],"depends":[89],"on":[90],"establishment":[91],"an":[93],"infection":[94],"within":[95,105],"ongoing":[99],"propagation":[100],"virus":[104,139,160],"itself.":[108],"Therefore,":[109],"target":[111],"itself":[112],"amplifies":[113],"This":[116],"introduces":[117],"complex":[118],"dynamics":[119,143,181],"especially":[120],"when":[121],"immune":[123],"system":[124],"taken":[126],"into":[127],"consideration":[128],"as":[129,131],"well":[130],"physical":[133],"biological":[136],"barriers":[137],"growth.":[140],"Understanding":[141],"these":[142,180],"not":[144],"only":[145],"requires":[146],"mathematical":[147],"computational":[149],"models":[150],"but":[151],"also":[152],"approaches":[153],"noninvasive":[156],"monitoring":[157],"populations.":[163],"In":[164],"this":[165,175],"perspective,":[166],"we":[167],"discuss":[168],"strategies":[169],"current":[171],"results":[172],"achieve":[174],"important":[176],"goal":[177],"understanding":[179],"pursuit":[183],"optimization":[185],"virotherapy.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-07-05T00:00:00"}