{"id":"https://openalex.org/W3173721769","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1151.4","title":"Epoxyeicosatrienoic acid\u2010dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation","display_name":"Epoxyeicosatrienoic acid\u2010dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W3173721769","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1151.4","mag":"3173721769"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.1151.4","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1151.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1151.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008999166","display_name":"xiaoguang liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"xiaoguang liu","raw_affiliation_strings":["Anesthesiology, The Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, The Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066735935","display_name":"Sung Hee Hwang","orcid":"https://orcid.org/0000-0002-9891-928X","observed_orcids":["https://orcid.org/0000-0002-9891-928X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung Hee Hwang","raw_affiliation_strings":["Department of Entomolgy, University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomolgy, University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul D Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D Jones","raw_affiliation_strings":["Department of Entomolgy, University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomolgy, University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026538320","display_name":"Bruce D. Hammock","orcid":"https://orcid.org/0000-0003-1408-8317","observed_orcids":["https://orcid.org/0000-0003-1408-8317","https://orcid.org/0000-0003-4277-4736"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D Hammock","raw_affiliation_strings":["Department of Entomolgy, University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomolgy, University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103375495","display_name":"Richard J. Roman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J Roman","raw_affiliation_strings":["Department of Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112119004","display_name":"David Rae Harder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R Harder","raw_affiliation_strings":["Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006130007","display_name":"Raymond C. Koehler","orcid":"https://orcid.org/0000-0002-5890-9992","observed_orcids":["https://orcid.org/0000-0002-5890-9992"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond C Koehler","raw_affiliation_strings":["Anesthesiology, The Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, The Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3964687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epoxyeicosatrienoic-acids","display_name":"epoxyeicosatrienoic acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cerebral-vasodilation","display_name":"cerebral vasodilation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9779999852180481},{"id":"https://openalex.org/keywords/neurovascular-coupling","display_name":"neurovascular coupling","score":0.949999988079071},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.906000018119812},{"id":"https://openalex.org/keywords/soluble-epoxide-hydrolase","display_name":"soluble epoxide hydrolase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/t-aucb","display_name":"t-AUCB","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mpep","display_name":"MPEP","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ly367385","display_name":"LY367385","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dhpg","display_name":"DHPG","score":0.8740000128746033},{"id":"https://openalex.org/keywords/20-hydroxyeicosatetraenoic-acid","display_name":"20-hydroxyeicosatetraenoic acid","score":0.7170000076293945},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.5860000252723694},{"id":"https://openalex.org/keywords/heme-oxygenase","display_name":"heme oxygenase","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.7796188592910767},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6949831247329712},{"id":"https://openalex.org/C18605011","wikidata":"https://www.wikidata.org/wiki/Q17916975","display_name":"Epoxide hydrolase 2","level":3,"score":0.6514837145805359},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.623748242855072},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5489330291748047},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5484524369239807},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5184494853019714},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5020337104797363},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.4427701532840729},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4287432134151459},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3403753638267517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27054929733276367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24133798480033875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22422277927398682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21276888251304626},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05592167377471924}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.1151.4","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1151.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1151.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000339258","display_name":null,"funder_award_id":"HL59996","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2162251525","https://openalex.org/W2161631313","https://openalex.org/W2061055107","https://openalex.org/W2118092118","https://openalex.org/W2156365091","https://openalex.org/W2224404009","https://openalex.org/W2042618355","https://openalex.org/W2287266105","https://openalex.org/W2056724427","https://openalex.org/W2105019965"],"abstract_inverted_index":{"Activation":[0],"of":[1,53,56,80,100,136,154,161],"metabotropic":[2],"glutamate":[3],"receptors":[4],"(mGluRs)":[5],"on":[6],"astrocytes":[7],"participates":[8],"in":[9,18,42],"neurovascular":[10],"coupling.":[11],"Epoxyeicosatrienoic":[12],"acids":[13],"(EETs)":[14],"may":[15],"be":[16],"involved":[17],"downstream":[19],"signaling.":[20],"3,5\u2010Dihydroxyphenylglycine":[21],"(DHPG)":[22],"was":[23,66,76,94,128,157],"used":[24],"as":[25],"a":[26,178],"type":[27,187],"I":[28,188],"mGluR":[29,70,189],"agonist":[30],"for":[31],"pharmacological":[32],"activation.":[33,202],"Cerebral":[34],"blood":[35],"flow":[36],"(CBF),":[37],"measured":[38],"by":[39,47,68,78,97,116,126,134,159,186,204],"laser\u2010Doppler":[40],"flowmetry":[41],"isoflurane":[43],"anesthetized":[44],"rats,":[45],"increased":[46],"30\u00b17%":[48,131],"(\u00b1SD)":[49],"at":[50,151],"20":[51],"min":[52,153],"subarachnoid":[54],"superfusion":[55,99,135],"DHPG":[57,93,127,146],"(1":[58],"mM)":[59],"over":[60],"the":[61,69,89,101,107,137,142,162,182,197],"cortical":[62],"surface.":[63],"The":[64,121],"increase":[65,124],"blocked":[67],"antagonists":[71],"MPEP":[72],"and":[73,167,191],"LY367385":[74],"but":[75,156],"unaffected":[77],"inhibitors":[79,164],"NO":[81],"synthase,":[82],"heme":[83],"oxygenase,":[84],"or":[85,106],"20\u2010HETE":[86],"synthesis.":[87],"However,":[88],"CBF":[90,123,143,198],"response":[91,144,199],"to":[92,132,145,149,181],"markedly":[95],"reduced":[96],"prior":[98],"EET":[102,108],"antagonist":[103],"14,15\u2010EEZE":[104],"(5\u00b111%)":[105],"synthesis":[109],"inhibitor":[110,139],"MS\u2010PPOH":[111],"(8\u00b17%).":[112],"EETs":[113,176,194],"are":[114,177],"metabolized":[115],"soluble":[117],"epoxide":[118],"hydrolase":[119],"(sEH).":[120],"maximal":[122],"induced":[125],"augmented":[129],"from":[130],"43\u00b16%":[133],"sEH":[138,163],"t\u2010AUCB.":[140],"Furthermore,":[141],"alone":[147],"subsided":[148],"12\u00b112%":[150],"60":[152],"superfusion,":[155],"sustained":[158],"co\u2010superfusion":[160],"t\u2010AUCB":[165],"(34\u00b114%)":[166],"MPTPU":[168],"(21":[169],"\u00b1":[170],"5%).":[171],"These":[172],"results":[173],"demonstrate":[174],"that":[175,192],"major":[179],"contributor":[180],"cerebral":[183],"vasodilation":[184],"evoked":[185],"activation":[190],"inhibiting":[193],"metabolism":[195],"augments":[196],"during":[200],"prolonged":[201],"(Supported":[203],"NIH":[205],"grant":[206],"HL59996)":[207]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}