{"id":"https://openalex.org/W3173582866","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.707.2","title":"ADAM17 via F11R/JAM\u2010A Shedding Regulates Flow/Wall Shear Stress Mechanosensing in Endothelial Cells","display_name":"ADAM17 via F11R/JAM\u2010A Shedding Regulates Flow/Wall Shear Stress Mechanosensing in Endothelial Cells","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W3173582866","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.707.2","mag":"3173582866"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2018.32.1_supplement.707.2","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.707.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.707.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047405694","display_name":"Stephenie Christianson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephenie Christianson","raw_affiliation_strings":["Augusta University, Augusta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070318563","display_name":"Huijuan Dou","orcid":"https://orcid.org/0000-0001-7394-8351","observed_orcids":["https://orcid.org/0000-0001-7394-8351"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huijuan Dou","raw_affiliation_strings":["Augusta University, Augusta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025053938","display_name":"Xueyi Li","orcid":"https://orcid.org/0000-0003-2358-5171","observed_orcids":["https://orcid.org/0000-0003-2358-5171"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueyi Li","raw_affiliation_strings":["Augusta University, Augusta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075774578","display_name":"David J. Fulton","orcid":"https://orcid.org/0000-0002-1528-1517","observed_orcids":["https://orcid.org/0000-0002-1528-1517"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Fulton","raw_affiliation_strings":["Augusta University, Augusta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072429509","display_name":"Daniel Rudic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Rudic","raw_affiliation_strings":["Augusta University, Augusta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015124366","display_name":"Zsolt A Bagi","orcid":"https://orcid.org/0000-0001-8755-2980","observed_orcids":["https://orcid.org/0000-0001-8755-2980"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zsolt Bagi","raw_affiliation_strings":["Augusta University, Augusta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24153086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.23029999434947968,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":1.0},{"id":"https://openalex.org/keywords/wall-shear-stress","display_name":"wall shear stress","score":0.7379999756813049},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/arterial-remodeling","display_name":"arterial remodeling","score":0.7319999933242798},{"id":"https://openalex.org/keywords/endothelial-cell-alignment","display_name":"endothelial cell alignment","score":0.7870000004768372},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5547463297843933},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.48117169737815857},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.4635540544986725},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.42271897196769714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3400116562843323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3349621891975403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3323967456817627},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1586172878742218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13321837782859802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11249196529388428},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.08091658353805542}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2018.32.1_supplement.707.2","doi":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.707.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2018.32.1_supplement.707.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3016456138","https://openalex.org/W3209113314","https://openalex.org/W4401619383","https://openalex.org/W2113111549","https://openalex.org/W2914266533","https://openalex.org/W4411879919","https://openalex.org/W2014171174","https://openalex.org/W1171483306","https://openalex.org/W2298541720","https://openalex.org/W1989807144"],"abstract_inverted_index":{"Reduced":[0],"or":[1,143,191],"increased":[2],"blood":[3],"flow":[4,69,79,172],"induces":[5],"arterial":[6,48],"remodeling":[7],"and":[8,25,41],"is":[9,198,206],"critically":[10],"mediated":[11],"by":[12,148],"proper":[13],"endothelial":[14,34],"cell":[15,35],"(EC)":[16],"mechanosensing":[17,59,187],"of":[18,78,91,112,117,127,131,140,146,161],"flow/wall":[19],"shear":[20],"stress":[21],"(WSS).":[22],"A":[23],"disintegrin":[24],"metalloproteinase":[26],"ADAM17":[27,40,56,142,147,163,182],"sheds":[28],"F11R/JAM\u2010A,":[29,118],"an":[30],"important":[31],"tight":[32],"junction\u2010located":[33],"adhesion":[36],"molecule.":[37],"Consequently,":[38],"both":[39],"F11/JAM\u2010A":[42],"have":[43],"been":[44],"previously":[45],"implicated":[46],"in":[47,88,169,183,188,216],"remodeling.":[49],"Therefore,":[50],"we":[51],"tested":[52],"the":[53,89,92,95,101,108,125,138,162,200],"hypothesis":[54],"that":[55,65],"regulates":[57],"EC":[58,135],"via":[60],"F11R/JAM\u2010A":[61,132],"shedding.":[62],"We":[63],"found":[64],"compared":[66],"to":[67,75,81,121,154,156],"static/zero":[68],"(WSS=0":[70],"dyne/cm2),":[71],"cultured":[72],"ECs":[73,96,119,152],"exposed":[74],"increasing":[76],"levels":[77,106],"(4":[80],"8":[82,103],"dyne/cm2)":[83],"progressively":[84],"changed":[85],"their":[86],"orientation":[87],"direction":[90,126],"flow.":[93,157],"Ultimately,":[94],"reaching":[97],"maximum":[98],"alignment":[99],"at":[100],"physiologic,":[102],"dyne/cm2":[104],"WSS":[105],"during":[107],"first":[109],"72":[110],"hours":[111],"culture.":[113],"After":[114],"siRNA\u2010mediated":[115],"silencing":[116],"failed":[120,153],"efficiently":[122],"orient":[123,155],"with":[124,212],"flow,":[128],"whereas":[129],"overexpression":[130],"facilitated":[133],"enhanced":[134],"alignment.":[136],"In":[137],"presence":[139],"recombinant":[141],"through":[144],"stimulation":[145],"phorbol":[149],"myristate":[150],"acetate,":[151],"Whereas":[158],"gene":[159],"transfer":[160],"cleavage":[164],"resistant,":[165],"mutated":[166],"JAM\u2010A(V227Y)":[167],"resulted":[168],"a":[170,177],"normal":[171],"orientation.":[173],"Our":[174],"results":[175],"uncover":[176],"novel":[178],"regulatory":[179],"role":[180],"for":[181],"modulating":[184],"F11R/JAM\u2010A\u2010dependent":[185],"flow/WSS":[186],"ECs.":[189],"Support":[190],"Funding":[192],"Information":[193],"NIH\u2010NIA":[194],"R01AG054651":[195],"This":[196],"abstract":[197,214],"from":[199],"Experimental":[201],"Biology":[202],"2018":[203],"Meeting.":[204],"There":[205],"no":[207],"full":[208],"text":[209],"article":[210],"associated":[211],"this":[213],"published":[215],"The":[217],"FASEB":[218],"Journal":[219],".":[220]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}
