{"id":"https://openalex.org/W3173431978","doi":"https://doi.org/10.1016/j.cej.2021.130906","title":"A dual-drug enhanced injectable hydrogel incorporated with neural stem cells for combination therapy in spinal cord injury","display_name":"A dual-drug enhanced injectable hydrogel incorporated with neural stem cells for combination therapy in spinal cord injury","publication_year":2021,"publication_date":"2021-06-21","ids":{"openalex":"https://openalex.org/W3173431978","doi":"https://doi.org/10.1016/j.cej.2021.130906","mag":"3173431978"},"language":"en","primary_location":{"id":"doi:10.1016/j.cej.2021.130906","doi":"https://doi.org/10.1016/j.cej.2021.130906","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cej.2021.130906","pdf_url":null,"source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019294284","display_name":"Zhiping Qi","orcid":"https://orcid.org/0000-0002-2163-3259","observed_orcids":["https://orcid.org/0000-0002-2163-3259","https://orcid.org/0000-0003-4898-104X","https://orcid.org/0009-0002-4011-5841"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiping Qi","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071259267","display_name":"Tianhui Zhang","orcid":"https://orcid.org/0000-0002-5162-5751","observed_orcids":["https://orcid.org/0000-0002-5162-5751"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianhui Zhang","raw_affiliation_strings":["Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016827281","display_name":"Weijian Kong","orcid":"https://orcid.org/0000-0003-4519-1181","observed_orcids":["https://orcid.org/0000-0003-4519-1181"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijian Kong","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101420681","display_name":"Chuan Fu","orcid":"https://orcid.org/0000-0002-2015-9989","observed_orcids":["https://orcid.org/0000-0002-2015-9989"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan Fu","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051365833","display_name":"Yuxin Chang","orcid":"https://orcid.org/0000-0003-0091-8316","observed_orcids":["https://orcid.org/0000-0003-0091-8316"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Chang","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100602273","display_name":"Hongru Li","orcid":"https://orcid.org/0000-0002-5422-2341","observed_orcids":["https://orcid.org/0000-0002-5422-2341"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongru Li","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025152107","display_name":"Xiaoyu Yang","orcid":"https://orcid.org/0000-0003-2516-440X","observed_orcids":["https://orcid.org/0000-0003-2516-440X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Yang","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100718872","display_name":"Pan Su","orcid":"https://orcid.org/0000-0002-7133-1777","observed_orcids":["https://orcid.org/0000-0002-7133-1777"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Su Pan","raw_affiliation_strings":["Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China"],"raw_orcid":"https://orcid.org/0000-0002-7133-1777","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, the Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun 130041, PR China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100718872"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":3.4518,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.94317576,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"427","issue":null,"first_page":"130906","last_page":"130906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/injectable-hydrogel","display_name":"injectable hydrogel","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dual-drug-delivery","display_name":"dual drug delivery","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hydrazone-crosslinking","display_name":"hydrazone crosslinking","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glial-scar-formation","display_name":"glial scar formation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.796999990940094},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/astrocyte-differentiation","display_name":"astrocyte differentiation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7822204232215881},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.712870717048645},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6402525901794434},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6198825836181641},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.6114100217819214},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5388597249984741},{"id":"https://openalex.org/C2777642821","wikidata":"https://www.wikidata.org/wiki/Q206060","display_name":"Scars","level":2,"score":0.5110520124435425},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.49971532821655273},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.4323926866054535},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4128112196922302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38789162039756775},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.34861093759536743},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34108036756515503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33685407042503357},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2904931902885437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24128630757331848},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17448103427886963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11596706509590149},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cej.2021.130906","doi":"https://doi.org/10.1016/j.cej.2021.130906","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cej.2021.130906","pdf_url":null,"source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327282","display_name":"Department of Science and Technology of Jilin Province","ror":"https://ror.org/049x38272"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W248055171","https://openalex.org/W1963586813","https://openalex.org/W1968534089","https://openalex.org/W1980859391","https://openalex.org/W1987467507","https://openalex.org/W2003873431","https://openalex.org/W2013885571","https://openalex.org/W2015440552","https://openalex.org/W2032334748","https://openalex.org/W2046232200","https://openalex.org/W2058983924","https://openalex.org/W2060299760","https://openalex.org/W2060675402","https://openalex.org/W2060835907","https://openalex.org/W2065759033","https://openalex.org/W2068681537","https://openalex.org/W2072742911","https://openalex.org/W2080215345","https://openalex.org/W2092662468","https://openalex.org/W2098737512","https://openalex.org/W2134208433","https://openalex.org/W2171311487","https://openalex.org/W2315234938","https://openalex.org/W2412905440","https://openalex.org/W2484283047","https://openalex.org/W2589856153","https://openalex.org/W2594567835","https://openalex.org/W2767325925","https://openalex.org/W2775940086","https://openalex.org/W2802189972","https://openalex.org/W2896918073","https://openalex.org/W2900036104","https://openalex.org/W2901261626","https://openalex.org/W2901405426","https://openalex.org/W2903798075","https://openalex.org/W2910355745","https://openalex.org/W2912707231","https://openalex.org/W2914099446","https://openalex.org/W2914271953","https://openalex.org/W2920577106","https://openalex.org/W2948888731","https://openalex.org/W2948910679","https://openalex.org/W2955492612","https://openalex.org/W2958157831","https://openalex.org/W2981934625","https://openalex.org/W2982487149","https://openalex.org/W3002556442","https://openalex.org/W3006011555","https://openalex.org/W3007449185","https://openalex.org/W3023738419","https://openalex.org/W3033066339","https://openalex.org/W3043507086"],"related_works":["https://openalex.org/W4412989032","https://openalex.org/W7140204040","https://openalex.org/W4385219787","https://openalex.org/W3109718881","https://openalex.org/W4400099336","https://openalex.org/W2776639011","https://openalex.org/W3132064700","https://openalex.org/W7084180945","https://openalex.org/W4402079668","https://openalex.org/W4384627431"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2021-07-05T00:00:00"}