{"id":"https://openalex.org/W3173348828","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.10","title":"Potassium ATP channel function is altered in mesenteric arteries of old high salt fed rats","display_name":"Potassium ATP channel function is altered in mesenteric arteries of old high salt fed rats","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W3173348828","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.10","mag":"3173348828"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.25.1_supplement.860.10","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.860.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103405997","display_name":"Melissa Ann Whidden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Ann Whidden","raw_affiliation_strings":["Pharmacology and Therapeutics, University of Florida, Gainesville, FL","Veterans Affairs Medical Center, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Therapeutics, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Gainesville, FL","institution_ids":["https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008171756","display_name":"Bilgen Ba\u015fgut","orcid":"https://orcid.org/0000-0002-5883-5583","observed_orcids":["https://orcid.org/0000-0002-5883-5583"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"Bilgen Basgut","raw_affiliation_strings":["Pharmacology, Gazi University, Ankara, Turkey","Pharmacology and Therapeutics, University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, Gazi University, Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]},{"raw_affiliation_string":"Pharmacology and Therapeutics, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012789065","display_name":"Nataliya Kirichenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nataliya Kirichenko","raw_affiliation_strings":["Pharmacology and Therapeutics, University of Florida, Gainesville, FL","Veterans Affairs Medical Center, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Therapeutics, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Gainesville, FL","institution_ids":["https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054686016","display_name":"Benedek Erd\u00f6s","orcid":"https://orcid.org/0000-0002-9074-2491","observed_orcids":["https://orcid.org/0000-0002-9074-2491"]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benedek Erdos","raw_affiliation_strings":["Pharmacology and Therapeutics, University of Florida, Gainesville, FL","Veterans Affairs Medical Center, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Therapeutics, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Gainesville, FL","institution_ids":["https://openalex.org/I2799886695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040614096","display_name":"Nihal T\u00fcmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nihal Tumer","raw_affiliation_strings":["Pharmacology and Therapeutics, University of Florida, Gainesville, FL","Veterans Affairs Medical Center, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Therapeutics, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Gainesville, FL","institution_ids":["https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.32975347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"25","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.20630000531673431,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.15000000596046448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mesenteric-arteries","display_name":"mesenteric arteries","score":0.8820000290870667},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.968999981880188},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7409999966621399},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cromakalim","display_name":"cromakalim","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vascular-function","display_name":"vascular function","score":0.5929999947547913},{"id":"https://openalex.org/keywords/resistance-vessels","display_name":"resistance vessels","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2780561956","wikidata":"https://www.wikidata.org/wiki/Q3698301","display_name":"Cromakalim","level":4,"score":0.7806636095046997},{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.7124776244163513},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.6468546390533447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6118853092193604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5942592620849609},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5052364468574524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5045417547225952},{"id":"https://openalex.org/C2777032099","wikidata":"https://www.wikidata.org/wiki/Q1225425","display_name":"Dilator","level":2,"score":0.4846963882446289},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.43633002042770386},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4321989119052887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37061238288879395},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.21973490715026855},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.25.1_supplement.860.10","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.860.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.860.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1563295086","display_name":null,"funder_award_id":"T32-AG000196","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2464503525","https://openalex.org/W3132023418","https://openalex.org/W1538863270","https://openalex.org/W3125729087","https://openalex.org/W2000752990","https://openalex.org/W2293426936","https://openalex.org/W2084206518","https://openalex.org/W2606178743","https://openalex.org/W1823217228","https://openalex.org/W2058450984"],"abstract_inverted_index":{"Hypertension":[0],"is":[1,11],"a":[2,12,38,70,131,221],"risk":[3],"factor":[4,14],"for":[5,77,87],"cardiovascular":[6],"disease":[7],"and":[8,56,62,80,234,253],"dietary":[9],"salt":[10,20,40,141,162,170,182,207],"contributing":[13],"to":[15,28,99,125,135,192],"high":[16,39],"blood":[17],"pressure.":[18],"Increased":[19],"intake":[21],"in":[22,50,105,111,127,139,160,180,198,205,218,231],"the":[23,44,116,225,236,243,248],"elderly":[24],"has":[25],"been":[26],"shown":[27],"impair":[29],"relaxation":[30,92,124,191],"of":[31,46,227,238,247,250],"resistance":[32],"vessels.":[33],"Therefore,":[34],"we":[35],"examined":[36],"whether":[37],"(HS)":[41],"diet":[42,74,223],"alters":[43,224],"function":[45,226],"K":[47,117,228],"ATP":[48,118,174,229],"channels":[49,230],"mesenteric":[51],"arteries":[52,151,208],"(MAs)":[53],"from":[54],"young":[55,106,128,161],"old":[57,63,112,140,149,169,181,187,199,206],"rats.":[58],"Young":[59],"(7":[60],"mo)":[61,65],"(29":[64],"F\u2010344xBN":[66],"rats":[67],"were":[68,85],"fed":[69],"control":[71,150,188,200],"or":[72],"HS":[73,132,222],"(8%":[75],"NaCl)":[76],"12":[78],"days":[79],"2":[81],"nd":[82],"order":[83],"MAs":[84,142,163,183,233],"used":[86],"vascular":[88],"measurements.":[89],"Acetylcholine":[90],"(Ach)\u2010induced":[91],"was":[93,101,137,178,194],"significantly":[94],"reduced":[95,123,138,157,179],"with":[96,115,148,186],"age.":[97],"Relaxation":[98],"Ach":[100,126,136],"92":[102],"\u00b1":[103,109,144,153,196,203],"2%":[104],"vs.":[107,201],"81":[108],"4%":[110],"arteries.":[113,189],"Pretreatment":[114],"channel":[119,175],"blocker":[120],"glibenclamide":[121],"only":[122],"MAs.":[129,171,219],"On":[130],"diet,":[133],"dilation":[134,159,177,217],"(60":[143],"3%)":[145],"when":[146,184],"compared":[147,185],"(81":[152],"4%;":[154],"P<0.001).":[155],"Glibenclamide":[156],"Ach\u2010induced":[158],"but":[164],"had":[165],"no":[166],"effect":[167],"on":[168],"Cromakalim":[172],"(K":[173],"opener)":[176],"Maximal":[190],"cromakalim":[193],"99":[195],"1%":[197],"85":[202],"5%":[204],"(P<0.05).":[209],"These":[210],"findings":[211],"demonstrate":[212],"that":[213],"age":[214],"impairs":[215],"endothelium\u2010dependent":[216],"Furthermore,":[220],"isolated":[232],"affects":[235],"mediation":[237],"dilator":[239],"stimuli.":[240],"Supported":[241],"by":[242],"Medical":[244],"Research":[245],"Service":[246],"Department":[249],"Veterans":[251],"Affairs":[252],"NIA":[254],"T32":[255],"AG000196":[256],"award.":[257]},"counts_by_year":[{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-07-05T00:00:00"}