{"id":"https://openalex.org/W3173088652","doi":null,"title":"Spatio-temporal characterization of the insulin signaling cascade and its role in regulating hemocyte proliferation in Aedes aegypti","display_name":"Spatio-temporal characterization of the insulin signaling cascade and its role in regulating hemocyte proliferation in Aedes aegypti","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W3173088652","mag":"3173088652"},"language":"en","primary_location":{"id":"mag:3173088652","doi":null,"is_oa":false,"landing_page_url":"https://athenaeum.libs.uga.edu/handle/10724/26864","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009670946","display_name":"Julio C\u00e9sar Castillo","orcid":"https://orcid.org/0000-0002-6921-810X","observed_orcids":["https://orcid.org/0000-0002-6921-810X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julio C. Castillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009670946"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.10670000314712524,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hemocyte-proliferation","display_name":"hemocyte proliferation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mosquito-immunity","display_name":"mosquito immunity","score":0.6449999809265137},{"id":"https://openalex.org/keywords/insect-innate-immunity","display_name":"insect innate immunity","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2777775583","wikidata":"https://www.wikidata.org/wiki/Q1148004","display_name":"Aedes aegypti","level":3,"score":0.8381376266479492},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5501006841659546},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.5362652540206909},{"id":"https://openalex.org/C2779625713","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hemocyte","level":3,"score":0.42630642652511597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4181663990020752},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23701289296150208},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2355341613292694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1809464991092682},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1270783543586731},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.06248652935028076},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3173088652","doi":null,"is_oa":false,"landing_page_url":"https://athenaeum.libs.uga.edu/handle/10724/26864","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":234,"referenced_works":["https://openalex.org/W42779428","https://openalex.org/W135526051","https://openalex.org/W1496640920","https://openalex.org/W1525327620","https://openalex.org/W1531617567","https://openalex.org/W1544775656","https://openalex.org/W1552845950","https://openalex.org/W1558343075","https://openalex.org/W1563442275","https://openalex.org/W1585751449","https://openalex.org/W1588097017","https://openalex.org/W1589917428","https://openalex.org/W1592033651","https://openalex.org/W1593349681","https://openalex.org/W1604799242","https://openalex.org/W1613040252","https://openalex.org/W1623604753","https://openalex.org/W1726652071","https://openalex.org/W1756021893","https://openalex.org/W1841050729","https://openalex.org/W1860240513","https://openalex.org/W1885479805","https://openalex.org/W1891228765","https://openalex.org/W1908445283","https://openalex.org/W1929383511","https://openalex.org/W1941096184","https://openalex.org/W1951853856","https://openalex.org/W1964305196","https://openalex.org/W1964487827","https://openalex.org/W1965947775","https://openalex.org/W1967899512","https://openalex.org/W1970617993","https://openalex.org/W1971817690","https://openalex.org/W1971973346","https://openalex.org/W1973365261","https://openalex.org/W1974555367","https://openalex.org/W1974787778","https://openalex.org/W1975761082","https://openalex.org/W1976023142","https://openalex.org/W1977408796","https://openalex.org/W1977472414","https://openalex.org/W1978477793","https://openalex.org/W1978849098","https://openalex.org/W1979801144","https://openalex.org/W1982046617","https://openalex.org/W1982426628","https://openalex.org/W1984091936","https://openalex.org/W1984568624","https://openalex.org/W1984670146","https://openalex.org/W1984980675","https://openalex.org/W1985680289","https://openalex.org/W1985908187","https://openalex.org/W1986559713","https://openalex.org/W1986741070","https://openalex.org/W1987219992","https://openalex.org/W1987942547","https://openalex.org/W1988219047","https://openalex.org/W1988363362","https://openalex.org/W1989095495","https://openalex.org/W1989559087","https://openalex.org/W1989658063","https://openalex.org/W1989958367","https://openalex.org/W1990767063","https://openalex.org/W1992630084","https://openalex.org/W1993855694","https://openalex.org/W1993985790","https://openalex.org/W1993993563","https://openalex.org/W1994928799","https://openalex.org/W1999133360","https://openalex.org/W2000033844","https://openalex.org/W2001848039","https://openalex.org/W2003350388","https://openalex.org/W2003525034","https://openalex.org/W2003587139","https://openalex.org/W2004141049","https://openalex.org/W2004767178","https://openalex.org/W2006239474","https://openalex.org/W2009210584","https://openalex.org/W2009386922","https://openalex.org/W2010242933","https://openalex.org/W2011479671","https://openalex.org/W2012911113","https://openalex.org/W2013938183","https://openalex.org/W2014887370","https://openalex.org/W2015434639","https://openalex.org/W2015597206","https://openalex.org/W2017255165","https://openalex.org/W2018596210","https://openalex.org/W2022496103","https://openalex.org/W2022531349","https://openalex.org/W2023010138","https://openalex.org/W2023542511","https://openalex.org/W2024271828","https://openalex.org/W2024306318","https://openalex.org/W2025124436","https://openalex.org/W2025176542","https://openalex.org/W2030026428","https://openalex.org/W2030241143","https://openalex.org/W2032965427","https://openalex.org/W2034863408","https://openalex.org/W2035004053","https://openalex.org/W2035877971","https://openalex.org/W2036056595","https://openalex.org/W2036868716","https://openalex.org/W2036960712","https://openalex.org/W2039065218","https://openalex.org/W2040233886","https://openalex.org/W2040236732","https://openalex.org/W2042136381","https://openalex.org/W2042251243","https://openalex.org/W2044190990","https://openalex.org/W2045130546","https://openalex.org/W2046867705","https://openalex.org/W2047478958","https://openalex.org/W2048121649","https://openalex.org/W2049497114","https://openalex.org/W2051485398","https://openalex.org/W2051909115","https://openalex.org/W2052722944","https://openalex.org/W2053202060","https://openalex.org/W2053265248","https://openalex.org/W2053683231","https://openalex.org/W2054162066","https://openalex.org/W2054652369","https://openalex.org/W2056048856","https://openalex.org/W2056525941","https://openalex.org/W2057795636","https://openalex.org/W2058193823","https://openalex.org/W2058268328","https://openalex.org/W2058872832","https://openalex.org/W2059237201","https://openalex.org/W2060458730","https://openalex.org/W2061423396","https://openalex.org/W2061543317","https://openalex.org/W2061812944","https://openalex.org/W2061921421","https://openalex.org/W2062049801","https://openalex.org/W2064490629","https://openalex.org/W2065813900","https://openalex.org/W2066373732","https://openalex.org/W2067471308","https://openalex.org/W2070356850","https://openalex.org/W2070420434","https://openalex.org/W2072025294","https://openalex.org/W2072317341","https://openalex.org/W2072833007","https://openalex.org/W2073567028","https://openalex.org/W2074136185","https://openalex.org/W2074966924","https://openalex.org/W2078992006","https://openalex.org/W2079102093","https://openalex.org/W2080957219","https://openalex.org/W2081063351","https://openalex.org/W2082138353","https://openalex.org/W2082190322","https://openalex.org/W2082614900","https://openalex.org/W2083850113","https://openalex.org/W2085900248","https://openalex.org/W2086082646","https://openalex.org/W2086108259","https://openalex.org/W2089073018","https://openalex.org/W2090830587","https://openalex.org/W2091727606","https://openalex.org/W2093486263","https://openalex.org/W2094068658","https://openalex.org/W2094271152","https://openalex.org/W2094419125","https://openalex.org/W2094440417","https://openalex.org/W2095102742","https://openalex.org/W2095178432","https://openalex.org/W2097767970","https://openalex.org/W2099193967","https://openalex.org/W2100943227","https://openalex.org/W2101850049","https://openalex.org/W2102791275","https://openalex.org/W2105086994","https://openalex.org/W2107720674","https://openalex.org/W2109770878","https://openalex.org/W2112516755","https://openalex.org/W2112721417","https://openalex.org/W2114145948","https://openalex.org/W2116755433","https://openalex.org/W2118343003","https://openalex.org/W2118688616","https://openalex.org/W2122661016","https://openalex.org/W2124971965","https://openalex.org/W2125021972","https://openalex.org/W2125322494","https://openalex.org/W2125686850","https://openalex.org/W2125912444","https://openalex.org/W2127108219","https://openalex.org/W2127924248","https://openalex.org/W2128569430","https://openalex.org/W2129345640","https://openalex.org/W2131874815","https://openalex.org/W2134975446","https://openalex.org/W2138479893","https://openalex.org/W2143863443","https://openalex.org/W2143880469","https://openalex.org/W2144182273","https://openalex.org/W2147872203","https://openalex.org/W2149911137","https://openalex.org/W2152834030","https://openalex.org/W2154084546","https://openalex.org/W2155045799","https://openalex.org/W2157791218","https://openalex.org/W2158677067","https://openalex.org/W2163235988","https://openalex.org/W2166445583","https://openalex.org/W2166910159","https://openalex.org/W2167779784","https://openalex.org/W2169089697","https://openalex.org/W2169554406","https://openalex.org/W2169788635","https://openalex.org/W2172020520","https://openalex.org/W2176307941","https://openalex.org/W2176314571","https://openalex.org/W2176506025","https://openalex.org/W2180206969","https://openalex.org/W2246141651","https://openalex.org/W2258974563","https://openalex.org/W2281210756","https://openalex.org/W2315562926","https://openalex.org/W2315758382","https://openalex.org/W2327165416","https://openalex.org/W2331907770","https://openalex.org/W2335252520","https://openalex.org/W2373305755","https://openalex.org/W2472281463","https://openalex.org/W2490290053","https://openalex.org/W2496042379","https://openalex.org/W2896998205","https://openalex.org/W3190376025","https://openalex.org/W4390807730"],"related_works":["https://openalex.org/W7098306147","https://openalex.org/W3211486208","https://openalex.org/W7099854386","https://openalex.org/W2016580331","https://openalex.org/W2965953827","https://openalex.org/W162623724","https://openalex.org/W4388024664","https://openalex.org/W4210938344","https://openalex.org/W2488312848","https://openalex.org/W4366279056"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}
