{"id":"https://openalex.org/W3172452608","doi":"https://doi.org/10.1093/ndt/gfab090.0011","title":"MO449VALIDATION OF MAYO CLINIC CLASSIFICATION AS A PREDICTOR OF FUTURE RENAL FUNCTION IMPAIRMENT IN PATIENTS WITH AUTOSOMAL POLYCYSTIC KIDNEY DISEASE (ADPKD) IN A POPULATION IN THE SOUTH OF SPAIN","display_name":"MO449VALIDATION OF MAYO CLINIC CLASSIFICATION AS A PREDICTOR OF FUTURE RENAL FUNCTION IMPAIRMENT IN PATIENTS WITH AUTOSOMAL POLYCYSTIC KIDNEY DISEASE (ADPKD) IN A POPULATION IN THE SOUTH OF SPAIN","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3172452608","doi":"https://doi.org/10.1093/ndt/gfab090.0011","mag":"3172452608"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfab090.0011","doi":"https://doi.org/10.1093/ndt/gfab090.0011","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfab090.0011","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022818817","display_name":"Francisco Jos\u00e9 Borrego Utiel","orcid":"https://orcid.org/0000-0001-8861-3132","observed_orcids":["https://orcid.org/0000-0001-8861-3132"]},"institutions":[{"id":"https://openalex.org/I4210117781","display_name":"Complejo Hospitalario de Ja\u00e9n","ror":"https://ror.org/02ecxgj38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210117781"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco-Jose Borrego-Utiel","raw_affiliation_strings":["Hospital Universitario de Ja\u00e9n, UGC Nefrolog\u00eda, Ja\u00e9n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Ja\u00e9n, UGC Nefrolog\u00eda, Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I4210117781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031044214","display_name":"Rafael Jos\u00e9 Esteban de la Rosa","orcid":"https://orcid.org/0000-0002-0558-0441","observed_orcids":["https://orcid.org/0000-0002-0558-0441"]},"institutions":[{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Jose Esteban de la Rosa","raw_affiliation_strings":["Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain","institution_ids":["https://openalex.org/I4210116170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111429994","display_name":"Enoc Merino Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117781","display_name":"Complejo Hospitalario de Ja\u00e9n","ror":"https://ror.org/02ecxgj38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210117781"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enoc Merino Garcia","raw_affiliation_strings":["Hospital Universitario de Ja\u00e9n, UGC Nefrolog\u00eda, Ja\u00e9n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Ja\u00e9n, UGC Nefrolog\u00eda, Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I4210117781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091973648","display_name":"Aurora Polo-Moyano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aurora Polo Moyano","raw_affiliation_strings":["Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain","institution_ids":["https://openalex.org/I4210116170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028910695","display_name":"Clara Moriana Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117781","display_name":"Complejo Hospitalario de Ja\u00e9n","ror":"https://ror.org/02ecxgj38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210117781"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Clara Moriana Dominguez","raw_affiliation_strings":["Hospital Universitario de Ja\u00e9n, UGC Nefrolog\u00eda, Ja\u00e9n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Ja\u00e9n, UGC Nefrolog\u00eda, Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I4210117781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101714356","display_name":"Ana Isabel Morales Garc\u00eda","orcid":"https://orcid.org/0000-0003-4033-0218","observed_orcids":["https://orcid.org/0000-0003-4033-0218"]},"institutions":[{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Isabel Morales Garc\u00eda","raw_affiliation_strings":["Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain","institution_ids":["https://openalex.org/I4210116170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058192358","display_name":"Juan Antonio Bravo Soto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Antonio Bravo Soto","raw_affiliation_strings":["Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital \u201cVirgen de las Nieves\u201d. Granada, UGC Nefrolog\u00eda, Spain","institution_ids":["https://openalex.org/I4210116170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3120,"currency":"EUR","value_usd":3820},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06989129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.6679999828338623},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/renal-survival","display_name":"renal survival","score":0.4659999907016754},{"id":"https://openalex.org/keywords/prediction-model-validation","display_name":"prediction model validation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/renal-replacement-therapy","display_name":"renal replacement therapy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9349278211593628},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.8684679269790649},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.7994186878204346},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6968700885772705},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.570309579372406},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5636573433876038},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5339096188545227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5067642331123352},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.4681577682495117},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.351665198802948},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfab090.0011","doi":"https://doi.org/10.1093/ndt/gfab090.0011","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfab090.0011","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3198269792","https://openalex.org/W4397044596","https://openalex.org/W4392169651","https://openalex.org/W2398385181","https://openalex.org/W2734626065","https://openalex.org/W2101067234","https://openalex.org/W2588642318","https://openalex.org/W4214931342","https://openalex.org/W2883069461","https://openalex.org/W7139957930"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,65,94,119,126,144,159,397,405,425,431,447,473,498],"Aims":[3],"The":[4,195,316,359,375,415,434,480,513],"Mayo":[5],"Clinic":[6],"classification":[7,203,464,482],"(MCC)":[8],"is":[9,56,465,483,522],"used":[10],"in":[11,34,43,58,191,411,443,505,539],"patients":[12,78,177,198,510,540],"with":[13,71,79,81,90,95,363,383,420,454,470,511,518,541],"ADPKD":[14,60,80],"to":[15,49,200,324],"identify":[16,69],"those":[17],"who":[18],"may":[19],"experience":[20],"a":[21,160,179,466,491,500,506,525,530],"more":[22,492],"rapid":[23,493],"deterioration":[24,437,494],"of":[25,83,112,122,135,163,173,197,284,378,422,436,438,468,485,495,502,509,515,532],"glomerular":[26],"filtration":[27],"rate":[28,121,319,435],"(GFR).":[29],"It":[30],"has":[31,39],"been":[32,41],"developed":[33],"the":[35,52,107,110,113,116,120,132,141,171,201,271,279,282,285,325,364,372,379,384,398,412,439,450,455,462,476,496,519,535],"American":[36],"population":[37,61,508],"but":[38],"not":[40,275,368,408],"validated":[42],"other":[44],"populations.":[45],"Our":[46],"objective":[47],"was":[48,274,320,367,387,401,407,418,441],"analyze":[50],"whether":[51,66],"CCM":[53],"predictive":[54,133],"model":[55],"valid":[57],"an":[59],"from":[62,371],"southern":[63],"Spain":[64],"it":[67,406,528],"can":[68],"populations":[70,487],"different":[72,276,322,370,410],"renal":[73,86,192,451,503],"survival.":[74],"Method":[75],"We":[76,105,130,150],"selected":[77],"measurements":[82],"height-adjusted":[84],"total":[85],"volume":[87],"(HtTKV)":[88],"performed":[89],"CT":[91],"or":[92,188],"MR":[93],"GFR":[96,108,123,180,273,280,317,361,381,440,497,517,543],"CKD-EPI>":[97],"15":[98],"mL":[99,182,265,308,348,391],"/":[100,102,183,185,266,309,311,349,351,354,392,394],"min":[101,184,310,350,393],"1.73":[103,186,312,352,395],"m2.":[104],"estimated":[106,382],"at":[109,170,281,534,544],"end":[111,172,283],"follow-up":[114,161,286],"using":[115,137,140,145],"Iraz\u00e1bal":[117,365,520],"equation":[118,366,386,521],"deterioration,":[124],"bias":[125,377,400],"precision":[127,417,533],"were":[128,189],"calculated.":[129],"analyzed":[131],"power":[134],"BC":[136],"survival":[138,452,504],"analysis":[139,453],"Kaplan-Meier":[142],"technique":[143],"Cox":[146,456],"regression":[147,457],"models.":[148],"Results":[149],"included":[151,190],"128":[152],"patients,":[153],"aged":[154],"44":[155,305],"\u00b1":[156,165,220,224,228,232,236,247,251,255,259,263,291,295,298,302,306,330,334,338,342,346,389,403],"13":[157],"years":[158],"time":[162],"79":[164],"45":[166],"months":[167],"(median":[168],"88),":[169],"which":[174],"22":[175],"(17.2%)":[176],"had":[178],"<10":[181],"m2":[187,313,353,396],"replacement":[193],"therapy.":[194],"distribution":[196],"according":[199,323],"CM":[202],"was:":[204],"1A":[205,218,245,289,328],"4.7%,":[206],"1B":[207,222,249,293,332],"28.1%,":[208],"1C":[209,226,253,336,430],"33.6%,":[210],"1D":[211,230,257,300,340,446,472],"22.7%,":[212],"1E":[213,234,261,304,344,432,474],"10.9%.":[214],"Age":[215],"decreased":[216,287],"progressively:":[217],"58":[219],"11,":[221],"48":[223,301],"14,":[225],"46":[227],"13,":[229],"40":[231],"8,":[233],"30":[235],"7":[237],"(p":[238,268,314,356],"<0.001).":[239,269,315],"In":[240,449],"contrast,":[241],"HtTKV":[242],"increased":[243],"significantly:":[244,288],"275":[246],"52,":[248],"486":[250],"191,":[252],"887":[254],"410,":[256],"1222":[258],"510,":[260],"1324":[262],"800":[264],"m":[267],"While":[270],"initial":[272],"between":[277],"classes,":[278],"59":[290],"36,":[292],"63":[294],"29,":[296],"1C54":[297],"35,":[299],"26,":[303],"33":[307],"variation":[318],"significantly":[321,369,409],"MCC":[326,413,463,481],"classes:":[327],"1.31":[329],"6.80,":[331],"-2.48":[333],"3.12,":[335],"-4.13":[337],"4.33,":[339],"-4.70":[341],"2.66,":[343],"-6.18":[345],"3.03":[347],"year":[355],"=":[357],"0.008).":[358],"final":[360,380],"predicted":[362],"real":[373],"one.":[374],"absolute":[376],"MC":[385],"2.6":[388],"16.0":[390],"relative":[399],"38.7":[402],"110,":[404],"classes.":[414],"P10":[416],"low,":[419],"values":[421],"65.1%,":[423],"51.7%":[424],"50%":[426],"for":[427],"classes":[428,444,471],"1C,":[429,445],"respectively.":[433],"underestimated":[442],"1E.":[448],"analysis,":[458],"we":[459],"found":[460],"that":[461,488],"predictor":[467],"survival,":[469],"having":[475],"worst":[477],"prognosis.":[478],"Conclusion":[479],"capable":[484],"identifying":[486],"will":[489],"suffer":[490],"constitutes":[499],"marker":[501],"Spanish":[507],"ADPKD.":[512],"prediction":[514],"future":[516],"acceptable":[523],"as":[524],"group,":[526],"although":[527],"shows":[529],"loss":[531],"individual":[536],"level,":[537],"especially":[538],"higher":[542],"baseline.":[545]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}