{"id":"https://openalex.org/W3172365342","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1192.10","title":"NF\u2010kB dependent mechanisms of high fat mediated cardioprotection.","display_name":"NF\u2010kB dependent mechanisms of high fat mediated cardioprotection.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W3172365342","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1192.10","mag":"3172365342"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.1192.10","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1192.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1192.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037025856","display_name":"Lauren Haar","orcid":"https://orcid.org/0000-0003-3659-793X","observed_orcids":["https://orcid.org/0000-0003-3659-793X"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Haar","raw_affiliation_strings":["Systems Biology & Physiology University of Cincinnati Cincinnati OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology & Physiology University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002769070","display_name":"Xiaoping Ren","orcid":"https://orcid.org/0000-0002-5967-9885","observed_orcids":["https://orcid.org/0000-0002-5967-9885"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Ren","raw_affiliation_strings":["Pharmacology & Cell Biophysics University of Cincinnati Cincinnati OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology & Cell Biophysics University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012840153","display_name":"Nina Bertaux\u2010Skeirik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Bertaux\u2010Skeirik","raw_affiliation_strings":["Systems Biology & Physiology University of Cincinnati Cincinnati OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology & Physiology University of Cincinnati Cincinnati OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023661918","display_name":"Trisha Tee","orcid":"https://orcid.org/0009-0003-5378-2923","observed_orcids":["https://orcid.org/0009-0003-5378-2923"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha Tee","raw_affiliation_strings":["Biomedical Engineering, University of Cincinnati, cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, University of Cincinnati, cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054509601","display_name":"Michael Tranter","orcid":"https://orcid.org/0000-0002-0609-3717","observed_orcids":["https://orcid.org/0000-0002-0609-3717"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Tranter","raw_affiliation_strings":["Internal Medicine Division of Cardiovascular Diseases, University of Cininnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division of Cardiovascular Diseases, University of Cininnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108279529","display_name":"WK Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WK Jones","raw_affiliation_strings":["Pharmacology & Cell Biophysics University of Cincinnati cincinnati OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology & Cell Biophysics University of Cincinnati cincinnati OH","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8109999895095825},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.871999979019165},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8069999814033508},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.6370000243186951},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.6549999713897705},{"id":"https://openalex.org/keywords/lipid-loading","display_name":"lipid loading","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neurohormonal-response","display_name":"neurohormonal response","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cytokines-and-chemokines","display_name":"cytokines and chemokines","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.9856092929840088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7685772180557251},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7270441651344299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5887473225593567},{"id":"https://openalex.org/C2779311647","wikidata":"https://www.wikidata.org/wiki/Q17148404","display_name":"Ischemic preconditioning","level":3,"score":0.48519399762153625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4808138608932495},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.45284122228622437},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.452737957239151},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4437682628631592},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32413700222969055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18215784430503845}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.1192.10","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1192.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1192.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2520571426","https://openalex.org/W2037902235","https://openalex.org/W1596750503","https://openalex.org/W2284740945","https://openalex.org/W1641064182","https://openalex.org/W3173547437","https://openalex.org/W1535552463","https://openalex.org/W1981417357","https://openalex.org/W2153749847","https://openalex.org/W2921649351"],"abstract_inverted_index":{"Clinical":[0],"and":[1,29,39,49,124],"epidemiological":[2],"studies":[3],"show":[4,157],"that":[5,189],"increases":[6,20],"in":[7,12,165,194,212],"serum":[8],"cholesterol":[9,19],"decrease":[10],"morbidity":[11],"patients":[13],"following":[14,130],"myocardial":[15,37,45,66,213],"infarction":[16],"(MI).":[17],"Serum":[18],"as":[21,43],"a":[22,62,73,90,101,135,146,166],"result":[23],"of":[24,27,54,65,106,132,140,149,152,159,172,179,191,208,228],"dietary":[25],"intake":[26],"fat":[28,57,75,181,202,214],"is":[30,115,145,197],"known":[31],"to":[32,83,97],"increase":[33],"risk":[34],"for":[35,77,127],"primary":[36],"events":[38],"associated":[40],"co\u2010morbidies":[41],"such":[42],"diabetes,":[44],"infarction,":[46],"athlerosclerotic":[47],"legions,":[48],"some":[50],"cancers.":[51],"The":[52],"effects":[53,207],"acute":[55],"high":[56,74,180,201],"feeding":[58,123],"were":[59],"assessed":[60,176],"with":[61,169],"murine":[63],"model":[64,168],"ischemia":[67],"reperfusion":[68],"injury.":[69],"Mice":[70],"fed":[71,99],"on":[72,100,183],"diet":[76,103,162,182],"24hrs":[78],"\u2013":[79],"2":[80],"wks":[81],"prior":[82],"ischemia/reperfusion":[84],"(30":[85],"min":[86],"coronary":[87],"ligation)":[88],"exhibited":[89],"profound":[91],"cardioprotection":[92,164],"against":[93],"resulting":[94],"MI":[95],"relative":[96],"mice":[98],"control":[102],"(~70%":[104],"reduction":[105],"infarct":[107],"size":[108],"P":[109],"\u2264":[110],"0.05).":[111],"This":[112],"cardioprotective":[113],"effect":[114,178],"not":[116],"apparent":[117],"until":[118],"12\u201324":[119],"hrs":[120,129],"after":[121],"initial":[122],"also":[125],"remained":[126],"24\u201348":[128],"cessation":[131],"feeding,":[133],"indicating":[134],"delayed":[136],"or":[137],"prolonged":[138],"phase":[139],"cardioprotection.":[141,154],"NF\u2010\u03baB\u2010dependent":[142,185,192],"gene":[143],"expression":[144,190],"well\u2010established":[147],"mediator":[148],"the":[150,177,195,200,206,226],"late\u2010phase":[151],"preconditioning":[153],"Our":[155],"results":[156],"abrogation":[158],"this":[160,229],"high\u2010fat":[161],"mediated":[163],"mouse":[167],"cardiac\u2010specific":[170],"blockade":[171],"NF\u2010\u03baB.":[173],"We":[174],"then":[175],"downstream":[184],"genes.":[186],"Results":[187],"suggest":[188],"genes":[193],"myocardium":[196],"triggered":[198],"by":[199,205],"diet,":[203],"perhaps":[204],"lipid":[209],"loading,":[210],"changes":[211],"composition,":[215],"neurohormonal,":[216],"and/or":[217],"cytokine/chemokine":[218],"responses.":[219],"Studies":[220],"will":[221],"be":[222],"directed":[223],"towards":[224],"understanding":[225],"mechanism":[227],"activation.":[230]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-06-22T00:00:00"}