{"id":"https://openalex.org/W3172339860","doi":"https://doi.org/10.1136/jitc-2021-002434","title":"Immune landscape and subtypes in primary resectable oral squamous cell carcinoma: prognostic significance and predictive of therapeutic response","display_name":"Immune landscape and subtypes in primary resectable oral squamous cell carcinoma: prognostic significance and predictive of therapeutic response","publication_year":2021,"publication_date":"2021-06-01","ids":{"openalex":"https://openalex.org/W3172339860","doi":"https://doi.org/10.1136/jitc-2021-002434","mag":"3172339860","pmid":"https://pubmed.ncbi.nlm.nih.gov/34130988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8208002"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2021-002434","doi":"https://doi.org/10.1136/jitc-2021-002434","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-002434","pdf_url":"https://jitc.bmj.com/content/jitc/9/6/e002434.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3172339860"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/9/6/e002434.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071929225","display_name":"Pengfei Diao","orcid":"https://orcid.org/0000-0002-1719-0686","observed_orcids":["https://orcid.org/0000-0002-1719-0686","https://orcid.org/0009-0006-4707-7808"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Diao","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yue Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Jiang","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724922","display_name":"Yuanyuan Li","orcid":"https://orcid.org/0000-0002-1864-6542","observed_orcids":["https://orcid.org/0000-0002-1864-6542"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Li","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068785315","display_name":"Xiang Wu","orcid":"https://orcid.org/0000-0002-0229-0203","observed_orcids":["https://orcid.org/0000-0002-0229-0203"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wu","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453326","display_name":"Jin Li","orcid":"https://orcid.org/0000-0001-9666-3332","observed_orcids":["https://orcid.org/0000-0001-9666-3332"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Li","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643854","display_name":"Chen Zhou","orcid":"https://orcid.org/0000-0002-7659-8083","observed_orcids":["https://orcid.org/0000-0002-7659-8083"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Zhou","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Jiangnan University, Wuxi, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Jiangnan University, Wuxi, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089840701","display_name":"Lei Jiang","orcid":"https://orcid.org/0000-0002-1292-269X","observed_orcids":["https://orcid.org/0000-0002-1292-269X"]},"institutions":[{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Jiang","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Lianyungang No 1 People's Hospital, Lianyungang, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Lianyungang No 1 People's Hospital, Lianyungang, Jiangsu, China","institution_ids":["https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664919","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-0798-667X","observed_orcids":["https://orcid.org/0000-0003-0798-667X"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Oral Pathology, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089738433","display_name":"Enshi Yan","orcid":"https://orcid.org/0000-0002-6566-4874","observed_orcids":["https://orcid.org/0000-0002-6566-4874"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Enshi Yan","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405820","display_name":"Ping Zhang","orcid":"https://orcid.org/0000-0002-7098-9657","observed_orcids":["https://orcid.org/0000-0002-7098-9657"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Zhang","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101853400","display_name":"Xu Ding","orcid":"https://orcid.org/0000-0002-0882-8078","observed_orcids":["https://orcid.org/0000-0002-0882-8078"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Ding","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005149399","display_name":"Heming Wu","orcid":"https://orcid.org/0000-0002-1876-9585","observed_orcids":["https://orcid.org/0000-0002-1876-9585"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heming Wu","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068102177","display_name":"Hua Yuan","orcid":"https://orcid.org/0000-0002-5855-2196","observed_orcids":["https://orcid.org/0000-0002-5855-2196"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Yuan","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017788565","display_name":"Jinhai Ye","orcid":"https://orcid.org/0000-0002-3789-551X","observed_orcids":["https://orcid.org/0000-0002-3789-551X"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhai Ye","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029551575","display_name":"Xiaomeng Song","orcid":"https://orcid.org/0000-0001-7103-6359","observed_orcids":["https://orcid.org/0000-0001-7103-6359"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaomeng Song","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108664950","display_name":"Linzhong Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linzhong Wan","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045696992","display_name":"Yunong Wu","orcid":"https://orcid.org/0000-0003-3256-4890","observed_orcids":["https://orcid.org/0000-0003-3256-4890"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunong Wu","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015313963","display_name":"Hongbing Jiang","orcid":"https://orcid.org/0000-0002-3748-0381","observed_orcids":["https://orcid.org/0000-0002-3748-0381"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbing Jiang","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393640","display_name":"Yanling Wang","orcid":"https://orcid.org/0000-0001-6645-9883","observed_orcids":["https://orcid.org/0000-0001-6645-9883"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Wang","raw_affiliation_strings":["Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084753924","display_name":"Jie Cheng","orcid":"https://orcid.org/0000-0001-9068-4271","observed_orcids":["https://orcid.org/0000-0001-9068-4271","https://orcid.org/0009-0001-8310-1119"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Cheng","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0001-9068-4271","affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084753924"],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.2009,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91289704,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"e002434","last_page":"e002434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.13600000739097595,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immune-landscape","display_name":"immune landscape","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-immune-subtypes","display_name":"tumor immune subtypes","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.7570000290870667},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5130000114440918},{"id":"https://openalex.org/keywords/consensus-clustering","display_name":"consensus clustering","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.709070086479187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6873886585235596},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6018945574760437},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5748127102851868},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5674635767936707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4362748861312866},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4268103241920471},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4267835021018982},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.414450466632843},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3210042119026184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26350387930870056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16651582717895508}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/jitc-2021-002434","doi":"https://doi.org/10.1136/jitc-2021-002434","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-002434","pdf_url":"https://jitc.bmj.com/content/jitc/9/6/e002434.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmid:34130988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34130988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8208002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8208002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3c1770e7d1c247ba9368f3fdc14a2924","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c1770e7d1c247ba9368f3fdc14a2924","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2021-002434","doi":"https://doi.org/10.1136/jitc-2021-002434","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-002434","pdf_url":"https://jitc.bmj.com/content/jitc/9/6/e002434.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1201788350","display_name":null,"funder_award_id":"201887","funder_id":"https://openalex.org/F4320327518","funder_display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions"},{"id":"https://openalex.org/G3582720075","display_name":null,"funder_award_id":"QNRC2016851","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G362233092","display_name":null,"funder_award_id":"[2018] 87","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5932494324","display_name":null,"funder_award_id":"QNRC2016851","funder_id":"https://openalex.org/F4320327518","funder_display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions"},{"id":"https://openalex.org/G7374197729","display_name":null,"funder_award_id":"82072991","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3172339860.pdf","grobid_xml":"https://content.openalex.org/works/W3172339860.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1107917109","https://openalex.org/W1966107523","https://openalex.org/W1980137951","https://openalex.org/W1985987855","https://openalex.org/W1986241711","https://openalex.org/W1991365889","https://openalex.org/W2001087320","https://openalex.org/W2002157461","https://openalex.org/W2010105078","https://openalex.org/W2049491375","https://openalex.org/W2071606440","https://openalex.org/W2106728539","https://openalex.org/W2120338564","https://openalex.org/W2128490578","https://openalex.org/W2157824068","https://openalex.org/W2237325298","https://openalex.org/W2401455386","https://openalex.org/W2527179423","https://openalex.org/W2537892258","https://openalex.org/W2562440474","https://openalex.org/W2568946517","https://openalex.org/W2579941249","https://openalex.org/W2626312449","https://openalex.org/W2655262992","https://openalex.org/W2737405537","https://openalex.org/W2796207838","https://openalex.org/W2797675217","https://openalex.org/W2801219124","https://openalex.org/W2801309958","https://openalex.org/W2802206159","https://openalex.org/W2809092757","https://openalex.org/W2884728705","https://openalex.org/W2899537750","https://openalex.org/W2904028121","https://openalex.org/W2904432405","https://openalex.org/W2913045418","https://openalex.org/W2919959993","https://openalex.org/W2959455602","https://openalex.org/W2960942904","https://openalex.org/W2973887189","https://openalex.org/W2999626196","https://openalex.org/W2999754525","https://openalex.org/W3000311037","https://openalex.org/W3000339487","https://openalex.org/W3014586446","https://openalex.org/W3019768286","https://openalex.org/W3026060226","https://openalex.org/W3028510743","https://openalex.org/W3047106569","https://openalex.org/W3093866409","https://openalex.org/W3132898342"],"related_works":["https://openalex.org/W4286424177","https://openalex.org/W2959455602","https://openalex.org/W4295955468","https://openalex.org/W4412720187","https://openalex.org/W4295941984","https://openalex.org/W4283797520","https://openalex.org/W4321002316","https://openalex.org/W3092230273","https://openalex.org/W4226278245"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immune":[1,144],"landscape":[2,259],"of":[3,28,54,79,82,86,146,168,234,282,293],"cancer":[4],"has":[5],"been":[6],"increasingly":[7],"recognized":[8],"as":[9,71,189,204,206,268],"a":[10],"key":[11,280],"feature":[12],"affecting":[13],"disease":[14],"progression,":[15],"prognosis":[16],"and":[17,40,47,69,74,88,132,140,154,161,174,191,221,237,244,246,249,260,275,278,284],"therapeutic":[18,48,276],"response.":[19],"Here,":[20],"we":[21,228],"sought":[22],"to":[23,194,210,271],"comprehensively":[24],"characterize":[25],"the":[26,138],"patterns":[27],"tumor-infiltrating":[29],"immune":[30,42,120,232,258],"cells":[31],"(TIIs)":[32],"in":[33,101,129,224,262],"primary":[34],"oral":[35,288],"squamous":[36],"cell":[37],"carcinoma":[38],"(OSCC)":[39],"develop":[41],"features-derived":[43],"models":[44,116,182,216],"for":[45],"prognostication":[46],"prediction.":[49,226],"METHODS:":[50],"A":[51],"total":[52],"number":[53],"392":[55],"patients":[56,173,196],"with":[57,96,157,178,199,251],"OSCC":[58,102,147,235],"receiving":[59],"ablative":[60],"surgery":[61],"at":[62,84],"three":[63],"independent":[64,130],"centers":[65],"were":[66,91,122,148,164,187],"retrospectively":[67],"enrolled":[68],"defined":[70],"training,":[72],"testing":[73],"validation":[75],"cohorts.":[76],"Detailed":[77],"features":[78,121,160],"12":[80],"types":[81,145],"TIIs":[83,99,169,186,242,283],"center":[85],"tumor":[87,179],"invasive":[89],"margin":[90],"assessed":[92],"by":[93,106,134,151],"immunohistochemistry":[94],"coupled":[95],"digital":[97],"quantification.":[98],"abundance":[100],"was":[103],"also":[104],"estimated":[105],"bioinformatics":[107],"approaches":[108],"using":[109],"multiple":[110,218],"publicly":[111],"available":[112],"data":[113],"sets.":[114],"Prognostic":[115,181],"based":[117,183],"on":[118,184],"selected":[119,185],"trained":[123],"via":[124],"machine":[125],"learning":[126],"approach,":[127],"validated":[128],"cohorts":[131],"evaluated":[133],"time-dependent":[135],"area":[136],"under":[137],"curves":[139],"concordance":[141],"index":[142],"(C-index).":[143],"further":[149],"identified":[150,188,229],"consensus":[152],"clustering":[153],"their":[155,265],"associations":[156],"genetic,":[158],"molecular":[159,247],"patient":[162,252,273],"survival":[163,203,274],"clarified.":[165],"RESULTS:":[166],"Patterns":[167],"infiltration":[170],"varied":[171],"among":[172],"dynamically":[175],"evolved":[176],"along":[177],"progression.":[180],"efficient":[190],"sensitive":[192],"biomarkers":[193,220,270],"stratify":[195],"into":[197],"subgroups":[198],"favorable":[200],"or":[201,208,213],"inferior":[202],"well":[205],"responders":[207],"non-responders":[209],"postoperative":[211],"radiotherapy":[212],"immunotherapy.":[214],"These":[215],"outperformed":[217],"conventional":[219],"immune-related":[222],"scores":[223],"prognostic":[225],"Furthermore,":[227],"two":[230],"main":[231],"subtypes":[233,261],"(immune-hot":[236],"immune-cold)":[238],"which":[239],"harbored":[240],"characteristic":[241],"infiltrations":[243],"genomic":[245],"features,":[248],"associated":[250],"survival.":[253],"CONCLUSIONS:":[254],"Our":[255],"results":[256],"delineated":[257],"OSCC,":[263],"consolidated":[264],"clinical":[266],"values":[267],"robust":[269],"predict":[272],"benefits":[277],"reinforced":[279],"roles":[281],"tumor-immune":[285],"interactions":[286],"underlying":[287],"tumorigenesis,":[289],"ultimately":[290],"facilitating":[291],"development":[292],"tailed":[294],"immunotherapeutic":[295],"strategies.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2021-06-22T00:00:00"}