{"id":"https://openalex.org/W3172307239","doi":"https://doi.org/10.1016/j.sna.2021.112874","title":"A micromachined force sensing apparatus and method for human engineered cardiac tissue and induced pluripotent stem cell characterization","display_name":"A micromachined force sensing apparatus and method for human engineered cardiac tissue and induced pluripotent stem cell characterization","publication_year":2021,"publication_date":"2021-05-31","ids":{"openalex":"https://openalex.org/W3172307239","doi":"https://doi.org/10.1016/j.sna.2021.112874","mag":"3172307239","pmid":"https://pubmed.ncbi.nlm.nih.gov/34305317","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8294102"},"language":"en","primary_location":{"id":"doi:10.1016/j.sna.2021.112874","doi":"https://doi.org/10.1016/j.sna.2021.112874","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sna.2021.112874","pdf_url":null,"source":{"id":"https://openalex.org/S16945967","display_name":"Sensors and Actuators A Physical","issn_l":"0924-4247","issn":["0924-4247","1873-3069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors and Actuators A: Physical","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8294102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045175789","display_name":"Irene C. Turnbull","orcid":"https://orcid.org/0000-0001-9105-8926","observed_orcids":["https://orcid.org/0000-0001-9105-8926"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irene C. Turnbull","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, New York 10029","Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States"],"raw_orcid":"https://orcid.org/0000-0001-9105-8926","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, New York 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070979582","display_name":"Weibin Zhu","orcid":"https://orcid.org/0000-0003-2310-0058","observed_orcids":["https://orcid.org/0000-0003-2310-0058"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weibin Zhu","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, New York 10029","Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, New York 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082374913","display_name":"Francesca Stillitano","orcid":"https://orcid.org/0000-0003-1898-5058","observed_orcids":["https://orcid.org/0000-0003-1898-5058"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Stillitano","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, New York 10029","Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States"],"raw_orcid":"https://orcid.org/0000-0003-1898-5058","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, New York 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chen-Chi Chien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen-Chi Chien","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, New York 10029","Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, New York 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027061615","display_name":"Angelo Gaitas","orcid":"https://orcid.org/0000-0003-4428-3949","observed_orcids":["https://orcid.org/0000-0003-4428-3949"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angelo Gaitas","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, New York 10029","Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, New York 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027061615","https://openalex.org/A5045175789"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":null,"fwci":0.5216,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55247843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"331","issue":null,"first_page":"112874","last_page":"112874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.843999981880188},{"id":"https://openalex.org/keywords/engineered-heart-tissue","display_name":"engineered heart tissue","score":0.9850000143051147},{"id":"https://openalex.org/keywords/axial-force","display_name":"axial force","score":0.8600000143051147},{"id":"https://openalex.org/keywords/vertical-force","display_name":"vertical force","score":0.9710000157356262},{"id":"https://openalex.org/keywords/atomic-force-microscopy","display_name":"atomic force microscopy","score":0.824999988079071},{"id":"https://openalex.org/keywords/single-cell-force-measurement","display_name":"single-cell force measurement","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.76499342918396},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6791681051254272},{"id":"https://openalex.org/C2780021956","wikidata":"https://www.wikidata.org/wiki/Q21020749","display_name":"Cell mechanics","level":4,"score":0.5871866941452026},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.5694808959960938},{"id":"https://openalex.org/C2910577704","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac cell","level":2,"score":0.5222124457359314},{"id":"https://openalex.org/C145991859","wikidata":"https://www.wikidata.org/wiki/Q1561445","display_name":"Load cell","level":2,"score":0.4733450710773468},{"id":"https://openalex.org/C141354745","wikidata":"https://www.wikidata.org/wiki/Q17227","display_name":"Cantilever","level":2,"score":0.4519798159599304},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4382237493991852},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.41323041915893555},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4003804624080658},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3607841432094574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29076823592185974},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.20197948813438416},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1927832067012787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17918312549591064},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12816300988197327},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.10618776082992554},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07196658849716187},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.sna.2021.112874","doi":"https://doi.org/10.1016/j.sna.2021.112874","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sna.2021.112874","pdf_url":null,"source":{"id":"https://openalex.org/S16945967","display_name":"Sensors and Actuators A Physical","issn_l":"0924-4247","issn":["0924-4247","1873-3069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors and Actuators A: Physical","raw_type":"journal-article"},{"id":"pmid:34305317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34305317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors and actuators. A, Physical","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8294102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8294102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sens Actuators A Phys","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8294102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8294102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sens Actuators A Phys","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1816199939","display_name":"Replacement of Small Animal Echocardiographic Instrumentation","funder_award_id":"1s10od010417-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6495341307","display_name":"Defining the role of non-myocytes to achieve biologically relevant engineered myocardial tissues","funder_award_id":"R03HL154286","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8069838819","display_name":"Harnessing the Benefits of Adult Stem Cell Exosomes for Enhancing Cardiac Contractile Function","funder_award_id":"K01HL133424","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000857382","display_name":"Training in Cardiovascular Physiology and Pharmacology","funder_award_id":"T32HL007444","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000874252","display_name":"UCSD Future Faculty of Cardiovascular Sciences (FOCUS)","funder_award_id":"R25HL145817","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000875556","display_name":"MoTrPAC Genomics, Epigenomics and Transcriptomics Chemical Analysis Site","funder_award_id":"U24DK112331","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W339121283","https://openalex.org/W1187698967","https://openalex.org/W1695434601","https://openalex.org/W1861824397","https://openalex.org/W1977325118","https://openalex.org/W1979526581","https://openalex.org/W1987363474","https://openalex.org/W2000437757","https://openalex.org/W2012001579","https://openalex.org/W2027519251","https://openalex.org/W2028355978","https://openalex.org/W2039276611","https://openalex.org/W2042010963","https://openalex.org/W2047253804","https://openalex.org/W2061910157","https://openalex.org/W2082957963","https://openalex.org/W2086557128","https://openalex.org/W2102389881","https://openalex.org/W2109460321","https://openalex.org/W2113927644","https://openalex.org/W2117852513","https://openalex.org/W2119614155","https://openalex.org/W2120807317","https://openalex.org/W2120949673","https://openalex.org/W2143745586","https://openalex.org/W2157645703","https://openalex.org/W2161311376","https://openalex.org/W2195150715","https://openalex.org/W2200325631","https://openalex.org/W2461980944","https://openalex.org/W2480510582","https://openalex.org/W2521650734","https://openalex.org/W2531760931","https://openalex.org/W2549107523","https://openalex.org/W2594781098","https://openalex.org/W2606169960","https://openalex.org/W2774069831","https://openalex.org/W2793879355","https://openalex.org/W2844037327","https://openalex.org/W2937014246","https://openalex.org/W2975125165","https://openalex.org/W2992601846","https://openalex.org/W2998633251","https://openalex.org/W2999181584","https://openalex.org/W4240351760","https://openalex.org/W4247923396"],"related_works":["https://openalex.org/W3087637790","https://openalex.org/W4386285444","https://openalex.org/W3186062169","https://openalex.org/W2743574493","https://openalex.org/W2916906850","https://openalex.org/W2803517221","https://openalex.org/W4211045936","https://openalex.org/W1991927225","https://openalex.org/W3191122383","https://openalex.org/W3186227825"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-06-22T00:00:00"}