{"id":"https://openalex.org/W3172297672","doi":"https://doi.org/10.1021/acs.jmedchem.1c00404","title":"Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel","display_name":"Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel","publication_year":2021,"publication_date":"2021-06-07","ids":{"openalex":"https://openalex.org/W3172297672","doi":"https://doi.org/10.1021/acs.jmedchem.1c00404","mag":"3172297672","pmid":"https://pubmed.ncbi.nlm.nih.gov/34097831"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.1c00404","doi":"https://doi.org/10.1021/acs.jmedchem.1c00404","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.1c00404","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052553184","display_name":"Brian Kawahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Kawahara","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082961597","display_name":"Kym Francis Faull","orcid":"https://orcid.org/0000-0001-9391-153X","observed_orcids":["https://orcid.org/0000-0001-9391-153X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kym F. Faull","raw_affiliation_strings":["Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012881292","display_name":"Carla Janzen","orcid":"https://orcid.org/0000-0001-5010-659X","observed_orcids":["https://orcid.org/0000-0001-5010-659X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Janzen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060131715","display_name":"Pradip K. Mascharak","orcid":"https://orcid.org/0000-0002-7044-944X","observed_orcids":["https://orcid.org/0000-0002-7044-944X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pradip K. Mascharak","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States"],"raw_orcid":"https://orcid.org/0000-0002-7044-944X","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060131715"],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":5.2561,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.96422196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"64","issue":"12","first_page":"8437","last_page":"8446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":1.0},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cyp2c8","display_name":"CYP2C8","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-p450-inhibition","display_name":"cytochrome P450 inhibition","score":0.9470000267028809},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9860000014305115},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hepatic-drug-metabolism","display_name":"hepatic drug metabolism","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.8558590412139893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7987425923347473},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.727372944355011},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7025789022445679},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5143493413925171},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5056412220001221},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5020511150360107},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4634532630443573},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42208701372146606},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35856732726097107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28838491439819336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2528759837150574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10629692673683167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10225799679756165}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D065687","descriptor_name":"Cytochrome P-450 CYP2C8 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065687","descriptor_name":"Cytochrome P-450 CYP2C8 Inhibitors","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D065692","descriptor_name":"Cytochrome P-450 CYP3A Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065692","descriptor_name":"Cytochrome P-450 CYP3A Inhibitors","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D065727","descriptor_name":"Cytochrome P-450 CYP2C8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.1c00404","doi":"https://doi.org/10.1021/acs.jmedchem.1c00404","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.1c00404","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:34097831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34097831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2505105999","display_name":null,"funder_award_id":"HD087221","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4230531428","display_name":null,"funder_award_id":"CTR-19-580346","funder_id":"https://openalex.org/F4320315321","funder_display_name":"Cancer Research Coordinating Committee"},{"id":"https://openalex.org/G4408790254","display_name":"Imaging Innovations for Placental Assessment in Response to Environmental Pollution","funder_award_id":"U01HD087221","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320315321","display_name":"Cancer Research Coordinating Committee","ror":null},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W652577554","https://openalex.org/W1492178786","https://openalex.org/W1498584605","https://openalex.org/W1509451141","https://openalex.org/W1779739875","https://openalex.org/W1967500610","https://openalex.org/W1968489022","https://openalex.org/W1977686559","https://openalex.org/W1980116913","https://openalex.org/W1980446817","https://openalex.org/W1982424532","https://openalex.org/W1990665786","https://openalex.org/W2002015295","https://openalex.org/W2011191997","https://openalex.org/W2019378745","https://openalex.org/W2021158896","https://openalex.org/W2022568799","https://openalex.org/W2032803546","https://openalex.org/W2048684314","https://openalex.org/W2055437752","https://openalex.org/W2065600081","https://openalex.org/W2068789617","https://openalex.org/W2072624946","https://openalex.org/W2074449987","https://openalex.org/W2076174476","https://openalex.org/W2077522929","https://openalex.org/W2079721202","https://openalex.org/W2090092477","https://openalex.org/W2109207908","https://openalex.org/W2122788008","https://openalex.org/W2124851572","https://openalex.org/W2125356639","https://openalex.org/W2139433200","https://openalex.org/W2149743209","https://openalex.org/W2256501514","https://openalex.org/W2259214628","https://openalex.org/W2283955056","https://openalex.org/W2298433762","https://openalex.org/W2316935074","https://openalex.org/W2527122351","https://openalex.org/W2575316783","https://openalex.org/W2578500678","https://openalex.org/W2704285213","https://openalex.org/W2751351484","https://openalex.org/W2767749330","https://openalex.org/W2884740260","https://openalex.org/W2900384229","https://openalex.org/W2904709653","https://openalex.org/W2938062190","https://openalex.org/W2945448715","https://openalex.org/W2958658309","https://openalex.org/W2979976592","https://openalex.org/W2991274658","https://openalex.org/W2999383544","https://openalex.org/W3004476697","https://openalex.org/W3036296376","https://openalex.org/W4234992581","https://openalex.org/W4242887325"],"related_works":["https://openalex.org/W4367665060","https://openalex.org/W6999365317","https://openalex.org/W1980246457","https://openalex.org/W2958658309","https://openalex.org/W7153971506","https://openalex.org/W1968397332","https://openalex.org/W4309643582","https://openalex.org/W3140850162","https://openalex.org/W2035313887","https://openalex.org/W3004476697"],"abstract_inverted_index":{"Paclitaxel":[0],"(PTX)":[1],"is":[2,57],"a":[3,92,138],"first-line":[4],"treatment":[5],"in":[6,25,30,75,109,146],"breast":[7,32,110,125,147],"cancer,":[8],"though":[9,44],"resistance":[10],"develops":[11],"quickly":[12],"and":[13,19,41,64,117],"frequently.":[14],"Cytochrome":[15],"P450":[16],"enzymes":[17],"CYP3A4":[18,34,49],"CYP2C8,":[20],"which":[21],"metabolically":[22],"inactivate":[23],"PTX":[24,38,52,108,144],"hepatic":[26],"tissue,":[27],"are":[28],"overexpressed":[29],"malignant":[31],"tissues.":[33],"expression":[35],"correlates":[36],"with":[37],"therapy":[39],"failure":[40],"poor":[42],"outcomes,":[43],"no":[45],"direct":[46],"evidence":[47],"of":[48,83,101,107,115,124,131],"contributing":[50],"to":[51,59,87,103,128,142],"sensitivity":[53,123],"exists.":[54],"Because":[55],"CYP3A4/2C8":[56,84,116,132],"susceptible":[58],"carbon":[60],"monoxide":[61],"(CO)-mediated":[62],"inhibition":[63,82,114],"CO":[65,102,120,134],"(a":[66],"gaseous":[67],"signaling":[68],"molecule)":[69],"has":[70],"previously":[71],"exhibited":[72],"drug-sensitizing":[73],"effects":[74],"cancer":[76,111,126],"cells,":[77],"we":[78,96],"hypothesized":[79],"that":[80,119],"CO-mediated":[81],"could":[85,135],"lead":[86],"enhanced":[88],"drug":[89],"sensitivity.":[90],"Using":[91],"photo-activated":[93],"CO-releasing":[94],"molecule,":[95],"have":[97],"assessed":[98],"the":[99,105],"ability":[100],"alter":[104],"pharmacokinetics":[106],"cells":[112,127],"via":[113],"determined":[118],"does":[121],"enhance":[122,143],"PTX.":[129],"Inhibition":[130],"by":[133],"therefore":[136],"be":[137],"promising":[139],"therapeutic":[140],"strategy":[141],"response":[145],"cancer.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-06-22T00:00:00"}
