{"id":"https://openalex.org/W3172002147","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.00182","title":"Myofibrillar (Network) Structures in Skeletal Muscles: An Evolutionarily Conserved Adaptation?","display_name":"Myofibrillar (Network) Structures in Skeletal Muscles: An Evolutionarily Conserved Adaptation?","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3172002147","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.00182","mag":"3172002147"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2021.35.s1.00182","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.00182","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2021.35.s1.00182","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052271976","display_name":"Peter T. Ajayi","orcid":"https://orcid.org/0000-0002-2378-5758","observed_orcids":["https://orcid.org/0000-0002-2378-5758"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Ajayi","raw_affiliation_strings":["National Heart, Lung, and Blood Institute Bethesda MD","National Heart, Lung, and Blood Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute Bethesda MD","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074509121","display_name":"Brad Willingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Willingham","raw_affiliation_strings":["National Heart, Lung, and Blood Institute Bethesda MD","National Heart, Lung, and Blood Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute Bethesda MD","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082092300","display_name":"Prasanna Katti","orcid":"https://orcid.org/0000-0002-6748-3460","observed_orcids":["https://orcid.org/0000-0002-6748-3460"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasanna Katti","raw_affiliation_strings":["National Heart, Lung, and Blood Institute Bethesda MD","National Heart, Lung, and Blood Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute Bethesda MD","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086554572","display_name":"Brian C. Glancy","orcid":"https://orcid.org/0000-0002-8571-244X","observed_orcids":["https://orcid.org/0000-0002-8571-244X"]},"institutions":[{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Glancy","raw_affiliation_strings":["National Heart, Lung, and Blood Institute Bethesda MD","National Institute of Arthritis and Musculoskeletal and Skin Diseases Bethesda MD","National Heart, Lung, and Blood Institute, Bethesda, MD","National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute Bethesda MD","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases Bethesda MD","institution_ids":["https://openalex.org/I4210087962"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD","institution_ids":["https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05439576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.3375999927520752,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9240000247955322},{"id":"https://openalex.org/keywords/indirect-flight-muscle","display_name":"indirect flight muscle","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lower-limb-muscles","display_name":"lower limb muscles","score":0.9760000109672546},{"id":"https://openalex.org/keywords/evolutionary-conservation","display_name":"evolutionary conservation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.9799745678901672},{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.9267399311065674},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5659300088882446},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5614681839942932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5373600721359253},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5218350291252136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4946396052837372},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.42876961827278137},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.41843557357788086},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3774898052215576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34595349431037903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23298180103302002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2021.35.s1.00182","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.00182","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2021.35.s1.00182","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2614062063","https://openalex.org/W3105473901","https://openalex.org/W3203374696","https://openalex.org/W2077459684","https://openalex.org/W2009820992","https://openalex.org/W3011024994","https://openalex.org/W2584170589","https://openalex.org/W2070780199","https://openalex.org/W3044874310","https://openalex.org/W2157221609"],"abstract_inverted_index":{"Skeletal":[0],"muscles":[1,197,217,243,257,268,349,375],"play":[2],"a":[3,59,83,410],"central":[4],"role":[5],"in":[6,63,92,131,160,166,213,230,266,305,317,329,343,373,385,409,417],"converting":[7],"biological":[8,352,431],"fuel":[9],"to":[10,30,68,113,127,186,202,221,232,263,377,415,422],"functional":[11],"force":[12],"via":[13],"the":[14,34,37,49,146,163,167,188,246,259,277,347,401],"contraction":[15],"of":[16,36,52,58,86,180,198,238,248,274,279,281,426],"myofibrils.":[17,235],"Until":[18],"recently,":[19],"myofibrils":[20,65,189,212,275],"were":[21,143],"characterized":[22],"as":[23,82,224,291],"individual":[24],"cylindrical":[25],"structures":[26,182],"that":[27,48,211,245,367,392,404],"run":[28],"parallel":[29],"each":[31,69,222,225],"other":[32,70,223],"along":[33],"length":[35],"muscle":[38,54,89,115,134,253,428],"cell.":[39],"However,":[40],"using":[41],"nanoscale":[42],"3D":[43,178],"imaging,":[44],"our":[45,282,424],"group":[46],"demonstrated":[47],"contractile":[50],"apparatus":[51],"vertebrate":[53,93],"cells":[55],"is":[56,100,105,290,395],"comprised":[57],"unified":[60],"myofibrillar":[61,80,103,129,181,206],"matrix":[62],"which":[64],"frequently":[66],"connect":[67,220],"through":[71],"branching":[72,250,261,265,288,368,394],"and":[73,97,150,155,158,170,195,241,332,358,363,388,433],"merging":[74],"events.":[75],"While":[76],"this":[77,381],"work":[78],"established":[79],"connectivity":[81,104],"fundamental":[84],"component":[85],"all":[87],"striated":[88,133],"cell":[90,116,135],"types":[91,136],"models,":[94],"including":[95],"mice":[96],"humans,":[98],"it":[99],"unknown":[101],"whether":[102],"evolutionarily":[106,397],"conserved":[107,398],"across":[108],"invertebrate":[109],"models":[110],"commonly":[111],"used":[112],"investigate":[114],"biology.":[117],"Here,":[118],"we":[119,209,390],"use":[120],"3\u2010dimensional":[121],"focused\u2010ion":[122],"beam":[123],"electron":[124],"microscopy":[125],"(FIB\u2010SEM)":[126],"evaluate":[128],"ultrastructure":[130],"different":[132],"from":[137],"Drosophila":[138,199],"melanogaster":[139],".":[140],"All":[141],"procedures":[142],"approved":[144],"by":[145,252,350],"National":[147],"Heart,":[148],"Lung,":[149],"Blood":[151],"Institute":[152],"Animal":[153,168],"Care":[154,169],"Use":[156],"Committee":[157],"performed":[159],"accordance":[161],"with":[162,255,284],"guidelines":[164],"described":[165],"Welfare":[171],"Act":[172],"(7":[173],"USC":[174],"2142":[175],"\u00a7":[176],"13).":[177],"reconstruction":[179],"revealed":[183,244],"that,":[184],"similar":[185],"vertebrates,":[187],"within":[190,276],"direct":[191],"flight":[192,215],"(DF),":[193],"jump,":[194,240,361],"leg":[196,242,256,306,356],"link":[200],"together":[201],"form":[203,233],"highly":[204],"connected":[205,229],"networks.":[207],"Alternatively,":[208],"found":[210],"indirect":[214],"(IF)":[216],"do":[218],"not":[219],"successive":[226],"sarcomere":[227,249,289,393],"was":[228],"series":[231],"isolated":[234],"Quantitative":[236],"assessment":[237],"DF,":[239,362],"frequency":[247,382],"differs":[251],"type":[254],"exhibiting":[258],"highest":[260],"compared":[262,376],"no":[264],"IF":[267,344,364],"(see":[269],"Supporting":[270],"Figures).":[271],"The":[272],"percentage":[273],"field":[278],"view":[280],"datasets":[283],"at":[285],"least":[286],"one":[287],"follows:":[292],"94":[293],"\u00b1":[294,297,309,321,334],"4.2%":[295],"(mean":[296],"SE,":[298],"3":[299],"cells,":[300,312,324,338],"150":[301,325],"myofibrils,":[302,314,326,340],"690":[303],"sarcomeres)":[304,316,328,342],"muscles,":[307,319,331],"77":[308],"5.0%":[310],"(4":[311],"200":[313],"1461":[315],"DF":[318],"50":[320],"3.7%":[322],"(3":[323,337],"1713":[327],"jump":[330],"0":[333,335],"%":[336],"114":[339],"982":[341],"muscles.":[345,379],"Classifying":[346],"analyzed":[348],"specialized":[351],"functions":[353],"(slow":[354],"oxidative:":[355],"muscle;":[357],"fast":[359],"oxidative/glycolytic:":[360],"muscles)":[365],"suggests":[366],"events":[369],"are":[370,406],"more":[371],"frequent":[372],"slow\u2010twitch":[374],"fast\u2010twitch":[378],"Since":[380],"pattern":[383],"arises":[384],"both":[386],"vertebrates":[387],"invertebrates,":[389],"posit":[391],"an":[396],"adaptation.":[399],"Therefore,":[400],"long\u2010standing":[402],"belief":[403],"sarcomeres":[405],"only":[407],"arranged":[408],"linear":[411],"fashion":[412],"(i.e.,":[413],"end":[414,416],"series)":[418],"must":[419],"be":[420],"revisited":[421],"improve":[423],"understanding":[425],"how":[427],"architecture":[429],"impacts":[430],"processes":[432],"musculoskeletal":[434],"pathologies.":[435]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}