{"id":"https://openalex.org/W3171982987","doi":"https://doi.org/10.3389/fimmu.2021.621153","title":"Structural Comparison Between MHC Classes I and II; in Evolution, a Class-II-Like Molecule Probably Came First","display_name":"Structural Comparison Between MHC Classes I and II; in Evolution, a Class-II-Like Molecule Probably Came First","publication_year":2021,"publication_date":"2021-06-14","ids":{"openalex":"https://openalex.org/W3171982987","doi":"https://doi.org/10.3389/fimmu.2021.621153","mag":"3171982987","pmid":"https://pubmed.ncbi.nlm.nih.gov/34194421"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.621153","doi":"https://doi.org/10.3389/fimmu.2021.621153","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.621153","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.621153/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.621153/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089536393","display_name":"Yanan Wu","orcid":"https://orcid.org/0000-0001-8326-2492","observed_orcids":["https://orcid.org/0000-0001-8326-2492","https://orcid.org/0000-0003-4964-888X"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Wu","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024248567","display_name":"Nianzhi Zhang","orcid":"https://orcid.org/0000-0002-1779-8675","observed_orcids":["https://orcid.org/0000-0002-1779-8675"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nianzhi Zhang","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112070815","display_name":"Keiichiro Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichiro Hashimoto","raw_affiliation_strings":["Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035893335","display_name":"Chun Xia","orcid":"https://orcid.org/0000-0002-3444-0624","observed_orcids":["https://orcid.org/0000-0002-3444-0624"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun Xia","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030979710","display_name":"Johannes Martinus Dijkstra","orcid":"https://orcid.org/0000-0001-7097-3826","observed_orcids":["https://orcid.org/0000-0001-7097-3826"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Johannes M. Dijkstra","raw_affiliation_strings":["Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan","institution_ids":["https://openalex.org/I145673806"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030979710","https://openalex.org/A5035893335"],"corresponding_institution_ids":["https://openalex.org/I145673806","https://openalex.org/I52158045"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.618,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84154624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"621153","last_page":"621153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":1.0},{"id":"https://openalex.org/keywords/mhc-evolution","display_name":"MHC evolution","score":0.8859999775886536},{"id":"https://openalex.org/keywords/peptide-binding-groove","display_name":"peptide binding groove","score":0.7360000014305115},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/peptide-selectivity","display_name":"peptide selectivity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/vertebrate-evolution","display_name":"vertebrate evolution","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.6275041103363037},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.535865843296051},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.44235512614250183},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.42912259697914124},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.42273804545402527},{"id":"https://openalex.org/C119997001","wikidata":"https://www.wikidata.org/wiki/Q21113110","display_name":"CD74","level":5,"score":0.4204868674278259},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38538414239883423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37315768003463745},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3574354648590088},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3516545295715332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28682076930999756},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19888174533843994},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1417957842350006},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12072837352752686},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2021.621153","doi":"https://doi.org/10.3389/fimmu.2021.621153","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.621153","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.621153/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:34194421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34194421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8236899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8236899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:502bfc837c8c4edcb15790eae1f30b29","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/502bfc837c8c4edcb15790eae1f30b29","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.621153","doi":"https://doi.org/10.3389/fimmu.2021.621153","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.621153","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.621153/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5780582141","display_name":"Molecular evolution of the MHC peptide-loading system","funder_award_id":"26440201","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3171982987.pdf","grobid_xml":"https://content.openalex.org/works/W3171982987.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W1141951150","https://openalex.org/W1485946719","https://openalex.org/W1490173113","https://openalex.org/W1493378783","https://openalex.org/W1536083038","https://openalex.org/W1788981306","https://openalex.org/W1884857780","https://openalex.org/W1966932459","https://openalex.org/W1967582433","https://openalex.org/W1971141213","https://openalex.org/W1975184547","https://openalex.org/W1976976204","https://openalex.org/W1990338379","https://openalex.org/W1991111651","https://openalex.org/W1991869086","https://openalex.org/W1994022052","https://openalex.org/W1996391102","https://openalex.org/W1996689445","https://openalex.org/W1997532526","https://openalex.org/W2000853564","https://openalex.org/W2001641653","https://openalex.org/W2005863622","https://openalex.org/W2008708467","https://openalex.org/W2010867882","https://openalex.org/W2012689365","https://openalex.org/W2016779929","https://openalex.org/W2019993505","https://openalex.org/W2024875935","https://openalex.org/W2025476985","https://openalex.org/W2031951044","https://openalex.org/W2035503835","https://openalex.org/W2044342378","https://openalex.org/W2045115066","https://openalex.org/W2052221307","https://openalex.org/W2056927502","https://openalex.org/W2061041720","https://openalex.org/W2061352595","https://openalex.org/W2062169290","https://openalex.org/W2073621589","https://openalex.org/W2076887570","https://openalex.org/W2079542677","https://openalex.org/W2080956086","https://openalex.org/W2085331797","https://openalex.org/W2087526889","https://openalex.org/W2087703661","https://openalex.org/W2098186012","https://openalex.org/W2099028937","https://openalex.org/W2103472483","https://openalex.org/W2108981718","https://openalex.org/W2109243619","https://openalex.org/W2110980437","https://openalex.org/W2111441225","https://openalex.org/W2114957284","https://openalex.org/W2119963535","https://openalex.org/W2131363383","https://openalex.org/W2136004131","https://openalex.org/W2136284683","https://openalex.org/W2137447323","https://openalex.org/W2142844745","https://openalex.org/W2144275420","https://openalex.org/W2155094810","https://openalex.org/W2155356126","https://openalex.org/W2156949340","https://openalex.org/W2158238509","https://openalex.org/W2162008966","https://openalex.org/W2176480377","https://openalex.org/W2311203695","https://openalex.org/W2466210007","https://openalex.org/W2507252565","https://openalex.org/W2517460440","https://openalex.org/W2586893617","https://openalex.org/W2613569171","https://openalex.org/W2761385332","https://openalex.org/W2764000439","https://openalex.org/W2766061678","https://openalex.org/W2767178058","https://openalex.org/W2773999481","https://openalex.org/W2779969850","https://openalex.org/W2810736643","https://openalex.org/W2886127861","https://openalex.org/W2896324646","https://openalex.org/W2899357929","https://openalex.org/W2916912325","https://openalex.org/W2943622371","https://openalex.org/W2944624531","https://openalex.org/W2946222253","https://openalex.org/W2971396417","https://openalex.org/W2971989236","https://openalex.org/W2981732342","https://openalex.org/W2993549444","https://openalex.org/W3005060794","https://openalex.org/W3010945460","https://openalex.org/W3020858248","https://openalex.org/W3166002983","https://openalex.org/W4230969272","https://openalex.org/W6725963058"],"related_works":["https://openalex.org/W2979173476","https://openalex.org/W51988033","https://openalex.org/W2126139339","https://openalex.org/W1840653008","https://openalex.org/W2166093455","https://openalex.org/W1607130586","https://openalex.org/W2154173448","https://openalex.org/W1637404187","https://openalex.org/W1551579535","https://openalex.org/W1661734742"],"abstract_inverted_index":{"Structures":[0],"of":[1,52,63,80,104,128,187,210,232],"peptide-loaded":[2],"major":[3,93],"histocompatibility":[4],"complex":[5,147],"class":[6,10,84,87,261,264],"I":[7,265],"(pMHC-I)":[8],"and":[9,23,33,49,65,74,139,152,178,185,235,241],"II":[11],"(pMHC-II)":[12],"complexes":[13,19,27],"are":[14],"similar.":[15],"However,":[16],"whereas":[17],"pMHC-II":[18,50,66,90],"include":[20,28],"similar-sized":[21],"II\u03b1":[22],"II\u03b2":[24],"chains,":[25],"pMHC-I":[26,48,64,105,169,225],"a":[29,34,60,97,122,136,176,188],"heavy":[30],"chain":[31],"(HC)":[32],"single":[35],"domain":[36,198],"molecule":[37],"\u03b2":[38,153,189],"2":[39,42,154,190],"-microglobulin":[40],"(\u03b2":[41],"-m).":[43],"Recently,":[44],"we":[45],"elucidated":[46],"several":[47],"structures":[51,67,91,162],"primitive":[53],"vertebrate":[54],"species.":[55],"In":[56,227],"the":[57,76,119,195],"present":[58],"study,":[59],"comprehensive":[61],"comparison":[62,202],"helps":[68],"to":[69,86,263],"understand":[70],"pMHC":[71],"structural":[72,126],"evolution":[73,82,259],"supports":[75],"earlier":[77],"proposed\u2014though":[78],"debated\u2014direction":[79],"MHC":[81],"from":[83,248,260],"II-type":[85,262],"I.":[88],"Extant":[89],"share":[92],"functional":[94],"characteristics":[95],"with":[96,161,220],"deduced":[98],"MHC-II-type":[99],"homodimer":[100],"ancestor.":[101],"Evolutionary":[102],"establishment":[103,166],"presumably":[106,246],"involved":[107],"important":[108],"new":[109,157],"functions":[110,158],"such":[111],"as":[112],"(i)":[113],"increased":[114,141],"peptide":[115,129,142,196,211],"selectivity":[116,143],"by":[117,133,144],"binding":[118,134,197,212],"peptides":[120],"in":[121,135,167],"closed":[123],"groove":[124],"(ii),":[125],"amplification":[127],"ligand":[130],"sequence":[131,208],"differences":[132],"non-relaxed":[137],"fashion,":[138],"(iii)":[140],"syngeneic":[145],"heterotrimer":[146],"formation":[148],"between":[149,203],"peptide,":[150],"HC,":[151],"-m.":[155],"These":[156],"were":[159,239],"associated":[160],"that":[163],"since":[164],"their":[165],"early":[168],"have":[170,267],"been":[171],"very":[172],"well":[173],"conserved,":[174],"including":[175],"shifted":[177],"reorganized":[179],"P1":[180],"pocket":[181],"(aka":[182],"A":[183,201],"pocket),":[184],"insertion":[186],"-m":[191],"hydrophobic":[192],"knob":[193],"into":[194],"\u03b2-sheet":[199],"floor.":[200],"divergent":[204],"species":[205],"indicates":[206],"better":[207],"conservation":[209],"domains":[213,238],"among":[214,217],"MHC-I":[215],"than":[216],"MHC-II,":[218,250],"agreeing":[219],"more":[221],"demanding":[222],"interactions":[223],"within":[224],"complexes.":[226],"lungfishes,":[228],"genes":[229,245],"encoding":[230],"fusions":[231],"all":[233],"MHC-II\u03b1":[234],"MHC-II\u03b2":[236],"extracellular":[237],"identified,":[240],"although":[242],"these":[243],"lungfish":[244],"derived":[247],"classical":[249],"they":[251],"provide":[252],"an":[253],"alternative":[254],"mechanistic":[255],"hypothesis":[256],"for":[257],"how":[258],"may":[266],"occurred.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}