{"id":"https://openalex.org/W3171270461","doi":"https://doi.org/10.1038/s41467-021-23954-8","title":"High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity","display_name":"High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity","publication_year":2021,"publication_date":"2021-06-18","ids":{"openalex":"https://openalex.org/W3171270461","doi":"https://doi.org/10.1038/s41467-021-23954-8","mag":"3171270461","pmid":"https://pubmed.ncbi.nlm.nih.gov/34145249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8213795"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-23954-8","doi":"https://doi.org/10.1038/s41467-021-23954-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-23954-8","pdf_url":"https://www.nature.com/articles/s41467-021-23954-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-021-23954-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022288069","display_name":"Zhou Fang","orcid":"https://orcid.org/0000-0001-7692-5040","observed_orcids":["https://orcid.org/0000-0001-7692-5040"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Fang","raw_affiliation_strings":["National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032763021","display_name":"Junjian Chen","orcid":"https://orcid.org/0000-0003-2897-5777","observed_orcids":["https://orcid.org/0000-0003-2897-5777"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjian Chen","raw_affiliation_strings":["School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721633","display_name":"Ye Zhu","orcid":"https://orcid.org/0000-0002-1845-6925","observed_orcids":["https://orcid.org/0000-0002-1845-6925"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ye Zhu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101988324","display_name":"Guansong Hu","orcid":"https://orcid.org/0000-0002-6033-0744","observed_orcids":["https://orcid.org/0000-0002-6033-0744"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guansong Hu","raw_affiliation_strings":["School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039729266","display_name":"Haoqian Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoqian Xin","raw_affiliation_strings":["National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020940903","display_name":"Kunzhong Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunzhong Guo","raw_affiliation_strings":["National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101833758","display_name":"Qingtao Li","orcid":"https://orcid.org/0000-0001-7658-4370","observed_orcids":["https://orcid.org/0000-0001-7658-4370"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingtao Li","raw_affiliation_strings":["National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035421707","display_name":"Liangxu Xie","orcid":"https://orcid.org/0000-0002-0609-5333","observed_orcids":["https://orcid.org/0000-0002-0609-5333"]},"institutions":[{"id":"https://openalex.org/I4210144214","display_name":"Jiangsu University of Technology","ror":"https://ror.org/04jabhf80","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210144214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangxu Xie","raw_affiliation_strings":["Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-0609-5333","affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou, China","institution_ids":["https://openalex.org/I4210144214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403149","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0002-1880-1143","observed_orcids":["https://orcid.org/0000-0002-1880-1143"]},"institutions":[{"id":"https://openalex.org/I4210107668","display_name":"Guangzhou Regenerative Medicine and Health Guangdong Laboratory","ror":"https://ror.org/01n179w26","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210107668"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China. wanglin3@scut.edu.cn","National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China. wanglin3@scut.edu.cn","National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-1880-1143","affiliations":[{"raw_affiliation_string":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China. wanglin3@scut.edu.cn","institution_ids":["https://openalex.org/I4210107668"]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China. wanglin3@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Center for Tissue Restoration and Reconstruction, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012733242","display_name":"Xuetao Shi","orcid":"https://orcid.org/0000-0003-3896-5097","observed_orcids":["https://orcid.org/0000-0003-3896-5097"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuetao Shi","raw_affiliation_strings":["School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China. shxt@scut.edu.cn","School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China. shxt@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Biomedical Science and Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101872526","display_name":"Yingjun Wang","orcid":"https://orcid.org/0000-0001-8218-9860","observed_orcids":["https://orcid.org/0000-0001-8218-9860"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingjun Wang","raw_affiliation_strings":["School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China. imwangyj@scut.edu.cn","School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China. imwangyj@scut.edu.cn","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science & Engineering, Higher Education Mega Center, South China University of Technology, Panyu, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008423769","display_name":"Chuanbin Mao","orcid":"https://orcid.org/0000-0002-8142-3659","observed_orcids":["https://orcid.org/0000-0002-8142-3659"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Chuanbin Mao","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA. maophage@gmail.com","School of Materials Science & Engineering, Zhejiang University, Hangzhou, China. maophage@gmail.com","Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA"],"raw_orcid":"https://orcid.org/0000-0002-8142-3659","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA. maophage@gmail.com","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"School of Materials Science & Engineering, Zhejiang University, Hangzhou, China. maophage@gmail.com","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008423769","https://openalex.org/A5012733242","https://openalex.org/A5100403149","https://openalex.org/A5101872526"],"corresponding_institution_ids":["https://openalex.org/I4210107668","https://openalex.org/I76130692","https://openalex.org/I8692664","https://openalex.org/I90610280"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":5560,"currency":"USD","value_usd":5560},"fwci":2.0613,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86905898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"3757","last_page":"3757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8899999856948853},{"id":"https://openalex.org/keywords/biofunctionalized-surfaces","display_name":"biofunctionalized surfaces","score":0.8740000128746033},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.7979999780654907},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9679999947547913},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.9259999990463257},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.7820000052452087},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.925000011920929},{"id":"https://openalex.org/keywords/biomaterial-surfaces","display_name":"biomaterial surfaces","score":0.671999990940094},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.8253582119941711},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7589967846870422},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.7008143663406372},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6107906103134155},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5839331746101379},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5807772278785706},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.559594452381134},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5204855799674988},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5147235989570618},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.5138302445411682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30513328313827515},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20834624767303467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15779083967208862},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10522940754890442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08394044637680054},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-021-23954-8","doi":"https://doi.org/10.1038/s41467-021-23954-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-23954-8","pdf_url":"https://www.nature.com/articles/s41467-021-23954-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8213795","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8213795","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:34145249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34145249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23954-8","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-021-23954-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2083601208254d64a240abb7d269889c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2083601208254d64a240abb7d269889c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-23954-8","doi":"https://doi.org/10.1038/s41467-021-23954-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-23954-8","pdf_url":"https://www.nature.com/articles/s41467-021-23954-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1196002422","display_name":null,"funder_award_id":"U1801252","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3057732859","display_name":null,"funder_award_id":"2016YFA0100900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G324481502","display_name":null,"funder_award_id":"32022041","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5178878423","display_name":null,"funder_award_id":"2020YFB0204803","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6393925922","display_name":null,"funder_award_id":"201804020060","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7218269082","display_name":null,"funder_award_id":"31771027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310179","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3171270461.pdf","grobid_xml":"https://content.openalex.org/works/W3171270461.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W292766764","https://openalex.org/W1512756234","https://openalex.org/W1547994764","https://openalex.org/W1893534297","https://openalex.org/W1968280004","https://openalex.org/W1969573130","https://openalex.org/W1977544983","https://openalex.org/W1984009847","https://openalex.org/W1987568997","https://openalex.org/W1988749430","https://openalex.org/W1989734247","https://openalex.org/W1993259011","https://openalex.org/W2000728634","https://openalex.org/W2008158617","https://openalex.org/W2008242644","https://openalex.org/W2008850772","https://openalex.org/W2010927895","https://openalex.org/W2018277210","https://openalex.org/W2027515049","https://openalex.org/W2031294040","https://openalex.org/W2038360548","https://openalex.org/W2042932016","https://openalex.org/W2049192104","https://openalex.org/W2050289020","https://openalex.org/W2051418592","https://openalex.org/W2062416480","https://openalex.org/W2063819883","https://openalex.org/W2065021511","https://openalex.org/W2065797710","https://openalex.org/W2067898604","https://openalex.org/W2071006031","https://openalex.org/W2075063303","https://openalex.org/W2080677469","https://openalex.org/W2081843020","https://openalex.org/W2085689516","https://openalex.org/W2085800477","https://openalex.org/W2088259422","https://openalex.org/W2090944145","https://openalex.org/W2092723238","https://openalex.org/W2100973222","https://openalex.org/W2113744963","https://openalex.org/W2115452633","https://openalex.org/W2116790557","https://openalex.org/W2119542591","https://openalex.org/W2134453337","https://openalex.org/W2140660145","https://openalex.org/W2143723445","https://openalex.org/W2169623896","https://openalex.org/W2172302070","https://openalex.org/W2190386353","https://openalex.org/W2226383423","https://openalex.org/W2251448886","https://openalex.org/W2262718271","https://openalex.org/W2288616517","https://openalex.org/W2290020541","https://openalex.org/W2291527225","https://openalex.org/W2312246235","https://openalex.org/W2327006783","https://openalex.org/W2332803459","https://openalex.org/W2382386981","https://openalex.org/W2469001361","https://openalex.org/W2552279711","https://openalex.org/W2582834719","https://openalex.org/W2592405106","https://openalex.org/W2604677411","https://openalex.org/W2611167584","https://openalex.org/W2617108725","https://openalex.org/W2625189637","https://openalex.org/W2727810658","https://openalex.org/W2741536882","https://openalex.org/W2750112004","https://openalex.org/W2762593451","https://openalex.org/W2773321737","https://openalex.org/W2790300990","https://openalex.org/W2792560436","https://openalex.org/W2794244135","https://openalex.org/W2794376963","https://openalex.org/W2795957159","https://openalex.org/W2885320996","https://openalex.org/W2891177174","https://openalex.org/W2892621414","https://openalex.org/W2895611544","https://openalex.org/W2897364181","https://openalex.org/W2904317544","https://openalex.org/W2911675580","https://openalex.org/W2918344879","https://openalex.org/W2944085181","https://openalex.org/W2944572535","https://openalex.org/W2951028627","https://openalex.org/W2974734470","https://openalex.org/W2990298304","https://openalex.org/W3016073037","https://openalex.org/W3111406768"],"related_works":["https://openalex.org/W2071006031","https://openalex.org/W4414281045","https://openalex.org/W1973954389","https://openalex.org/W4414397773","https://openalex.org/W1838368015","https://openalex.org/W7163024516","https://openalex.org/W2054075535","https://openalex.org/W2005735793","https://openalex.org/W2932525291","https://openalex.org/W4413045340"],"abstract_inverted_index":{"Peptides":[0],"are":[1,79,96],"widely":[2],"used":[3],"for":[4,43,141],"surface":[5],"modification":[6],"to":[7,27,70,81,99,127],"develop":[8,50],"improved":[9],"implants,":[10],"such":[11,45],"as":[12,67],"cell":[13],"adhesion":[14],"RGD":[15],"peptide":[16,19,62],"and":[17,40,87,103,116,144],"antimicrobial":[18,112],"(AMP).":[20],"However,":[21],"it":[22],"is":[23],"a":[24,46,51,59,68],"daunting":[25],"challenge":[26],"identify":[28],"an":[29],"optimized":[30,82],"condition":[31],"with":[32,58,74,108],"the":[33,41,72,134],"two":[34],"peptides":[35],"showing":[36],"their":[37],"intended":[38],"activities":[39],"parameters":[42,84,90,95],"reaching":[44],"condition.":[47],"Herein,":[48],"we":[49,131],"high-throughput":[52,135],"strategy,":[53],"preparing":[54],"titanium":[55],"(Ti)":[56],"surfaces":[57,107],"gradient":[60],"in":[61,114,117],"density":[63],"by":[64],"click":[65],"reaction":[66],"platform,":[69],"screen":[71],"positions":[73,78],"desired":[75,109],"functions.":[76],"Such":[77],"corresponding":[80],"molecular":[83],"(peptide":[85],"densities/ratios)":[86],"associated":[88],"preparation":[89,145],"(reaction":[91],"times/reactant":[92],"concentrations).":[93],"These":[94],"then":[97],"extracted":[98],"prepare":[100],"nongradient":[101],"mono-":[102],"dual-peptide":[104],"functionalized":[105],"Ti":[106],"biocompatibility":[110],"or/and":[111],"activity":[113],"vitro":[115],"vivo.":[118],"We":[119],"also":[120],"demonstrate":[121],"this":[122],"strategy":[123,137],"could":[124],"be":[125],"extended":[126],"other":[128],"materials.":[129],"Here,":[130],"show":[132],"that":[133],"versatile":[136],"holds":[138],"great":[139],"promise":[140],"rational":[142],"design":[143],"of":[146],"functional":[147],"biomaterial":[148],"surfaces.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}
