{"id":"https://openalex.org/W3170638413","doi":"https://doi.org/10.1136/annrheumdis-2021-220512","title":"Comparison of two dose escalation strategies of methotrexate in active rheumatoid arthritis: a multicentre, parallel group, randomised controlled trial","display_name":"Comparison of two dose escalation strategies of methotrexate in active rheumatoid arthritis: a multicentre, parallel group, randomised controlled trial","publication_year":2021,"publication_date":"2021-06-10","ids":{"openalex":"https://openalex.org/W3170638413","doi":"https://doi.org/10.1136/annrheumdis-2021-220512","mag":"3170638413","pmid":"https://pubmed.ncbi.nlm.nih.gov/34112656"},"language":"en","primary_location":{"id":"doi:10.1136/annrheumdis-2021-220512","doi":"https://doi.org/10.1136/annrheumdis-2021-220512","is_oa":false,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2021-220512","pdf_url":null,"source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100612205","display_name":"Siddharth Jain","orcid":"https://orcid.org/0000-0003-4065-5880","observed_orcids":["https://orcid.org/0000-0003-4065-5880"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Siddharth Jain","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023276710","display_name":"Varun Dhir","orcid":"https://orcid.org/0000-0002-3626-0694","observed_orcids":["https://orcid.org/0000-0002-3626-0694"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Varun Dhir","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India varundhir@gmail.com","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India varundhir@gmail.com","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054123086","display_name":"Amita Aggarwal","orcid":"https://orcid.org/0000-0002-2187-5186","observed_orcids":["https://orcid.org/0000-0002-2187-5186"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amita Aggarwal","raw_affiliation_strings":["Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India","Department of Clinical Immunology and Rheumatology","Sanjay Gandhi Postgraduate Institute of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I161370692"]},{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology","institution_ids":[]},{"raw_affiliation_string":"Sanjay Gandhi Postgraduate Institute of Medical Sciences","institution_ids":["https://openalex.org/I161370692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061854119","display_name":"Ranjan Gupta","orcid":"https://orcid.org/0000-0003-3965-5410","observed_orcids":["https://orcid.org/0000-0003-3965-5410"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ranjan Gupta","raw_affiliation_strings":["Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India","All India Institute of Medical Sciences","Department of Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"All India Institute of Medical Sciences","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"Department of Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057363434","display_name":"Bidyalaxmi Leishangthem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bidyalaxmi Leishangthem","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031651262","display_name":"GSRSNK Naidu","orcid":"https://orcid.org/0000-0002-9727-044X","observed_orcids":["https://orcid.org/0000-0002-9727-044X"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shankar Naidu","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113665530","display_name":"Aastha Khullar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aastha Khullar","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Supriya Maurya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Supriya Maurya","raw_affiliation_strings":["Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India","Department of Clinical Immunology and Rheumatology","Sanjay Gandhi Postgraduate Institute of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I161370692"]},{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology","institution_ids":[]},{"raw_affiliation_string":"Sanjay Gandhi Postgraduate Institute of Medical Sciences","institution_ids":["https://openalex.org/I161370692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076070097","display_name":"Veena Dhawan","orcid":"https://orcid.org/0000-0001-9464-1033","observed_orcids":["https://orcid.org/0000-0001-9464-1033","https://orcid.org/0000-0003-4265-9068"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Veena Dhawan","raw_affiliation_strings":["Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Department of Experimental Medicine and Biotechnology","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Department of Experimental Medicine and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034387013","display_name":"Shefali Sharma","orcid":"https://orcid.org/0000-0002-8821-6652","observed_orcids":["https://orcid.org/0000-0002-8821-6652"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shefali Khanna Sharma","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071896405","display_name":"Aman Sharma","orcid":"https://orcid.org/0000-0003-0813-1243","observed_orcids":["https://orcid.org/0000-0003-0813-1243"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aman Sharma","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081621315","display_name":"Sanjay Jain","orcid":"https://orcid.org/0000-0002-0141-7655","observed_orcids":["https://orcid.org/0000-0002-0141-7655"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjay Jain","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","Post Graduate Institute of Medical Education and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Post Graduate Institute of Medical Education and Research","institution_ids":["https://openalex.org/I45294948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023276710"],"corresponding_institution_ids":["https://openalex.org/I45294948"],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":1.2967,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7777275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"80","issue":"11","first_page":"1376","last_page":"1384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oral-methotrexate","display_name":"oral methotrexate","score":0.7860000133514404},{"id":"https://openalex.org/keywords/das28-crp","display_name":"DAS28-CRP","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cytopenia","display_name":"cytopenia","score":0.6000000238418579},{"id":"https://openalex.org/keywords/elevated-liver-enzymes","display_name":"elevated liver enzymes","score":0.7509999871253967},{"id":"https://openalex.org/keywords/health-assessment-questionnaire","display_name":"Health Assessment Questionnaire","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9709880948066711},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8677526712417603},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7501450777053833},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4983060359954834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4795915186405182},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.42930343747138977},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4001352787017822}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011099","descriptor_name":"Polyglutamic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011099","descriptor_name":"Polyglutamic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1136/annrheumdis-2021-220512","doi":"https://doi.org/10.1136/annrheumdis-2021-220512","is_oa":false,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2021-220512","pdf_url":null,"source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},{"id":"pmid:34112656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34112656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the rheumatic diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312298","display_name":"Indian Rheumatology Association","ror":"https://ror.org/006evjj22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1573288623","https://openalex.org/W1588877163","https://openalex.org/W1594638363","https://openalex.org/W1606725998","https://openalex.org/W2036156337","https://openalex.org/W2066441931","https://openalex.org/W2072500831","https://openalex.org/W2083614315","https://openalex.org/W2104669609","https://openalex.org/W2104729127","https://openalex.org/W2109237866","https://openalex.org/W2117738981","https://openalex.org/W2142004396","https://openalex.org/W2146502982","https://openalex.org/W2155692225","https://openalex.org/W2577302416","https://openalex.org/W2643731286","https://openalex.org/W2810052876","https://openalex.org/W2920605646","https://openalex.org/W2939582487","https://openalex.org/W2999836852","https://openalex.org/W3106080603","https://openalex.org/W3110423360","https://openalex.org/W4231972505","https://openalex.org/W4308769923","https://openalex.org/W6635135829","https://openalex.org/W6786987718"],"related_works":["https://openalex.org/W3164007077","https://openalex.org/W2010707109","https://openalex.org/W2754608770","https://openalex.org/W7143311256","https://openalex.org/W2066441931","https://openalex.org/W4392470627","https://openalex.org/W1995672164","https://openalex.org/W2750437158","https://openalex.org/W2121311666","https://openalex.org/W2755996102"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}