{"id":"https://openalex.org/W3170469149","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1121.8","title":"Low\u2010dose cadmium (Cd) exposure up\u2010regulates glutathione (GSH) synthesis in cultured choroid plexus","display_name":"Low\u2010dose cadmium (Cd) exposure up\u2010regulates glutathione (GSH) synthesis in cultured choroid plexus","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W3170469149","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1121.8","mag":"3170469149"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.1121.8","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1121.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1121.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073906106","display_name":"Alice R. A. Villalobos","orcid":"https://orcid.org/0000-0001-5811-9547","observed_orcids":["https://orcid.org/0000-0001-5811-9547"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Villalobos","raw_affiliation_strings":["Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021117306","display_name":"Robin K Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Young","raw_affiliation_strings":["Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000076581","display_name":"Samantha D. Francis Stuart","orcid":"https://orcid.org/0000-0002-7462-8912","observed_orcids":["https://orcid.org/0000-0002-7462-8912"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Francis Stuart","raw_affiliation_strings":["Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.2444,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66333626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.8159999847412109},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8539999723434448},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9829999804496765},{"id":"https://openalex.org/keywords/metallothionein-1","display_name":"metallothionein-1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gamma-glutamylcysteine-synthetase","display_name":"gamma-glutamylcysteine synthetase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/choline-uptake","display_name":"choline uptake","score":0.7639999985694885},{"id":"https://openalex.org/keywords/buthionine-sulfoximine","display_name":"buthionine sulfoximine","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2779881523","wikidata":"https://www.wikidata.org/wiki/Q18026129","display_name":"GCLC","level":4,"score":0.9616171717643738},{"id":"https://openalex.org/C2781173740","wikidata":"https://www.wikidata.org/wiki/Q18026132","display_name":"GCLM","level":5,"score":0.9576100707054138},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.9032849669456482},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6062990427017212},{"id":"https://openalex.org/C2777476445","wikidata":"https://www.wikidata.org/wiki/Q5002519","display_name":"Buthionine sulfoximine","level":4,"score":0.5957693457603455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5507534146308899},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5135736465454102},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.4992372989654541},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.4625716805458069},{"id":"https://openalex.org/C2779179908","wikidata":"https://www.wikidata.org/wiki/Q3324838","display_name":"Glutathione disulfide","level":4,"score":0.42889833450317383},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4260629713535309},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4121250510215759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3087916374206543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22660207748413086},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13920095562934875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.1121.8","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1121.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1121.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3195656272","https://openalex.org/W1602004016","https://openalex.org/W2058589841","https://openalex.org/W7005208688","https://openalex.org/W2016157964","https://openalex.org/W2023007235","https://openalex.org/W1972631875","https://openalex.org/W2409746420","https://openalex.org/W2266714057","https://openalex.org/W2033775260"],"abstract_inverted_index":{"Having":[0],"shown":[1],"in":[2,27,101,176,196,225],"primary":[3,35],"cultures":[4,36],"of":[5,25,94,155,183,191],"rat":[6],"choroid":[7],"plexus":[8,34],"that":[9],"Cd":[10,31,157,205],"induced":[11,62,76,85,123],"oxidative":[12],"stress":[13],"and":[14,51,59,72,80,91,125,134,162,171,188,194,213,221],"stimulated":[15],"apical":[16],"choline":[17,192,226],"uptake,":[18,193],"we":[19],"aim":[20],"to":[21,30,42,141,204],"elucidate":[22],"the":[23,98,119,201],"role":[24],"GSH":[26,102,133,159,168,207,216],"cellular":[28],"adaptation":[29],"exposure.":[32],"Choroid":[33],"were":[37,61,74,105,122],"exposed":[38],"for":[39],"12":[40,65,88,128],"h":[41],"0":[43,142],"or":[44,143],"500":[45],"nM":[46,145],"CdCl":[47,146],"2":[48,147],".":[49],"Immunoblot":[50],"qRT\u2010PCR":[52],"analyses":[53],"indicated":[54],"heme":[55],"oxygenase\u20101":[56],"(HO\u20101)":[57],"gene":[58,71],"protein":[60,68,73,108],"50\u2010fold":[63,86],"at":[64,77,87,110,116,127,211],"h.":[66,89,129],"Heat\u2010shock":[67],"70":[69],"(HSP70)":[70],"maximally":[75],"6":[78,111],"h,":[79,112],"metallothionein\u20101":[81],"(MT\u20101)":[82],"mRNA":[83],"was":[84],"Catalytic":[90],"modifier":[92],"subunits":[93],"glutamate\u2010cysteine":[95],"ligase":[96],"(GCL),":[97],"rate\u2010limiting":[99],"enzyme":[100],"synthesis,":[103],"also":[104,131],"induced.":[106],"GCLC":[107,187],"peaked":[109,115],"while":[113],"GCLM":[114],"9":[117],"h;":[118],"respective":[120],"genes":[121],"5\u2010fold":[124],"4\u2010fold":[126],"We":[130],"assayed":[132],"oxidized":[135],"glutathione":[136],"(GSSG)":[137],"after":[138],"12\u2010h":[139],"exposure":[140,206],"250":[144],"100":[148],"\u03bcM":[149],"buthionine":[150],"sulfoximine":[151],"(BSO),":[152],"an":[153],"inhibitor":[154],"GCL.":[156],"increased":[158],"by":[160,164,169],"2\u2010fold":[161],"GSSG":[163],"30\u2010fold.":[165],"BSO":[166,180],"reduced":[167],"92%":[170],"further":[172],"decreased":[173],"GSH:GSSG":[174],"ratios":[175],"Cd\u2010treated":[177,197],"cells.":[178,198],"Furthermore,":[179],"enhanced":[181],"induction":[182],"HO\u20101,":[184],"HSP70,":[185],"MT\u20101,":[186],"GCLM,":[189],"stimulation":[190],"cytotoxicity":[195],"Thus,":[199],"as":[200],"epithelium":[202],"adapts":[203],"synthesis":[208],"is":[209],"up\u2010regulated":[210],"transcriptional":[212],"translational":[214],"levels.":[215],"may":[217],"facilitate":[218],"cell":[219],"survival":[220],"temper":[222],"stress\u2010induced":[223],"changes":[224],"transport.":[227]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2021-06-22T00:00:00"}