{"id":"https://openalex.org/W3170157724","doi":"https://doi.org/10.1016/j.toxlet.2021.05.012","title":"The inhibition of NF\u043aB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity","display_name":"The inhibition of NF\u043aB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity","publication_year":2021,"publication_date":"2021-06-02","ids":{"openalex":"https://openalex.org/W3170157724","doi":"https://doi.org/10.1016/j.toxlet.2021.05.012","mag":"3170157724","pmid":"https://pubmed.ncbi.nlm.nih.gov/34089816"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxlet.2021.05.012","doi":"https://doi.org/10.1016/j.toxlet.2021.05.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2021.05.012","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103978719","display_name":"Asrin Ahmadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["CN","IR"],"is_corresponding":false,"raw_author_name":"Asrin Ahmadi","raw_affiliation_strings":["College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I119868032","https://openalex.org/I194604659"]},{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","institution_ids":["https://openalex.org/I119868032"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]},{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052115831","display_name":"Hossein Niknahad","orcid":"https://orcid.org/0000-0001-6211-5936","observed_orcids":["https://orcid.org/0000-0001-6211-5936"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Niknahad","raw_affiliation_strings":["Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]},{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034535851","display_name":"Huifeng Li","orcid":"https://orcid.org/0000-0002-0257-3967","observed_orcids":["https://orcid.org/0000-0002-0257-3967"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifeng Li","raw_affiliation_strings":["College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013076020","display_name":"Ali Mobasheri","orcid":"https://orcid.org/0000-0001-6261-1286","observed_orcids":["https://orcid.org/0000-0001-6261-1286"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210102467","display_name":"State Research Institute Centre for Innovative Medicine","ror":"https://ror.org/00zqn6a72","country_code":"LT","type":"facility","lineage":["https://openalex.org/I4210102467"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["CN","FI","LT","NL"],"is_corresponding":false,"raw_author_name":"Ali Mobasheri","raw_affiliation_strings":["Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014, Oulu, Finland; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406, Vilnius, Lithuania; Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 508 GA, Utrecht, The Netherlands; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China","Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China","Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406, Vilnius, Lithuania","Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 508 GA, Utrecht, The Netherlands","Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014, Oulu, Finland; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406, Vilnius, Lithuania; Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 508 GA, Utrecht, The Netherlands; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210102467","https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406, Vilnius, Lithuania","institution_ids":["https://openalex.org/I4210102467"]},{"raw_affiliation_string":"Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 508 GA, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031753368","display_name":"Ram Kumar Manthari","orcid":"https://orcid.org/0000-0002-1294-9788","observed_orcids":["https://orcid.org/0000-0002-1294-9788"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ram Kumar Manthari","raw_affiliation_strings":["Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management, Visakhapatnam, 530045, Andhra Pradesh, India"],"raw_orcid":"https://orcid.org/0000-0002-1294-9788","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management, Visakhapatnam, 530045, Andhra Pradesh, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064585849","display_name":"Negar Azarpira","orcid":"https://orcid.org/0000-0002-5549-0057","observed_orcids":["https://orcid.org/0000-0002-5549-0057","https://orcid.org/0000-0002-1518-1583"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Negar Azarpira","raw_affiliation_strings":["Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016920531","display_name":"Khadijeh Mousavi","orcid":"https://orcid.org/0000-0003-3372-2862","observed_orcids":["https://orcid.org/0000-0003-3372-2862"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["CN","IR"],"is_corresponding":false,"raw_author_name":"Khadijeh Mousavi","raw_affiliation_strings":["College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I119868032","https://openalex.org/I194604659"]},{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","institution_ids":["https://openalex.org/I119868032"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]},{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113932819","display_name":"Bahman Khalvati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128112","display_name":"Yasuj University of Medical Sciences","ror":"https://ror.org/037s33w94","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210128112"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bahman Khalvati","raw_affiliation_strings":["Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran"],"raw_orcid":"https://orcid.org/0000-0001-7550-9002","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran","institution_ids":["https://openalex.org/I4210128112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016270639","display_name":"Yangfei Zhao","orcid":"https://orcid.org/0000-0002-8375-5091","observed_orcids":["https://orcid.org/0000-0002-8375-5091"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangfei Zhao","raw_affiliation_strings":["Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine, Shanxi Agricultural University, Taiyuan, 030031, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine, Shanxi Agricultural University, Taiyuan, 030031, Shanxi, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101344199","display_name":"Jianyu Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyu Sun","raw_affiliation_strings":["College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050903121","display_name":"Yuqi Zong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Zong","raw_affiliation_strings":["College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084018887","display_name":"Mohammad Mehdi Ommati","orcid":"https://orcid.org/0000-0003-0514-2414","observed_orcids":["https://orcid.org/0000-0003-0514-2414"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["CN","IR"],"is_corresponding":true,"raw_author_name":"Mohammad Mehdi Ommati","raw_affiliation_strings":["College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mehdi_ommati@sums.ac.ir","College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":"https://orcid.org/0000-0003-0514-2414","affiliations":[{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mehdi_ommati@sums.ac.ir","institution_ids":["https://openalex.org/I119868032","https://openalex.org/I194604659"]},{"raw_affiliation_string":"College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China","institution_ids":["https://openalex.org/I119868032"]},{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091300576","display_name":"Reza Heidari","orcid":"https://orcid.org/0000-0002-7038-9838","observed_orcids":["https://orcid.org/0000-0002-7038-9838","https://orcid.org/0000-0003-0926-0004","https://orcid.org/0000-0001-8507-1905"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Reza Heidari","raw_affiliation_strings":["Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: rheidari@sums.ac.ir","Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":"https://orcid.org/0000-0002-7038-9838","affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: rheidari@sums.ac.ir","institution_ids":["https://openalex.org/I194604659"]},{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5084018887","https://openalex.org/A5091300576"],"corresponding_institution_ids":["https://openalex.org/I119868032","https://openalex.org/I194604659"],"apc_list":{"value":3420,"currency":"USD","value_usd":3420},"apc_paid":null,"fwci":6.6403,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.98564069,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"349","issue":null,"first_page":"12","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.1784999966621399,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bile-acid-toxicity","display_name":"bile acid toxicity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.656000018119812},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nf-kappab-inhibitors","display_name":"NF-\u03baB inhibitors","score":0.5230000019073486},{"id":"https://openalex.org/keywords/cholestatic-liver-injury","display_name":"cholestatic liver injury","score":0.7580000162124634},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.800000011920929},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.9161672592163086},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6714408993721008},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6627887487411499},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.6599763631820679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6255486607551575},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4912087321281433},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.4901357591152191},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4525423049926758},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4364651143550873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3747377395629883},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3611994981765747},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35257917642593384}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003135","descriptor_name":"Common Bile Duct","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxlet.2021.05.012","doi":"https://doi.org/10.1016/j.toxlet.2021.05.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2021.05.012","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},{"id":"pmid:34089816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34089816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322545","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692"},{"id":"https://openalex.org/F4320328120","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W143899296","https://openalex.org/W1489240209","https://openalex.org/W1584309458","https://openalex.org/W1811633950","https://openalex.org/W1964257182","https://openalex.org/W1965224247","https://openalex.org/W1969891196","https://openalex.org/W1975286853","https://openalex.org/W1976772672","https://openalex.org/W1976777085","https://openalex.org/W1979425960","https://openalex.org/W1981781254","https://openalex.org/W1983475981","https://openalex.org/W1993778379","https://openalex.org/W2001877887","https://openalex.org/W2006041438","https://openalex.org/W2006626994","https://openalex.org/W2011496352","https://openalex.org/W2024251369","https://openalex.org/W2025577284","https://openalex.org/W2031163855","https://openalex.org/W2031658333","https://openalex.org/W2031987646","https://openalex.org/W2038554369","https://openalex.org/W2040469451","https://openalex.org/W2050176313","https://openalex.org/W2059799265","https://openalex.org/W2065235584","https://openalex.org/W2069194720","https://openalex.org/W2074921810","https://openalex.org/W2079853302","https://openalex.org/W2085329819","https://openalex.org/W2099546329","https://openalex.org/W2111074132","https://openalex.org/W2111551037","https://openalex.org/W2117825601","https://openalex.org/W2125407940","https://openalex.org/W2125911539","https://openalex.org/W2132618157","https://openalex.org/W2134924632","https://openalex.org/W2137847782","https://openalex.org/W2140843798","https://openalex.org/W2153119343","https://openalex.org/W2159414724","https://openalex.org/W2167248390","https://openalex.org/W2177270249","https://openalex.org/W2206892810","https://openalex.org/W2316677161","https://openalex.org/W2337012617","https://openalex.org/W2534182961","https://openalex.org/W2567070990","https://openalex.org/W2593108503","https://openalex.org/W2593604375","https://openalex.org/W2613460655","https://openalex.org/W2616108314","https://openalex.org/W2735527928","https://openalex.org/W2745430660","https://openalex.org/W2772102149","https://openalex.org/W2774878064","https://openalex.org/W2781609920","https://openalex.org/W2782630985","https://openalex.org/W2808671107","https://openalex.org/W2893835498","https://openalex.org/W2898784166","https://openalex.org/W2899271615","https://openalex.org/W2911697458","https://openalex.org/W2923876478","https://openalex.org/W2941687336","https://openalex.org/W2947161907","https://openalex.org/W2950019081","https://openalex.org/W2972069433","https://openalex.org/W2978408509","https://openalex.org/W2998993773","https://openalex.org/W3026005967","https://openalex.org/W3029555135","https://openalex.org/W3032971582","https://openalex.org/W3036647320","https://openalex.org/W3043311868","https://openalex.org/W3056030447","https://openalex.org/W3105886029","https://openalex.org/W3170148256","https://openalex.org/W4236669115","https://openalex.org/W4405984134","https://openalex.org/W6809289137"],"related_works":["https://openalex.org/W2042175298","https://openalex.org/W2083701361","https://openalex.org/W3187879494","https://openalex.org/W2593108503","https://openalex.org/W1493889156","https://openalex.org/W2164110949","https://openalex.org/W2624907482","https://openalex.org/W2593604375","https://openalex.org/W1980631749","https://openalex.org/W2904955186"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-06-22T00:00:00"}