{"id":"https://openalex.org/W3170123907","doi":"https://doi.org/10.1016/j.omto.2021.05.009","title":"Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation","display_name":"Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation","publication_year":2021,"publication_date":"2021-05-29","ids":{"openalex":"https://openalex.org/W3170123907","doi":"https://doi.org/10.1016/j.omto.2021.05.009","mag":"3170123907","pmid":"https://pubmed.ncbi.nlm.nih.gov/34377767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8321894"},"language":"en","primary_location":{"id":"doi:10.1016/j.omto.2021.05.009","doi":"https://doi.org/10.1016/j.omto.2021.05.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omto.2021.05.009","pdf_url":"http://www.cell.com/article/S2372770521000759/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2372770521000759/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073397491","display_name":"Mart\u00ed Farrera-Sal","orcid":"https://orcid.org/0000-0002-8170-1276","observed_orcids":["https://orcid.org/0000-0002-8170-1276"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mart\u00ed Farrera-Sal","raw_affiliation_strings":["ProCure Program, IDIBELL-Institut Catal\u00e0 d'Oncologia, l'Hospitalet de Llobregat, Barcelona 08908, Spain","VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8170-1276","affiliations":[{"raw_affiliation_string":"ProCure Program, IDIBELL-Institut Catal\u00e0 d'Oncologia, l'Hospitalet de Llobregat, Barcelona 08908, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]},{"raw_affiliation_string":"VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070513666","display_name":"Rafael Moreno","orcid":"https://orcid.org/0000-0001-9957-3105","observed_orcids":["https://orcid.org/0000-0001-9957-3105"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Moreno","raw_affiliation_strings":["ProCure Program, IDIBELL-Institut Catal\u00e0 d'Oncologia, l'Hospitalet de Llobregat, Barcelona 08908, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProCure Program, IDIBELL-Institut Catal\u00e0 d'Oncologia, l'Hospitalet de Llobregat, Barcelona 08908, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046300715","display_name":"Ana Mato-Berciano","orcid":"https://orcid.org/0009-0005-0811-3581","observed_orcids":["https://orcid.org/0009-0005-0811-3581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Mato-Berciano","raw_affiliation_strings":["VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026232524","display_name":"Mar\u00eda Victoria Maliandi","orcid":"https://orcid.org/0000-0001-5447-2343","observed_orcids":["https://orcid.org/0000-0001-5447-2343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Victoria Maliandi","raw_affiliation_strings":["VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023223057","display_name":"Miriam Baz\u00e1n\u2010Peregrino","orcid":"https://orcid.org/0000-0001-7367-8304","observed_orcids":["https://orcid.org/0000-0001-7367-8304"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Miriam Bazan-Peregrino","raw_affiliation_strings":["VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7367-8304","affiliations":[{"raw_affiliation_string":"VCN Biosciences S.L., Sant Cugat del Vall\u00e8s, Barcelona 08174, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084444653","display_name":"Ram\u00f3n Alemany","orcid":"https://orcid.org/0000-0001-8660-550X","observed_orcids":["https://orcid.org/0000-0001-8660-550X"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ramon Alemany","raw_affiliation_strings":["ProCure Program, IDIBELL-Institut Catal\u00e0 d'Oncologia, l'Hospitalet de Llobregat, Barcelona 08908, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8660-550X","affiliations":[{"raw_affiliation_string":"ProCure Program, IDIBELL-Institut Catal\u00e0 d'Oncologia, l'Hospitalet de Llobregat, Barcelona 08908, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023223057","https://openalex.org/A5084444653"],"corresponding_institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":2.5332,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90720711,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":null,"first_page":"27","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-extracellular-matrix","display_name":"tumor extracellular matrix","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7649999856948853},{"id":"https://openalex.org/keywords/t-cell-accumulation","display_name":"T cell accumulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9524115324020386},{"id":"https://openalex.org/C2780375986","wikidata":"https://www.wikidata.org/wiki/Q904015","display_name":"Hyaluronidase","level":3,"score":0.5951092839241028},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5787690877914429},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.48823001980781555},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.42897331714630127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3550475835800171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3315281867980957},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23993027210235596},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16281166672706604},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14470863342285156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10356858372688293},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.08222422003746033}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.omto.2021.05.009","doi":"https://doi.org/10.1016/j.omto.2021.05.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omto.2021.05.009","pdf_url":"http://www.cell.com/article/S2372770521000759/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},{"id":"pmid:34377767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34377767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy oncolytics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8321894","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8321894/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Oncolytics","raw_type":"Text"},{"id":"pmh:oai:diposit.ub.edu:2445/180605","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/180605","pdf_url":"http://hdl.handle.net/2445/180605","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Institut d'lnvestigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL))","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:53162dbaea10419f849febb02f78afae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/53162dbaea10419f849febb02f78afae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 27-35 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omto.2021.05.009","doi":"https://doi.org/10.1016/j.omto.2021.05.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omto.2021.05.009","pdf_url":"http://www.cell.com/article/S2372770521000759/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1443770301","display_name":null,"funder_award_id":"2017SGR449","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G1675389915","display_name":null,"funder_award_id":"BIO2017\u201389754-C2\u20131-R","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G1737677751","display_name":null,"funder_award_id":"BIO2017\u201389754-C2\u20131-R","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G3142637025","display_name":null,"funder_award_id":"2015 DI 0070","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G4225314231","display_name":null,"funder_award_id":"BIO2017\u201389754-C2\u20131-R","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G6430230722","display_name":null,"funder_award_id":"2017SGR449","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G7770070234","display_name":null,"funder_award_id":"BIO2017\u201389754-C2\u20131-R","funder_id":"https://openalex.org/F4320326262","funder_display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a"},{"id":"https://openalex.org/G8927299908","display_name":null,"funder_award_id":"2017SGR449","funder_id":"https://openalex.org/F4320326262","funder_display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320321919","display_name":"Euskal Herriko Unibertsitatea","ror":"https://ror.org/000xsnr85"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320326262","display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","ror":"https://ror.org/03sv46s19"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3170123907.pdf","grobid_xml":"https://content.openalex.org/works/W3170123907.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1536517252","https://openalex.org/W1827720726","https://openalex.org/W1913328895","https://openalex.org/W1966397710","https://openalex.org/W2001989483","https://openalex.org/W2016847036","https://openalex.org/W2029437600","https://openalex.org/W2030605936","https://openalex.org/W2047848650","https://openalex.org/W2052617606","https://openalex.org/W2059146777","https://openalex.org/W2070927339","https://openalex.org/W2087077422","https://openalex.org/W2089764697","https://openalex.org/W2093189160","https://openalex.org/W2105865292","https://openalex.org/W2108504660","https://openalex.org/W2119208802","https://openalex.org/W2121042425","https://openalex.org/W2126002712","https://openalex.org/W2127223031","https://openalex.org/W2138023988","https://openalex.org/W2145597335","https://openalex.org/W2147112708","https://openalex.org/W2151047671","https://openalex.org/W2152617650","https://openalex.org/W2157123144","https://openalex.org/W2166373990","https://openalex.org/W2167279371","https://openalex.org/W2167864307","https://openalex.org/W2174333513","https://openalex.org/W2299651777","https://openalex.org/W2412996686","https://openalex.org/W2585478002","https://openalex.org/W2611098716","https://openalex.org/W2753160699","https://openalex.org/W2787292387","https://openalex.org/W2788644076","https://openalex.org/W2911889173","https://openalex.org/W2955974212","https://openalex.org/W2977560487","https://openalex.org/W3045329199","https://openalex.org/W4211238487"],"related_works":["https://openalex.org/W1966397710","https://openalex.org/W2147112708","https://openalex.org/W4392594417","https://openalex.org/W2905120446","https://openalex.org/W6981526996","https://openalex.org/W3171624798","https://openalex.org/W4406908816","https://openalex.org/W2166373990","https://openalex.org/W3135467267","https://openalex.org/W4415543319"],"abstract_inverted_index":{"Oncolytic":[0],"viruses":[1],"(OVs)":[2],"preferentially":[3],"infect":[4],"and":[5,26,37,63,93,120],"selectively":[6],"replicate":[7],"in":[8,15,21,66,114,134,148],"cancer":[9],"cells.":[10],"OVs":[11],"have":[12],"been":[13],"tested":[14],"clinical":[16],"trials":[17],"as":[18],"monotherapy":[19],"or":[20],"combination":[22],"with":[23,145],"chemotherapy,":[24],"radiotherapy,":[25],"immunotherapy.":[27],"However,":[28],"the":[29,34,78,99,137],"dense":[30,151],"extracellular":[31],"matrix":[32],"hampers":[33],"intratumoral":[35,61],"spreading":[36],"efficacy":[38,113],"of":[39,52,80,139],"OVs.":[40],"Previously":[41],"we":[42,70,125],"described":[43],"VCN-01,":[44],"an":[45,89,121],"oncolytic":[46,73],"adenovirus":[47],"expressing":[48,95],"a":[49,116,140],"soluble":[50],"version":[51],"human":[53],"sperm":[54],"hyaluronidase":[55],"(hyal)":[56],"PH20,":[57],"which":[58],"exhibited":[59],"enhanced":[60],"distribution":[62],"antitumor":[64,112],"activity":[65,110,129],"different":[67],"models.":[68],"Here,":[69],"present":[71],"two":[72],"adenoviruses":[74],"designed":[75],"to":[76,83,98],"increase":[77],"secretion":[79],"PH20":[81,87,96],"compared":[82],"VCN-01.":[84],"ICO15K-40SAPH20,":[85],"encoding":[86],"under":[88],"Ad40":[90],"splice":[91],"acceptor,":[92],"ICO15K-E1aPH20":[94],"fused":[97],"E1A":[100],"gene":[101],"by":[102],"P2A":[103],"peptide.":[104],"We":[105],"demonstrate":[106],"that":[107,127],"increased":[108],"hyal":[109,128],"improves":[111],"both":[115],"sensitive":[117],"immunodeficient":[118],"model":[119],"immunocompetent":[122],"model.":[123],"Moreover,":[124],"show":[126],"impacts":[130],"T":[131],"cell":[132],"accumulation":[133],"tumors,":[135],"highlighting":[136],"value":[138],"hyaluronidase-expressing":[141],"virus":[142],"for":[143],"combinations":[144],"other":[146],"immunotherapies":[147],"cancers":[149],"involving":[150],"stroma.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-06-22T00:00:00"}
