{"id":"https://openalex.org/W3169979986","doi":"https://doi.org/10.32322/jhsm.895444","title":"Histological changes in methotrexate hepatotoxicity after boron application and evaluation of serum thiol-disulfide balance","display_name":"Histological changes in methotrexate hepatotoxicity after boron application and evaluation of serum thiol-disulfide balance","publication_year":2021,"publication_date":"2021-05-21","ids":{"openalex":"https://openalex.org/W3169979986","doi":"https://doi.org/10.32322/jhsm.895444","mag":"3169979986"},"language":"en","primary_location":{"id":"doi:10.32322/jhsm.895444","doi":"https://doi.org/10.32322/jhsm.895444","is_oa":true,"landing_page_url":"https://doi.org/10.32322/jhsm.895444","pdf_url":null,"source":{"id":"https://openalex.org/S4210179195","display_name":"Journal of Health Sciences and Medicine","issn_l":"2636-8579","issn":["2636-8579"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Health Sciences and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.32322/jhsm.895444","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5127099986","display_name":"anda\u00e7 kipalev ne\u015felio\u011flu","orcid":"https://orcid.org/0000-0002-2404-9672","observed_orcids":["https://orcid.org/0000-0002-2404-9672"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]},{"id":"https://openalex.org/I4210150808","display_name":"Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University","ror":"https://ror.org/05ryemn72","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210150808"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Anda\u00e7 K\u0130PALEV NE\u015eEL\u0130O\u011eLU","raw_affiliation_strings":["ankara y\u0131ld\u0131r\u0131m beyaz\u0131t \u00fcniversitesi t\u0131p fak\u00fcltesi","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0002-2404-9672","affiliations":[{"raw_affiliation_string":"ankara y\u0131ld\u0131r\u0131m beyaz\u0131t \u00fcniversitesi t\u0131p fak\u00fcltesi","institution_ids":["https://openalex.org/I4210150808"]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027268084","display_name":"G\u00fclben Akcan","orcid":"https://orcid.org/0000-0003-3587-2725","observed_orcids":["https://orcid.org/0000-0003-3587-2725"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fclben AKCAN","raw_affiliation_strings":["FACULTY OF MEDICINE","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0003-3587-2725","affiliations":[{"raw_affiliation_string":"FACULTY OF MEDICINE","institution_ids":[]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000133763","display_name":"Hilal Nakka\u015f","orcid":"https://orcid.org/0000-0003-0901-8875","observed_orcids":["https://orcid.org/0000-0003-0901-8875"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hilal NAKKA\u015e","raw_affiliation_strings":["FACULTY OF MEDICINE","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0003-0901-8875","affiliations":[{"raw_affiliation_string":"FACULTY OF MEDICINE","institution_ids":[]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054050266","display_name":"Salim Ne\u015feli\u0307o\u011flu","orcid":"https://orcid.org/0000-0002-0974-5717","observed_orcids":["https://orcid.org/0000-0002-0974-5717"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Salim NE\u015eEL\u0130O\u011eLU","raw_affiliation_strings":["FACULTY OF MEDICINE","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0002-0974-5717","affiliations":[{"raw_affiliation_string":"FACULTY OF MEDICINE","institution_ids":[]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012778283","display_name":"\u00d6zcan Erel","orcid":"https://orcid.org/0000-0002-2996-3236","observed_orcids":["https://orcid.org/0000-0002-2996-3236"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6zcan EREL","raw_affiliation_strings":["FACULTY OF MEDICINE","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0002-2996-3236","affiliations":[{"raw_affiliation_string":"FACULTY OF MEDICINE","institution_ids":[]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027977725","display_name":"Oya Evirgen","orcid":"https://orcid.org/0000-0001-6456-1083","observed_orcids":["https://orcid.org/0000-0001-6456-1083"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Oya EV\u0130RGEN","raw_affiliation_strings":["ANKARA UNIVERSITY, FACULTY OF MEDICINE","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0001-6456-1083","affiliations":[{"raw_affiliation_string":"ANKARA UNIVERSITY, FACULTY OF MEDICINE","institution_ids":["https://openalex.org/I149218525"]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090068945","display_name":"Meltem \u00d6zg\u00fcner","orcid":"https://orcid.org/0000-0003-0364-5907","observed_orcids":["https://orcid.org/0000-0003-0364-5907"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]},{"id":"https://openalex.org/I4210150808","display_name":"Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University","ror":"https://ror.org/05ryemn72","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210150808"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Meltem \u00d6ZG\u00dcNER","raw_affiliation_strings":["ANKARA YILDIRIM BEYAZIT UNIVERSITY, FACULTY OF MEDICINE","University , of Medicine , of and , Ankara , , of , of , , , of of"],"raw_orcid":"https://orcid.org/0000-0003-0364-5907","affiliations":[{"raw_affiliation_string":"ANKARA YILDIRIM BEYAZIT UNIVERSITY, FACULTY OF MEDICINE","institution_ids":["https://openalex.org/I4210150808"]},{"raw_affiliation_string":"University , of Medicine , of and , Ankara , , of , of , , , of of","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09215596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"3","first_page":"277","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/boric-acid","display_name":"boric acid","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.781000018119812},{"id":"https://openalex.org/keywords/thiol-disulfide-balance","display_name":"thiol-disulfide balance","score":0.9300000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.984000027179718},{"id":"https://openalex.org/keywords/lipid-hydroperoxides","display_name":"lipid hydroperoxides","score":0.824999988079071},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hepatocyte-degeneration","display_name":"hepatocyte degeneration","score":0.718999981880188},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.738036036491394},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.692008376121521},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.6313117742538452},{"id":"https://openalex.org/C501308230","wikidata":"https://www.wikidata.org/wiki/Q618","display_name":"Boron","level":2,"score":0.5928397178649902},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4776122272014618},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4399407207965851},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2707701325416565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2663792371749878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2601030468940735},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08961308002471924},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.0837424099445343}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.32322/jhsm.895444","doi":"https://doi.org/10.32322/jhsm.895444","is_oa":true,"landing_page_url":"https://doi.org/10.32322/jhsm.895444","pdf_url":null,"source":{"id":"https://openalex.org/S4210179195","display_name":"Journal of Health Sciences and Medicine","issn_l":"2636-8579","issn":["2636-8579"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Health Sciences and Medicine","raw_type":"journal-article"},{"id":"pmh:b51e1c8e-61e1-4956-a365-78fad44d7784","doi":null,"is_oa":false,"landing_page_url":"https://avesis.aybu.edu.tr/publication/details/b51e1c8e-61e1-4956-a365-78fad44d7784/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055213","display_name":"AYBU AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/895444","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jhsm/issue/62390/895444","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.32322/jhsm.895444","doi":"https://doi.org/10.32322/jhsm.895444","is_oa":true,"landing_page_url":"https://doi.org/10.32322/jhsm.895444","pdf_url":null,"source":{"id":"https://openalex.org/S4210179195","display_name":"Journal of Health Sciences and Medicine","issn_l":"2636-8579","issn":["2636-8579"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Health Sciences and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1457781966","https://openalex.org/W1508021342","https://openalex.org/W1560955538","https://openalex.org/W1964219681","https://openalex.org/W1972549422","https://openalex.org/W1974008725","https://openalex.org/W1995874341","https://openalex.org/W2044004638","https://openalex.org/W2051639904","https://openalex.org/W2055292843","https://openalex.org/W2070675022","https://openalex.org/W2072831792","https://openalex.org/W2078843599","https://openalex.org/W2110141736","https://openalex.org/W2119554650","https://openalex.org/W2162700377","https://openalex.org/W2327109161","https://openalex.org/W2471191768","https://openalex.org/W2555490982","https://openalex.org/W2594620327","https://openalex.org/W2754533516","https://openalex.org/W2765915695","https://openalex.org/W2790469649","https://openalex.org/W2894827636","https://openalex.org/W2962564916","https://openalex.org/W3031626216","https://openalex.org/W3032971582","https://openalex.org/W3047942716","https://openalex.org/W3083941966","https://openalex.org/W3098376973","https://openalex.org/W3112884023"],"related_works":["https://openalex.org/W2736726977","https://openalex.org/W2046419623","https://openalex.org/W1534245930","https://openalex.org/W2767752678","https://openalex.org/W3093587595","https://openalex.org/W4296591891","https://openalex.org/W2993481317","https://openalex.org/W2107526772","https://openalex.org/W2795581452","https://openalex.org/W4408851105"],"abstract_inverted_index":{"Aim:":[0],"Methotrexate,":[1],"a":[2,7,69],"folic":[3],"acid":[4,37,83,112,148,206],"antagonist,":[5],"is":[6,29],"chemotherapeutic":[8],"drug":[9],"used":[10,67],"in":[11,63,78,87,93,106,131,213,235],"the":[12,30,33,39,76,85,91,104,132,143,156,160,177,201,210,226],"treatment":[13],"of":[14,25,32,35,43,57,134,146,162,179,204,237],"various":[15],"inflammatory":[16,129],"diseases":[17],"as":[18,20,68,167,183],"well":[19],"some":[21],"cancer":[22],"types.The":[23],"purpose":[24],"this":[26,195],"study;":[27],"It":[28,139],"study":[31],"effects":[34,42],"boric":[36,82,102,111,147,205],"against":[38],"hepatotoxic":[40],"side":[41],"methotrexate.":[44,116,138,218],"Materials":[45],"and":[46,81,100,114,128,171,188,230],"Methods:":[47],"Male":[48],"wistar":[49],"albino":[50],"rats":[51,62,77,86,92,105,135],"were":[52,66,96,109],"divided":[53],"into":[54],"five":[55],"groups":[56,157],"six":[58],"animals":[59],"each.":[60],"The":[61],"group":[64,79,88,94,107],"1":[65],"control":[70],"group.":[71],"Methotrexate":[72],"was":[73,140,149,198,207],"administered":[74,110],"to":[75,84,233],"2":[80],"3.":[89],"While":[90],"4":[95],"given":[97,158],"first":[98,113],"methotrexate":[99,223],"then":[101,115],"acid,":[103],"5":[108],"Results:":[117],"Light":[118],"microscopic":[119],"examination":[120],"revealed":[121],"sinusoidal":[122],"dilatation,":[123],"hepatocyte":[124],"degeneration,":[125],"vascular":[126],"congestion-thrombosis,":[127],"infiltration":[130],"livers":[133],"treated":[136],"with":[137],"observed":[141],"that":[142,200],"protective":[144,202],"effect":[145,203,212],"more":[150,208],"effective":[151],"than":[152,209],"its":[153],"treatment.":[154],"In":[155,194],"methotrexate,":[159],"level":[161,178],"oxidative":[163],"stress-related":[164],"parameters":[165,181],"such":[166,182],"lipid":[168],"hydroperoxide,":[169],"MPO":[170],"disulfide":[172,228],"increased":[173],"(p<":[174,191],"0.05),":[175],"whereas":[176],"antioxidant":[180],"native":[184],"thiol,":[185],"total":[186],"thiol":[187,227],"catalase":[189],"decreased":[190],"0.05).":[192],"Conclusion:":[193],"study,":[196],"it":[197,232],"determined":[199],"therapeutic":[211],"liver":[214],"damage":[215],"caused":[216,231],"by":[217],"Oxidative":[219],"hepatotoxicity":[220],"resulting":[221],"from":[222],"application":[224],"disrupted":[225],"balance":[229],"shift":[234],"favor":[236],"oxidation.":[238]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2021-06-22T00:00:00"}
