{"id":"https://openalex.org/W3168380458","doi":"https://doi.org/10.3390/cancers13112832","title":"Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications","display_name":"Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications","publication_year":2021,"publication_date":"2021-06-06","ids":{"openalex":"https://openalex.org/W3168380458","doi":"https://doi.org/10.3390/cancers13112832","mag":"3168380458","pmid":"https://pubmed.ncbi.nlm.nih.gov/34204148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8200981"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13112832","doi":"https://doi.org/10.3390/cancers13112832","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13112832","pdf_url":"https://www.mdpi.com/2072-6694/13/11/2832/pdf?version=1623059762","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/11/2832/pdf?version=1623059762","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":["Cancer Center, Zhejiang University, Hangzhou 310058, China","Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388575","display_name":"Lu Zhang","orcid":"https://orcid.org/0000-0001-8276-2604","observed_orcids":["https://orcid.org/0000-0001-8276-2604"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Zhang","raw_affiliation_strings":["Cancer Center, Zhejiang University, Hangzhou 310058, China","Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100703565","display_name":"Xiang Li","orcid":"https://orcid.org/0000-0003-1526-6103","observed_orcids":["https://orcid.org/0000-0003-1526-6103"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Li","raw_affiliation_strings":["Cancer Center, Zhejiang University, Hangzhou 310058, China","Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031338308","display_name":"Wei Zhuo","orcid":"https://orcid.org/0000-0002-8251-4210","observed_orcids":["https://orcid.org/0000-0002-8251-4210"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhuo","raw_affiliation_strings":["Cancer Center, Zhejiang University, Hangzhou 310058, China","Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China"],"raw_orcid":"https://orcid.org/0000-0002-8251-4210","affiliations":[{"raw_affiliation_string":"Cancer Center, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031338308"],"corresponding_institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":1.0173,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.741183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"13","issue":"11","first_page":"2832","last_page":"2832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5659999847412109},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.972000002861023},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.9309999942779541},{"id":"https://openalex.org/keywords/metastatic-colonization","display_name":"metastatic colonization","score":0.6470000147819519},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7739999890327454},{"id":"https://openalex.org/keywords/chromatin-release","display_name":"chromatin release","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.9046580791473389},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.693092942237854},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6509400010108948},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5622466802597046},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5355695486068726},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5038835406303406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4844420254230499},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4709288477897644},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.46628662943840027},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.4371234178543091},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4337008595466614},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37152737379074097},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32396799325942993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28915882110595703},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2634791135787964},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24719882011413574},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15651726722717285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers13112832","doi":"https://doi.org/10.3390/cancers13112832","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13112832","pdf_url":"https://www.mdpi.com/2072-6694/13/11/2832/pdf?version=1623059762","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8200981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8200981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:34204148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34204148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5c74b82228d9435f89552c7d42b8b937","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5c74b82228d9435f89552c7d42b8b937","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 2832, p 2832 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers13112832","doi":"https://doi.org/10.3390/cancers13112832","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13112832","pdf_url":"https://www.mdpi.com/2072-6694/13/11/2832/pdf?version=1623059762","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1684435528","display_name":null,"funder_award_id":"2021QNA7004","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G3315949569","display_name":null,"funder_award_id":"81972276","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3469407581","display_name":null,"funder_award_id":"31771540","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3979568098","display_name":null,"funder_award_id":"31771540, 81972276","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3168380458.pdf","grobid_xml":"https://content.openalex.org/works/W3168380458.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W1602299201","https://openalex.org/W1637737628","https://openalex.org/W1881900824","https://openalex.org/W1925096404","https://openalex.org/W1966774641","https://openalex.org/W1967539606","https://openalex.org/W1968562444","https://openalex.org/W1977521172","https://openalex.org/W1982906652","https://openalex.org/W1994606929","https://openalex.org/W2006986876","https://openalex.org/W2007897263","https://openalex.org/W2011491918","https://openalex.org/W2014678245","https://openalex.org/W2019210852","https://openalex.org/W2031474938","https://openalex.org/W2034808365","https://openalex.org/W2037265282","https://openalex.org/W2037435076","https://openalex.org/W2042633087","https://openalex.org/W2045819100","https://openalex.org/W2050975242","https://openalex.org/W2056112680","https://openalex.org/W2065663086","https://openalex.org/W2066544620","https://openalex.org/W2067216566","https://openalex.org/W2067716683","https://openalex.org/W2068992138","https://openalex.org/W2070117107","https://openalex.org/W2072545281","https://openalex.org/W2075207920","https://openalex.org/W2093756791","https://openalex.org/W2093921289","https://openalex.org/W2095917499","https://openalex.org/W2098610477","https://openalex.org/W2100568503","https://openalex.org/W2104934425","https://openalex.org/W2106351507","https://openalex.org/W2112543741","https://openalex.org/W2115848444","https://openalex.org/W2115959782","https://openalex.org/W2118217258","https://openalex.org/W2122039897","https://openalex.org/W2125910602","https://openalex.org/W2128350579","https://openalex.org/W2140995313","https://openalex.org/W2141074379","https://openalex.org/W2152502508","https://openalex.org/W2155542819","https://openalex.org/W2164304811","https://openalex.org/W2167661845","https://openalex.org/W2237361742","https://openalex.org/W2239871737","https://openalex.org/W2253526228","https://openalex.org/W2266814182","https://openalex.org/W2303309927","https://openalex.org/W2322353178","https://openalex.org/W2340990804","https://openalex.org/W2384327114","https://openalex.org/W2509901843","https://openalex.org/W2525715101","https://openalex.org/W2534066964","https://openalex.org/W2586679548","https://openalex.org/W2593144838","https://openalex.org/W2596133050","https://openalex.org/W2605998856","https://openalex.org/W2612492001","https://openalex.org/W2736959940","https://openalex.org/W2740782836","https://openalex.org/W2748091479","https://openalex.org/W2753229994","https://openalex.org/W2765467375","https://openalex.org/W2783257097","https://openalex.org/W2783462370","https://openalex.org/W2783550932","https://openalex.org/W2785265611","https://openalex.org/W2786765075","https://openalex.org/W2788388528","https://openalex.org/W2788640168","https://openalex.org/W2789788951","https://openalex.org/W2791575516","https://openalex.org/W2796081998","https://openalex.org/W2796704538","https://openalex.org/W2796883066","https://openalex.org/W2802307550","https://openalex.org/W2804578944","https://openalex.org/W2806058593","https://openalex.org/W2808850708","https://openalex.org/W2809459633","https://openalex.org/W2883240788","https://openalex.org/W2885534125","https://openalex.org/W2885977543","https://openalex.org/W2889256987","https://openalex.org/W2894451493","https://openalex.org/W2904189039","https://openalex.org/W2911027500","https://openalex.org/W2911167430","https://openalex.org/W2911633980","https://openalex.org/W2912740521","https://openalex.org/W2925230746","https://openalex.org/W2937032868","https://openalex.org/W2943815170","https://openalex.org/W2951616328","https://openalex.org/W2952233927","https://openalex.org/W2963309491","https://openalex.org/W2965111812","https://openalex.org/W2967611300","https://openalex.org/W2972917954","https://openalex.org/W2981524284","https://openalex.org/W2981949307","https://openalex.org/W2996672683","https://openalex.org/W3014062497","https://openalex.org/W3016135526","https://openalex.org/W3034318868","https://openalex.org/W3084567979","https://openalex.org/W3095540116","https://openalex.org/W3120670329","https://openalex.org/W3135674431","https://openalex.org/W4200608290"],"related_works":["https://openalex.org/W4413655221","https://openalex.org/W3190537188","https://openalex.org/W3089011735","https://openalex.org/W4225764500","https://openalex.org/W2988969090","https://openalex.org/W3084567979","https://openalex.org/W4294146548","https://openalex.org/W3198368127","https://openalex.org/W4412856481","https://openalex.org/W7134259484"],"abstract_inverted_index":{"Neutrophil":[0],"extracellular":[1,28],"trap":[2],"(NET)":[3],"formation":[4],"is":[5],"an":[6],"ability":[7],"of":[8,47,98,110],"neutrophils":[9],"to":[10],"capture":[11],"and":[12,24,37,80,84,117],"kill":[13],"pathogens":[14],"by":[15,34],"releasing":[16],"chromatin":[17],"scaffolds,":[18],"along":[19],"with":[20],"associated":[21],"cytotoxic":[22],"enzymes":[23],"proteases,":[25],"into":[26],"the":[27,95,101,108],"space.":[29],"NETs":[30,70,99,111],"are":[31,71],"usually":[32],"stimulated":[33],"pathogenic":[35],"microorganisms":[36],"their":[38],"products,":[39],"surgical":[40],"pressure":[41],"or":[42],"hypoxia.":[43],"Interestingly,":[44],"a":[45,113],"number":[46],"recent":[48],"studies":[49,67],"suggest":[50],"that":[51,69],"tumor":[52,62,88,102],"cells":[53],"can":[54],"induce":[55],"NET":[56],"formation,":[57],"which":[58],"in":[59,73,100],"turn":[60],"confers":[61],"cell":[63],"malignancy.":[64],"Notably,":[65],"emerging":[66],"indicate":[68],"involved":[72],"enhancing":[74],"local":[75],"invasion,":[76],"increasing":[77],"vascular":[78],"permeability":[79],"facilitating":[81],"immune":[82],"escape":[83],"colonization,":[85],"thus":[86],"promoting":[87],"metastasis.":[89],"In":[90],"this":[91],"article,":[92],"we":[93],"review":[94],"pivotal":[96],"roles":[97],"metastasis":[103],"cascade.":[104],"We":[105],"also":[106],"recapitulate":[107],"potential":[109],"as":[112],"cancer":[114],"prognostic":[115],"biomarker":[116],"therapeutic":[118],"target.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}