{"id":"https://openalex.org/W3168072005","doi":"https://doi.org/10.1159/000516368","title":"Safety of High-Dose Dabigatran in Elderly and Younger Patients with a Low Bleeding Risk: A Prospective Observational Study","display_name":"Safety of High-Dose Dabigatran in Elderly and Younger Patients with a Low Bleeding Risk: A Prospective Observational Study","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3168072005","doi":"https://doi.org/10.1159/000516368","mag":"3168072005","pmid":"https://pubmed.ncbi.nlm.nih.gov/34120112"},"language":"en","primary_location":{"id":"doi:10.1159/000516368","doi":"https://doi.org/10.1159/000516368","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000516368","pdf_url":null,"source":{"id":"https://openalex.org/S4210184113","display_name":"Cardiology","issn_l":"0008-6312","issn":["0008-6312","1421-9751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060817655","display_name":"Aharon Erez","orcid":"https://orcid.org/0000-0002-3561-5852","observed_orcids":["https://orcid.org/0000-0002-3561-5852"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aharon Erez","raw_affiliation_strings":["Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002486222","display_name":"Gregory Golovchiner","orcid":"https://orcid.org/0000-0002-2452-9510","observed_orcids":["https://orcid.org/0000-0002-2452-9510"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gregory Golovchiner","raw_affiliation_strings":["Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087690567","display_name":"Robert Klempfner","orcid":"https://orcid.org/0000-0002-7754-6736","observed_orcids":["https://orcid.org/0000-0002-7754-6736"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Robert Klempfner","raw_affiliation_strings":["Heart Institute, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Institute, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073347761","display_name":"Ehud Kadmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ehud Kadmon","raw_affiliation_strings":["Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005052215","display_name":"Gustavo Ruben Goldenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gustavo Ruben Goldenberg","raw_affiliation_strings":["Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103077830","display_name":"Ilan Goldenberg","orcid":"https://orcid.org/0000-0002-5806-3325","observed_orcids":["https://orcid.org/0000-0002-5806-3325"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilan Goldenberg","raw_affiliation_strings":["Clinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York, USA","Clinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"Clinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075060212","display_name":"Alon Barsheshet","orcid":"https://orcid.org/0000-0002-7219-9552","observed_orcids":["https://orcid.org/0000-0002-7219-9552"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alon Barsheshet","raw_affiliation_strings":["Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Rabin Medical Center, Petah-Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3349,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59742917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"146","issue":"5","first_page":"641","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dabigatran","display_name":"dabigatran","score":0.9829999804496765},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.925000011920929},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.7839999794960022},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.753000020980835},{"id":"https://openalex.org/keywords/has-bled-score","display_name":"HAS-BLED score","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.8349999785423279},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9440000057220459},{"id":"https://openalex.org/keywords/anticoagulation-safety","display_name":"anticoagulant safety","score":0.7730000019073486},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.8080000281333923},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8119999766349792},{"id":"https://openalex.org/keywords/systemic-embolism","display_name":"systemic embolism","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9281761050224304},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.8228999376296997},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.6823426485061646},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6578168869018555},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6386371850967407},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5758477449417114},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5512908697128296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5428845882415771},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5297191143035889},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5148298144340515},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4709625840187073},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.45118528604507446},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4221882224082947},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.1873970329761505},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.18217387795448303},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069604","descriptor_name":"Dabigatran","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000516368","doi":"https://doi.org/10.1159/000516368","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000516368","pdf_url":null,"source":{"id":"https://openalex.org/S4210184113","display_name":"Cardiology","issn_l":"0008-6312","issn":["0008-6312","1421-9751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology","raw_type":"journal-article"},{"id":"pmid:34120112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34120112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1829866114","https://openalex.org/W2064357176","https://openalex.org/W2080559678","https://openalex.org/W2136489990","https://openalex.org/W2292767717","https://openalex.org/W2943689861","https://openalex.org/W3023357416"],"related_works":["https://openalex.org/W2118322677","https://openalex.org/W2064357176","https://openalex.org/W2063976695","https://openalex.org/W2589092766","https://openalex.org/W3029547584","https://openalex.org/W7143344658","https://openalex.org/W4382052044","https://openalex.org/W2326219544","https://openalex.org/W4319069009","https://openalex.org/W2327440853"],"abstract_inverted_index":{"INTRODUCTION:":[0],"In":[1,70],"patients":[2,41,77,91,97,134,146,189,208,259],"with":[3,31,60,78,137,143,193,210,260],"atrial":[4],"fibrillation":[5],"(AF)":[6],"at":[7,36,158],"risk":[8,35,65,201],"for":[9,22,185,202,236],"stroke,":[10,112],"dabigatran":[11],"150":[12,247],"mg":[13,248],"twice":[14,249],"a":[15,57,120,196,250],"day":[16,251],"(DE150)":[17],"is":[18,27],"superior":[19],"to":[20,33,46,54,95],"warfarin":[21,55,174,211],"stroke":[23],"prevention.":[24],"However,":[25],"there":[26],"paucity":[28],"of":[29,50,89,109,123,160,166],"data":[30],"respect":[32],"bleeding":[34,64,117,262],"this":[37,71],"dose":[38],"in":[39,52,56,170,199],"elderly":[40,90,131,215,257],"(\u226575":[42],"years).":[43,100],"We":[44,86],"aimed":[45],"evaluate":[47],"the":[48,106,148,152,156,162,167,171,200,203,214,218],"safety":[49],"DE150":[51,172,194],"comparison":[53],"real-world":[58],"population":[59,220],"AF":[61,79,258],"and":[62,80,115,139,173,177,187,216,227],"low":[63,261],"(HAS-BLED":[66],"score":[67,82],"\u22642).":[68],"METHODS:":[69],"prospective":[72],"observational":[73],"study,":[74],"754":[75],"consecutive":[76],"HAS-BLED":[81],"\u22642":[83],"were":[84,128,135,141,191],"included.":[85],"compared":[87],"outcome":[88],"(age":[92,98],"\u226575":[93],"tears)":[94],"younger":[96,219],"<75":[99],"The":[101],"primary":[102,149],"end":[103,205],"point":[104,206],"was":[105,175],"combined":[107,168,204],"incidence":[108],"all-cause":[110],"mortality,":[111],"systemic":[113],"emboli,":[114],"major":[116],"event":[118,164],"during":[119,151],"mean":[121],"follow-up":[122],"1":[124],"year.":[125],"RESULTS:":[126],"There":[127],"230":[129],"(30%)":[130],"patients,":[132],"151":[133],"treated":[136,142,192,209],"warfarin,":[138],"79":[140],"DE150.":[144],"Fifty-two":[145],"experienced":[147],"endpoint":[150,169],"1-year":[153,159],"follow-up.":[154],"Among":[155],"elderly,":[157],"follow-up,":[161],"cumulative":[163],"rate":[165],"8.9":[176],"15.9%":[178],"respectively":[179,234],"(p":[180],"=":[181,225,229,239],"0.14).":[182],"After":[183],"adjustment":[184],"age":[186],"gender,":[188],"who":[190],"had":[195],"nonsignificant":[197],"difference":[198],"as":[207],"both":[212],"among":[213,217,256],"(HR":[221],"0.58,":[222],"95%":[223,231],"C.I":[224,232],"0.25-1.39":[226],"HR":[228],"1.12,":[230],"0.62-2.00,":[233],"[p":[235],"age-group-by-treatment":[237],"interaction":[238],"0.83).":[240],"CONCLUSIONS:":[241],"Our":[242],"results":[243],"suggest":[244],"that":[245],"Dabigatran":[246],"can":[252],"be":[253],"safely":[254],"used":[255],"risk.":[263]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-06-22T00:00:00"}
