{"id":"https://openalex.org/W3167944540","doi":"https://doi.org/10.1101/2021.06.29.450249","title":"Design, synthesis, and characterization of [ 18 F]mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2","display_name":"Design, synthesis, and characterization of [ 18 F]mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3167944540","doi":"https://doi.org/10.1101/2021.06.29.450249","mag":"3167944540"},"language":"en","primary_location":{"id":"doi:10.1101/2021.06.29.450249","doi":"https://doi.org/10.1101/2021.06.29.450249","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.29.450249","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/01/2021.06.29.450249.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/01/2021.06.29.450249.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025164190","display_name":"Gengyang Yuan","orcid":"https://orcid.org/0000-0003-4817-0052","observed_orcids":["https://orcid.org/0000-0003-4817-0052"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gengyang Yuan","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0003-4817-0052","affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043683105","display_name":"Ma\u00ebva Dhaynaut","orcid":"https://orcid.org/0000-0002-8529-5746","observed_orcids":["https://orcid.org/0000-0002-8529-5746"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maeva Dhaynaut","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0002-8529-5746","affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035181499","display_name":"Nicolas J. Guehl","orcid":"https://orcid.org/0000-0001-6876-8292","observed_orcids":["https://orcid.org/0000-0001-6876-8292"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas J. Guehl","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0001-6876-8292","affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sepideh Afshar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sepideh Afshar","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dalena Huynh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalena Huynh","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sung-Hyun Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung-Hyun Moon","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suhasini Iyengar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suhasini Iyengar","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hye Jin Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye Jin Kang","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27514, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27514, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041030878","display_name":"Mary Jo Ondrechen","orcid":"https://orcid.org/0000-0003-2456-4313","observed_orcids":["https://orcid.org/0000-0003-2456-4313"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Jo Ondrechen","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA"],"raw_orcid":"https://orcid.org/0000-0003-2456-4313","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053436378","display_name":"Georges El Fakhri","orcid":"https://orcid.org/0000-0002-9005-6993","observed_orcids":["https://orcid.org/0000-0002-9005-6993"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georges El Fakhri","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0002-9005-6993","affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083968212","display_name":"Marc D. Normandin","orcid":"https://orcid.org/0000-0003-1645-523X","observed_orcids":["https://orcid.org/0000-0003-1645-523X","https://orcid.org/0000-0001-9239-2600"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc D. Normandin","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011686386","display_name":"Anna\u2010Liisa Brownell","orcid":"https://orcid.org/0000-0002-3814-868X","observed_orcids":["https://orcid.org/0000-0002-3814-868X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna-Liisa Brownell","raw_affiliation_strings":["Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0002-3814-868X","affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011686386","https://openalex.org/A5025164190"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mglur2","display_name":"mGluR2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/triazolopyridines","display_name":"triazolopyridines","score":0.8059999942779541},{"id":"https://openalex.org/keywords/positive-allosteric-modulators","display_name":"positive allosteric modulators","score":0.9520000219345093},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.6169999837875366},{"id":"https://openalex.org/keywords/brain-receptor-imaging","display_name":"brain receptor imaging","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C119128870","wikidata":"https://www.wikidata.org/wiki/Q4859538","display_name":"Metabotropic glutamate receptor 2","level":5,"score":0.8531000018119812},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.746399998664856},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.7181000113487244},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.5735999941825867},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.5709999799728394},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.5591999888420105},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5449000000953674},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5253000259399414},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5103999972343445},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43290001153945923},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4146000146865845},{"id":"https://openalex.org/C200385062","wikidata":"https://www.wikidata.org/wiki/Q6594119","display_name":"Metabotropic glutamate receptor 3","level":5,"score":0.4018999934196472},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40119999647140503},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.392300009727478},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.3912000060081482},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.3495999872684479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3450999855995178},{"id":"https://openalex.org/C198684833","wikidata":"https://www.wikidata.org/wiki/Q2823748","display_name":"Specific activity","level":3,"score":0.3407999873161316},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C116592611","wikidata":"https://www.wikidata.org/wiki/Q21113349","display_name":"Metabotropic glutamate receptor 4","level":5,"score":0.32179999351501465},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.3068000078201294},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.2757999897003174},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.06.29.450249","doi":"https://doi.org/10.1101/2021.06.29.450249","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.29.450249","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/01/2021.06.29.450249.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.06.29.450249","doi":"https://doi.org/10.1101/2021.06.29.450249","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.29.450249","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/01/2021.06.29.450249.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6512338984","display_name":"Electronics Upgrade for 11.7 T","funder_award_id":"S10OD025234","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8182212443","display_name":"F-18 Synthesizer","funder_award_id":"S10RR023452","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3167944540.pdf","grobid_xml":"https://content.openalex.org/works/W3167944540.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1818204029","https://openalex.org/W1964643672","https://openalex.org/W1964699523","https://openalex.org/W1966710580","https://openalex.org/W1970840966","https://openalex.org/W1972722155","https://openalex.org/W1975691556","https://openalex.org/W1990535802","https://openalex.org/W1991483463","https://openalex.org/W1992038146","https://openalex.org/W2001980919","https://openalex.org/W2003736358","https://openalex.org/W2016798730","https://openalex.org/W2023434269","https://openalex.org/W2025944036","https://openalex.org/W2028046413","https://openalex.org/W2031090984","https://openalex.org/W2042255217","https://openalex.org/W2045861729","https://openalex.org/W2048709650","https://openalex.org/W2059233321","https://openalex.org/W2067795636","https://openalex.org/W2070437253","https://openalex.org/W2070624290","https://openalex.org/W2090187096","https://openalex.org/W2092869027","https://openalex.org/W2096036238","https://openalex.org/W2097444644","https://openalex.org/W2106042714","https://openalex.org/W2113113845","https://openalex.org/W2116386279","https://openalex.org/W2120743050","https://openalex.org/W2122532139","https://openalex.org/W2132405167","https://openalex.org/W2133179281","https://openalex.org/W2142635246","https://openalex.org/W2147197593","https://openalex.org/W2166241992","https://openalex.org/W2171826008","https://openalex.org/W2173841464","https://openalex.org/W2321363913","https://openalex.org/W2339380182","https://openalex.org/W2408148586","https://openalex.org/W2504181566","https://openalex.org/W2507959744","https://openalex.org/W2561153484","https://openalex.org/W2755237954","https://openalex.org/W2790426489","https://openalex.org/W2805731514","https://openalex.org/W2846351308","https://openalex.org/W2949495981","https://openalex.org/W2977883299","https://openalex.org/W3040497880","https://openalex.org/W3088183439","https://openalex.org/W3126665290","https://openalex.org/W4247985395","https://openalex.org/W4285719527","https://openalex.org/W4297503474"],"related_works":["https://openalex.org/W3126665290","https://openalex.org/W2319496949","https://openalex.org/W7146462956","https://openalex.org/W7208046274","https://openalex.org/W7208520964","https://openalex.org/W3088183439","https://openalex.org/W7028985976","https://openalex.org/W2904592169","https://openalex.org/W3086955810","https://openalex.org/W3173996646"],"abstract_inverted_index":{"ABSTRACT":[0],"An":[1],"array":[2],"of":[3,57,114,148,168,182,223],"triazolopyridines":[4],"based":[5],"on":[6],"JNJ-46356479":[7],"(":[8],"6":[9,54,209],")":[10],"were":[11,88],"synthesized":[12],"as":[13],"potential":[14,249],"PET":[15],"imaging":[16],"ligands":[17],"for":[18,154,253],"metabotropic":[19],"glutamate":[20],"receptor":[21],"2":[22],"(mGluR2)":[23],"in":[24,71,124,187,196,230],"the":[25,68,72,151,166,239,248],"brain.":[26],"The":[27],"selected":[28],"candidates":[29],"8":[30,59,82,118,159],"-":[31],"11":[32],"featured":[33],"an":[34,44,219],"enhanced":[35,150,220],"positive":[36],"allosteric":[37],"modulator":[38],"(PAM)":[39],"activity":[40,48,100],"(37-fold":[41],"max.)":[42,50],"and":[43,60,83,104,107,119,140,160,172,200],"apparent":[45],"mGluR2":[46],"agonist":[47],"(25-fold":[49],"compared":[51],"to":[52,176,218,250],"compound":[53],".":[55,210],"Radiolabeling":[56],"compounds":[58],"9":[61,87,123,135,164,186,227,246],"(also":[62],"named":[63],"mG2P026)":[64],"was":[65,236],"achieved":[66],"via":[67],"Cu(I)-mediated":[69],"radiofluorination":[70],"automated":[73],"TRACERLab":[74],"TM":[75],"FXF-N":[76],"platform.":[77],"Both":[78],"[":[79,84,115,120,132,156,161,183,206,224,243],"18":[80,85,116,121,133,157,162,184,207,225,244],"F]":[81,86,117,122,134,158,163,185,208,226,245],"obtained":[89],"with":[90,131,145,212,238],"satisfactory":[91],"radiochemical":[92,108],"yields":[93],"(>":[94,101,110],"5%,":[95],"non-decay":[96],"corrected),":[97],"high":[98,231],"molar":[99],"180":[102],"GBq/\u03bcmol),":[103],"excellent":[105,128],"chemical":[106],"purities":[109],"98%).":[111],"Preliminary":[112],"characterization":[113],"rats":[125],"confirmed":[126,191],"their":[127,177],"brain":[129,138,194,221],"permeability":[130],"showing":[136],"better":[137],"heterogeneity":[139,195],"favorable":[141],"binding":[142,204],"kinetics.":[143],"Pretreatment":[144,211],"different":[146],"classes":[147],"PAMs":[149],"radioactivity":[152],"uptake":[153,222,233],"both":[155],"at":[165],"regions":[167,234],"interest":[169],"by":[170,228],"20.3-40.9%":[171],"16.7-81.6%,":[173],"respectively,":[174],"due":[175],"pharmacological":[178],"effects.":[179],"Further":[180],"evaluation":[181],"a":[188],"nonhuman":[189],"primate":[190],"its":[192,201],"superior":[193],"mapping":[197],"mGlu2":[198],"receptors":[199],"higher":[202],"specific":[203],"than":[205],"0.5":[213],"mg/kg":[214],"BINA":[215],"led":[216],"(2)":[217],"3%":[229],"tracer":[232],"that":[235],"consistent":[237],"rat":[240],"studies.":[241,255],"Therefore,":[242],"has":[247],"be":[251],"translated":[252],"human":[254]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-06-22T00:00:00"}