{"id":"https://openalex.org/W3167749136","doi":"https://doi.org/10.3389/fcell.2021.640703","title":"Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions","display_name":"Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions","publication_year":2021,"publication_date":"2021-06-02","ids":{"openalex":"https://openalex.org/W3167749136","doi":"https://doi.org/10.3389/fcell.2021.640703","mag":"3167749136","pmid":"https://pubmed.ncbi.nlm.nih.gov/34150747","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8207294"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2021.640703","doi":"https://doi.org/10.3389/fcell.2021.640703","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.640703","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.640703/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.640703/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049507039","display_name":"Irina V. Lyadova","orcid":"https://orcid.org/0000-0003-3147-5386","observed_orcids":["https://orcid.org/0000-0003-3147-5386"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210122187","display_name":"Koltzov Institute of Developmental Biology","ror":"https://ror.org/02mh2cd26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210122187","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Irina Lyadova","raw_affiliation_strings":["Laboratory of Cellular and Molecular Basis of Histogenesis, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Basis of Histogenesis, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210122187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029401435","display_name":"Tatiana Gerasimova","orcid":"https://orcid.org/0000-0002-3858-4561","observed_orcids":["https://orcid.org/0000-0002-3858-4561"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210122187","display_name":"Koltzov Institute of Developmental Biology","ror":"https://ror.org/02mh2cd26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210122187","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana Gerasimova","raw_affiliation_strings":["Laboratory of Cellular and Molecular Basis of Histogenesis, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Basis of Histogenesis, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210122187"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089093211","display_name":"Tatiana A. Nenasheva","orcid":"https://orcid.org/0000-0002-1669-5244","observed_orcids":["https://orcid.org/0000-0002-1669-5244"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210122187","display_name":"Koltzov Institute of Developmental Biology","ror":"https://ror.org/02mh2cd26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210122187","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana Nenasheva","raw_affiliation_strings":["Laboratory of Cellular and Molecular Basis of Histogenesis, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Basis of Histogenesis, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210122187"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049507039"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210122187"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0392,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.72978986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"640703","last_page":"640703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.843999981880188},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/differentiation-trajectories","display_name":"differentiation trajectories","score":0.6200000047683716},{"id":"https://openalex.org/keywords/protocol-standardization","display_name":"protocol standardization","score":0.7099999785423279},{"id":"https://openalex.org/keywords/macrophage-therapy","display_name":"macrophage therapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6906815767288208},{"id":"https://openalex.org/C2910924664","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Human Induced Pluripotent Stem Cells","level":5,"score":0.6287781000137329},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5308440923690796},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.519556999206543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49834322929382324},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.49025705456733704},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.47902384400367737},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.4503379166126251},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44840362668037415},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.44214504957199097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3016928434371948},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.27242588996887207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11866331100463867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0718717873096466},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2021.640703","doi":"https://doi.org/10.3389/fcell.2021.640703","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.640703","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.640703/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8207294","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8207294","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:34150747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34150747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b0667da7af154ab5a96a50b8e81fb2cf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b0667da7af154ab5a96a50b8e81fb2cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2021.640703","doi":"https://doi.org/10.3389/fcell.2021.640703","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.640703","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.640703/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3846938467","display_name":null,"funder_award_id":"19-75-20176","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3167749136.pdf","grobid_xml":"https://content.openalex.org/works/W3167749136.grobid-xml"},"referenced_works_count":240,"referenced_works":["https://openalex.org/W70098085","https://openalex.org/W77986286","https://openalex.org/W78744612","https://openalex.org/W149295740","https://openalex.org/W184726500","https://openalex.org/W193519295","https://openalex.org/W266652616","https://openalex.org/W1518894239","https://openalex.org/W1520064365","https://openalex.org/W1593327493","https://openalex.org/W1603508604","https://openalex.org/W1627121503","https://openalex.org/W1641142612","https://openalex.org/W1696562329","https://openalex.org/W1772525525","https://openalex.org/W1797422316","https://openalex.org/W1861261316","https://openalex.org/W1901510837","https://openalex.org/W1932261119","https://openalex.org/W1934287581","https://openalex.org/W1957225075","https://openalex.org/W1965258554","https://openalex.org/W1965346184","https://openalex.org/W1972935344","https://openalex.org/W1973433801","https://openalex.org/W1973882186","https://openalex.org/W1974815398","https://openalex.org/W1976747229","https://openalex.org/W1977120253","https://openalex.org/W1977536320","https://openalex.org/W1978961715","https://openalex.org/W1980096700","https://openalex.org/W1981077232","https://openalex.org/W1986852869","https://openalex.org/W1986960611","https://openalex.org/W1990654511","https://openalex.org/W1990896527","https://openalex.org/W1995477411","https://openalex.org/W1995489322","https://openalex.org/W1997283164","https://openalex.org/W2001941062","https://openalex.org/W2003538143","https://openalex.org/W2005757388","https://openalex.org/W2006604617","https://openalex.org/W2008995006","https://openalex.org/W2010484682","https://openalex.org/W2010876644","https://openalex.org/W2011108652","https://openalex.org/W2011324987","https://openalex.org/W2011687861","https://openalex.org/W2011856955","https://openalex.org/W2014732115","https://openalex.org/W2015127296","https://openalex.org/W2015141049","https://openalex.org/W2017955228","https://openalex.org/W2018420076","https://openalex.org/W2019073526","https://openalex.org/W2020956724","https://openalex.org/W2023666964","https://openalex.org/W2024631759","https://openalex.org/W2024704592","https://openalex.org/W2025162592","https://openalex.org/W2025349474","https://openalex.org/W2025576061","https://openalex.org/W2030537668","https://openalex.org/W2033188260","https://openalex.org/W2033242304","https://openalex.org/W2034477306","https://openalex.org/W2036314082","https://openalex.org/W2036326354","https://openalex.org/W2039730578","https://openalex.org/W2046516822","https://openalex.org/W2048107295","https://openalex.org/W2048745419","https://openalex.org/W2050835562","https://openalex.org/W2050867439","https://openalex.org/W2053481440","https://openalex.org/W2055224823","https://openalex.org/W2055348159","https://openalex.org/W2056089399","https://openalex.org/W2057941074","https://openalex.org/W2058258787","https://openalex.org/W2059382129","https://openalex.org/W2065561900","https://openalex.org/W2066236572","https://openalex.org/W2075091190","https://openalex.org/W2077062756","https://openalex.org/W2081102375","https://openalex.org/W2081554709","https://openalex.org/W2081953211","https://openalex.org/W2087325416","https://openalex.org/W2087990669","https://openalex.org/W2092125592","https://openalex.org/W2093498435","https://openalex.org/W2094869608","https://openalex.org/W2095022753","https://openalex.org/W2095442157","https://openalex.org/W2096179876","https://openalex.org/W2098954540","https://openalex.org/W2099697301","https://openalex.org/W2099944775","https://openalex.org/W2100541459","https://openalex.org/W2100646399","https://openalex.org/W2109570573","https://openalex.org/W2114795812","https://openalex.org/W2115736737","https://openalex.org/W2115933858","https://openalex.org/W2121999038","https://openalex.org/W2124841332","https://openalex.org/W2126672295","https://openalex.org/W2127815991","https://openalex.org/W2127851311","https://openalex.org/W2130139077","https://openalex.org/W2130594874","https://openalex.org/W2131827027","https://openalex.org/W2132104888","https://openalex.org/W2135245626","https://openalex.org/W2136722399","https://openalex.org/W2138015041","https://openalex.org/W2139020188","https://openalex.org/W2139413110","https://openalex.org/W2140347191","https://openalex.org/W2143604401","https://openalex.org/W2144470070","https://openalex.org/W2146180782","https://openalex.org/W2148898943","https://openalex.org/W2149660935","https://openalex.org/W2151060192","https://openalex.org/W2151222524","https://openalex.org/W2153406260","https://openalex.org/W2155733789","https://openalex.org/W2156750162","https://openalex.org/W2165347529","https://openalex.org/W2167312662","https://openalex.org/W2175657468","https://openalex.org/W2176189120","https://openalex.org/W2197012898","https://openalex.org/W2197675272","https://openalex.org/W2280729002","https://openalex.org/W2301038687","https://openalex.org/W2301044272","https://openalex.org/W2306353815","https://openalex.org/W2400831006","https://openalex.org/W2403681274","https://openalex.org/W2405633121","https://openalex.org/W2409593987","https://openalex.org/W2464353788","https://openalex.org/W2467662596","https://openalex.org/W2468493734","https://openalex.org/W2474755764","https://openalex.org/W2506000063","https://openalex.org/W2514059345","https://openalex.org/W2518250200","https://openalex.org/W2530424978","https://openalex.org/W2543995928","https://openalex.org/W2566992148","https://openalex.org/W2575042032","https://openalex.org/W2575298708","https://openalex.org/W2595074661","https://openalex.org/W2604785806","https://openalex.org/W2610140032","https://openalex.org/W2614953780","https://openalex.org/W2617622088","https://openalex.org/W2620810594","https://openalex.org/W2625850243","https://openalex.org/W2626842659","https://openalex.org/W2728938210","https://openalex.org/W2735789032","https://openalex.org/W2736895630","https://openalex.org/W2745862042","https://openalex.org/W2752228441","https://openalex.org/W2760652497","https://openalex.org/W2763341318","https://openalex.org/W2763908993","https://openalex.org/W2765895857","https://openalex.org/W2773512909","https://openalex.org/W2780020548","https://openalex.org/W2783643850","https://openalex.org/W2784395700","https://openalex.org/W2791017844","https://openalex.org/W2794760100","https://openalex.org/W2795808866","https://openalex.org/W2795947971","https://openalex.org/W2799497345","https://openalex.org/W2803429166","https://openalex.org/W2810678423","https://openalex.org/W2857548536","https://openalex.org/W2860281242","https://openalex.org/W2884546223","https://openalex.org/W2888236179","https://openalex.org/W2888773054","https://openalex.org/W2888803570","https://openalex.org/W2889416980","https://openalex.org/W2889537463","https://openalex.org/W2890934004","https://openalex.org/W2897700340","https://openalex.org/W2898372731","https://openalex.org/W2898415660","https://openalex.org/W2901165948","https://openalex.org/W2902342830","https://openalex.org/W2903688784","https://openalex.org/W2905503365","https://openalex.org/W2913136103","https://openalex.org/W2915406286","https://openalex.org/W2915423594","https://openalex.org/W2939604020","https://openalex.org/W2945953423","https://openalex.org/W2951114798","https://openalex.org/W2952814417","https://openalex.org/W2956842366","https://openalex.org/W2966421713","https://openalex.org/W2972433621","https://openalex.org/W2972460919","https://openalex.org/W2974703082","https://openalex.org/W2974918809","https://openalex.org/W2981561237","https://openalex.org/W2981568852","https://openalex.org/W2981845755","https://openalex.org/W2982291259","https://openalex.org/W2982627553","https://openalex.org/W2986099211","https://openalex.org/W2991882421","https://openalex.org/W3005343507","https://openalex.org/W3006012565","https://openalex.org/W3008329795","https://openalex.org/W3015076075","https://openalex.org/W3017211376","https://openalex.org/W3018580939","https://openalex.org/W3023982717","https://openalex.org/W3024578227","https://openalex.org/W3031500693","https://openalex.org/W3033031190","https://openalex.org/W3039988661","https://openalex.org/W3044185459","https://openalex.org/W3049327133","https://openalex.org/W3086811648","https://openalex.org/W3092251037","https://openalex.org/W3092551009","https://openalex.org/W3100678887","https://openalex.org/W3132447645"],"related_works":["https://openalex.org/W4283158843","https://openalex.org/W4224251731","https://openalex.org/W4312195109","https://openalex.org/W2903688784","https://openalex.org/W7122704894","https://openalex.org/W2803429166","https://openalex.org/W4251843058","https://openalex.org/W4392267053","https://openalex.org/W4406052334","https://openalex.org/W3153767862"],"abstract_inverted_index":{"Macrophages":[0],"(M\u03c6)":[1],"derived":[2],"from":[3],"induced":[4],"pluripotent":[5],"stem":[6],"cells":[7,63],"(iMphs)":[8],"represent":[9],"a":[10,65,121,135,155],"novel":[11],"and":[12,20,22,49,61,76,103,109,124,161,170],"promising":[13],"model":[14],"for":[15,130,148],"studying":[16],"human":[17,41,152],"M\u03c6":[18,42],"function":[19],"differentiation":[21,87,101,166],"developing":[23],"new":[24],"therapeutic":[25],"strategies":[26],"based":[27],"on":[28],"or":[29],"oriented":[30],"at":[31],"M\u03c6s.":[32,51],"iMphs":[33,72,119],"have":[34],"several":[35],"advantages":[36,53],"over":[37],"the":[38,55,83,107,141,145,149,159,162,172],"traditionally":[39],"used":[40,91],"models,":[43],"such":[44],"as":[45],"immortalized":[46],"cell":[47],"lines":[48],"monocyte-derived":[50],"The":[52],"include":[54],"possibility":[56],"of":[57,71,85,106,111,151,158,174],"obtaining":[58,118],"genetically":[59],"identical":[60],"editable":[62],"in":[64,99,120,138],"potentially":[66],"scalable":[67],"way.":[68],"Various":[69],"applications":[70],"are":[73,89,128],"being":[74],"developed,":[75],"their":[77],"number":[78],"is":[79],"rapidly":[80],"growing.":[81],"However,":[82],"protocols":[84,108,167],"iMph":[86,100,132,165,175],"that":[88,115],"currently":[90,168],"vary":[92],"substantially,":[93],"which":[94],"may":[95],"lead":[96],"to":[97],"differences":[98,163],"trajectories":[102],"properties.":[104],"Standardization":[105],"identification":[110],"minimum":[112],"required":[113],"conditions":[114],"would":[116],"allow":[117],"large-scale,":[122],"inexpensive,":[123],"clinically":[125],"suitable":[126],"mode":[127],"needed":[129],"future":[131],"applications.":[133,176],"As":[134],"first":[136],"step":[137],"this":[139],"direction,":[140],"current":[142],"review":[143],"discusses":[144,171],"fundamental":[146],"basis":[147],"generation":[150],"iMphs,":[153],"performs":[154],"detailed":[156],"analysis":[157],"generalities":[160],"between":[164],"employed,":[169],"prospects":[173]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}
