{"id":"https://openalex.org/W3167728624","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.03594","title":"Assessing Gene Expression Patterns in Mouse Models to Test Hypotheses About Human Head Evolution","display_name":"Assessing Gene Expression Patterns in Mouse Models to Test Hypotheses About Human Head Evolution","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3167728624","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.03594","mag":"3167728624"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2021.35.s1.03594","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.03594","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2021.35.s1.03594","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2445/180296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Maria Rovira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Rovira","raw_affiliation_strings":["Universitat de Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat de Barcelona, Barcelona","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037293361","display_name":"Roger Mateu\u2010Estivill","orcid":"https://orcid.org/0000-0003-4728-2239","observed_orcids":["https://orcid.org/0000-0003-4728-2239"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roger Mateu","raw_affiliation_strings":["Universitat de Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat de Barcelona, Barcelona","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081902442","display_name":"Jaume Sastre Tomas","orcid":"https://orcid.org/0000-0001-9053-2390","observed_orcids":["https://orcid.org/0000-0001-9053-2390"]},"institutions":[{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaume Sastre","raw_affiliation_strings":["Universitat Illes Balears, Mallorca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat Illes Balears, Mallorca","institution_ids":["https://openalex.org/I50441567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001396411","display_name":"Alexandre Robert\u2010Moreno","orcid":"https://orcid.org/0000-0001-9042-1316","observed_orcids":["https://orcid.org/0000-0001-9042-1316"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alexandre Robert\u2010Moreno","raw_affiliation_strings":["EMBL Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Barcelona, Barcelona","institution_ids":["https://openalex.org/I4210097140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082631026","display_name":"Jim Swoger","orcid":"https://orcid.org/0000-0003-3805-0073","observed_orcids":["https://orcid.org/0000-0003-3805-0073"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jim Swoger","raw_affiliation_strings":["EMBL Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Barcelona, Barcelona","institution_ids":["https://openalex.org/I4210097140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077835125","display_name":"Susan M. Motch Perrine","orcid":"https://orcid.org/0000-0003-3412-221X","observed_orcids":["https://orcid.org/0000-0003-3412-221X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Motch Perrine","raw_affiliation_strings":["Pennsylvania State University, State College, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065793304","display_name":"Kazuhiko Kawasaki","orcid":"https://orcid.org/0000-0003-1090-5340","observed_orcids":["https://orcid.org/0000-0003-1090-5340"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiko Kawasaki","raw_affiliation_strings":["Pennsylvania State University, State College, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075973380","display_name":"James A. Sharpe","orcid":"https://orcid.org/0000-0002-1434-9743","observed_orcids":["https://orcid.org/0000-0002-1434-9743"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"James Sharpe","raw_affiliation_strings":["EMBL Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Barcelona, Barcelona","institution_ids":["https://openalex.org/I4210097140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015648857","display_name":"Joan T. Richtsmeier","orcid":"https://orcid.org/0000-0002-0239-5822","observed_orcids":["https://orcid.org/0000-0002-0239-5822"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Richtsmeier","raw_affiliation_strings":["Pennsylvania State University, State College, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030740506","display_name":"Neus Mart\u00ednez\u2010Abad\u00edas","orcid":"https://orcid.org/0000-0003-3061-2123","observed_orcids":["https://orcid.org/0000-0003-3061-2123"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Neus Mart\u00ednez\u2010Abad\u00edas","raw_affiliation_strings":["Universitat de Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat de Barcelona, Barcelona","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11367433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.41749998927116394,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/craniofacial-development","display_name":"craniofacial development","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":0.7620000243186951},{"id":"https://openalex.org/keywords/apert-syndrome","display_name":"Apert syndrome","score":0.921999990940094},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dusp6","display_name":"DUSP6","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hand2","display_name":"Hand2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression-patterns","display_name":"gene expression patterns","score":0.7799999713897705},{"id":"https://openalex.org/keywords/encephalization","display_name":"encephalization","score":0.9179999828338623},{"id":"https://openalex.org/keywords/midface-hypoplasia","display_name":"midface hypoplasia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6340000033378601},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7598685026168823},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.5815135836601257},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5699180960655212},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4956904649734497},{"id":"https://openalex.org/C168601633","wikidata":"https://www.wikidata.org/wiki/Q1044484","display_name":"Evolutionary developmental biology","level":2,"score":0.4487713873386383},{"id":"https://openalex.org/C185554395","wikidata":"https://www.wikidata.org/wiki/Q83944","display_name":"Human evolution","level":2,"score":0.44596636295318604},{"id":"https://openalex.org/C2779300802","wikidata":"https://www.wikidata.org/wiki/Q13147","display_name":"Skull","level":2,"score":0.43889322876930237},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42561736702919006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4064868986606598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39928314089775085},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21925261616706848}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.2021.35.s1.03594","doi":"https://doi.org/10.1096/fasebj.2021.35.s1.03594","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2021.35.s1.03594","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:diposit.ub.edu:2445/180296","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/180296","pdf_url":"http://hdl.handle.net/2445/180296","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ci\u00e8ncies Ambientals)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/180296","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/180296","pdf_url":"http://hdl.handle.net/2445/180296","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ci\u00e8ncies Ambientals)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7083190786","display_name":null,"funder_award_id":"NIDCR R01DE02298","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000243501","display_name":null,"funder_award_id":"NICHD P01HD078233","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3167728624.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3193922732","https://openalex.org/W2125218188","https://openalex.org/W2068346413","https://openalex.org/W7100518936","https://openalex.org/W2133285281","https://openalex.org/W7100144923","https://openalex.org/W2112302265","https://openalex.org/W149630771","https://openalex.org/W2161528222","https://openalex.org/W4280559782"],"abstract_inverted_index":{"Continuous":[0],"fossil":[1],"discoveries":[2],"and":[3,67,87,108,111,161,171,199,222,243,251,261,267,280,289,301,304,310,321,331,337],"recent":[4],"analysis":[5],"of":[6,24,36,60,74,83,136,173,208,217,235,239,312,354,374],"genomic":[7],"data":[8],"are":[9,247,275,345],"revealing":[10],"that":[11,28,98,124,246,272,293,305,328,358],"anatomically":[12],"modern":[13,228,375],"traits":[14,38],"evolved":[15,32,334],"following":[16],"a":[17,34,205,218,223],"complex":[18,368],"evolutionary":[19],"path.":[20],"Our":[21],"current":[22],"understanding":[23],"human":[25,85,146,376],"evolution":[26,82,216,373],"considers":[27],"the":[29,50,58,61,68,80,84,94,133,145,168,215,232,258,278,294,308,326,367,372],"skull":[30,86],"likely":[31,333],"as":[33,49,335],"mosaic":[35],"correlated":[37,317,338],"whose":[39],"development":[40,115],"is":[41,90,193],"in":[42,153,167,188,214,227,254,277,299,307,319,362,371],"turn":[43],"integrated":[44,81],"with":[45,195,282],"other":[46],"organs,":[47],"such":[48],"brain.":[51],"However,":[52],"we":[53,149],"still":[54],"know":[55],"little":[56],"about":[57,138],"complexity":[59],"genetic":[62,117],"networks":[63],"supervising":[64],"these":[65],"processes":[66,209],"developmental":[69,125,287],"mechanisms":[70],"underlying":[71],"observed":[72],"patterns":[73,97,176,234,357],"morphological":[75,141],"evolution.":[76],"To":[77],"further":[78],"understand":[79],"brain,":[88],"it":[89],"crucial":[91],"to":[92,102,112,164,211,340,350,365],"characterize":[93],"gene":[95,174,313,355],"expression":[96,175,233,314,356],"provide":[99,204],"detailed":[100],"instructions":[101],"organize":[103],"cell":[104],"behavior,":[105],"tissue":[106],"growth,":[107],"organ":[109],"patterning":[110],"investigate":[113],"how":[114,139],"translates":[116],"variation":[118],"into":[119],"phenotypic":[120],"variation.":[121],"We":[122,180,230,344],"propose":[123],"biology":[126],"analyses":[127,364],"using":[128],"mouse":[129,186],"models":[130],"can":[131,315,359],"enable":[132],"experimental":[134],"test":[135],"hypotheses":[137],"craniofacial":[140,252,322],"diversification":[142],"occurred":[143],"across":[144],"lineage.":[147],"Here,":[148],"combine":[150],"molecular":[151],"(Whole\u2010Mount":[152],"situ":[154],"Hybridization),":[155],"3D":[156],"imaging":[157],"(Optical":[158],"Projection":[159],"Tomography),":[160],"morphometric":[162],"techniques":[163],"assess":[165],"changes":[166,306,318],"space,":[169],"time,":[170],"intensity":[172,284],"during":[177],"embryonic":[178],"development.":[179],"used":[181,361],"Fgfr2":[182,191,240,259],"+/P253R":[183],"Apert":[184],"syndrome":[185],"models,":[187],"which":[189],"an":[190],"mutation":[192,260],"associated":[194],"midfacial":[196],"hypoplasia,":[197],"brachycephaly,":[198],"macrocephaly.":[200],"These":[201],"pathological":[202],"phenotypes":[203],"practical":[206],"model":[207],"similar":[210],"those":[212],"involved":[213],"large":[219],"globular":[220],"braincase":[221],"small,":[224],"retracted":[225],"face":[226,281,302],"humans.":[229],"compared":[231],"two":[236],"downstream":[237],"targets":[238],",":[241,245],"Dusp6":[242],"Hand2":[244],"relevant":[248],"for":[249],"brain":[250,279,300,320],"development,":[253],"25":[255],"mice":[256],"carrying":[257],"27":[262],"littermates":[263],"collected":[264],"between":[265],"E10.5":[266],"E11.5.":[268],"Qualitative":[269],"comparisons":[270],"revealed":[271],"both":[273],"genes":[274],"co\u2010expressed":[276],"variable":[283],"depending":[285],"on":[286],"time":[288],"genotype.":[290],"Results":[291],"suggest":[292],"FGF":[295],"signaling":[296,342],"pathway":[297],"participates":[298],"morphogenesis":[303],"location":[309],"timing":[311],"induce":[316],"systems.":[323],"This":[324],"supports":[325],"hypothesis":[327],"facial":[329],"retraction":[330],"encephalization":[332],"direct":[336],"responses":[339],"common":[341],"pathways.":[343],"testing":[346],"high":[347],"throughput":[348],"methods":[349],"produce":[351],"objective":[352],"quantifications":[353],"be":[360],"future":[363],"reveal":[366],"genotype\u2010phenotype":[369],"correspondence":[370],"traits.":[377]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-06-22T00:00:00"}