{"id":"https://openalex.org/W3167713143","doi":"https://doi.org/10.1042/bcj20200867","title":"PKA C\u03b2: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies","display_name":"PKA C\u03b2: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies","publication_year":2021,"publication_date":"2021-06-11","ids":{"openalex":"https://openalex.org/W3167713143","doi":"https://doi.org/10.1042/bcj20200867","mag":"3167713143","pmid":"https://pubmed.ncbi.nlm.nih.gov/34115095"},"language":"en","primary_location":{"id":"doi:10.1042/bcj20200867","doi":"https://doi.org/10.1042/bcj20200867","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bcj20200867","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045962448","display_name":"Susan Serota Taylor","orcid":"https://orcid.org/0000-0002-7702-6108","observed_orcids":["https://orcid.org/0000-0002-7702-6108"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan S. Taylor","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A","Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-7702-6108","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043793429","display_name":"Maximilian Wallbott","orcid":"https://orcid.org/0000-0002-7946-2579","observed_orcids":["https://orcid.org/0000-0002-7946-2579"]},"institutions":[{"id":"https://openalex.org/I106157433","display_name":"University of Kassel","ror":"https://ror.org/04zc7p361","country_code":"DE","type":"education","lineage":["https://openalex.org/I106157433"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Wallbott","raw_affiliation_strings":["Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany","institution_ids":["https://openalex.org/I106157433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027144841","display_name":"Erik M.F. Machal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106157433","display_name":"University of Kassel","ror":"https://ror.org/04zc7p361","country_code":"DE","type":"education","lineage":["https://openalex.org/I106157433"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erik M. F. Machal","raw_affiliation_strings":["Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany","institution_ids":["https://openalex.org/I106157433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073169189","display_name":"Kristoffer S\u00f8berg","orcid":"https://orcid.org/0000-0001-8010-2610","observed_orcids":["https://orcid.org/0000-0001-8010-2610"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristoffer S\u00f8berg","raw_affiliation_strings":["Department of Medical Genetics, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023282054","display_name":"Faihaa Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faihaa Ahmed","raw_affiliation_strings":["Department of Kinesiology, North Carolina A&T State University, Greensboro, NC, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, North Carolina A&T State University, Greensboro, NC, U.S.A","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109437219","display_name":"Jessica G. H. Bruystens","orcid":"https://orcid.org/0009-0000-8192-814X","observed_orcids":["https://orcid.org/0009-0000-8192-814X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Bruystens","raw_affiliation_strings":["Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069369328","display_name":"Lily Vu","orcid":"https://orcid.org/0000-0003-4444-1847","observed_orcids":["https://orcid.org/0000-0003-4444-1847"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Vu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Blaine Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaine Baker","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010230212","display_name":"Jian Wu","orcid":"https://orcid.org/0000-0002-8031-9462","observed_orcids":["https://orcid.org/0000-0002-8031-9462"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Wu","raw_affiliation_strings":["Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069978192","display_name":"Francesco Raimondi","orcid":"https://orcid.org/0000-0002-6891-3178","observed_orcids":["https://orcid.org/0000-0002-6891-3178"]},"institutions":[{"id":"https://openalex.org/I157210198","display_name":"Scuola Normale Superiore","ror":"https://ror.org/03aydme10","country_code":"IT","type":"education","lineage":["https://openalex.org/I157210198"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Raimondi","raw_affiliation_strings":["Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy","institution_ids":["https://openalex.org/I157210198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014221529","display_name":"Elimelda Moige Ongeri","orcid":"https://orcid.org/0000-0002-2963-4379","observed_orcids":["https://orcid.org/0000-0002-2963-4379"]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elimelda M. Ongeri","raw_affiliation_strings":["Department of Kinesiology, North Carolina A&T State University, Greensboro, NC, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, North Carolina A&T State University, Greensboro, NC, U.S.A","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006568947","display_name":"Friedrich W. Herberg","orcid":"https://orcid.org/0000-0001-7117-7653","observed_orcids":["https://orcid.org/0000-0001-7117-7653"]},"institutions":[{"id":"https://openalex.org/I106157433","display_name":"University of Kassel","ror":"https://ror.org/04zc7p361","country_code":"DE","type":"education","lineage":["https://openalex.org/I106157433"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedrich W. Herberg","raw_affiliation_strings":["Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7117-7653","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany","institution_ids":["https://openalex.org/I106157433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047437982","display_name":"Bj\u00f8rn Steen Sk\u00e5lhegg","orcid":"https://orcid.org/0000-0002-3481-8084","observed_orcids":["https://orcid.org/0000-0002-3481-8084"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Bj\u00f8rn S. Sk\u00e5lhegg","raw_affiliation_strings":["Division for Molecular Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division for Molecular Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5045962448"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.4797,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.42206428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"478","issue":"11","first_page":"2101","last_page":"2119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.07580000162124634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pka-catalytic-subunit","display_name":"PKA catalytic subunit","score":0.8679999709129333},{"id":"https://openalex.org/keywords/prkacb","display_name":"PRKACB","score":0.8209999799728394},{"id":"https://openalex.org/keywords/prkaca","display_name":"PRKACA","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pka-signaling","display_name":"PKA signaling","score":0.6340000033378601},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6959433555603027},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6532202363014221},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.626052975654602},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5663872361183167},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.518814742565155},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.4872106909751892},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4455116391181946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42859187722206116},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.42643308639526367},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4195474088191986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36054202914237976},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35558217763900757},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15674129128456116}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054751","descriptor_name":"Cyclic AMP-Dependent Protein Kinase Catalytic Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054751","descriptor_name":"Cyclic AMP-Dependent Protein Kinase Catalytic Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054751","descriptor_name":"Cyclic AMP-Dependent Protein Kinase Catalytic Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/bcj20200867","doi":"https://doi.org/10.1042/bcj20200867","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bcj20200867","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:34115095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34115095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:ricerca.sns.it:11384/158663","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11384/158663","pdf_url":null,"source":{"id":"https://openalex.org/S7407050981","display_name":"Scuola Normale Superiore di Pisa","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W69093701","https://openalex.org/W1485602922","https://openalex.org/W1551027803","https://openalex.org/W1576381397","https://openalex.org/W1576399086","https://openalex.org/W1580311327","https://openalex.org/W1584232738","https://openalex.org/W1585895556","https://openalex.org/W1593273547","https://openalex.org/W1606654234","https://openalex.org/W1671494447","https://openalex.org/W1698064934","https://openalex.org/W1739859666","https://openalex.org/W1771087982","https://openalex.org/W1938309912","https://openalex.org/W1951802364","https://openalex.org/W1966998035","https://openalex.org/W1968746042","https://openalex.org/W1969994632","https://openalex.org/W1974489853","https://openalex.org/W1983142061","https://openalex.org/W1986638333","https://openalex.org/W1991275732","https://openalex.org/W1991848000","https://openalex.org/W1994268275","https://openalex.org/W1996774458","https://openalex.org/W2000390423","https://openalex.org/W2008566951","https://openalex.org/W2010002190","https://openalex.org/W2011621143","https://openalex.org/W2013137419","https://openalex.org/W2018981978","https://openalex.org/W2018989596","https://openalex.org/W2019047965","https://openalex.org/W2020257412","https://openalex.org/W2020688327","https://openalex.org/W2020841780","https://openalex.org/W2023196077","https://openalex.org/W2030205108","https://openalex.org/W2034404899","https://openalex.org/W2035119251","https://openalex.org/W2037574869","https://openalex.org/W2040816499","https://openalex.org/W2043224156","https://openalex.org/W2046526895","https://openalex.org/W2054994243","https://openalex.org/W2055350432","https://openalex.org/W2055775683","https://openalex.org/W2056867084","https://openalex.org/W2059000943","https://openalex.org/W2067405360","https://openalex.org/W2071740910","https://openalex.org/W2076059393","https://openalex.org/W2079162518","https://openalex.org/W2083850374","https://openalex.org/W2085472231","https://openalex.org/W2094110989","https://openalex.org/W2098385481","https://openalex.org/W2098956821","https://openalex.org/W2109220072","https://openalex.org/W2113244737","https://openalex.org/W2113693290","https://openalex.org/W2128859932","https://openalex.org/W2136411301","https://openalex.org/W2141161860","https://openalex.org/W2141164230","https://openalex.org/W2141580692","https://openalex.org/W2148824141","https://openalex.org/W2149246103","https://openalex.org/W2157350553","https://openalex.org/W2162587289","https://openalex.org/W2162664608","https://openalex.org/W2166821607","https://openalex.org/W2408379892","https://openalex.org/W2604632658","https://openalex.org/W2738247688","https://openalex.org/W2746706484","https://openalex.org/W2754155872","https://openalex.org/W2801631623","https://openalex.org/W2891250762","https://openalex.org/W2941937232","https://openalex.org/W2943927579","https://openalex.org/W2944440933","https://openalex.org/W2953208604","https://openalex.org/W2982493618","https://openalex.org/W3010796541","https://openalex.org/W3080790767","https://openalex.org/W3087720566","https://openalex.org/W3090166145","https://openalex.org/W3092759671","https://openalex.org/W3113884781","https://openalex.org/W3134740672","https://openalex.org/W3140986746","https://openalex.org/W4322388712"],"related_works":["https://openalex.org/W2738247688","https://openalex.org/W1671494447","https://openalex.org/W7048150295","https://openalex.org/W1938309912","https://openalex.org/W4225398551","https://openalex.org/W1907152339","https://openalex.org/W2192682263","https://openalex.org/W2076144774","https://openalex.org/W2004173572","https://openalex.org/W1571272182"],"abstract_inverted_index":{"3',5'-cyclic":[0],"adenosine":[1],"monophosphate":[2],"(cAMP)":[3],"dependent":[4],"protein":[5,8,22],"kinase":[6,9],"or":[7],"A":[10],"(PKA)":[11],"has":[12],"served":[13],"as":[14,183],"a":[15,77,132,137],"prototype":[16],"for":[17,28,210],"the":[18,41,57,62,68,112,147,160,169,176],"large":[19],"family":[20],"of":[21,96,162],"kinases":[23],"that":[24,185,194],"are":[25,38,86,119,166,201],"crucially":[26],"important":[27],"signal":[29],"transduction":[30],"in":[31,76,108,122,146],"eukaryotic":[32],"cells.":[33,124],"The":[34,49,83,192],"PKA":[35],"catalytic":[36,134],"subunits":[37],"encoded":[39,140],"by":[40,141],"two":[42,53],"major":[43],"genes":[44,180],"PRKACA":[45,50,148,177],"and":[46,61,80,92,98,111,115,127,136,149,155,164,178,188,196],"PRKACB,":[47],"respectively.":[48,152],"gene":[51,70],"encodes":[52,71],"known":[54],"splice":[55,73,129,157,198],"variants,":[56],"ubiquitously":[58,103],"expressed":[59,64,75,121],"C\u03b11":[60,163],"sperm-specifically":[63],"C\u03b12.":[65],"In":[66],"contrast,":[67],"PRKACB":[69,150,179],"several":[72],"variants":[74,95,118,130,158],"highly":[78],"cell":[79],"tissue-specific":[81],"manner.":[82],"C\u03b2":[84,128,156,197],"proteins":[85],"called":[87],"C\u03b21,":[88],"C\u03b22,":[89],"C\u03b23,":[90,113],"C\u03b24":[91,114],"so-called":[93],"abc":[94,117],"C\u03b23":[97],"C\u03b24.":[99],"Whereas":[100],"C\u03b21":[101,165],"is":[102,106],"expressed,":[104],"C\u03b22":[105],"enriched":[107],"immune":[109],"cells":[110],"their":[116],"solely":[120],"neuronal":[123],"All":[125,153],"C\u03b1":[126,154,195],"share":[131],"kinase-conserved":[133],"core":[135],"C-terminal":[138],"tail":[139],"exons":[142],"2":[143],"through":[144],"10":[145],"genes,":[151],"with":[159,203],"exception":[161],"hyper-variable":[167],"at":[168],"N-terminus.":[170],"Here,":[171],"we":[172],"will":[173],"discuss":[174],"how":[175],"have":[181],"developed":[182],"paralogs":[184],"encode":[186],"distinct":[187],"functionally":[189],"non-redundant":[190],"proteins.":[191],"fact":[193],"variant":[199],"mutations":[200],"associated":[202],"numerous":[204],"diseases":[205],"further":[206],"opens":[207],"new":[208],"windows":[209],"PKA-induced":[211],"disease":[212],"pathologies.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-06-22T00:00:00"}
