{"id":"https://openalex.org/W3167584524","doi":null,"title":"TERT-dependent senescence and inflammation in ageing, using zebrafish as a model","display_name":"TERT-dependent senescence and inflammation in ageing, using zebrafish as a model","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3167584524","mag":"3167584524"},"language":"en","primary_location":{"id":"pmh:oai:etheses.whiterose.ac.uk:27790","doi":null,"is_oa":true,"landing_page_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","pdf_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014466425","display_name":"Raquel Rua Martins","orcid":"https://orcid.org/0000-0003-3952-8649","observed_orcids":["https://orcid.org/0000-0003-3952-8649"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Raquel R. Martins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3952-8649","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014466425"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.699999988079071},{"id":"https://openalex.org/keywords/visual-impairment","display_name":"visual impairment","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6589999794960022},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.5849999785423279},{"id":"https://openalex.org/keywords/diencephalon","display_name":"diencephalon","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":1.0},{"id":"https://openalex.org/keywords/retinal-regeneration","display_name":"retinal regeneration","score":0.7039999961853027},{"id":"https://openalex.org/keywords/zebrafish-model","display_name":"zebrafish model","score":0.7450000047683716},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8446567058563232},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7340314388275146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7175162434577942},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5855990648269653},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5551943182945251},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.5192115902900696},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5049453377723694},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5049105286598206},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.47293686866760254},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.47209686040878296},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.42648112773895264},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.42523109912872314},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.412602961063385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20789563655853271},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16399291157722473},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15798449516296387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1495041847229004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12746334075927734},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11627370119094849},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.whiterose.ac.uk:27790","doi":null,"is_oa":true,"landing_page_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","pdf_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3167584524","doi":null,"is_oa":false,"landing_page_url":"https://etheses.whiterose.ac.uk/27790/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.whiterose.ac.uk:27790","doi":null,"is_oa":true,"landing_page_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","pdf_url":"https://etheses.whiterose.ac.uk/27790/1/PhD%20thesis_Raquel%20Martins_161014804.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3167584524.pdf","grobid_xml":"https://content.openalex.org/works/W3167584524.grobid-xml"},"referenced_works_count":232,"referenced_works":["https://openalex.org/W1285309","https://openalex.org/W172046951","https://openalex.org/W239602587","https://openalex.org/W1491137616","https://openalex.org/W1502607570","https://openalex.org/W1515146347","https://openalex.org/W1516272650","https://openalex.org/W1541631182","https://openalex.org/W1545082774","https://openalex.org/W1558100964","https://openalex.org/W1570233039","https://openalex.org/W1574222693","https://openalex.org/W1588685142","https://openalex.org/W1772653906","https://openalex.org/W1793336671","https://openalex.org/W1963704214","https://openalex.org/W1965777905","https://openalex.org/W1970918274","https://openalex.org/W1970924670","https://openalex.org/W1971800922","https://openalex.org/W1975502679","https://openalex.org/W1977233815","https://openalex.org/W1977362098","https://openalex.org/W1979765208","https://openalex.org/W1981118528","https://openalex.org/W1981239255","https://openalex.org/W1982763980","https://openalex.org/W1984815704","https://openalex.org/W1987804790","https://openalex.org/W1988354925","https://openalex.org/W1989994721","https://openalex.org/W1993571663","https://openalex.org/W1994067034","https://openalex.org/W1994675927","https://openalex.org/W1994714027","https://openalex.org/W1995205742","https://openalex.org/W1997007011","https://openalex.org/W1998991620","https://openalex.org/W1999603779","https://openalex.org/W2004035417","https://openalex.org/W2004273407","https://openalex.org/W2004314923","https://openalex.org/W2004893579","https://openalex.org/W2006475219","https://openalex.org/W2010882280","https://openalex.org/W2013237968","https://openalex.org/W2013340612","https://openalex.org/W2013987722","https://openalex.org/W2014012238","https://openalex.org/W2014567183","https://openalex.org/W2015966587","https://openalex.org/W2016224014","https://openalex.org/W2018219363","https://openalex.org/W2020607530","https://openalex.org/W2021827510","https://openalex.org/W2022507419","https://openalex.org/W2023832732","https://openalex.org/W2024557782","https://openalex.org/W2024689857","https://openalex.org/W2026433865","https://openalex.org/W2027581280","https://openalex.org/W2030803494","https://openalex.org/W2031640082","https://openalex.org/W2033861401","https://openalex.org/W2037516621","https://openalex.org/W2038963685","https://openalex.org/W2039568446","https://openalex.org/W2042140414","https://openalex.org/W2042716686","https://openalex.org/W2042913858","https://openalex.org/W2043156370","https://openalex.org/W2043764151","https://openalex.org/W2044444301","https://openalex.org/W2044627868","https://openalex.org/W2046913611","https://openalex.org/W2047119143","https://openalex.org/W2047330128","https://openalex.org/W2050195517","https://openalex.org/W2051765035","https://openalex.org/W2051916393","https://openalex.org/W2053233241","https://openalex.org/W2053352181","https://openalex.org/W2057348944","https://openalex.org/W2057636635","https://openalex.org/W2058084688","https://openalex.org/W2058286861","https://openalex.org/W2060648351","https://openalex.org/W2061878632","https://openalex.org/W2063192538","https://openalex.org/W2063319656","https://openalex.org/W2063509106","https://openalex.org/W2065564965","https://openalex.org/W2066442023","https://openalex.org/W2070548807","https://openalex.org/W2072170174","https://openalex.org/W2075418806","https://openalex.org/W2078632611","https://openalex.org/W2078786713","https://openalex.org/W2079120654","https://openalex.org/W2081168739","https://openalex.org/W2081527689","https://openalex.org/W2084484454","https://openalex.org/W2084652820","https://openalex.org/W2085197755","https://openalex.org/W2085283725","https://openalex.org/W2085786821","https://openalex.org/W2086316954","https://openalex.org/W2086877549","https://openalex.org/W2087404852","https://openalex.org/W2088265599","https://openalex.org/W2091637792","https://openalex.org/W2096587251","https://openalex.org/W2096707864","https://openalex.org/W2097049162","https://openalex.org/W2101142880","https://openalex.org/W2104329724","https://openalex.org/W2104908670","https://openalex.org/W2106876162","https://openalex.org/W2107277218","https://openalex.org/W2108482850","https://openalex.org/W2108887402","https://openalex.org/W2109229110","https://openalex.org/W2112365416","https://openalex.org/W2112857608","https://openalex.org/W2113540542","https://openalex.org/W2114966893","https://openalex.org/W2115852450","https://openalex.org/W2117059102","https://openalex.org/W2118145895","https://openalex.org/W2124013587","https://openalex.org/W2127529642","https://openalex.org/W2127960841","https://openalex.org/W2129155846","https://openalex.org/W2130272241","https://openalex.org/W2130458932","https://openalex.org/W2131416478","https://openalex.org/W2131680380","https://openalex.org/W2135046848","https://openalex.org/W2139808613","https://openalex.org/W2140150317","https://openalex.org/W2140930678","https://openalex.org/W2141344358","https://openalex.org/W2143166286","https://openalex.org/W2150490516","https://openalex.org/W2153002514","https://openalex.org/W2156257249","https://openalex.org/W2156576736","https://openalex.org/W2158928937","https://openalex.org/W2159349156","https://openalex.org/W2159524064","https://openalex.org/W2159675211","https://openalex.org/W2162463187","https://openalex.org/W2163523630","https://openalex.org/W2163759450","https://openalex.org/W2164686456","https://openalex.org/W2165766480","https://openalex.org/W2167265200","https://openalex.org/W2170174281","https://openalex.org/W2173462178","https://openalex.org/W2180014160","https://openalex.org/W2180290202","https://openalex.org/W2261726127","https://openalex.org/W2263774645","https://openalex.org/W2266290735","https://openalex.org/W2266584572","https://openalex.org/W2273856223","https://openalex.org/W2276727190","https://openalex.org/W2294223443","https://openalex.org/W2321856601","https://openalex.org/W2345780203","https://openalex.org/W2402678912","https://openalex.org/W2411060299","https://openalex.org/W2440938456","https://openalex.org/W2476178591","https://openalex.org/W2508551815","https://openalex.org/W2511047441","https://openalex.org/W2512796610","https://openalex.org/W2530549727","https://openalex.org/W2537936919","https://openalex.org/W2539471741","https://openalex.org/W2544670169","https://openalex.org/W2558041282","https://openalex.org/W2565668513","https://openalex.org/W2577194681","https://openalex.org/W2591114726","https://openalex.org/W2593704665","https://openalex.org/W2596333106","https://openalex.org/W2606959512","https://openalex.org/W2607434574","https://openalex.org/W2626924766","https://openalex.org/W2735840980","https://openalex.org/W2737675606","https://openalex.org/W2740605299","https://openalex.org/W2749511637","https://openalex.org/W2749571447","https://openalex.org/W2761242899","https://openalex.org/W2766966419","https://openalex.org/W2769411350","https://openalex.org/W2783839013","https://openalex.org/W2784643190","https://openalex.org/W2787042069","https://openalex.org/W2788548733","https://openalex.org/W2791998898","https://openalex.org/W2792013802","https://openalex.org/W2792892933","https://openalex.org/W2794622099","https://openalex.org/W2799503867","https://openalex.org/W2801564203","https://openalex.org/W2802777894","https://openalex.org/W2889003642","https://openalex.org/W2889622838","https://openalex.org/W2890865075","https://openalex.org/W2891606407","https://openalex.org/W2898971660","https://openalex.org/W2900569176","https://openalex.org/W2901480087","https://openalex.org/W2906721882","https://openalex.org/W2916837254","https://openalex.org/W2921152928","https://openalex.org/W2928665623","https://openalex.org/W2944275008","https://openalex.org/W2950192924","https://openalex.org/W2950478324","https://openalex.org/W2953304144","https://openalex.org/W2966831529","https://openalex.org/W2974643180","https://openalex.org/W2982456513","https://openalex.org/W2990358987","https://openalex.org/W2995359774","https://openalex.org/W3002676854","https://openalex.org/W3007774565","https://openalex.org/W3015544530"],"related_works":["https://openalex.org/W4415620729","https://openalex.org/W4403777096","https://openalex.org/W2898971660","https://openalex.org/W2114375142","https://openalex.org/W2079850046","https://openalex.org/W2521070945","https://openalex.org/W7025578719","https://openalex.org/W4417147358","https://openalex.org/W2913076019","https://openalex.org/W2207476239"],"abstract_inverted_index":{"Uncovering":[0],"the":[1,6,22,55,71,75,78,89,132,155,175,187,193,196,203,218,235,246,256],"mechanisms":[2,56,67,151,271],"underlying":[3,57],"ageing":[4,69,236],"of":[5,44,68,182,215,227,248,253,265,272],"central":[7],"nervous":[8],"system":[9],"(CNS)":[10],"is":[11,24,241],"crucial":[12],"to":[13,17,64,123,148,152,161,167,243,275,281,288],"identify":[14,224],"therapeutic":[15,285],"targets":[16,286],"promote":[18],"healthy":[19],"ageing.":[20,295],"Although":[21],"CNS":[23],"considered":[25],"predominantly":[26],"post-mitotic,":[27],"it":[28],"has":[29,47],"been":[30],"suggested":[31],"that":[32,97,108,207],"telomerase,":[33],"mostly":[34],"known":[35],"for":[36],"its":[37,118],"role":[38,50,212],"in":[39,70,74,111,121,139,154,186,195,202,217,231,234,255],"cell":[40],"division":[41],"through":[42],"maintenance":[43],"telomere":[45],"length,":[46],"a":[48,112,145,164,210,225,278],"protective":[49,211],"against":[51,213],"cellular":[52],"senescence.":[53],"However,":[54],"this":[58,177,261],"remain":[59],"unclear.":[60],"Here,":[61,221],"I":[62,83,222],"aimed":[63],"determine":[65],"telomerase-dependent":[66,268],"CNS,":[72],"particularly":[73],"retina":[76,100,135,290],"and":[77,102,107,189,269,291],"brain.":[79,220,259],"To":[80],"do":[81],"so,":[82],"used":[84],"wild-type":[85],"zebrafish":[86,92,98,134,143,258,276],"alongside":[87],"with":[88,105,192,294],"telomerase-mutant":[90],"(tert-/-)":[91],"model.":[93],"\\nThis":[94],"study":[95,178],"shows":[96,179],"display":[99],"degeneration":[101,293],"visual":[103],"impairment":[104],"ageing,":[106,159,273],"these":[109,198,249],"occur":[110],"telomerase":[113],"independent":[114,270],"manner.":[115],"Despite":[116],"preserving":[117],"regenerative":[119],"capacity":[120],"response":[122],"acute":[124],"damage":[125],"until":[126],"old":[127],"ages,":[128],"rather":[129],"than":[130],"regeneration,":[131],"aged":[133,219,257],"undergoes":[136],"gliosis,":[137],"like":[138],"humans.":[140],"This":[141],"highlights":[142],"as":[144,163,277],"suitable":[146],"model":[147,280],"explore":[149,168,283],"relevant":[150],"neurodegeneration":[153],"human":[156],"retina,":[157,194],"during":[158],"pointing":[160,274],"gliosis":[162],"key":[165],"target":[166],"endogenous":[169],"regeneration":[170],"mechanisms.":[171],"\\nWhen":[172],"looking":[173],"at":[174],"brain,":[176,197,237],"an":[180],"accumulation":[181,214,252],"senescence":[183,216,233,254],"markers,":[184],"specifically":[185],"diencephalon":[188],"cerebellum.":[190],"Contrasting":[191],"hallmarks":[199],"were":[200],"accelerated":[201],"tert-/-":[204],"model,":[205],"suggesting":[206],"TERT":[208],"exerts":[209],"also":[223],"set":[226],"genes":[228,250],"potentially":[229],"involved":[230],"TERT-dependent":[232],"but":[238],"further":[239,282],"investigation":[240,266],"required":[242],"test":[244],"whether":[245],"expression":[247],"delay":[251],"\\nTogether,":[260],"opens":[262],"new":[263],"lines":[264],"on":[267],"valuable":[279],"potential":[284],"aiming":[287],"ameliorate":[289],"brain":[292]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-06-22T00:00:00"}
